Uitslagenmatrix
| ALM | CAM | DBO | DOR | EIN | EXC | GOA | GRA | HEL | JAJ | JAZ | JPS | JUT | MVV | NAC | NEC | ROD | TEL | TOP | VOL | |
| Almere City FC | * | |||||||||||||||||||
| SC Cambuur | * | |||||||||||||||||||
| FC Den Bosch | * | |||||||||||||||||||
| FC Dordrecht | * | |||||||||||||||||||
| FC Eindhoven | * | |||||||||||||||||||
| Excelsior | * | |||||||||||||||||||
| Go Ahead Eagles | * | |||||||||||||||||||
| De Graafschap | * | |||||||||||||||||||
| Helmond Sport | * | |||||||||||||||||||
| Jong Ajax | * | |||||||||||||||||||
| Jong AZ Alkmaar | * | |||||||||||||||||||
| Jong PSV | * | |||||||||||||||||||
| Jong FC Utrecht | * | |||||||||||||||||||
| MVV Maastricht | * | |||||||||||||||||||
| NAC Breda | * | |||||||||||||||||||
| NEC | * | |||||||||||||||||||
| Roda JC Kerkrade | * | |||||||||||||||||||
| Telstar | * | |||||||||||||||||||
| TOP Oss | * | |||||||||||||||||||
| FC Volendam | * |
Wedstrijden
Uitslagenmatrix
| ALM | CAM | DBO | DOR | EIN | GOA | HEL | JAJ | JAZ | JPS | JUT | MVV | NEC | RKC | ROD | SPA | TEL | TOP | TWE | VOL | |
| Almere City FC | * | 2-1 | 3-1 | 1-1 | 2-0 | 0-1 | 3-0 | 2-3 | 2-0 | 2-1 | 3-1 | 2-2 | 1-0 | 2-1 | 1-2 | 1-3 | 2-0 | 3-0 | 1-3 | 0-2 |
| SC Cambuur | 0-1 | * | 2-0 | 1-3 | 1-3 | 1-1 | 3-1 | 2-1 | 2-1 | 3-1 | 4-1 | 4-1 | 1-1 | 2-0 | 0-1 | 3-3 | 2-0 | 0-0 | 0-1 | 1-1 |
| FC Den Bosch | 1-4 | 1-1 | * | 1-0 | 3-1 | 2-0 | 3-0 | 1-1 | 3-1 | 3-1 | 2-2 | 1-2 | 3-2 | 2-3 | 2-0 | 1-1 | 3-4 | 3-0 | 2-1 | 1-1 |
| FC Dordrecht | 3-2 | 2-1 | 2-6 | * | 0-3 | 1-3 | 0-0 | 3-3 | 1-1 | 1-3 | 1-2 | 1-1 | 2-2 | 2-0 | 3-1 | 1-4 | 1-4 | 0-1 | 0-2 | 1-2 |
| FC Eindhoven | 0-2 | 2-2 | 2-0 | 8-1 | * | 1-2 | 2-1 | 1-1 | 0-1 | 1-2 | 0-0 | 0-1 | 3-2 | 1-3 | 1-2 | 0-0 | 1-2 | 2-1 | 1-1 | 1-1 |
| Go Ahead Eagles | 2-1 | 2-0 | 0-0 | 2-1 | 0-1 | * | 1-0 | 2-1 | 1-0 | 2-1 | 5-0 | 2-0 | 4-4 | 1-4 | 3-0 | 2-2 | 2-3 | 0-1 | 1-2 | 3-0 |
| Helmond Sport | 1-2 | 0-1 | 0-2 | 1-2 | 2-1 | 1-1 | * | 1-3 | 1-3 | 0-2 | 2-0 | 1-1 | 2-3 | 0-2 | 4-0 | 3-0 | 1-2 | 0-4 | 2-2 | 2-2 |
| Jong Ajax | 8-0 | 0-6 | 2-2 | 5-2 | 0-3 | 5-2 | 2-0 | * | 1-1 | 2-2 | 3-3 | 0-1 | 4-0 | 2-1 | 5-1 | 2-0 | 3-0 | 1-0 | 2-5 | 1-3 |
| Jong AZ | 2-3 | 2-1 | 0-0 | 0-1 | 1-2 | 3-2 | 2-2 | 0-1 | * | 0-0 | 2-2 | 2-3 | 4-0 | 2-4 | 1-1 | 3-2 | 0-2 | 1-3 | 1-2 | 1-1 |
| Jong PSV | 5-2 | 1-2 | 0-1 | 2-2 | 2-1 | 5-1 | 1-1 | 2-1 | 3-1 | * | 3-1 | 2-2 | 1-2 | 2-1 | 2-2 | 2-0 | 2-0 | 3-1 | 0-2 | 1-0 |
| Jong FC Utrecht | 0-2 | 0-0 | 1-1 | 4-1 | 1-3 | 2-4 | 1-1 | 4-3 | 1-3 | 3-2 | * | 0-0 | 1-2 | 1-2 | 1-2 | 1-5 | 0-1 | 1-2 | 1-6 | 3-1 |
| MVV Maastricht | 1-1 | 1-2 | 0-3 | 2-1 | 1-1 | 1-2 | 3-0 | 1-0 | 1-1 | 2-2 | 4-2 | * | 1-1 | 1-4 | 2-0 | 0-2 | 2-0 | 0-2 | 0-2 | 1-1 |
| NEC | 5-0 | 2-2 | 5-0 | 1-0 | 0-1 | 1-1 | 3-2 | 1-2 | 3-1 | 4-4 | 4-1 | 0-1 | * | 2-1 | 1-0 | 1-1 | 1-1 | 1-5 | 4-0 | 5-1 |
| RKC Waalwijk | 0-1 | 0-2 | 2-1 | 4-4 | 3-1 | 1-3 | 2-1 | 4-1 | 2-2 | 3-5 | 3-2 | 3-1 | 1-0 | * | 0-1 | 0-1 | 1-0 | 0-0 | 4-1 | 3-3 |
| Roda JC Kerkrade | 1-2 | 1-0 | 0-2 | 2-2 | 0-0 | 3-1 | 3-0 | 2-1 | 6-2 | 2-3 | 2-1 | 2-2 | 2-3 | 0-0 | * | 1-1 | 3-0 | 1-1 | 1-1 | 2-1 |
| Sparta Rotterdam | 6-1 | 3-0 | 2-0 | 3-2 | 2-0 | 6-1 | 3-1 | 2-2 | 5-0 | 0-0 | 4-2 | 2-0 | 1-0 | 2-1 | 2-2 | * | 3-2 | 1-4 | 0-3 | 2-0 |
| Telstar | 1-1 | 4-2 | 1-4 | 1-0 | 1-1 | 2-1 | 1-1 | 0-2 | 1-0 | 2-4 | 2-0 | 0-1 | 0-3 | 0-3 | 4-0 | 1-1 | * | 1-0 | 1-3 | 1-1 |
| TOP Oss | 2-0 | 1-3 | 0-1 | 1-0 | 2-0 | 1-0 | 1-1 | 2-1 | 1-0 | 4-1 | 2-1 | 1-3 | 1-1 | 1-2 | 0-5 | 0-0 | 1-0 | * | 0-2 | 0-0 |
| FC Twente | 1-0 | 2-2 | 1-0 | 0-1 | 1-0 | 0-1 | 4-1 | 2-5 | 0-0 | 2-1 | 1-0 | 0-1 | 2-0 | 3-1 | 3-1 | 2-1 | 1-0 | 1-2 | * | 5-0 |
| FC Volendam | 2-2 | 0-1 | 1-2 | 3-4 | 1-3 | 0-1 | 1-0 | 3-1 | 1-1 | 0-3 | 2-0 | 3-2 | 2-3 | 1-0 | 1-1 | 2-2 | 1-0 | 0-0 | 1-2 | * |
Eindstand
| 1 | FC Twente * ♦ | 38 | 25 | 5 | 8 | 80 | 72 | 39 | + 33 |
| 2 | Sparta Rotterdam + ♦ | 38 | 19 | 12 | 7 | 69 | 78 | 47 | + 31 |
| 3 | Jong PSV | 38 | 18 | 9 | 11 | 63 | 77 | 59 | + 18 |
| 4 | FC Den Bosch + | 38 | 18 | 9 | 11 | 63 | 64 | 49 | + 15 |
| 5 | Go Ahead Eagles + | 38 | 19 | 6 | 13 | 63 | 63 | 57 | + 6 |
| 6 | TOP Oss + | 38 | 18 | 8 | 12 | 62 | 48 | 40 | + 8 |
| 7 | Almere City FC + | 38 | 19 | 5 | 14 | 62 | 60 | 63 | −3 |
| 8 | RKC Waalwijk + ♦ | 38 | 18 | 5 | 15 | 59 | 69 | 57 | + 12 |
| 9 | NEC + | 38 | 16 | 10 | 12 | 58 | 73 | 60 | + 13 |
| 10 | SC Cambuur + | 38 | 16 | 10 | 12 | 58 | 61 | 48 | + 13 |
| 11 | Jong Ajax | 38 | 16 | 8 | 14 | 56 | 81 | 67 | + 14 |
| 12 | MVV Maastricht | 38 | 14 | 12 | 12 | 54 | 49 | 53 | −4 |
| 13 | Roda JC Kerkrade | 38 | 14 | 11 | 13 | 53 | 57 | 59 | −2 |
| 14 | FC Eindhoven | 38 | 13 | 9 | 16 | 48 | 52 | 48 | + 4 |
| 15 | Telstar | 38 | 14 | 6 | 18 | 48 | 45 | 58 | −13 |
| 16 | FC Volendam | 38 | 9 | 14 | 15 | 41 | 46 | 62 | −16 |
| 17 | FC Dordrecht | 38 | 9 | 9 | 20 | 36 | 54 | 84 | −30 |
| 18 | Jong AZ | 38 | 7 | 12 | 19 | 33 | 46 | 67 | −21 |
| 19 | Jong FC Utrecht | 38 | 5 | 8 | 25 | 23 | 47 | 90 | −43 |
| 20 | Helmond Sport | 38 | 4 | 10 | 24 | 22 | 37 | 72 | −35 |
Wedstrijden
| R | Datum: | Thuis: | Uit: | Sc.: | Ts.: | Ar: | Details: |
|---|---|---|---|---|---|---|---|
| 1 | 17/08/2018 | FC Volendam | FC Den Bosch | 1-2 | 2.757 | Oostrom | 1-0 Veerman, 1-1 Bouyaghlafen, 1-2 Sappinen |
| 1 | 17/08/2018 | FC Dordrecht | Helmond Sport | 0-0 | 2.445 | Vd Eijk | |
| 1 | 17/08/2018 | RKC Waalwijk | Telstar | 1-0 | 2.448 | Gerrets | 1-0 Hansson |
| 1 | 17/08/2018 | MVV Maastricht | TOP Oss | 0-2 | 4.714 | Teuben | 0-1 en 0-2 Dogan |
| 1 | 17/08/2018 | Go Ahead Eagles | Jong FC Utrecht | 5-0 | 7.812 | Perez | 1-0 Van der Venne, 2-0 Bosz, 3-0 Verheijdt, 4-0 Pouwels, 5-0 Van Moorsel |
| 1 | 17/08/2018 | NEC | SC Cambuur | 2-2 | 9.888 | Bax | 1-0 Achahbar, 2-0 Braken, 2-1 Sturing (e.d.), 2-2 Mbende |
| 1 | 17/08/2018 | Roda JC Kerkrade | Jong Ajax | 2-1 | 7.692 | Vd Graaf | 1-0 Engels, 1-1 Ekkelenkamp, 2-1 Engels |
| 1 | 17/08/2018 | FC Twente | Sparta Rotterdam | 2-1 | 27.200 | Kamphuis | 1-0 Bapoh, 1-1 Veldwijk, 2-1 Boere (pen) |
| 1 | 17/08/2018 | Jong PSV | FC Eindhoven | 2-1 | 1.523 | Ruperti | 0-1 Van der Heyden, 1-1 Verreth, 2-1 Teze |
| 1 | 20/08/2018 | Jong AZ | Almere City FC | 2-3 | 700 | Van Herk | 0-1 Vossebelt, 0-2 Receveur, 0-3 Meijer, 1-3 Reijnders, 2-3 Druijf; R: Seck (Alm) |
| 2 | 24/08/2018 | SC Cambuur | Jong AZ | 2-1 | 6.422 | Mulder | 1-0 Mathieu. 1-1 Druijf (pen), 2-1 Rossi |
| 2 | 24/08/2018 | Sparta Rotterdam | FC Volendam | 2-0 | 9.213 | Vd Graaf | 1-0 en 2-0 Dervisoglu |
| 2 | 24/08/2018 | FC Den Bosch | RKC Waalwijk | 2-3 | 3.126 | Vd Eijk | 1-0 Beltrame, 1-1 Lammers, 2-1 Sappinen, 2-2 en 2-3 Bilate |
| 2 | 24/08/2018 | TOP Oss | Jong PSV | 4-1 | 2.431 | Bijl | 1-0 Nieveld, 2-0 Dogan, 2-1 Lundqvist (pen), 3-1 Dogan (pen), 4-1 Smeets |
| 2 | 24/08/2018 | Almere City FC | Roda JC Kerkrade | 1-2 | 1.955 | Vd Kerkhof | 0-1 Engels, 1-1 Calcan, 1-2 Engels |
| 2 | 24/08/2018 | Telstar | MVV Maastricht | 0-1 | 2.114 | Dieperink | 0-1 Schroyen; R: Lopes Cabral (Tel) |
| 2 | 24/08/2018 | Jong Ajax | FC Dordrecht | 5-2 | 518 | Van Herk | 1-0 en 2-0 (pen) Sierhuis, 2-1 Kok, 3-1 Nunnely, 4-1 en 5-1 Pereira, 5-2 Maletic |
| 2 | 24/08/2018 | FC Eindhoven | Go Ahead Eagles | 1-2 | 2.109 | Blank | 0-1 Bakx, 1-1 Lopes, 1-2 Van der Venne R: Idzes (Ein), Lelieveld (GoA) |
| 2 | 24/08/2018 | Helmond Sport | FC Twente | 2-2 | 2.634 | Van Boekel | 1-0 Zeldenrust, 1-1 Boere (pen), 2-1 Meijers, 2-2 Oosterwijk |
| 2 | 27/08/2018 | Jong FC Utrecht | NEC | 1-2 | 951 | Kooij | 1-0 Venema, 1-1 Achahbar, 1-2 Braken |
| 3 | 31/08/2018 | RKC Waalwijk | Sparta Rotterdam | 0-1 | 2.493 | Blank | 0-1 Rayhi |
| 3 | 31/08/2018 | MVV Maastricht | Go Ahead Eagles | 1-2 | 4.764 | Bax | 1-0 Mares, 1-1 Van der Venne, 1-2 Pouwels R: Gunst (MVV) |
| 3 | 31/08/2018 | FC Den Bosch | Jong Ajax | 1-1 | 2.837 | C. Mulder | 1-0 Beltrame, 1-1 Ekkelenkamp R: Bouyaghlafen (DBo) |
| 3 | 31/08/2018 | NEC | FC Dordrecht | 1-0 | 9.631 | Martens | 1-0 Achahbar |
| 3 | 31/08/2018 | TOP Oss | SC Cambuur | 1-3 | 1.412 | Ruperti | 1-0 Smeets, 1-1, 1-2 en 1-3 Rossi |
| 3 | 31/08/2018 | FC Twente | Roda JC Kerkrade | 3-1 | 26.000 | S. Mulder | 0-1 Paulissen, 1-1 Hölscher, 2-1 Boere (pen), 3-1 Bapoh |
| 3 | 31/08/2018 | FC Volendam | Jong AZ | 1-1 | 1.500 | Bijl | 1-0 Ten Den, 1-1 Druijf |
| 3 | 31/08/2018 | Telstar | Jong FC Utrecht | 2-0 | 1.870 | Oostrom | 1-0 Lescano (pen), 2-0 Van Huizen |
| 3 | 31/08/2018 | FC Eindhoven | Almere City FC | 0-2 | 1.500 | Gerrets | 0-1 Vossebelt, 0-2 Calcan; R: Daniëls (Ein) |
| 3 | 31/08/2018 | Jong PSV | Helmond Sport | 1-1 | 472 | Nagtegaal | 1-0 Abels, 1-1 Verkennis |
| 4 | 07/09/2018 | SC Cambuur | RKC Waalwijk | 2-0 | 7.381 | Van Herk | 1-0 Rossi, 2-0 Mathieu |
| 4 | 07/09/2018 | Sparta Rotterdam | FC Eindhoven | 2-0 | 8.823 | Perez | 1-0 Drenthe, 2-0 Auassar |
| 4 | 07/09/2018 | FC Dordrecht | Telstar | 1-4 | 1.532 | Bijl | 0-1 Stankov (e.d.), 1-1 Maletic, 1-2 en 1-3 Saegal, 1-4 Lescano |
| 4 | 07/09/2018 | Go Ahead Eagles | FC Volendam | 3-0 | 8.819 | Vd Eijk | 1-0 Dzepar, 2-0 Navratil, 3-0 Verheijdt |
| 4 | 07/09/2018 | Almere City FC | MVV Maastricht | 2-2 | 1.948 | Blank | 0-1 Van den Hurk, 1-1 Calcan, 2-1 Van den Hurk (e.d.), 2-2 Nys |
| 4 | 07/09/2018 | Jong FC Utrecht | Jong PSV | 3-2 | 342 | Vd Laan | 1-0 Hilterman, 1-1 Lundqvist, 2-1 Venema, 2-2 Verreth, 3-2 Venema |
| 4 | 07/09/2018 | Helmond Sport | FC Den Bosch | 0-2 | 1.830 | Vermeiren | 0-1 Holla, 0-2 Blummel |
| 4 | 08/09/2018 | FC Twente | TOP Oss | 1-2 | 25.000 | Vd Graaf | 0-1 Smeets, 0-2 Dogan, 1-2 Catalapiedra |
| 4 | 08/09/2018 | Roda JC Kerkrade | NEC | 2-3 | 8.559 | Nijhuis | 0-1 Engels, 1-1 Okita, 2-1 Paulissen, 2-2 Braken, 2-3 Achahbar |
| 4 | 10/09/2018 | Jong AZ | Jong Ajax | 0-1 | 1.924 | Teuben | 0-1 Danilo; R: Opdam |
| 5 | 14/09/2018 | SC Cambuur | Telstar | 2-0 | 7.362 | S. Mulder | 1-0 Van Kippersluis, 2-0 Mathieu R: Van Heertum (Tel) |
| 5 | 14/09/2018 | FC Volendam | TOP Oss | 0-0 | 2.000 | Dieperink | |
| 5 | 14/09/2018 | FC Dordrecht | FC Twente | 0-2 | 2.662 | Gerrets | 0-1 Bijen, 0-2 Stankov (e.d.) |
| 5 | 14/09/2018 | RKC Waalwijk | Roda JC Kerkrade | 0-1 | 2.140 | Kooij | 0-1 Dijkhuizen |
| 5 | 14/09/2018 | FC Eindhoven | MVV Maastricht | 0-1 | 2.713 | Vd Graaf | 0-1 Schroyen (pen) |
| 5 | 14/09/2018 | NEC | Jong PSV | 4-4 | 9.000 | Vd Kerkhof | 1-0 en 2-0 Braken, 2-1 Verreth, 2-2 Piroe, 2-3 en 2-4 Ramselaar, 3-4 Romeny, 4-4 Kvida |
| 5 | 14/09/2018 | Almere City FC | Jong FC Utrecht | 3-1 | 1.824 | C. Mulder | 1-0 Soleri, 2-0 Efmorfidis, 2-1 Venema, 3-1 Kip |
| 5 | 14/09/2018 | Jong AZ | Go Ahead Eagles | 3-2 | 540 | Oostrom | 1-0 Druijf (pen), 1-1 Verheijdt, 2-1 Druijf (pen), 3-1 Jacobs, 3-2 Van der Venne |
| 5 | 16/09/2018 | Sparta Rotterdam | FC Den Bosch | 2-0 | 8.634 | Manschot | 1-0 Veldwijk, 2-0 Rayhi |
| 5 | 17/09/2018 | Jong Ajax | Helmond Sport | 2-0 | 880 | Ruperti | 1-0 en 2-0 De Wit |
| 6 | 21/09/2018 | Jong FC Utrecht | SC Cambuur | 0-0 | 473 | Vergoote | |
| 6 | 21/09/2018 | RKC Waalwijk | Jong AZ | 2-2 | 1.940 | Vd Laan | 1-0 Bilate, 1-1 Reijnders, 1-2 Druijf, 2-2 Baggerman |
| 6 | 21/09/2018 | Jong PSV | FC Volendam | 1-0 | 418 | Teuben | 1-0 Gakpo |
| 6 | 21/09/2018 | MVV Maastricht | FC Dordrecht | 2-1 | 4.434 | Perez | 1-0 Schroyen, 2-0 Houben (pen), 2-1 Haydari |
| 6 | 21/09/2018 | Go Ahead Eagles | Jong Ajax | 2-1 | 8.287 | Van Herk | 1-0 Van der Venne, 1-1 De Wit, 2-1 Verheijdt |
| 6 | 21/09/2018 | FC Den Bosch | Almere City FC | 1-4 | 2.451 | Nagtegaal | 0-1 Vossebelt (pen), 1-1 Sappinen, 1-2 Vossebelt, 1-3 Soleri, 1-4 Kip; R: Kersten (DBo) |
| 6 | 21/09/2018 | Roda JC Kerkrade | FC Eindhoven | 0-0 | 7.790 | Bax | |
| 6 | 21/09/2018 | TOP Oss | Sparta Rotterdam | 0-0 | 3.097 | Vd Kerkhof | |
| 6 | 21/09/2018 | Telstar | FC Twente | 1-3 | 3.263 | Gözübüyük | 1-0 Sno, 1-1 Boere, 1-2 Oosterwijk, 1-3 Zekhnini |
| 6 | 21/09/2018 | Helmond Sport | NEC | 2-3 | 2.011 | Martens | 0-1 Achahbar, 0-2 Darri, 1-2 (pen) en 2-2 Zeldenrust, 2-3 Achahbar |
| 7 | 28/09/2018 | SC Cambuur | Roda JC Kerkrade | 0-1 | 7.654 | Vd Graaf | 0-1 Van Velzen |
| 7 | 28/09/2018 | Sparta Rotterdam | FC Dordrecht | 3-2 | 8.432 | Dieperink | 0-1 Cijntje, 0-2 Montsma, 1-2 Duarte, 2-2 Veldwijk, 3-2 Drenthe |
| 7 | 28/09/2018 | FC Den Bosch | Jong AZ | 3-1 | 2.387 | Gerrets | 1-0 Sapinnen, 2-0 Blummel, 3-0 Oulad Omar, 3-1 Druijf |
| 7 | 28/09/2018 | NEC | Go Ahead Eagles | 1-1 | 9.842 | Blom | 1-0 Braken, 1-1 Van Moorsel |
| 7 | 28/09/2018 | Almere City FC | RKC Waalwijk | 2-1 | 1.773 | Ruperti | 1-0 Vossebelt, 1-1 Koenraad, 2-1 Vossebelt |
| 7 | 28/09/2018 | Telstar | TOP Oss | 1-0 | 1.845 | Nagtegaal | 1-0 Lopes Cabral |
| 7 | 30/09/2018 | FC Twente | Jong PSV | 2-1 | 25.000 | Lindhout | 0-1 Rigo, 1-1 Boere, 2-1 Cantalapiedra |
| 7 | 28/09/2018 | Helmond Sport | FC Volendam | 2-2 | 1.891 | C. Mulder | 0-1 Stroo, 1-1 Poelmans, 2-1 Zeldenrust, 2-2 Kaars |
| 7 | 28/09/2018 | Jong Ajax | FC Eindhoven | 0-3 | 469 | Oostrom | 0-1 Daniels, 0-2 Seedorf, 0-3 Kabangu |
| 7 | 01/10/2018 | Jong FC Utrecht | MVV Maastricht | 0-0 | 317 | Van Herk | |
| 8 | 05/10/2018 | FC Volendam | RKC Waalwijk | 1-0 | 2.721 | Bos | 1-0 Peters; R: Van Weert (RKC) |
| 8 | 05/10/2018 | FC Dordrecht | SC Cambuur | 3-1 | 1.658 | Oostrom | 1-0 Peijenburg, 1-1 Conraad, 2-1 (pen) en 3-1 Mourgos |
| 8 | 05/10/2018 | MVV Maastricht | FC Den Bosch | 0-3 | 4.189 | Vd Eijk | 0-1 Beltrame, 0-2 Blummel, 0-3 Sappinen |
| 8 | 05/10/2018 | FC Eindhoven | FC Twente | 1-1 | 2.507 | Blank | 0-1 Cantalapiedra, 1-1 Seedorf |
| 8 | 05/10/2018 | Go Ahead Eagles | Sparta Rotterdam | 2-2 | 8.846 | Nijhuis | 1-0 Veldmate, 2-0 Bliek, 2-1 Drenthe, 2-2 Veldwijk |
| 8 | 05/10/2018 | Roda JC Kerkrade | Jong PSV | 2-3 | 7.002 | Gerrets | 1-0 (pen) en 2-0 Engels, 2-1 Mauro Junior, 2-2 Verreth, 2-3 Lundqvist R: Daneels (PSV), Milts, Makrini (Rod) |
| 8 | 05/10/2018 | Jong Ajax | Telstar | 3-0 | 887 | Cantineau | 1-0 Van Iperen (e.d.), 2-0 Danilo, 3-0 Johnsen |
| 8 | 05/10/2018 | TOP Oss | Jong FC Utrecht | 2-1 | 1.318 | Teuben | 1-0 Dogan, 1-1 El Azrak, 2-1 Ladan |
| 8 | 05/10/2018 | Almere City FC | NEC | 1-0 | 2.573 | Bax | 1-0 Soleri |
| 8 | 05/10/2018 | Jong AZ | Helmond Sport | 2-2 | 520 | Nagtegaal | 0-1 Naudts, 1-1 Druijf, 1-2 Naudts, 2-2 Hoedemakers |
| 9 | 12/10/2018 | FC Volendam | Almere City FC | 2-2 | 3.000 | Vd Kerkhof | 1-0 Doodeman, 1-1 Luckassen, 1-2 Efmorfidis, 2-2 Doodeman |
| 9 | 12/10/2018 | RKC Waalwijk | TOP Oss | 0-0 | 1.889 | Bijl | R: Baggerman (RKC) |
| 9 | 12/10/2018 | FC Den Bosch | FC Dordrecht | 1-0 | 2.334 | Van Herk | 1-0 Beltrame |
| 9 | 12/10/2018 | NEC | FC Eindhoven | 0-1 | 8.230 | Ruperti | 0-1 Van den Boomen |
| 9 | 12/10/2018 | Helmond Sport | Telstar | 1-2 | 1.833 | Vd Graaf | 0-1 Scott (pen), 0-2 Najah, 1-2 Meijers R: verkennis (Hel) |
| 9 | 12/10/2018 | Jong AZ | Jong FC Utrecht | 2-2 | 500 | Mulder | 1-0 Druif (pen), 1-1 Sow, 1-2 Hilterman, 2-2 Druijf |
| 9 | 14/10/2018 | Go Ahead Eagles | Roda JC Kerkrade | 3-0 | 9.288 | Gözübüyük | 1-0 Van Moorsel, 2-0 Verheijdt, 3-0 Van Moorsel |
| 9 | 14/10/2018 | Sparta Rotterdam | SC Cambuur | 3-0 | 8.878 | Martens | 1-0 Sambisa (e.d.), 2-0 Veldwijk (pen), 3-0 Rayhi |
| 9 | 14/10/2018 | FC Twente | MVV Maastricht | 0-1 | 25.000 | Dieperink | 0-1 Van den Hurk |
| 9 | 15/10/2018 | Jong PSV | Jong Ajax | 2-1 | 1.923 | Vd Laan | 0-1 Bijleveld, 1-1 Lundqvist (pen), 2-1 Piroe |
| 10 | 19/10/2018 | SC Cambuur | Helmond Sport | 20:00 | |||
| 10 | 19/10/2018 | FC Dordrecht | Jong AZ | 20:00 | |||
| 10 | 19/10/2018 | MVV Maastricht | Jong PSV | 20:00 | |||
| 10 | 19/10/2018 | FC Eindhoven | FC Volendam | 20:00 | |||
| 10 | 19/10/2018 | Roda JC Kerkrade | Sparta Rotterdam | 20:00 | |||
| 10 | 19/10/2018 | TOP Oss | FC Den Bosch | 20:00 | |||
| 10 | 19/10/2018 | Almere City FC | Go Ahead Eagles | 20:00 | |||
| 10 | 19/10/2018 | Telstar | NEC | 20:00 | |||
| 10 | 19/10/2018 | Jong Ajax | RKC Waalwijk | 20:00 | |||
| 10 | 22/10/2018 | Jong FC Utrecht | FC Twente | 20:00 | |||
| 11 | 26/10/2018 | Sparta Rotterdam | Telstar | 20:00 | |||
| 11 | 26/10/2018 | FC Volendam | Jong Ajax | 20:00 | |||
| 11 | 26/10/2018 | RKC Waalwijk | Jong FC Utrecht | 20:00 | |||
| 11 | 26/10/2018 | Jong PSV | FC Dordrecht | 20:00 | |||
| 11 | 26/10/2018 | Go Ahead Eagles | SC Cambuur | 20:00 | |||
| 11 | 26/10/2018 | FC Den Bosch | FC Eindhoven | 20:00 | |||
| 11 | 26/10/2018 | NEC | TOP Oss | 20:00 | |||
| 11 | 26/10/2018 | FC Twente | Almere City FC | 20:00 | |||
| 11 | 26/10/2018 | Helmond Sport | MVV Maastricht | 20:00 | |||
| 11 | 26/10/2018 | Jong AZ | Roda JC Kerkrade | 20:00 | |||
| 12 | 02/11/2018 | FC Dordrecht | FC Volendam | 20:00 | |||
| 12 | 02/11/2018 | SC Cambuur | Jong Ajax | 20:00 | |||
| 12 | 02/11/2018 | MVV Maastricht | Sparta Rotterdam | 20:00 | |||
| 12 | 02/11/2018 | NEC | Jong AZ | 20:00 | |||
| 12 | 02/11/2018 | TOP Oss | FC Eindhoven | 20:00 | |||
| 12 | 02/11/2018 | Telstar | Go Ahead Eagles | 20:00 | |||
| 12 | 02/11/2018 | FC Twente | RKC Waalwijk | 20:00 | |||
| 12 | 02/11/2018 | Helmond Sport | Almere City FC | 20:00 | |||
| 12 | 02/11/2018 | Jong FC Utrecht | Roda JC Kerkrade | 20:00 | |||
| 12 | 05/11/2018 | Jong PSV | FC Den Bosch | 20:00 | |||
| 13 | 09/11/2018 | Go Ahead Eagles | FC Dordrecht | 20:00 | |||
| 13 | 09/11/2018 | Sparta Rotterdam | Jong FC Utrecht | 20:00 | |||
| 13 | 09/11/2018 | FC Volendam | MVV Maastricht | 20:00 | |||
| 13 | 09/11/2018 | RKC Waalwijk | Jong PSV | 20:00 | |||
| 13 | 09/11/2018 | FC Eindhoven | Telstar | 20:00 | |||
| 13 | 09/11/2018 | FC Den Bosch | FC Twente | 20:00 | |||
| 13 | 09/11/2018 | Roda JC Kerkrade | Helmond Sport | 20:00 | |||
| 13 | 09/11/2018 | Jong Ajax | NEC | 20:00 | |||
| 13 | 09/11/2018 | Almere City FC | SC Cambuur | 20:00 | |||
| 13 | 09/11/2018 | Jong AZ | TOP Oss | 20:00 | |||
| 14 | 17/11/2018 | Jong PSV | Jong AZ | 18:30 | |||
| 14 | 17/11/2018 | FC Dordrecht | FC Eindhoven | 19:45 | |||
| 14 | 17/11/2018 | TOP Oss | Almere City FC | 19:45 | |||
| 14 | 17/11/2018 | Helmond Sport | RKC Waalwijk | 19:45 | |||
| 14 | 17/11/2018 | SC Cambuur | FC Volendam | 20:45 | |||
| 14 | 18/11/2018 | MVV Maastricht | Roda JC Kerkrade | 12:15 | |||
| 14 | 18/11/2018 | Telstar | FC Den Bosch | 14:30 | |||
| 14 | 18/11/2018 | FC Twente | Go Ahead Eagles | 14:30 | |||
| 14 | 18/11/2018 | NEC | Sparta Rotterdam | 16:45 | |||
| 14 | 20/11/2018 | Jong FC Utrecht | Jong Ajax | 20:00 | |||
| 15 | 23/11/2018 | Sparta Rotterdam | Jong PSV | 20:00 | |||
| 15 | 23/11/2018 | FC Volendam | Jong FC Utrecht | 20:00 | |||
| 15 | 23/11/2018 | RKC Waalwijk | NEC | 20:00 | |||
| 15 | 23/11/2018 | FC Eindhoven | Helmond Sport | 20:00 | |||
| 15 | 23/11/2018 | Go Ahead Eagles | TOP Oss | 20:00 | |||
| 15 | 23/11/2018 | FC Den Bosch | SC Cambuur | 20:00 | |||
| 15 | 23/11/2018 | Roda JC Kerkrade | Telstar | 20:00 | |||
| 15 | 23/11/2018 | Almere City FC | FC Dordrecht | 20:00 | |||
| 15 | 23/11/2018 | Jong Ajax | MVV Maastricht | 20:00 | |||
| 15 | 26/11/2018 | Jong AZ | FC Twente | 20:00 | |||
| 16 | 30/11/2018 | FC Dordrecht | RKC Waalwijk | 20:00 | |||
| 16 | 30/11/2018 | SC Cambuur | FC Eindhoven | 20:00 | |||
| 16 | 30/11/2018 | MVV Maastricht | Jong AZ | 20:00 | |||
| 16 | 30/11/2018 | NEC | FC Volendam | 20:00 | |||
| 16 | 30/11/2018 | TOP Oss | Roda JC Kerkrade | 20:00 | |||
| 16 | 30/11/2018 | Telstar | Almere City FC | 20:00 | |||
| 16 | 30/11/2018 | FC Twente | Jong Ajax | 20:00 | |||
| 16 | 30/11/2018 | Helmond Sport | Sparta Rotterdam | 20:00 | |||
| 16 | 03/12/2018 | Jong FC Utrecht | FC Den Bosch | 20:00 | |||
| 16 | 03/12/2018 | Jong PSV | Go Ahead Eagles | 20:00 | |||
| 17 | 07/12/2018 | Sparta Rotterdam | Almere City FC | 20:00 | |||
| 17 | 07/12/2018 | FC Volendam | FC Twente | 20:00 | |||
| 17 | 07/12/2018 | RKC Waalwijk | MVV Maastricht | 20:00 | |||
| 17 | 07/12/2018 | FC Eindhoven | Jong FC Utrecht | 20:00 | |||
| 17 | 07/12/2018 | Go Ahead Eagles | Helmond Sport | 20:00 | |||
| 17 | 07/12/2018 | FC Den Bosch | NEC | 20:00 | |||
| 17 | 07/12/2018 | Roda JC Kerkrade | FC Dordrecht | 20:00 | |||
| 17 | 07/12/2018 | Jong Ajax | TOP Oss | 20:00 | |||
| 17 | 10/12/2018 | Jong PSV | SC Cambuur | 20:00 | |||
| 17 | 10/12/2018 | Jong AZ | Telstar | 20:00 | |||
| 18 | 14/12/2018 | SC Cambuur | FC Twente | 20:00 | |||
| 18 | 14/12/2018 | Jong FC Utrecht | FC Dordrecht | 20:00 | |||
| 18 | 14/12/2018 | Sparta Rotterdam | Jong AZ | 20:00 | |||
| 18 | 14/12/2018 | FC Eindhoven | RKC Waalwijk | 20:00 | |||
| 18 | 14/12/2018 | Go Ahead Eagles | FC Den Bosch | 20:00 | |||
| 18 | 14/12/2018 | NEC | MVV Maastricht | 20:00 | |||
| 18 | 14/12/2018 | Roda JC Kerkrade | FC Volendam | 20:00 | |||
| 18 | 14/12/2018 | TOP Oss | Helmond Sport | 20:00 | |||
| 18 | 14/12/2018 | Almere City FC | Jong Ajax | 20:00 | |||
| 18 | 14/12/2018 | Telstar | Jong PSV | 20:00 | |||
| 19 | 21/12/2018 | FC Volendam | Telstar | 20:00 | |||
| 19 | 21/12/2018 | FC Dordrecht | TOP Oss | 20:00 | |||
| 19 | 21/12/2018 | RKC Waalwijk | Go Ahead Eagles | 20:00 | |||
| 19 | 21/12/2018 | Jong PSV | Almere City FC | 20:00 | |||
| 19 | 21/12/2018 | MVV Maastricht | SC Cambuur | 20:00 | |||
| 19 | 21/12/2018 | FC Den Bosch | Roda JC Kerkrade | 20:00 | |||
| 19 | 21/12/2018 | Jong Ajax | Sparta Rotterdam | 20:00 | |||
| 19 | 21/12/2018 | FC Twente | NEC | 20:00 | |||
| 19 | 21/12/2018 | Helmond Sport | Jong FC Utrecht | 20:00 | |||
| 19 | 21/12/2018 | Jong AZ | FC Eindhoven | 20:00 | |||
| 20 | 13/01/2019 | SC Cambuur | Sparta Rotterdam | 14:30 | |||
| 20 | 13/01/2019 | Jong FC Utrecht | Jong AZ | 14:30 | |||
| 20 | 13/01/2019 | FC Dordrecht | FC Den Bosch | 14:30 | |||
| 20 | 13/01/2019 | MVV Maastricht | FC Twente | 14:30 | |||
| 20 | 13/01/2019 | FC Eindhoven | NEC | 14:30 | |||
| 20 | 13/01/2019 | Roda JC Kerkrade | Go Ahead Eagles | 14:30 | |||
| 20 | 13/01/2019 | Jong Ajax | Jong PSV | 14:30 | |||
| 20 | 13/01/2019 | TOP Oss | RKC Waalwijk | 14:30 | |||
| 20 | 13/01/2019 | Almere City FC | FC Volendam | 14:30 | |||
| 20 | 13/01/2019 | Telstar | Helmond Sport | 14:30 | |||
| 21 | 18/01/2019 | Sparta Rotterdam | Roda JC Kerkrade | 20:00 | |||
| 21 | 18/01/2019 | FC Volendam | FC Eindhoven | 20:00 | |||
| 21 | 18/01/2019 | RKC Waalwijk | Jong Ajax | 20:00 | |||
| 21 | 18/01/2019 | Go Ahead Eagles | Almere City FC | 20:00 | |||
| 21 | 18/01/2019 | FC Den Bosch | TOP Oss | 20:00 | |||
| 21 | 18/01/2019 | NEC | Telstar | 20:00 | |||
| 21 | 18/01/2019 | Helmond Sport | SC Cambuur | 20:00 | |||
| 21 | 18/01/2019 | Jong AZ | FC Dordrecht | 20:00 | |||
| 21 | 18/01/2019 | FC Twente | Jong FC Utrecht | 20:00 | |||
| 21 | 22/01/2019 | Jong PSV | MVV Maastricht | 20:00 | |||
| 22 | 25/01/2019 | SC Cambuur | Go Ahead Eagles | 20:00 | |||
| 22 | 25/01/2019 | FC Dordrecht | Jong PSV | 20:00 | |||
| 22 | 25/01/2019 | MVV Maastricht | Helmond Sport | 20:00 | |||
| 22 | 25/01/2019 | FC Eindhoven | FC Den Bosch | 20:00 | |||
| 22 | 25/01/2019 | Roda JC Kerkrade | Jong AZ | 20:00 | |||
| 22 | 25/01/2019 | TOP Oss | NEC | 20:00 | |||
| 22 | 25/01/2019 | Almere City FC | FC Twente | 20:00 | |||
| 22 | 25/01/2019 | Telstar | Sparta Rotterdam | 20:00 | |||
| 22 | 28/01/2019 | Jong FC Utrecht | RKC Waalwijk | 20:00 | |||
| 22 | 28/01/2019 | Jong Ajax | FC Volendam | 20:00 | |||
| 23 | 01/02/2019 | FC Volendam | Sparta Rotterdam | 20:00 | |||
| 23 | 01/02/2019 | FC Dordrecht | Jong Ajax | 20:00 | |||
| 23 | 01/02/2019 | RKC Waalwijk | FC Den Bosch | 20:00 | |||
| 23 | 01/02/2019 | MVV Maastricht | Telstar | 20:00 | |||
| 23 | 01/02/2019 | Go Ahead Eagles | FC Eindhoven | 20:00 | |||
| 23 | 01/02/2019 | NEC | Jong FC Utrecht | 20:00 | |||
| 23 | 01/02/2019 | Roda JC Kerkrade | Almere City FC | 20:00 | |||
| 23 | 01/02/2019 | FC Twente | Helmond Sport | 20:00 | |||
| 23 | 04/02/2019 | Jong PSV | TOP Oss | 20:00 | |||
| 23 | 04/02/2019 | Jong AZ | SC Cambuur | 20:00 | |||
| 24 | 08/02/2019 | SC Cambuur | NEC | 20:00 | |||
| 24 | 08/02/2019 | Sparta Rotterdam | FC Twente | 20:00 | |||
| 24 | 08/02/2019 | FC Den Bosch | FC Volendam | 20:00 | |||
| 24 | 08/02/2019 | TOP Oss | MVV Maastricht | 20:00 | |||
| 24 | 08/02/2019 | Almere City FC | Jong AZ | 20:00 | |||
| 24 | 08/02/2019 | Telstar | RKC Waalwijk | 20:00 | |||
| 24 | 08/02/2019 | FC Eindhoven | Jong PSV | 20:00 | |||
| 24 | 08/02/2019 | Helmond Sport | FC Dordrecht | 20:00 | |||
| 24 | 11/02/2019 | Jong FC Utrecht | Go Ahead Eagles | 20:00 | |||
| 24 | 11/02/2019 | Jong Ajax | Roda JC Kerkrade | 20:00 | |||
| 25 | 15/02/2019 | FC Volendam | Helmond Sport | 20:00 | |||
| 25 | 15/02/2019 | FC Dordrecht | Sparta Rotterdam | 20:00 | |||
| 25 | 15/02/2019 | RKC Waalwijk | Almere City FC | 20:00 | |||
| 25 | 15/02/2019 | MVV Maastricht | Jong FC Utrecht | 20:00 | |||
| 25 | 15/02/2019 | FC Eindhoven | Jong Ajax | 20:00 | |||
| 25 | 15/02/2019 | Go Ahead Eagles | NEC | 20:00 | |||
| 25 | 15/02/2019 | Roda JC Kerkrade | SC Cambuur | 20:00 | |||
| 25 | 15/02/2019 | TOP Oss | Telstar | 20:00 | |||
| 25 | 15/02/2019 | Jong AZ | FC Den Bosch | 20:00 | |||
| 25 | 18/02/2019 | Jong PSV | FC Twente | 20:00 | |||
| 26 | 22/02/2019 | SC Cambuur | FC Dordrecht | 20:00 | |||
| 26 | 22/02/2019 | RKC Waalwijk | FC Volendam | 20:00 | |||
| 26 | 22/02/2019 | FC Den Bosch | MVV Maastricht | 20:00 | |||
| 26 | 22/02/2019 | NEC | Almere City FC | 20:00 | |||
| 26 | 22/02/2019 | Telstar | Jong Ajax | 20:00 | |||
| 26 | 22/02/2019 | FC Twente | FC Eindhoven | 20:00 | |||
| 26 | 22/02/2019 | Helmond Sport | Jong AZ | 20:00 | |||
| 26 | 22/02/2019 | Jong PSV | Roda JC Kerkrade | 20:00 | |||
| 26 | 24/02/2019 | Sparta Rotterdam | Go Ahead Eagles | 14:30 | |||
| 26 | 25/02/2019 | Jong FC Utrecht | TOP Oss | 20:00 | |||
| 27 | 01/03/2019 | SC Cambuur | TOP Oss | 20:00 | |||
| 27 | 01/03/2019 | Go Ahead Eagles | MVV Maastricht | 20:00 | |||
| 27 | 01/03/2019 | Roda JC Kerkrade | FC Twente | 20:00 | |||
| 27 | 01/03/2019 | Almere City FC | FC Eindhoven | 20:00 | |||
| 27 | 01/03/2019 | Helmond Sport | Jong PSV | 20:00 | |||
| 27 | 01/03/2019 | Sparta Rotterdam | RKC Waalwijk | 20:00 | |||
| 27 | 01/03/2019 | FC Dordrecht | NEC | 20:00 | |||
| 27 | 01/03/2019 | Jong Ajax | FC Den Bosch | 20:00 | |||
| 27 | 01/03/2019 | Jong FC Utrecht | Telstar | 20:00 | |||
| 27 | 04/03/2019 | Jong AZ | FC Volendam | 20:00 | |||
| 28 | 08/03/2019 | RKC Waalwijk | SC Cambuur | 20:00 | |||
| 28 | 08/03/2019 | MVV Maastricht | Almere City FC | 20:00 | |||
| 28 | 08/03/2019 | FC Eindhoven | Sparta Rotterdam | 20:00 | |||
| 28 | 08/03/2019 | FC Den Bosch | Helmond Sport | 20:00 | |||
| 28 | 08/03/2019 | NEC | Roda JC Kerkrade | 20:00 | |||
| 28 | 08/03/2019 | TOP Oss | FC Twente | 20:00 | |||
| 28 | 08/03/2019 | FC Volendam | Go Ahead Eagles | 20:00 | |||
| 28 | 08/03/2019 | Telstar | FC Dordrecht | 20:00 | |||
| 28 | 08/03/2019 | Jong PSV | Jong FC Utrecht | 20:00 | |||
| 28 | 11/03/2019 | Jong Ajax | Jong AZ | 20:00 | |||
| 29 | 15/03/2019 | SC Cambuur | Jong PSV | 20:00 | |||
| 29 | 15/03/2019 | Jong FC Utrecht | FC Eindhoven | 20:00 | |||
| 29 | 15/03/2019 | FC Dordrecht | Roda JC Kerkrade | 20:00 | |||
| 29 | 15/03/2019 | MVV Maastricht | RKC Waalwijk | 20:00 | |||
| 29 | 15/03/2019 | NEC | FC Den Bosch | 20:00 | |||
| 29 | 15/03/2019 | TOP Oss | Jong Ajax | 20:00 | |||
| 29 | 15/03/2019 | Almere City FC | Sparta Rotterdam | 20:00 | |||
| 29 | 15/03/2019 | Telstar | Jong AZ | 20:00 | |||
| 29 | 15/03/2019 | FC Twente | FC Volendam | 20:00 | |||
| 29 | 15/03/2019 | Helmond Sport | Go Ahead Eagles | 20:00 | |||
| 30 | 22/03/2019 | FC Volendam | SC Cambuur | 20:00 | |||
| 30 | 22/03/2019 | RKC Waalwijk | Helmond Sport | 20:00 | |||
| 30 | 22/03/2019 | FC Eindhoven | FC Dordrecht | 20:00 | |||
| 30 | 22/03/2019 | FC Den Bosch | Telstar | 20:00 | |||
| 30 | 22/03/2019 | Almere City FC | TOP Oss | 20:00 | |||
| 30 | 24/03/2019 | Sparta Rotterdam | NEC | 12:15 | |||
| 30 | 24/03/2019 | Go Ahead Eagles | FC Twente | 14:30 | |||
| 30 | 24/03/2019 | Roda JC Kerkrade | MVV Maastricht | 16:45 | |||
| 30 | 25/03/2019 | Jong Ajax | Jong FC Utrecht | 20:00 | |||
| 30 | 25/03/2019 | Jong AZ | Jong PSV | 20:00 | |||
| 31 | 29/03/2019 | SC Cambuur | Almere City FC | 20:00 | |||
| 31 | 29/03/2019 | Jong FC Utrecht | Sparta Rotterdam | 20:00 | |||
| 31 | 29/03/2019 | FC Dordrecht | Go Ahead Eagles | 20:00 | |||
| 31 | 29/03/2019 | Jong PSV | RKC Waalwijk | 20:00 | |||
| 31 | 29/03/2019 | MVV Maastricht | FC Volendam | 20:00 | |||
| 31 | 29/03/2019 | NEC | Jong Ajax | 20:00 | |||
| 31 | 29/03/2019 | TOP Oss | Jong AZ | 20:00 | |||
| 31 | 29/03/2019 | Telstar | FC Eindhoven | 20:00 | |||
| 31 | 29/03/2019 | FC Twente | FC Den Bosch | 20:00 | |||
| 31 | 29/03/2019 | Helmond Sport | Roda JC Kerkrade | 20:00 | |||
| 32 | 01/04/2019 | Sparta Rotterdam | MVV Maastricht | 20:00 | |||
| 32 | 01/04/2019 | FC Volendam | FC Dordrecht | 20:00 | |||
| 32 | 01/04/2019 | RKC Waalwijk | FC Twente | 20:00 | |||
| 32 | 01/04/2019 | FC Eindhoven | TOP Oss | 20:00 | |||
| 32 | 01/04/2019 | Go Ahead Eagles | Telstar | 20:00 | |||
| 32 | 01/04/2019 | FC Den Bosch | Jong PSV | 20:00 | |||
| 32 | 01/04/2019 | Roda JC Kerkrade | Jong FC Utrecht | 20:00 | |||
| 32 | 01/04/2019 | Jong Ajax | SC Cambuur | 20:00 | |||
| 32 | 01/04/2019 | Almere City FC | Helmond Sport | 20:00 | |||
| 32 | 01/04/2019 | Jong AZ | NEC | 20:00 | |||
| 33 | 05/04/2019 | MVV Maastricht | FC Eindhoven | 20:00 | |||
| 33 | 05/04/2019 | Go Ahead Eagles | Jong AZ | 20:00 | |||
| 33 | 05/04/2019 | FC Den Bosch | Sparta Rotterdam | 20:00 | |||
| 33 | 05/04/2019 | Roda JC Kerkrade | RKC Waalwijk | 20:00 | |||
| 33 | 05/04/2019 | TOP Oss | FC Volendam | 20:00 | |||
| 33 | 05/04/2019 | Telstar | SC Cambuur | 20:00 | |||
| 33 | 05/04/2019 | FC Twente | FC Dordrecht | 20:00 | |||
| 33 | 05/04/2019 | Helmond Sport | Jong Ajax | 20:00 | |||
| 33 | 05/04/2019 | Jong FC Utrecht | Almere City FC | 20:00 | |||
| 33 | 08/04/2019 | Jong PSV | NEC | 20:00 | |||
| 34 | 12/04/2019 | SC Cambuur | Jong FC Utrecht | 20:00 | |||
| 34 | 12/04/2019 | FC Volendam | Jong PSV | 20:00 | |||
| 34 | 12/04/2019 | FC Dordrecht | MVV Maastricht | 20:00 | |||
| 34 | 12/04/2019 | FC Eindhoven | Roda JC Kerkrade | 20:00 | |||
| 34 | 12/04/2019 | NEC | Helmond Sport | 20:00 | |||
| 34 | 12/04/2019 | Almere City FC | FC Den Bosch | 20:00 | |||
| 34 | 12/04/2019 | FC Twente | Telstar | 20:00 | |||
| 34 | 12/04/2019 | Jong AZ | RKC Waalwijk | 20:00 | |||
| 34 | 14/04/2019 | Sparta Rotterdam | TOP Oss | 14:30 | |||
| 34 | 15/04/2019 | Jong Ajax | Go Ahead Eagles | 20:00 | |||
| 35 | 19/04/2019 | Sparta Rotterdam | Helmond Sport | 20:00 | |||
| 35 | 19/04/2019 | FC Volendam | NEC | 20:00 | |||
| 35 | 19/04/2019 | RKC Waalwijk | FC Dordrecht | 20:00 | |||
| 35 | 19/04/2019 | FC Eindhoven | SC Cambuur | 20:00 | |||
| 35 | 19/04/2019 | Go Ahead Eagles | Jong PSV | 20:00 | |||
| 35 | 19/04/2019 | FC Den Bosch | Jong FC Utrecht | 20:00 | |||
| 35 | 19/04/2019 | Roda JC Kerkrade | TOP Oss | 20:00 | |||
| 35 | 19/04/2019 | Jong Ajax | FC Twente | 20:00 | |||
| 35 | 19/04/2019 | Almere City FC | Telstar | 20:00 | |||
| 35 | 19/04/2019 | Jong AZ | MVV Maastricht | 20:00 | |||
| 36 | 22/04/2019 | SC Cambuur | FC Den Bosch | 14:30 | |||
| 36 | 22/04/2019 | Jong FC Utrecht | FC Volendam | 14:30 | |||
| 36 | 22/04/2019 | FC Dordrecht | Almere City FC | 14:30 | |||
| 36 | 22/04/2019 | Jong PSV | Sparta Rotterdam | 14:30 | |||
| 36 | 22/04/2019 | MVV Maastricht | Jong Ajax | 14:30 | |||
| 36 | 22/04/2019 | NEC | RKC Waalwijk | 14:30 | |||
| 36 | 22/04/2019 | TOP Oss | Go Ahead Eagles | 14:30 | |||
| 36 | 22/04/2019 | Telstar | Roda JC Kerkrade | 14:30 | |||
| 36 | 22/04/2019 | FC Twente | Jong AZ | 14:30 | |||
| 36 | 22/04/2019 | Helmond Sport | FC Eindhoven | 14:30 | |||
| 37 | 26/04/2019 | SC Cambuur | MVV Maastricht | 20:00 | |||
| 37 | 26/04/2019 | Jong FC Utrecht | Helmond Sport | 20:00 | |||
| 37 | 26/04/2019 | Sparta Rotterdam | Jong Ajax | 20:00 | |||
| 37 | 26/04/2019 | FC Eindhoven | Jong AZ | 20:00 | |||
| 37 | 26/04/2019 | Go Ahead Eagles | RKC Waalwijk | 20:00 | |||
| 37 | 26/04/2019 | NEC | FC Twente | 20:00 | |||
| 37 | 26/04/2019 | Roda JC Kerkrade | FC Den Bosch | 20:00 | |||
| 37 | 26/04/2019 | TOP Oss | FC Dordrecht | 20:00 | |||
| 37 | 26/04/2019 | Almere City FC | Jong PSV | 20:00 | |||
| 37 | 26/04/2019 | Telstar | FC Volendam | 20:00 | |||
| 38 | 03/05/2019 | FC Volendam | Roda JC Kerkrade | 20:00 | |||
| 38 | 03/05/2019 | FC Dordrecht | Jong FC Utrecht | 20:00 | |||
| 38 | 03/05/2019 | RKC Waalwijk | FC Eindhoven | 20:00 | |||
| 38 | 03/05/2019 | Jong PSV | Telstar | 20:00 | |||
| 38 | 03/05/2019 | MVV Maastricht | NEC | 20:00 | |||
| 38 | 03/05/2019 | FC Den Bosch | Go Ahead Eagles | 20:00 | |||
| 38 | 03/05/2019 | Jong Ajax | Almere City FC | 20:00 | |||
| 38 | 03/05/2019 | FC Twente | SC Cambuur | 20:00 | |||
| 38 | 03/05/2019 | Helmond Sport | TOP Oss | 20:00 | |||
| 38 | 03/05/2019 | Jong AZ | Sparta Rotterdam | 20:00 |
Play offs voor promotie/degradatie
| 1e ronde | ||||||
| 10/05/2019 | NEC | RKC Waalwijk | 2-0 | 8.261 | Bax | 1-0 Ndayishimiye, 2-0 Bruijn |
| 10/05/2019 | SC Cambuur | Almere City FC | 2-2 | 6.843 | Lindhout | 0-1 Bansabouh, 1-1 Mbende, 1-2 Meijer, 2-2 Ciganiks |
| 14/05/2019 | RKC Waalwijk | NEC | 3-0 | 3.249 | Kamphuis | 1-0 Seys, 2-0 Spierings, 3-0 Bilate |
| 14/05/2019 | Almere City FC | SC Cambuur | 1-2 | 2.569 | Vd Kerkhof | 0-1 Robertha, 0-2 Bansabouh (e.d.), 1-2 Vossebelt |
| 2e ronde | ||||||
| 19/05/2019 | RKC Waalwijk | Excelsior | 2-1 | 4.319 | Martens | 1-0 Bilate, 1-1 Fortes, 2-1 Gaari |
| 19/05/2019 | Go Ahead Eagles | FC Den Bosch | 2-2 | 9.467 | Kamphuis | 0-1 Van der Sande, 1-1 Lelieveld, 1-2 Brouwers, 2-2 Navratil |
| 19/05/2019 | TOP Oss | Sparta Rotterdam | 0-2 | 4.346 | Bax | 0-1 en 0-2 Harroui |
| 19/05/2019 | SC Cambuur | De Graafschap | 1-1 | 8.542 | Manschot | 0-1 Narsingh, 1-1 Maulun; R: Mbende (Cam) |
| 22/05/2019 | Excelsior | RKC Waalwijk | 1-1 | 4.400 | Vd Graaf | 0-1 Spierings, 1-1 Omarsson; R: Spierings (RKC) |
| 22/05/2019 | FC Den Bosch | Go Ahead Eagles | 0-1 | 6.900 | Vd Kerkhof | 0-1 Veldmate |
| 22/05/2019 | Sparta Rotterdam | TOP Oss | 3-0 | 10.020 | Makkelie | 1-0 Vriends, 2-0 en 3-0 Ache |
| 22/05/2019 | De Graafschap | SC Cambuur | 2-0 | 10.611 | Mulder | 1-0 en 2-0 (pen) Benschop |
| 3e ronde | ||||||
| 25/05/2019 | RKC Waalwijk | Go Ahead Eagles | 0-0 | 6.182 | Lindhout | |
| 25/05/2019 | Sparta Rotterdam | De Graafschap | 1-2 | 10.031 | Kamphuis | 1-0 Auassar, 1-1 Bahoui, 1-2 El Jebli (pen); R: Vriends (Spa) |
| 28/05/2019 | Go Ahead Eagles | RKC Waalwijk | 4-5 | 9.800 | Higler | 0-1 Hansson (pen), 0-2 Spierings, 1-2 Veldmate (pen), 2-2 Van der Venne, 3-2 Bakx, 3-3 Mulder, 4-3 Langedijk, 4-4 Spierings, 4-5 Bilate (pen) |
| 28/05/2019 | De Graafschap | Sparta Rotterdam | 0-2 | 12.600 | Blom | 0-1 Dervisoglu, 0-2 Auassar |
RKC Waalwijk en Sparta Rotterdam gepromoveerd; Excelsior en De Graafschap gedegradeerd
Topscorers
| 1 | Ferdy Druijf | Jong AZ / NEC | 29 |
| 2 | Mario Engels | Roda JC Kerkrade | 24 |
| 3 | Lars Veldwijk | Sparta Rotterdam | 24 |
| 4 | Huseyin Dogan | TOP Oss | 21 |
| 5 | Danilo Pereira da Silva | Jong Ajax | 19 |
| 6 | Tom Boere | FC Twente | 16 |
| 7 | Nick Venema | Jong FC Utrecht | 16 |
| 8 | Anthony van den Hurk | MVV Maastricht | 15 |
| 9 | Jonathan Okita | NEC | 15 |
| 10 | Stefano Beltrame | FC Den Bosch | 14 |
Het seizoen 2017-2018 wordt uiteindelijk het jaar van de wederopstanding van Fortuna Sittard. Na de degradatie uit de Eredivisie in 2001 ging de club door diepe dalen, hing het voortbestaan regelmatig aan een zijden draadje, maar keert het dit jaar terug aan de top met promotie als gevolg. Dat het kampioenschap uiteindelijk niet wordt behaald (dat gaat naar de beloften van Ajax) is uiteindelijk niet meer dan een voetnootje bij de feestvreugde.
Daarnaast is er nog een heuse primeur met de promotie van FC Emmen via de nacompetitie. Sinds de entree in de Eerste Divisie in 1985, lukte het nooit om te promoveren, maar verrassenderwijs lukt het dit jaar wel, door in de play-offs NEC en Sparta te verslaan. Een derde grote stunt – promotie van Almere City – zit er net niet in. De laatste promotieplek gaat naar De Graafschap, de club die de heen en veer van FC Volendam heeft overgenomen.
Onderin wil het nog altijd niet vlotten met de doorstroom tussen Eerste en Tweede Divisie. In het najaar wordt besloten promotie- en degradatie maar weer eens op te schorten, omdat de KNVB en de clubs het niet eens kunnen worden over de voorwaarden, waaronder dat moet gebeurden. In het rechterrijtje gaat de competitie daarom wederom als een nachtkaars uit.
Uitslagenmatrix
| ALM | CAM | DBO | DOR | EIN | EMM | FOR | GOA | GRA | HEL | AJA | JAZ | PSV | UTR | MVV | NEC | OSS | RKC | TEL | VOL | |
| Almere City FC | * | 1-1 | 1-1 | 1-2 | 5-1 | 2-2 | 1-4 | 2-0 | 2-1 | 3-1 | 1-2 | 3-2 | 2-1 | 2-1 | 3-2 | 3-2 | 2-2 | 3-2 | 2-3 | 2-0 |
| SC Cambuur | 2-1 | * | 2-2 | 3-0 | 3-2 | 1-1 | 1-0 | 2-1 | 3-2 | 4-1 | 1-2 | 3-2 | 0-1 | 2-2 | 0-2 | 1-1 | 1-3 | 1-1 | 2-1 | 2-2 |
| FC Den Bosch | 1-3 | 1-2 | * | 4-1 | 4-0 | 1-2 | 2-4 | 3-0 | 1-1 | 2-2 | 2-5 | 1-3 | 5-0 | 1-0 | 2-1 | 3-0 | 0-0 | 0-0 | 3-2 | 3-1 |
| FC Dordrecht | 1-1 | 0-3 | 0-3 | * | 4-3 | 2-2 | 3-0 | 1-2 | 1-1 | 3-2 | 2-3 | 3-2 | 2-3 | 2-1 | 2-4 | 3-3 | 2-0 | 1-0 | 2-3 | 2-2 |
| FC Eindhoven | 3-2 | 2-1 | 0-1 | 0-1 | * | 2-1 | 1-3 | 3-2 | 2-4 | 3-2 | 2-3 | 1-3 | 1-2 | 5-2 | 3-2 | 3-2 | 1-3 | 3-1 | 2-2 | 1-0 |
| FC Emmen | 2-2 | 2-0 | 2-2 | 1-3 | 1-1 | * | 0-0 | 0-0 | 5-2 | 0-0 | 2-2 | 0-2 | 3-1 | 0-0 | 2-1 | 1-0 | 1-1 | 2-1 | 2-3 | 2-3 |
| Fortuna Sittard | 2-1 | 3-2 | 2-0 | 5-1 | 2-2 | 1-2 | * | 2-1 | 1-1 | 3-0 | 2-1 | 5-1 | 1-0 | 3-1 | 3-0 | 1-2 | 4-0 | 6-0 | 1-1 | 1-0 |
| Go Ahead Eagles | 2-1 | 1-3 | 1-2 | 0-3 | 1-3 | 0-1 | 0-1 | * | 0-4 | 3-1 | 4-1 | 2-1 | 1-1 | 0-0 | 3-1 | 1-1 | 2-1 | 0-0 | 1-1 | 1-1 |
| De Graafschap | 4-2 | 2-0 | 2-1 | 0-1 | 4-0 | 2-2 | 2-0 | 1-1 | * | 1-0 | 2-4 | 1-0 | 2-3 | 7-0 | 1-2 | 1-3 | 1-1 | 1-0 | 1-0 | 2-1 |
| Helmond Sport | 1-2 | 3-0 | 3-1 | 1-2 | 0-0 | 3-1 | 1-3 | 1-1 | 0-2 | * | 1-4 | 3-0 | 1-2 | 2-0 | 2-3 | 1-2 | 2-1 | 2-2 | 1-2 | 1-4 |
| Jong Ajax | 3-0 | 3-2 | 1-0 | 3-0 | 4-0 | 3-2 | 4-2 | 0-2 | 0-5 | 2-0 | * | 0-1 | 0-3 | 2-1 | 2-1 | 1-0 | 2-0 | 1-1 | 1-1 | 7-0 |
| Jong AZ | 4-1 | 0-1 | 1-1 | 3-1 | 1-2 | 2-1 | 2-0 | 0-0 | 2-2 | 1-3 | 4-2 | * | 2-1 | 1-3 | 3-1 | 2-7 | 3-1 | 2-1 | 2-2 | 0-2 |
| Jong PSV | 3-2 | 1-1 | 2-1 | 4-2 | 4-1 | 1-1 | 2-3 | 6-0 | 2-2 | 1-2 | 0-3 | 1-2 | * | 2-0 | 1-0 | 3-3 | 5-1 | 3-2 | 6-0 | 2-1 |
| Jong Utrecht | 2-4 | 1-3 | 1-1 | 0-2 | 1-2 | 1-2 | 0-1 | 1-0 | 1-4 | 0-0 | 2-1 | 1-0 | 1-4 | * | 2-1 | 0-2 | 0-3 | 5-2 | 0-1 | 2-1 |
| MVV Maastricht | 3-0 | 1-1 | 3-0 | 1-0 | 2-0 | 0-1 | 1-2 | 4-3 | 1-3 | 3-1 | 0-4 | 3-0 | 0-0 | 3-1 | * | 4-1 | 1-1 | 0-0 | 0-0 | 2-1 |
| NEC | 3-1 | 3-1 | 1-0 | 6-0 | 2-1 | 1-1 | 1-1 | 5-1 | 1-1 | 1-1 | 2-1 | 2-0 | 2-0 | 3-1 | 4-1 | * | 2-1 | 2-0 | 3-0 | 3-0 |
| FC Oss | 5-1 | 2-1 | 1-1 | 3-1 | 1-1 | 2-3 | 1-2 | 1-6 | 1-4 | 0-0 | 0-3 | 2-1 | 0-3 | 2-0 | 1-0 | 3-0 | * | 3-1 | 0-0 | 1-0 |
| RKC Waalwijk | 0-4 | 0-0 | 1-1 | 1-0 | 0-1 | 0-2 | 1-1 | 2-1 | 0-0 | 1-0 | 2-4 | 1-0 | 3-2 | 2-2 | 1-1 | 0-2 | 2-1 | * | 4-1 | 1-3 |
| Telstar | 4-0 | 0-1 | 3-2 | 3-0 | 4-1 | 0-0 | 0-6 | 3-1 | 3-2 | 2-3 | 3-3 | 2-1 | 0-0 | 1-0 | 0-0 | 3-2 | 3-3 | 0-0 | * | 5-2 |
| FC Volendam | 1-1 | 0-1 | 1-0 | 4-1 | 3-2 | 2-3 | 2-0 | 4-3 | 0-0 | 2-2 | 1-2 | 4-1 | 1-0 | 2-1 | 2-2 | 0-2 | 3-1 | 0-1 | 3-4 | * |
Eindstand
| 1 | Jong Ajax * | 38 | 25 | 4 | 9 | 79 | 89 | 54 | +35 | 951 |
| 2 | Fortuna Sittard ♦ | 38 | 24 | 6 | 8 | 78 | 81 | 41 | +40 | 4.851 |
| 3 | NEC + | 38 | 22 | 8 | 8 | 74 | 82 | 46 | +36 | 9.636 |
| 4 | De Graafschap + ♦ | 38 | 18 | 11 | 9 | 65 | 78 | 47 | +31 | 8.387 |
| 5 | Jong PSV | 38 | 19 | 7 | 12 | 64 | 76 | 54 | +22 | 644 |
| 6 | Telstar + | 38 | 16 | 13 | 9 | 61 | 66 | 63 | +3 | 2.753 |
| 7 | FC Emmen + ♦ | 38 | 14 | 16 | 8 | 58 | 58 | 50 | +8 | 3.112 |
| 8 | SC Cambuur + | 38 | 16 | 10 | 12 | 58 | 58 | 53 | +5 | 7.286 |
| 9 | Almere City FC + | 38 | 15 | 7 | 16 | 52 | 70 | 76 | -6 | 1.648 |
| 10 | MVV Maastricht + | 38 | 14 | 8 | 16 | 50 | 57 | 56 | +1 | 4.857 |
| 11 | FC Den Bosch | 38 | 12 | 11 | 15 | 47 | 59 | 55 | +4 | 2.790 |
| 12 | FC Eindhoven | 38 | 14 | 5 | 19 | 47 | 61 | 83 | _22 | 2.227 |
| 13 | FC Dordrecht + | 38 | 14 | 5 | 19 | 47 | 57 | 81 | -24 | 1.543 |
| 14 | FC Volendam | 38 | 13 | 7 | 18 | 46 | 59 | 67 | -8 | 2.836 |
| 15 | FC Oss | 38 | 12 | 10 | 16 | 46 | 53 | 65 | -12 | 1.991 |
| 16 | Jong AZ | 38 | 14 | 4 | 20 | 46 | 57 | 70 | -13 | 691 |
| 17 | Go Ahead Eagles | 38 | 9 | 10 | 19 | 37 | 48 | 68 | -20 | 6.901 |
| 18 | RKC Waalwijk | 38 | 8 | 13 | 17 | 37 | 37 | 61 | -24 | 2.143 |
| 19 | Helmond Sport | 38 | 9 | 9 | 20 | 36 | 50 | 67 | -17 | 1.649 |
| 20 | Jong FC Utrecht | 38 | 7 | 6 | 25 | 27 | 37 | 76 | -39 | 679 |
Wedstrijden
| R: | Datum: | Thuis: | Uit: | Sc.: | Ts.: | Ar.: | Details: |
|---|---|---|---|---|---|---|---|
| 1 | 18/08/2017 | SC Cambuur | Jong Ajax | 1-2 | 7.334 | Blank | 0-1 Sidioel, 0-2 Cassierra, 1-2 Steenvoorden R: Peersman (Cam) |
| 1 | 18/08/2017 | FC Volendam | Helmond Sport | 2-2 | 2.581 | Bax | 1-0 Runderkamp, 2-0 Ten Den, 2-1 Naudts, 2-2 Janzen |
| 1 | 18/08/2017 | RKC Waalwijk | FC Emmen | 0-2 | 1.931 | Vd Kerkhof | 0-1 Peters (pen), 0-2 Loen |
| 1 | 18/08/2017 | MVV Maastricht | Go Ahead Eagles | 4-3 | 4.915 | Manschot | 0-1 Hendriks, 1-1 Janssen, 1-2 Hendriks, 2-2 Okita, 2-3 Langedijk, 3-3 Ogunjimi, 4-3 Okita |
| 1 | 18/08/2017 | FC Eindhoven | Telstar | 2-2 | 2.408 | Van Herk | 0-1 Júnior, 1-1 Kabangu, 1-2 Rodrigues, 2-2 Kabangu; R: Platje (Tel) |
| 1 | 18/08/2017 | FC Den Bosch | Jong AZ | 1-3 | 2.882 | Oostrom | 1-0 Mert, 1-1 El Hasnaoui, 1-2 Helmer (pen), 1-3 Einarsson |
| 1 | 18/08/2017 | Fortuna Sittard | FC Dordrecht | 5-1 | 3.165 | Perez | 1-0 Semedo, 2-0 en 3-0 Stokkers, 3-1 Hamer, 4-1 Vidigal, 5-1 Askovski; R: V. Wermeskerken (Dor) |
| 1 | 18/08/2017 | NEC | Almere City FC | 3-1 | 9.502 | Janssen | 1-0 Larsson, 1-1 Valpoort, 2-1 Groeneveld, 3-1 Larsson |
| 1 | 21/08/2017 | Jong FC Utrecht | FC Oss | 0-3 | 892 | Gerrets | 0-1 Quekel, 0-2 Van der Venne, 0-3 Kamaci |
| 1 | 21/08/2017 | Jong PSV | De Graafschap | 2-2 | 1.104 | Mulder | 0-1 Serrarens, 1-1 Van Vlerken, 2-1 De Wijs, 2-2 Van den Hurk |
| 2 | 25/08/2017 | FC Dordrecht | Jong FC Utrecht | 2-1 | 1.203 | Kooij | 1-0 Mutzers, 2-0 Mahmudov (pen), 2-1 Hilterman |
| 2 | 25/08/2017 | Go Ahead Eagles | NEC | 1-1 | 8.324 | S. Mulder | 0-1 Braken, 1-1 Hendriks |
| 2 | 25/08/2017 | De Graafschap | SC Cambuur | 2-0 | 8.014 | Vd Graaf | 1-0 Serrarens, 2-0 Van Mieghem |
| 2 | 25/08/2017 | Jong Ajax | Fortuna Sittard | 4-2 | 799 | Dieperink | 1-0 Cassierra, 2-0 en 3-0 Muric, 3-1 Schuurs, 3-2 Semedo, 4-2 Johnsen |
| 2 | 25/08/2017 | FC Oss | FC Volendam | 1-0 | 1.455 | Vd Eijk | 1-0 Van Pol |
| 2 | 25/08/2017 | Almere City FC | FC Den Bosch | 1-1 | 1.500 | Lindhout | 1-0 Salasiwa, 1-1 Blummel |
| 2 | 25/08/2017 | Telstar | MVV Maastricht | 0-0 | 1.400 | Perez | |
| 2 | 25/08/2017 | Helmond Sport | Jong PSV | 1-2 | 2.211 | Van Herk | 1-0 Zeldenrust, 1-1 en 1-2 Laursen |
| 2 | 25/08/2017 | FC Emmen | FC Eindhoven | 1-1 | 2.540 | Bax | 0-1 Lieder, 1-1 Bakker |
| 2 | 25/08/2017 | Jong AZ | RKC Waalwijk | 2-1 | 1.000 | Martens | 1-0 Jacobs, 1-1 De Graauw, 2-1 Helmer |
| 3 | 01/09/2017 | Jong FC Utrecht | Jong AZ | 1-0 | 533 | Van Herk | 1-0 Hatzidiakos (e.d.) |
| 3 | 01/09/2017 | FC Dordrecht | FC Emmen | 2-2 | 1.375 | Vd Eijk | 0-1 Siekman, 1-1 Calcan, 2-1 Mutzers, 2-2 Loen |
| 3 | 01/09/2017 | Jong PSV | Jong Ajax | 0-3 | 2.278 | Oostrom | 0-1 Cassiera, 0-2 Neres, 0-3 Flemming |
| 3 | 01/09/2017 | MVV Maastricht | FC Den Bosch | 3-0 | 4.987 | Vd Graaf | 1-0 Okita, 2-0 Nys, 3-0 Yildirim |
| 3 | 01/09/2017 | Fortuna Sittard | Almere City FC | 2-1 | 3.162 | Bax | 1-0 en 2-0 Askovski, 3-0 Valpoort |
| 3 | 01/09/2017 | NEC | FC Eindhoven | 2-1 | 8.489 | Lindhout | 1-0 Braken, 1-1 De Silva, 2-1 Braken |
| 3 | 01/09/2017 | Telstar | FC Oss | 3-3 | 1.963 | C. Mulder | 0-1 Van der Venne, 0-2 Bax, 1-3, 2-3 en 3-3 Hamdaoui, 3-3 Schouten (e.d.) |
| 3 | 01/09/2017 | Helmond Sport | Go Ahead Eagles | 1-1 | 1.993 | Vd Kerkhof | 0-1 De Kogel, 1-1 Thomassen |
| 3 | 02/09/2017 | RKC Waalwijk | De Graafschap | 0-0 | 1.948 | Gerrets | R: Receveur (Gra) |
| 3 | 03/09/2017 | FC Volendam | SC Cambuur | 0-1 | 3.259 | Manschot | 0-1 Houtkoop |
| 4 | 08/09/2017 | SC Cambuur | Jong FC Utrecht | 2-2 | 6.732 | Oostrom | 1-0 Daniels, 1-1 Venema, 2-1 Steenvoorden, 2-2 Peijnenburg; R: Schils (Cam), Ould Chikh (Utr, |
| 4 | 08/09/2017 | FC Eindhoven | Jong PSV | 1-2 | 2.700 | Vd Eijk | 0-1 Lammers, 1-1 Lieder, 1-2 Junior |
| 4 | 08/09/2017 | Go Ahead Eagles | FC Volendam | 1-1 | 7.331 | Van Boekel | 1-0 Beltrame, 1-1 Ten Den |
| 4 | 08/09/2017 | FC Den Bosch | NEC | 3-0 | 3.188 | Kamphuis | 1-0 Kaars, 2-0 Vossebelt, 3-0 Mert |
| 4 | 08/09/2017 | De Graafschap | MVV Maastricht | 1-2 | 8.023 | Vd Kerkhof | 0-1 Badnarek (e.d.), 0-2 Mmaee, 1-2 Diemers |
| 4 | 08/09/2017 | FC Oss | FC Dordrecht | 3-1 | 1.881 | Dieperink | 0-1 Mahmudov, 1-1 Kamaci, 2-1 Van der Venne, 3-1 Kamaci; R: Hamer (Dor) |
| 4 | 08/09/2017 | Almere City FC | Helmond Sport | 3-1 | 1.300 | Martens | 1-0 Mirani, 2-0 en 3-0 Valpoort, 3-1 Zeldenrust (pen) |
| 4 | 08/09/2017 | FC Emmen | Fortuna Sittard | 0-0 | 2.267 | C. Mulder | R: Peters |
| 4 | 11/09/2017 | Jong Ajax | RKC Waalwijk | 1-1 | 703 | Perez | 1-0 Eiting, 1-1 Drost |
| 4 | 12/09/2017 | Jong AZ | Telstar | 2-2 | 1.647 | Kooij | 1-0 Koopmeiners, 1-1 Novakovich, 2-1 Friday, 2-2 Van Iperen |
| 5 | 15/09/2017 | Jong FC Utrecht | De Graafschap | 1-4 | 660 | Dieperink | 1-0 Venema, 1-1 Van Mieghem, 1-2 Ars, 1-3 Diemers, 1-4 Van den Hurk |
| 5 | 15/09/2017 | FC Dordrecht | Almere City FC | 1-1 | 1.403 | Oostrom | 1-0 Calcan, 1-1 Valpoort |
| 5 | 15/09/2017 | RKC Waalwijk | FC Eindhoven | 0-1 | 1.987 | Vd Graaf | 0-1 Carlone |
| 5 | 15/09/2017 | MVV Maastricht | Jong PSV | 0-0 | 5.083 | Bax | |
| 5 | 15/09/2017 | Go Ahead Eagles | SC Cambuur | 3-1 | 7.859 | Janssen | 0-1 Matieu, 1-1 Hendriks, 2-1 Rossi, 3-1 Barto |
| 5 | 15/09/2017 | Fortuna Sittard | FC Volendam | 1-0 | 2.750 | Martens | 1-0 Ospitalieri |
| 5 | 15/09/2017 | NEC | FC Emmen | 1-1 | 9.550 | Blom | 1-0 Schuurman, 1-1 Bakker |
| 5 | 15/09/2017 | Telstar | FC Den Bosch | 3-2 | 1.815 | Vd Eijk | 1-0 Rodrigues, 1-1 Blummel, 2-1 Platje, 2-2 Kaars, 3-2 Novakovich |
| 5 | 15/09/2017 | Helmond Sport | Jong Ajax | 1-4 | 1.911 | Gerrets | 0-1 Eiting, 1-1 Zeldenrust (pen), 1-2 en 1-3 Cassierra, 1-4 Johnsen |
| 6 | 22/09/2017 | FC Volendam | De Graafschap | 0-0 | 3.202 | Bax | |
| 6 | 22/09/2017 | RKC Waalwijk | Jong FC Utrecht | 2-2 | 1.339 | Blank | 1-0 Rienstra, 1-1 Sow, 2-1 Bergkamp, 2-2 Loukili |
| 6 | 22/09/2017 | MVV Maastricht | SC Cambuur | 1-1 | 4.903 | Higler | 1-0 Okita, 1-1 Barto; R: Pereira (MVV) |
| 6 | 22/09/2017 | FC Eindhoven | FC Den Bosch | 0-1 | 2.263 | d'Hondt | 0-1 Blummel |
| 6 | 22/09/2017 | Fortuna Sittard | Jong AZ | 5-1 | 2.822 | Gerrets | 1-0 en 2-0 (pen) Dianessy, 2-1 Reijnders, 3-1 Semedo, 4-1 Schuurs, 5-1 Semedo |
| 6 | 22/09/2017 | Almere City FC | FC Oss | 2-2 | 1.000 | Perez | 0-1 Bakx, 0-2 Vd Venne, 1-2 en 2-2 Vd Heijden |
| 6 | 22/09/2017 | Helmond Sport | FC Dordrecht | 1-2 | 1.731 | Vd Graaf | 1-0 Zeldenrust (pen), 1-1 Arias, 1-2 Misidjan R: Warmolts (Hel) |
| 6 | 22/09/2017 | FC Emmen | Go Ahead Eagles | 0-0 | 3.045 | Lindhout | |
| 6 | 25/09/2017 | Jong PSV | NEC | 3-3 | 1.463 | Kooij | 1-0 Gudmundsson, 1-1 Joppen, 1-2 Van de Pavert, 1-3 Golla, 2-3 en 3-3 Lammers; R: Paal (PSV) |
| 6 | 25/09/2017 | Jong Ajax | Telstar | 1-1 | 1.750 | Martens | 0-1 Van Huizen, 1-1 Bijleveld |
| 7 | 29/09/2017 | SC Cambuur | RKC Waalwijk | 1-1 | 7.355 | Vd Kerkhof | 0-1 Voskamp, 1-1 Kallon; R: Mezghrani (RKC) |
| 7 | 29/09/2017 | Jong FC Utrecht | Helmond Sport | 0-0 | 565 | Vd Eijk | |
| 7 | 29/09/2017 | FC Dordrecht | FC Volendam | 2-2 | 1.434 | Ruperti | 0-1 Visser, 1-1 Arias, 1-2 Veerman, 2-2 Stankov |
| 7 | 29/09/2017 | Go Ahead Eagles | Almere City FC | 2-1 | 7.673 | Kooij | 1-0 Hendriks, 1-1 Brands, 2-1 Hendriks |
| 7 | 29/09/2017 | FC Den Bosch | Jong PSV | 5-0 | 2.875 | Van Herk | 1-0 Vossebelt (pen), 2-0 Kaars, 3-0 (pen) en 4-0 Vossebelt, 5-0 Sirani |
| 7 | 29/09/2017 | De Graafschap | FC Emmen | 2-2 | 7.671 | Martens | 0-1 Bannink, 0-2 Haydary, 1-2 Ars, 2-2 Van den Hurk |
| 7 | 29/09/2017 | NEC | MVV Maastricht | 4-1 | 9.106 | Vd Graaf | 1-0 Golla, 1-1 Gölpek, 2-1 Rayhi, 3-1 Kadioglu, 4-1 Groeneveld |
| 7 | 29/09/2017 | FC Oss | Jong Ajax | 1-2 | 3.321 | Blank | 0-1 De Wit, 0-2 Cassierra, 0-3 Mazraoui |
| 7 | 29/09/2017 | Telstar | Fortuna Sittard | 0-6 | 1.982 | Oostrom | 0-1 Schuurs, 0-2 Vidigal, 0-3 Dammers, 0-4 Vidigal, 0-5 Stokkers, 0-6 Vidigal |
| 7 | 29/09/2017 | Jong AZ | FC Eindhoven | 1-2 | 573 | Dieperink | 0-1 Lider, 1-1 Garcia, 1-2 Lieder |
| 8 | 06/10/2017 | FC Volendam | Telstar | 3-4 | 3.189 | Blank | 1-0 Veerman, 1-1 Hamdaoui, 1-2 (p) en 1-3 Novakovich, 2-3 Veerman (pen), 2-4 Korpershoek, 3-4 Stroo |
| 8 | 06/10/2017 | FC Dordrecht | FC Eindhoven | 4-3 | 1.159 | C. Mulder | 1-0 Mutzers, 2-0 Mahmudov (pen), 3-0 Arias, 3-1 Lieder (pen), 4-1 Mutzers, 4-2 V. Vaerenbergh, 4-3 Matthys |
| 8 | 08/10/2017 | RKC Waalwijk | FC Den Bosch | 1-1 | 2.705 | Bax | 0-1 Deijl, 1-1 Van Weert |
| 8 | 06/10/2017 | Jong PSV | Jong AZ | 1-2 | 468 | Ruperti | 0-1 en 0-2 Friday, 1-2 Verreth |
| 8 | 06/10/2017 | Fortuna Sittard | NEC | 1-2 | 4.567 | Perez | 1-0 Stokkers, 1-1 Rayhi, 1-2 Joppen R: Joppen (NEC) |
| 8 | 06/10/2017 | Jong Ajax | Jong FC Utrecht | 2-1 | 776 | Van Herk | 1-0 S. de Jong, 1-1 Sow, 2-1 Cassierra |
| 8 | 06/10/2017 | FC Oss | Go Ahead Eagles | 1-6 | 2.001 | Martens | 0-1 Langedijk, 0-2 en 0-3 (pen) Hendriks, 0-4 Werkhoven, 1-4 Kamaci (pen), 1-5 Maneschijn, 1-6 Suk |
| 8 | 06/10/2017 | Almere City FC | MVV Maastricht | 3-2 | 1.537 | Dieperink | 0-1 Yildirim, 1-1 en 2-1 Valpoort, 3-1 Walian, 3-2 Yildirim |
| 8 | 06/10/2017 | Helmond Sport | De Graafschap | 0-2 | 2.047 | Vermeiren | 0-1 Van Mieghem, 0-2 Diemers |
| 8 | 06/10/2017 | FC Emmen | SC Cambuur | 2-0 | 4.018 | Vd Graaf | 1-0 Peters, 2-0 Haydary |
| 9 | 13/10/2017 | SC Cambuur | FC Oss | 1-3 | 7.072 | Vd Eijk | 0-1 Dogan, 0-2 Kamaci, 1-2 Boerlage, 1-3 Adarabioyo |
| 9 | 13/10/2017 | MVV Maastricht | Fortuna Sittard | 1-2 | 8.152 | Janssen | 1-0 Okita, 1-1 Semedo, 1-2 Vidigal R: Semedo (For) |
| 9 | 13/10/2017 | FC Eindhoven | FC Volendam | 1-0 | 1.987 | Perez | 1-0 Kabangu |
| 9 | 13/10/2017 | FC Den Bosch | Jong FC Utrecht | 1-0 | 2.688 | Kooij | 1-0 Blummel |
| 9 | 13/10/2017 | NEC | RKC Waalwijk | 2-0 | 9.016 | Kamphuis | 1-0 Braken, 2-0 Rayhi |
| 9 | 13/10/2017 | Telstar | FC Dordrecht | 3-0 | 2.249 | Teuben | 1-0 Novakovich (pen), 2-0 Osman, 3-0 Van Huizen R: Rodrigues (Tel) |
| 9 | 13/10/2017 | FC Emmen | Jong PSV | 3-1 | 3.043 | Blank | 1-0- Bannink, 1-1 Lammers, 2-1 Peters, 3-1 Haydary |
| 9 | 15/10/2017 | De Graafschap | Go Ahead Eagles | 1-1 | 9.311 | Nijhuis | 0-1 Langedijk, 1-1 Ars |
| 9 | 16/10/2017 | Jong Ajax | Almere City FC | 3-0 | 1.396 | Bax | 1-0 Cassierra, 2-0 Cerny, 3-0 Mazraoui |
| 9 | 16/10/2017 | Jong AZ | Helmond Sport | 1-3 | 713 | Gerrets | 0-1 Braber, 1-1 Friday, 1-2 Damen, 1-3 Naudts |
| 10 | 20/10/2017 | Jong FC Utrecht | MVV Maastricht | 2-1 | 692 | Gerrets | 0-1 Yildirim, 1-1 en 2-1 Venema |
| 10 | 20/10/2017 | FC Volendam | NEC | 0-2 | 2.480 | Dieperink | 0-1 Groeneveld, 0-2 Braken |
| 10 | 20/10/2017 | FC Dordrecht | De Graafschap | 1-1 | 1.824 | Kooij | 0-1 Nieuwpoort, 1-1 Duarte Lopes |
| 10 | 20/10/2017 | Jong PSV | RKC Waalwijk | 3-2 | 428 | Van Damme | 1-0 Ritzmaier, 2-0 Gudmundsson, 2-1 Bergkamp, 2-2 Voskamp (pen), 3-2 Gudmundson |
| 10 | 20/10/2017 | Go Ahead Eagles | Jong Ajax | 4-1 | 8.452 | Vd Eijk | 0-1 Johnsen, 1-1 Hendriks, 2-1 Suk, 3-1 Schenk, 4-1 De Kogel; R: Zeefuik (Aja) |
| 10 | 20/10/2017 | Fortuna Sittard | FC Eindhoven | 2-2 | 5.266 | Teuben | 1-0 Dianessy, 1-1 Lieder (pen), 2-1 Askovski, 2-2 Deschilder |
| 10 | 20/10/2017 | FC Oss | FC Den Bosch | 1-1 | 3.341 | Higler | 0-1 Vossebelt (pen), 1-1 Dogan |
| 10 | 20/10/2017 | Almere City FC | SC Cambuur | 1-1 | 1.400 | Martens | 1-0 Van der Heijden, 1-1 Boerlage |
| 10 | 20/10/2017 | Helmond Sport | Telstar | 1-2 | 1.579 | Ruperti | 0-1 Novakovich, 1-1 Naudts, 1-2 Hamdaoui |
| 10 | 20/10/2017 | Jong AZ | FC Emmen | 2-1 | 587 | C. Mulder | 1-0 Dos Santos, 2-0 Jacobs, 2-1 Hemmen |
| 5 | 23/10/2017 | FC Oss | Jong AZ | 2-1 | 1.232 | Van Herk | 1-0 Church (e.d.), 2-0 Kamaci, 2-1 Friday |
| 11 | 27/10/2017 | SC Cambuur | Jong PSV | 0-1 | 7.245 | Gerrets | 0-1 Duarte |
| 11 | 27/10/2017 | RKC Waalwijk | FC Dordrecht | 0-1 | 2.301 | Manschot | 0-1 Seys |
| 11 | 29/10/2017 | MVV Maastricht | FC Volendam | 2-1 | 4.563 | Kamphuis | 1-0 Gölpek, 1-1 Doodeman, 2-1 Ciranni |
| 11 | 27/10/2017 | FC Eindhoven | Jong Ajax | 2-3 | 2.913 | Oostrom | 1-0 Lieder, 1-1 De Wit, 1-2 Eiting, 1-3 De Wit, 2-3 Lieder |
| 11 | 27/10/2017 | Go Ahead Eagles | Jong AZ | 2-1 | 7.398 | Teuben | 0-1 Friday, 1-1 Langedijk, 2-1 Hendriks |
| 11 | 27/10/2017 | FC Den Bosch | Helmond Sport | 2-2 | 2.659 | Van Herk | 1-0 Kaars, 1-1 Naudts, 1-2 Vicento, 2-2 Biemans |
| 11 | 27/10/2017 | De Graafschap | Fortuna Sittard | 2-0 | 9.201 | Vd Kerkhof | 1-0 Van Mieghem, 2-0 Serrarens |
| 11 | 27/10/2017 | NEC | Jong FC Utrecht | 3-1 | 8.768 | Blank | 1-0 Braken, 2-0 Groeneveld, 2-1 Ould-Chikh, 3-1 Van de Pavert |
| 11 | 29/10/2017 | Telstar | Almere City FC | 4-0 | 2.549 | Vd Eijk | 1-0 Platje, 2-0 Novakovich, 3-0 Platje, 4-0 Osman (pen) |
| 11 | 27/10/2017 | FC Emmen | FC Oss | 1-1 | 3.369 | Kooij | 1-0 Peters, 1-1 Stuy van den Herik |
| 12 | 03/11/2017 | Jong FC Utrecht | FC Eindhoven | 1-2 | 685 | Ruperti | 1-0 Hilterman, 1-1 en 1-2 Lieder |
| 12 | 03/11/2017 | FC Volendam | Jong PSV | 1-0 | 2.886 | Mulder | 1-0 Schilder |
| 12 | 03/11/2017 | FC Dordrecht | FC Den Bosch | 0-3 | 1.352 | Blank | 0-1 Bouyaghlafen, 0-2 Blummel, 0-3 Mert |
| 12 | 03/11/2017 | MVV Maastricht | RKC Waalwijk | 0-0 | 4.637 | Teuben | |
| 12 | 03/11/2017 | Fortuna Sittard | FC Oss | 4-0 | 3.103 | Vergoote | 1-0 Semedo, 2-0 Askovski, 3-0 Stokkers, 4-0 Dianessy |
| 12 | 03/11/2017 | NEC | SC Cambuur | 3-1 | 9.163 | Bax | 0-1 Van Kippersluis, 1-1 en 2-1 Rayhi, 3-1 Langil |
| 12 | 03/11/2017 | Jong Ajax | De Graafschap | 0-5 | 1.103 | Vd Graaf | 0-1 El Jebli, 0-2 Ars, 0-3 Van den Hurk (pen), 0-4 Van Mieghem, 0-5 Receveur; R: Sierhuis (Aja) |
| 12 | 03/11/2017 | Almere City FC | Jong AZ | 3-2 | 1.301 | Oostrom | 1-0 Salasiwa (pen), 1-1 Wijndal, 2-1 Walian, 2-2 Friday, 3-2 Van der Heijden (pen) |
| 12 | 03/11/2017 | Telstar | Go Ahead Eagles | 3-1 | 2.756 | S. Mulder | 1-0 Schouten, 2-0 Osman, 2-1 Hendriks, 3-1 Osman |
| 12 | 03/11/2017 | Helmond Sport | FC Emmen | 3-1 | 1.331 | Martens | 0-1 Loen, 1-1 Naudts, 2-1 en 3-1 Edwards |
| 13 | 17/11/2017 | SC Cambuur | Fortuna Sittard | 1-0 | 7.094 | Van Boekel | 1-0 Peersman; R: Smeets (Cam) |
| 13 | 17/11/2017 | RKC Waalwijk | Telstar | 4-1 | 1.576 | Vd Kerkhof | 1-0 Bakari, 2-0 Mulder, 3-0 De Boer (e.d.), 3-1 Rodrigues, 4-1 Greene |
| 13 | 17/11/2017 | FC Eindhoven | MVV Maastricht | 3-2 | 2.265 | S. Mulder | 1-0, 2-0 en 3-0 Lieder, 3-1 Okita, 3-2 Loshaj |
| 13 | 17/11/2017 | Go Ahead Eagles | FC Dordrecht | 0-3 | 7.762 | Janssen | 0-1 Bliek, 0-2 Duarte Lopes, 0-3 Hamer |
| 13 | 17/11/2017 | FC Den Bosch | FC Volendam | 3-1 | 2.836 | Vd Eijk | 1-0 Vossebelt, 1-1 Stroo, 2-1 Van der Sande, 3-1 Blummel |
| 13 | 17/11/2017 | De Graafschap | NEC | 1-3 | 11.228 | Gözübüyük | 0-1 Groeneveld, 1-1 Van Mieghem, 1-2 Braken, 1-3 Golla |
| 13 | 17/11/2017 | FC Oss | Helmond Sport | 0-0 | 1.923 | Gerrets | R: Fecunda (Hel) |
| 13 | 17/11/2017 | FC Emmen | Almere City FC | 2-2 | 2.517 | Dieperink | 1-0 Peters, 2-0 Bijl, 2-1 Mirani, 2-2 Van der Water |
| 13 | 20/11/2017 | Jong PSV | Jong FC Utrecht | 2-0 | 344 | Kooij | 1-0 Lammers, 2-0 Gudmundsson |
| 13 | 20/11/2017 | Jong AZ | Jong Ajax | 4-2 | 2.471 | Ruperti | 0-1 Mazraoui, 0-2 Cassierra, 1-2 Helmer, 2-2 Reijnders, 3-2 Seuntjens, 4-2 Garcia |
| 14 | 24/11/2017 | SC Cambuur | FC Den Bosch | 2-2 | 7.044 | Manschot | 1-0 Van Kippersluis, 1-1 Mert, 2-1 Steenvoorden, 2-2 Schilder (e.d.) |
| 14 | 24/11/2017 | Jong FC Utrecht | Almere City FC | 2-4 | 511 | Teuben | 1-0 Sow, 1-1 Valpoort, 2-1 Venema, 2-2 Walian, 2-3 Valpoort, 2-4 MacDonald |
| 14 | 24/11/2017 | FC Volendam | FC Emmen | 2-3 | 1.500 | Van Herk | 0-1 Peters (pen), 1-1 Doodeman, 2-1 Stroo, 2-2 Veldmate, 2-3 Hemmen |
| 14 | 24/11/2017 | FC Dordrecht | Jong AZ | 3-2 | 1.234 | Van Damme | 1-0 Calcan, 1-1 Reijnders, 1-2 Hoedemakers, 2-2 Duarte Lopes, 3-2 Mahmudov |
| 14 | 24/11/2017 | RKC Waalwijk | FC Oss | 2-1 | 2.378 | Ruperti | 0-1 Kamaci, 1-1 Mulder, 2-1 Greene |
| 14 | 24/11/2017 | Jong PSV | Telstar | 6-0 | 506 | Dieperink | 1-0 Gudmundsson, 2-0 Verreth, 3-0 en 4-0 Malen, 5-0 Rigo, 6-0 Laursen; R: Lopes Cabral (Tel) |
| 14 | 24/11/2017 | MVV Maastricht | Helmond Sport | 3-1 | 4.429 | Bax | 1-0 Okita, 2-0 Kostons, 2-1 Naudts, 3-1 Koolhof |
| 14 | 24/11/2017 | Fortuna Sittard | Go Ahead Eagles | 2-1 | 3.186 | Higler | 0-1 Hendriks, 1-1 en 2-1 Dammers |
| 14 | 24/11/2017 | De Graafschap | FC Eindhoven | 4-0 | 8.245 | Blank | 1-0 Van Mieghem, 2-0 Nieuwpoort, 3-0 Van den Hurk (pen), 4-0 Receveur R: Matthys (Ein) |
| 14 | 24/11/2017 | NEC | Jong Ajax | 2-1 | 11.037 | Martens | 0-1 Mazraoui, 1-1 Rayhi, 2-1 Joppen |
| 15 | 27/11/2017 | FC Eindhoven | SC Cambuur | 2-1 | 1.335 | C. Mulder | 1-0 Van de Velde, 1-1 Barto, 2-1 Lieder (pen) |
| 15 | 27/11/2017 | Go Ahead Eagles | Jong FC Utrecht | 0-0 | 6.118 | Oostrom | |
| 15 | 27/11/2017 | FC Den Bosch | De Graafschap | 1-1 | 2.653 | Bax | 1-0 Blummel, 1-1 Ars |
| 15 | 27/11/2017 | Jong Ajax | FC Dordrecht | 3-0 | 580 | Gerrets | 1-0 Johnsen, 2-0 De Wit, 3-0 Nunnely |
| 15 | 27/11/2017 | FC Oss | Jong PSV | 0-3 | 1.106 | Blank | 0-1 Laursen, 0-2 Lammers, 0-3 Malen |
| 15 | 27/11/2017 | Almere City FC | RKC Waalwijk | 3-2 | 1.503 | Van Herk | 1-0 VAlpoort (pen), 1-1 Lammers, 2-1 Walian, 3-1 Van de Water, 3-2 Seys |
| 15 | 27/11/2017 | Telstar | NEC | 3-2 | 2.563 | Vd Graaf | 1-0 Van Huizen, 2-0 Osman, 2-1 Achahbar, 2-2 Braken, 3-2 Platje |
| 15 | 27/11/2017 | Helmond Sport | Fortuna Sittard | 1-3 | 1.031 | Manschot | 0-1 Vidigal, 1-1 Naudts, 1-2 Vidigal, 1-3 Askovski |
| 15 | 27/11/2017 | FC Emmen | MVV Maastricht | 2-1 | 2.163 | Blom | 1-0 en 2-0 Peters, 2-1 Gölpek |
| 15 | 27/11/2017 | Jong AZ | FC Volendam | 0-2 | 1.366 | Perez | 0-1 Veerman, 0-2 Antwi |
| 16 | 01/12/2017 | SC Cambuur | Telstar | 2-1 | 6.769 | Kooij | 0-1 Hamdaoui, 1-1 Narsingh, 2-1 Kip (pen) |
| 16 | 01/12/2017 | FC Volendam | Almere City FC | 1-1 | 2.000 | Blank | 0-1 Valpoort, 1-1 Antwi; R; Schilder (Vol) |
| 16 | 01/12/2017 | RKC Waalwijk | Helmond Sport | 1-0 | 2.411 | C. Mulder | 1-0 Greene |
| 16 | 01/12/2017 | MVV Maastricht | Jong Ajax | 0-4 | 4.861 | Perez | 0-1 en 0-2 Sierhuis, 0-3 en 0-4 Flemming |
| 16 | 01/12/2017 | FC Eindhoven | FC Oss | 1-3 | 1.962 | Teuben | 1-0 Lieder, 1-1 Van der Venne, 1-2 Van Pol, 1-3 Van der Sluys; R: Matthys (Ein) |
| 16 | 01/12/2017 | FC Den Bosch | Go Ahead Eagles | 3-0 | 3.173 | Vd Graaf | 1-0 en 2-0 Van der Sande, 3-0 Vossebelt |
| 16 | 01/12/2017 | De Graafschap | Jong AZ | 1-0 | 7.508 | Van Herk | 1-0 Van Mieghem |
| 16 | 01/12/2017 | NEC | FC Dordrecht | 6-0 | 9.038 | Lindhout | 1-0 Larsson, 2-0 (pen) en 3-0 Langil, 4-0 Kadioglu, 5-0 Langil (pen), 6-0 Achahbar |
| 16 | 04/12/2017 | Jong FC Utrecht | FC Emmen | 1-2 | 698 | Ruperti | 1-0 David, 1-1 Bannink, 1-2 Hemmen |
| 16 | 04/12/2017 | Jong PSV | Fortuna Sittard | 2-3 | 603 | Oostrom | 1-0 Malen, 2-0 Lammers, 2-1 Askovski, 2-2 Semedo (p), 2-3 Askovski R: Gudmundsson (PSV) |
| 17 | 08/12/2017 | FC Volendam | Jong FC Utrecht | 2-1 | 1.000 | Gerrets | 1-0 Doodeman, 2-0 Stroo, 2-1 Peijnenburg R: Ten Den (Vol) |
| 17 | 08/12/2017 | FC Dordrecht | MVV Maastricht | 2-4 | 1.245 | Oostrom | 1-0 Mmaee (e.d.), 1-1 Ciranni, 2-1 Arias (pen), 2-2 Koolhof, 2-3 Mmaee, 2-4 Alkan (e.d.) |
| 17 | 12/12/2017 | Go Ahead Eagles | Jong PSV | 1-1 | 4.318 | Bax | 0-1 Malen, 1-1 Beltrame |
| 17 | 08/12/2017 | Fortuna Sittard | RKC Waalwijk | 6-0 | 2.887 | Kooij | 1-0 en 2-0 Schuurs, 3-0 Askovski, 4-0 Stokkers, 5-0 Dianessy (pen), 6-0 Hutten R: Quasten, Greene (RKC) |
| 17 | 08/12/2017 | Almere City FC | De Graafschap | 2-1 | 1.845 | Vd Kerkhof | 0-1 Van den Hurk, 1-1 Van der Water, 2-1 Van der Heijden |
| 17 | 08/12/2017 | Telstar | FC Emmen | 0-0 | 2.142 | C. Mulder | |
| 17 | 18/12/2017 | Helmond Sport | FC Eindhoven | 0-0 | 2.891 | Van Herk | |
| 17 | 18/12/2017 | Jong Ajax | FC Den Bosch | 1-0 | 400 | Dieperink | 1-0 Nunnely |
| 18 | 15/12/2017 | SC Cambuur | FC Dordrecht | 3-0 | 6.912 | Ruperti | 1-0 Kallon, 2-0 Houtkoop, 3-0 Kip |
| 18 | 15/12/2017 | Jong FC Utrecht | Telstar | 0-1 | 431 | Blank | 0-1 Platje |
| 18 | 15/12/2017 | RKC Waalwijk | FC Volendam | 1-3 | 1.918 | Vermeire | 1-0 Seys, 1-1 Kwakman, 1-2 en 1-3 Stroo |
| 18 | 15/12/2017 | MVV Maastricht | Jong AZ | 3-0 | 4.278 | Martens | 1-0 Koolhof, 2-0 Yildirim, 3-0 Houben |
| 18 | 15/12/2017 | FC Eindhoven | Go Ahead Eagles | 3-2 | 1.843 | Kooij | 0-1 Hendriks, 1-1 Kabangu, 2-1 Lieder, 2-2 Beltrame, 3-2 Kabangu |
| 18 | 15/12/2017 | Jong PSV | Almere City FC | 3-2 | 305 | Gerrets | 1-0 Obispo, 1-1 Van der Water, 1-2 Valpoort, 2-2 en 3-2 Malen |
| 18 | 15/12/2017 | FC Den Bosch | Fortuna Sittard | 2-4 | 3.586 | Perez | 0-1 Saddiki, 0-2 Dianessy, 1-2 Vossebelt, 1-3 Semedo, 2-3 Kaars, 2-4 Dianessy |
| 18 | 15/12/2017 | De Graafschap | FC Oss | 1-1 | 8.102 | Vd Graaf | 1-0 Van Mieghem, 1-1 Grotenbreg |
| 18 | 15/12/2017 | NEC | Helmond Sport | 1-1 | 9.251 | Van Boekel | 1-0 Larsson, 1-1 Hiwat |
| 18 | 15/12/2017 | FC Emmen | Jong Ajax | 2-2 | 4.766 | Oostrom | 0-1 Veendorp (e.d.), 1-1 Peters, 2-1 Hemmen, 2-2 Lang |
| 19 | 22/12/2017 | FC Dordrecht | Jong PSV | 2-3 | 1.333 | Teuben | 0-1 Statia (e.d.), 0-2 Lonwijk, 1-2 Duarte Lopes, 1-3 Malen, 2-3 Duarte Lopes |
| 19 | 22/12/2017 | Go Ahead Eagles | RKC Waalwijk | 0-0 | 6.278 | Vd Kerkhof | |
| 19 | 23/12/2017 | Fortuna Sittard | Jong FC Utrecht | 3-1 | 7.032 | Dieperink | 1-0 en 2-0 Stokkers, 2-1 Mallahi, 3-1 Stokkers |
| 19 | 22/12/2017 | Jong Ajax | FC Volendam | 7-0 | 931 | C. Mulder | 1-0 en 2-0 Cassierra, 3-0 Nunnely, 4-0 Cassierra, 5-0 Mazraoui (pen), 6-0 en 7-0 Sierhuis |
| 19 | 22/12/2017 | FC Oss | MVV Maastricht | 1-0 | 1.521 | Ruperti | 1-0 Van der Venne |
| 19 | 22/12/2017 | Almere City FC | FC Eindhoven | 5-1 | 1.364 | Gözübüyük | 1-0 Valpoort, 1-1 Van Landschoot, 2-1 Overtoom, 3-1 Salasiwa, 4-1 en 5-1 Overtoom |
| 19 | 22/12/2017 | Telstar | De Graafschap | 3-2 | 2.736 | Perez | 0-1 Van den Hurk, 1-1 en 2-1 Novakovich, 2-2 Serrarens, 3-2 Platje |
| 19 | 22/12/2017 | Helmond Sport | SC Cambuur | 3-0 | 1.163 | Vd Graaf | 1-0 Bourdouxhe, 2-0 Braber, 3-0 Thomassen R: Peersman (Cam) |
| 19 | 22/12/2017 | FC Emmen | FC Den Bosch | 2-2 | 2.408 | Kooij | 0-1 Mert, 1-1 Peters, 1-2 Vossebelt (pen), 2-2 Peters (pen) |
| 19 | 22/12/2017 | Jong AZ | NEC | 2-7 | 475 | Oostrom | 0-1 en 0-2 Achahbar, 0-3 Breinburg, 1-3 Duin, 1-4 Heinloth, 1-5 Achahbar, 1-6 Kadioglu, 2-6 Bakker, 2-7 Braken |
| 20 | 12/01/2018 | SC Cambuur | De Graafschap | 3-2 | 7.277 | Kamphuis | 0-1 Ars, 1-1 Robertha, 2-1 Houtkoop, 3-1 Robertha, 3-2 Schilder (e.d.) R: S. Nieuwpoort (Gra) |
| 20 | 12/01/2018 | Jong FC Utrecht | FC Dordrecht | 0-2 | 406 | Mulder | 0-1 Mutzers, 0-2 Arias (pen) |
| 20 | 12/01/2018 | FC Volendam | FC Oss | 3-1 | 2.000 | Martens | 1-0 Doodeman, 2-0 Stroo, 3-0 Runderkamp, 3-1 Van der Sluys |
| 20 | 12/01/2018 | RKC Waalwijk | Jong AZ | 1-0 | 2.018 | Gerrets | 1-0 Greene |
| 20 | 12/01/2018 | Jong PSV | Helmond Sport | 1-2 | 528 | Dieperink | 1-0 Verreth, 1-1 Thomassen, 1-2 Edwards |
| 20 | 12/01/2018 | MVV Maastricht | Telstar | 0-0 | 4.419 | Vd Kerkhof | |
| 20 | 12/01/2018 | FC Eindhoven | FC Emmen | 2-1 | 2.216 | Blank | 1-0 Kabangu, 2-0 Van den Boomen, 2-1 Haydari |
| 20 | 12/01/2018 | FC Den Bosch | Almere City FC | 1-3 | 2.525 | Oostrom | 1-0 Blummel, 1-1 Overtoom, 1-2 Van der Heijden, 1-3 Van der Water; R: Salasiwa (Alm) |
| 20 | 12/01/2018 | Fortuna Sittard | Jong Ajax | 2-1 | 7.143 | Vd Graaf | 1-0 en 2-0 Dianessy, 2-1 De Wit |
| 20 | 12/01/2018 | NEC | Go Ahead Eagles | 5-1 | 10.097 | Bax | 1-0 Achahbar, 1-1 Nemane, 2-1 Kadioglu, 3-1 Schuurman, 4-1 en 5-1 Achahbar |
| 17 | 15/01/2018 | FC Oss | NEC | 3-0 | 2.234 | Wiedemeijer | 1-0 Sturing (e.d.), 2-0 Bakx, 3-0 Van Pol R: Grotenbreg (Oss) |
| 17 | 15/01/2018 | Jong AZ | SC Cambuur | 0-1 | 290 | Teuben | 0-1 Houtkoop |
| 21 | 19/01/2018 | FC Dordrecht | Fortuna Sittard | 3-0 | 1.505 | Perez | 1-0 Arias, 2-0 Mutzers, 3-0 Arias |
| 21 | 19/01/2018 | Go Ahead Eagles | MVV Maastricht | 3-1 | 7.684 | Manschot | 1-0 en 2-0 Hendriks, 3-0 Beltrame, 3-1 Okita |
| 21 | 19/01/2018 | De Graafschap | Jong PSV | 2-3 | 8.072 | Ruperti | 1-0 Nieuwpoort, 2-0 El Jebli, 2-1 Gakpo, 2-2 Rigo (pen), 2-3 Gakpo |
| 21 | 19/01/2018 | FC Oss | Jong FC Utrecht | 2-0 | 1.451 | Van Damme | 1-0 Kamaci, 2-0 Oratmangoen |
| 21 | 19/01/2018 | Almere City FC | NEC | 3-2 | 1.750 | Blom | 1-0 Hoefdraad, 2-0 Ahannach, 2-1 Braken, 3-1 Van de Water, 3-2 Braken; R: Romeny (NEC) |
| 21 | 19/01/2018 | Telstar | FC Eindhoven | 4-1 | 2.489 | S. Mulder | 1-0 Novakovich, 1-1 Lieder, 2-1 Platje, 3-1 Novakovich, 4-1 Osman |
| 21 | 19/01/2018 | Helmond Sport | FC Volendam | 1-4 | 1.367 | Kooij | 0-1 Stroo, 0-2 Veerman, 0-3 Visser, 1-3 Thomassen, 1-4 Antwi |
| 21 | 19/01/2018 | FC Emmen | RKC Waalwijk | 2-1 | 3.019 | Teuben | 0-1 Voskamp, 1-1 en 2-1 Jansen; R: Ndefe (RKC) |
| 21 | 22/01/2018 | Jong Ajax | SC Cambuur | 3-2 | 485 | Martens | 1-0 Cassierra, 2-0 Lang, 3-0 Eiting, 3-1 en 3-2 Robertha |
| 21 | 22/01/2018 | Jong AZ | FC Den Bosch | 1-1 | 400 | Bijl | 1-0 Druijf, 1-1 Blummel |
| 22 | 26/01/2018 | FC Dordrecht | FC Oss | 2-0 | 1.272 | Bax | 1-0 Arias, 2-0 Mahmudov R: Janssen (Oss), Groothusen (Dor) |
| 22 | 26/01/2018 | RKC Waalwijk | Jong Ajax | 2-4 | 3.246 | D'Hondt | 0-1 De Wit, 0-2 Sierehuis, 1-2 Seys, 1-3 en 1-4 De Wit, 2-4 Seys |
| 22 | 26/01/2018 | MVV Maastricht | De Graafschap | 1-3 | 4.658 | Van Boekel | 0-1 (pen) en 0-2 Ars, 1-2 Okita, 1-3 Serrarens |
| 22 | 26/01/2018 | Fortuna Sittard | FC Emmen | 1-2 | 3.604 | Lindhout | 0-1 Jansen, 0-2 Bannink,1-2 Stokkers |
| 22 | 26/01/2018 | NEC | FC Den Bosch | 1-0 | 9.539 | Kamphuis | 1-0 Langil (pen) |
| 22 | 26/01/2018 | Telstar | Jong AZ | 2-1 | 2.838 | Oostrom | 0-1 Druijf, 1-1 Osman, 2-1 Platje |
| 22 | 26/01/2018 | Helmond Sport | Almere City FC | 1-2 | 1.176 | Vd Kerkhof | 1-0 Hiwat, 1-1 Van der Heijden, 1-2 Mac-Intosch R: VAn Heugten (Hel) |
| 22 | 28/01/2018 | FC Volendam | Go Ahead Eagles | 4-3 | 3.301 | Vd Graaf | 1-0 Visser, 2-0 Stroo, 2-1 Hendriks, 2-2 Evers (e.d.), 2-3 Beltrame, 3-3 Antwi, 4-3 Stroo |
| 22 | 29/01/2018 | Jong FC Utrecht | SC Cambuur | 1-3 | 500 | Bijl | 0-1 Robertha, 0-2 Barto, 1-2 Venema (pen), 1-3 Rosheuvel |
| 22 | 29/01/2018 | Jong PSV | FC Eindhoven | 4-1 | 803 | C. Mulder | 1-0 Geze, 2-0 Gakpo, 3-0 Lundqvist, 4-0 Gudmundsson, 4-1 Lieder |
| 23 | 02/02/2018 | SC Cambuur | Go Ahead Eagles | 2-1 | 7.954 | Vd Kerkhof | 1-0 en 2-0 Barto, 2-1 Andrade |
| 23 | 02/02/2018 | FC Volendam | Fortuna Sittard | 2-0 | 2.939 | Dieperink | 1-0 Pedro, 2-0 Smal |
| 23 | 02/02/2018 | FC Eindhoven | RKC Waalwijk | 3-1 | 2.036 | Martens | 1-0 Lieder, 1-1 Seys, 2-1 Lieder, 3-1 Van Landschoot |
| 23 | 02/02/2018 | FC Den Bosch | Telstar | 3-2 | 2.565 | Blank | 0-1 Platje (pen), 1-1 Vossebelt, 2-1 Vd Winden, 2-2 Schouten, 3-2 Kaars; R: Van Iperen (Tel) |
| 23 | 02/02/2018 | De Graafschap | Jong FC Utrecht | 7-0 | 7.711 | Perez | 1-0 en 2-0 Diemers, 3-0 Van Mieghem, 4-0 Serrarens (pen), 5-0 Diemers, 6-0 El Jebli, 7-0 Tissoudali |
| 23 | 02/02/2018 | Almere City FC | FC Dordrecht | 1-2 | 1.497 | Vd Graaf | 0-1 Arias (pen), 1-1 Van der Water, 1-2 Calcan |
| 23 | 02/02/2018 | FC Emmen | NEC | 1-0 | 3.788 | S. Mulder | 1-0 Bannink |
| 23 | 05/02/2018 | Jong PSV | MVV Maastricht | 1-0 | 501 | Gerrets | 1-0 Duarte |
| 23 | 05/02/2018 | Jong Ajax | Helmond Sport | 2-0 | 398 | Ruperti | 1-0 Younes, 2-0 Jensen |
| 23 | 05/02/2018 | Jong AZ | FC Oss | 3-1 | 315 | C. Mulder | 1-0 Druijf, 2-0 Kaandorp, 3-0 Koreniuk, 3-1 Kamaci (pen) |
| 24 | 08/02/2018 | NEC | Jong PSV | 2-0 | 8.815 | Martens | 1-0 Abels (e.d.), 2-0 Groeneveld; R: Abels (PSV) |
| 24 | 09/02/2018 | SC Cambuur | MVV Maastricht | 0-2 | 7.476 | Kooij | 0-1 Houben, 0-2 Mmaee |
| 24 | 09/02/2018 | FC Dordrecht | Helmond Sport | 3-2 | 1.143 | De Cremer | 1-0 Mahmudov, 1-1 Thomassen, 2-1 Mutzers, 3-1 Hamer, 3-2 Thomassen |
| 24 | 12/02/2018 | Go Ahead Eagles | FC Emmen | 0-1 | 4.177 | Kamphuis | 0-1 Bannink; R: Bijl (Emm) |
| 24 | 09/02/2018 | FC Den Bosch | FC Eindhoven | 4-0 | 2.211 | Teuben | 1-0 Van der Winden 2-0 Vossebelt, 3-0 Blummel, 4-0 Vossebelt |
| 24 | 09/02/2018 | De Graafschap | FC Volendam | 2-1 | 7.746 | Bax | 1-0 en 2-0 Diemers, 2-1 Veerman |
| 24 | 09/02/2018 | FC Oss | Almere City FC | 5-1 | 1.376 | Blank | 1-0 Bakx, 1-1 Valpoort, 2-1 Van der Venne, 3-1 Dogan, 4-1 en 5-1 Van der Venne |
| 24 | 09/02/2018 | Telstar | Jong Ajax | 3-3 | 3.223 | Dieperink | 1-0 Hamdaoui, 2-0 Novakovich, 2-1 Cassierra, 2-2 Flemming, 2-3 Orejuela, 3-3 Schouten |
| 24 | 09/02/2018 | Jong FC Utrecht | RKC Waalwijk | 5-2 | 378 | Oostrom | 0-1 Van Weert, 1-1 Sow, 2-1 Mallahi, 3-1 Sow, 4-1 Mallahi, 5-1 Sow, 5-2 Van Weert |
| 24 | 12/02/2018 | Jong AZ | Fortuna Sittard | 2-0 | 445 | Gerrets | 1-0 Druijf, 2-0 Wijndal; R: Schuurs (For) |
| 25 | 16/02/2018 | FC Volendam | FC Dordrecht | 4-1 | 2.876 | Vd Kerkhof | 1-0 Visser, 2-0 Stroo, 3-0 Vlak, 4-0 Vissers, 4-1 Mutzers |
| 25 | 16/02/2018 | RKC Waalwijk | SC Cambuur | 0-0 | 1.701 | C. Mulder | R: Van Weert (RKC) |
| 25 | 16/02/2018 | MVV Maastricht | NEC | 4-1 | 4.844 | Makkelie | 1-0 Yildirim, 2-0 Nys, 2-1 Rayhi (pen), 3-1 Schroyen, 4-1 Okita |
| 25 | 16/02/2018 | FC Eindhoven | Jong AZ | 1-3 | 1.986 | Alen | 0-1 Druijf (pen), 1-1 Van den Boomen, 1-2 Druijf, 1-3 Koreniuk; R: Kramer (AZ) |
| 25 | 16/02/2018 | Fortuna Sittard | Telstar | 1-1 | 3.019 | Bax | 0-1 Hamdaoui, 1-1 Semedo (pen) |
| 25 | 16/02/2018 | Almere City FC | Go Ahead Eagles | 2-0 | 1.588 | S. Mulder | 1-0 en 2-0 Salasiwa |
| 25 | 16/02/2018 | Helmond Sport | Jong FC Utrecht | 2-0 | 1.131 | Blank | 1-0 Vicento, 2-0 Van Heugten R: Hoogenhout (Utr) |
| 25 | 16/02/2018 | FC Emmen | De Graafschap | 5-2 | 3.889 | Wiedemeijer | 1-0 Bannink, 1-1 Van Mieghem, 1-2 Tissoudali, 2-2 Nieuwpoort (e.d.), 3-2 Bakker, 4-2 Bannink, 5-2 Aslanyan |
| 25 | 19/02/2018 | Jong PSV | FC Den Bosch | 2-1 | 264 | Perez | 1-0 Gudmundsson (pen), 1-1 Mert, 2-1 Lammers |
| 25 | 19/02/2018 | Jong Ajax | FC Oss | 2-0 | 601 | Bijl | 1-0 en 2-0 De Wit |
| 26 | 23/02/2018 | SC Cambuur | FC Emmen | 1-1 | 7.476 | Vd Graaf | 1-0 Daniëls (pen), 1-1 Peters |
| 26 | 23/02/2018 | MVV Maastricht | Almere City FC | 3-0 | 4.364 | Boterberg | 1-0 Nys, 2-0 Okita, 3-0 Yildirim |
| 26 | 23/02/2018 | FC Eindhoven | FC Dordrecht | 0-1 | 1.936 | Kooij | 0-1 Mahmudov |
| 26 | 23/02/2018 | Go Ahead Eagles | FC Oss | 2-1 | 4.868 | Vd Eijk | 0-1 Oratmangoen, 1-1 Dekker, 2-1 Ketting R: Stuy van den Herik (Oss) |
| 26 | 23/02/2018 | FC Den Bosch | RKC Waalwijk | 0-0 | 2.788 | Van Herk | R: Van der Winden (DBo), Greene, Mulder (RKC) |
| 26 | 23/02/2018 | De Graafschap | Helmond Sport | 1-0 | 7.411 | Oostrom | 1-0 Diemers |
| 26 | 23/02/2018 | NEC | Fortuna Sittard | 1-1 | 10.920 | Vd Kerkhof | 0-1 Cantwell, 1-1 Groeneveld |
| 26 | 23/02/2018 | Telstar | FC Volendam | 5-2 | 2.850 | Lindhout | 1-0 en 2-0 Hamdaoui, 3-0 Sno, 4-0 Platje, 5-0 Novakovich, 5-1 Stroo, 5-2 Smal |
| 26 | 26/02/2018 | Jong FC Utrecht | Jong Ajax | 2-1 | 404 | Teuben | 1-0 Joosten, 1-1 Sierhuis, 2-1 Sow |
| 26 | 26/02/2018 | Jong AZ | Jong PSV | 2-1 | 400 | Ruperti | 1-0 Jacobs, 2-0 Reijnders, 2-1 Gakpo |
| 27 | 02/03/2018 | FC Volendam | FC Eindhoven | 3-2 | 2.910 | Vermeire | 1-0 Stroo, 1-1 Schilder (e.d.), 1-2 Thomas (pen), 2-2 Doodeman, 3-2 Veerman |
| 27 | 02/03/2018 | FC Dordrecht | Telstar | 2-3 | 1.048 | Martens | 1-0 Breedijk, 1-1 en 1-2 Novakovich, 1-3 Hamdaoui, 2-3 Mutzers |
| 27 | 02/03/2018 | RKC Waalwijk | NEC | 0-2 | 1.813 | Vd Graaf | 0-1 Sturing, 0-2 Achahbar; R: Ndefe (RKC) |
| 27 | 05/03/2018 | Fortuna Sittard | MVV Maastricht | 3-0 | 7.283 | Higler | 1-0 Dianessy, 2-0 Semedo (pen), 3-0 Askovski R: Martina (MVV) |
| 27 | 02/03/2018 | FC Oss | SC Cambuur | 2-1 | 1.432 | S. Mulder | 1-0 Van der Venne, 1-1 Boerlage, 2-1 Nieveld |
| 27 | 02/03/2018 | Almere City FC | Jong Ajax | 1-2 | 2.323 | Bax | 1-0 Van der Water, 1-1 en 1-2 Flemming |
| 27 | 02/03/2018 | Helmond Sport | Jong AZ | 3-0 | 833 | Vd Eijk | 1-0 Van Koesveld, 2-0 en 3-0 Thomassen |
| 27 | 04/03/2018 | Go Ahead Eagles | De Graafschap | 0-4 | 9.180 | Dieperink | 0-1 Van Mieghem, 0-2 Olijve, 0-3 Tissoudali, 0-4 Serrarens |
| 27 | 05/03/2018 | Jong FC Utrecht | FC Den Bosch | 1-1 | 633 | Gerrets | 1-0 Joosten, 1-1 Mert |
| 27 | 05/03/2018 | Jong PSV | FC Emmen | 1-1 | 313 | Vd Kerkhof | 0-1 Jansen, 1-1 Lammers |
| 28 | 09/03/2018 | SC Cambuur | Almere City FC | 2-1 | 7.036 | Perez | 0-1 Van der Water, 1-1 Barto, 2-1 Mathieu |
| 28 | 09/03/2018 | RKC Waalwijk | Jong PSV | 3-2 | 2.223 | Teuben | 0-1 Laursen, 1-1 Voskamp, 1-2 Laursen, 2-2 Mezghrani, 3-2 Voskamp |
| 28 | 09/03/2018 | MVV Maastricht | Jong FC Utrecht | 3-1 | 4.266 | Ruperti | 1-0 en 2-0 Nwakali, 2-1 Venema, 3-1 Yildirim |
| 28 | 09/03/2018 | FC Eindhoven | Fortuna Sittard | 1-3 | 2.230 | Vd Graaf | 0-1 Dianessy, 0-2 Cantwell, 1-2 Kortstam, 1-3 Askovski |
| 28 | 09/03/2018 | FC Den Bosch | FC Oss | 0-0 | 3.214 | Dieperink | |
| 28 | 09/03/2018 | De Graafschap | FC Dordrecht | 0-1 | 8.311 | Gözübüyük | 0-1 Mahmudov (pen) |
| 28 | 09/03/2018 | NEC | FC Volendam | 3-0 | 9.695 | Van Boekel | 1-0 Groeneveld, 2-0 Verdonk, 3-0 Joppen |
| 28 | 09/03/2018 | Jong Ajax | Go Ahead Eagles | 0-2 | 700 | Van Herk | 0-1 Ketting, 0-2 Langedijk; R: Matusiwa (Aja) |
| 28 | 09/03/2018 | Telstar | Helmond Sport | 2-3 | 2.874 | Vd Kerkhof | 1-0 Platje, 1-1 en 1-2 Thomassen, 2-2 Platje, 2-3 Janzen; R: De Braal (Hel) |
| 28 | 09/03/2018 | FC Emmen | Jong AZ | 0-2 | 4.213 | Bax | 0-1 Klok (e.d.), 0-2 Duijn (pen) |
| 29 | 12/03/2018 | Jong FC Utrecht | NEC | 0-2 | 890 | Vd Eijk | 0-1 Kadioglu, 0-2 Verdonk |
| 29 | 12/03/2018 | FC Volendam | MVV Maastricht | 2-2 | 2.760 | Wiedemeijer | 0-1 Okita, 0-2 Martina, 1-2 Stroo, 2-2 Doodeman |
| 29 | 12/03/2018 | FC Dordrecht | RKC Waalwijk | 1-0 | 3.148 | Blank | 1-0 Mahmudov |
| 29 | 12/03/2018 | Jong PSV | SC Cambuur | 1-1 | 321 | Gerrets | 1-0 Gakpo, 1-1 Kip |
| 29 | 12/03/2018 | Fortuna Sittard | De Graafschap | 1-1 | 3.642 | S. Mulder | 0-1 Tissoudali, 1-1 Schuurs; R: Serrarens (Gra) |
| 29 | 12/03/2018 | Jong Ajax | FC Eindhoven | 4-0 | 408 | Oostrom | 1-0 Johnsen, 2-0 Mazraoui, 3-0 en 4-0 De Wit |
| 29 | 12/03/2018 | FC Oss | FC Emmen | 2-3 | 1.432 | Manschot | 0-1 Bilate, 1-1 Kamaci, 1-2 Bijl, 2-2 Van der Venne, 2-3 Peters (pen) |
| 29 | 12/03/2018 | Almere City FC | Telstar | 2-3 | 1.250 | Vd Graaf | 0-1 Mirani (e.d.), 0-2 en 0-3 Novakovich, 1-3 Kvida, 2-3 Van der Water |
| 29 | 12/03/2018 | Helmond Sport | FC Den Bosch | 3-1 | 1.476 | C. Mulder | 0-1 Vossebelt (pen), 1-1 Braber, 2-1 Thomassen, 3-1 Zeldenrust |
| 29 | 12/03/2018 | Jong AZ | Go Ahead Eagles | 0-0 | 480 | Teuben | |
| 30 | 16/03/2018 | SC Cambuur | NEC | 1-1 | 7.262 | Kamphuis | 0-1 Achahbar, 1-1 Van Deelen |
| 30 | 16/03/2018 | RKC Waalwijk | MVV Maastricht | 1-1 | 1.938 | Bijl | 1-0 Janssens, 1-1 Okita |
| 30 | 16/03/2018 | Jong PSV | FC Volendam | 2-1 | 298 | Blank | 1-0 Malen, 2-0 Verreth, 2-1 Tol; R: Evers (Vol) |
| 30 | 16/03/2018 | FC Eindhoven | Jong FC Utrecht | 5-2 | 2.346 | Van Herk | 1-0 Lieder, 2-0 Kabangu, 2-1 Venema, 3-1 Lieder (pen), 4-1 Swinnen, 5-1 Lieder, 5-2 Venema |
| 30 | 16/03/2018 | Go Ahead Eagles | Telstar | 1-1 | 6.788 | Perez | 1-0 Werkhoven, 1-1 Novakovich |
| 30 | 16/03/2018 | FC Den Bosch | FC Dordrecht | 4-1 | 2.186 | Bax | 1-0 en 2-0 Vossebelt (pen), 3-0 Blummel, 3-1 Boumediene, 4-1 Felida |
| 30 | 16/03/2018 | De Graafschap | Jong Ajax | 2-4 | 9.114 | Vd Graaf | 0-1 Sierhuis, 1-1 Van Mieghem, 1-2 Sierhuis, 2-2 El Jebli, 2-3 Sierhuis (pen), 2-4 Nunnely R: Nieuwpoort, Abena (Gra) |
| 30 | 16/03/2018 | FC Oss | Fortuna Sittard | 1-2 | 1.472 | Kooij | 1-0 Van der Venne, 1-1 Schuurs, 1-2 Askovski |
| 30 | 16/03/2018 | FC Emmen | Helmond Sport | 0-0 | 2.850 | Dieperink | |
| 30 | 16/03/2018 | Jong AZ | Almere City FC | 4-1 | 300 | C. Mulder | 1-0 Einarsson, 2-0 Jacobs, 2-1 MacDonald, 3-1 Hoedemakers, 4-1 Fase |
| 31 | 23/03/2018 | Jong FC Utrecht | Jong PSV | 1-4 | 250 | C. Mulder | 0-1 Van der Moot, 0-2 Ritzmaier, 0-3 Verreth, 1-3 Zwartjens, 1-4 Verreth |
| 31 | 25/03/2018 | FC Dordrecht | Go Ahead Eagles | 1-2 | 1.721 | Gerrets | 0-1 Stans, 1-1 Mahmudov, 1-2 Schenk |
| 31 | 23/03/2018 | MVV Maastricht | FC Eindhoven | 2-0 | 5.011 | Bax | 1-0 Ciranni, 2-0 Nwakali (pen) |
| 31 | 23/03/2018 | Fortuna Sittard | SC Cambuur | 3-2 | 3.520 | Dieperink | 0-1 Steenvoorden, 0-2 Kip, 1-2, 2-2 (pen) en 3-2 (pen) Semedo |
| 31 | 23/03/2018 | NEC | De Graafschap | 1-1 | 11.402 | Nijhuis | 1-0 Achahbar, 1-1 El Jabli |
| 31 | 25/03/2018 | Jong Ajax | Jong AZ | 0-1 | 1.353 | Perez | 0-1 Reijnders |
| 31 | 25/03/2018 | Almere City FC | FC Emmen | 2-2 | 1.420 | Kooij | 1-0 Van der Water, 2-0 Valpoort, 2-1 Bilate, 2-2 Mirani (e.d.) |
| 31 | 24/03/2018 | Telstar | RKC Waalwijk | 0-0 | 2.663 | Vd Eijk | |
| 31 | 23/03/2018 | Helmond Sport | FC Oss | 2-1 | 1.791 | Ruperti | 1-0 Janzen, 2-0 Hiwat, 2-1 Dogan |
| 31 | 25/03/2018 | FC Volendam | FC Den Bosch | 1-0 | 3.423 | Martens | 1-0 Antwi |
| 32 | 30/03/2018 | SC Cambuur | FC Volendam | 2-2 | 7.283 | Vd Graaf | 1-0 Houtkoop, 1-1 Antwi, 2-1 Crowley, 2-2 Berenstein |
| 32 | 30/03/2018 | FC Eindhoven | NEC | 3-2 | 2.487 | Mulder | 1-0 en 2-0 Kabangu, 3-0 De Silva, 3-1 Achahbar, 3-2 Golla |
| 32 | 30/03/2018 | Go Ahead Eagles | Helmond Sport | 3-1 | 7.173 | Blank | 1-0 Suk, 1-1 Zeldenrust, 2-1 en 3-1 Werkhoven R: Warmolts (Hel) |
| 32 | 30/03/2018 | FC Den Bosch | MVV Maastricht | 2-1 | 2.889 | Dieperink | 1-0 en 2-0 Van der Sande, 2-1 Okita; R: Nys (MVV) |
| 32 | 30/03/2018 | De Graafschap | RKC Waalwijk | 1-0 | 8.233 | Martens | 1-0 Tissoudali |
| 32 | 30/03/2018 | Jong Ajax | Jong PSV | 0-3 | 1.351 | Ruperti | 0-1 Verreth, 0-2 Daneels, 0-3 Laursen |
| 32 | 30/03/2018 | FC Oss | Telstar | 0-0 | 2.921 | Bijl | |
| 32 | 30/03/2018 | Almere City FC | Fortuna Sittard | 1-4 | 2.332 | Vd Kerkhof | 0-1, 0-2 en 0-3 (pen) Vidigal, 0-4 Stokkers, 1-4 Mac-Intosch |
| 32 | 30/03/2018 | FC Emmen | FC Dordrecht | 1-3 | 2.661 | Perez | 0-1 Mahmudov, 0-2 en 0-3 Mutzers, 1-3 Loen |
| 32 | 30/03/2018 | Jong AZ | Jong FC Utrecht | 1-3 | 390 | Teuben | 0-1, 0-2 (pen) en 0-3 Venema, 1-3 Reijnders |
| 33 | 02/04/2018 | SC Cambuur | FC Eindhoven | 3-2 | 7.796 | Nijhuis | 0-1 Lieder, 1-1 en 2-1 Barto, 2-2 Lieder,3-2 Crowley |
| 33 | 02/04/2018 | Jong FC Utrecht | Go Ahead Eagles | 1-0 | 566 | Oostrom | 1-0 Özbozkurt |
| 33 | 02/04/2018 | FC Volendam | Jong AZ | 4-1 | 3.530 | Ruperti | 0-1 Druijf, 1-1 Berenstein, 2-1 Ten Den, 3-1 Visser, 4-1 Ten Den |
| 33 | 02/04/2018 | FC Dordrecht | Jong Ajax | 2-3 | 1.642 | Teuben | 1-0 Mutzers, 1-1 Nunnely, 1-2 Cassierra, 2-2 Mahmudov, 2-3 Bijleveld |
| 33 | 02/04/2018 | RKC Waalwijk | Almere City FC | 0-4 | 2.039 | Van Herk | 0-1 Hoefdraad, 0-2 Overtoom, 0-3 Salasiwa, 0-4 Owusu |
| 33 | 02/04/2018 | Jong PSV | FC Oss | 4-1 | 700 | Perez | 1-0 Malen, 1-1 Van der Venne, 2-1 Lammers, 3-1 Gakpo, 4-1 en 5-1 Malen |
| 33 | 02/04/2018 | MVV Maastricht | FC Emmen | 0-1 | 4.426 | Blank | 0-1 Peters |
| 33 | 02/04/2018 | Fortuna Sittard | Helmond Sport | 3-0 | 6.012 | Vd Eijk | 1-0 Hutten, 2-0 Pinto, 3-0 Semedo |
| 33 | 02/04/2018 | De Graafschap | FC Den Bosch | 2-1 | 8.911 | Vd Kerkhof | 1-0 Serrarens, 2-0 Van Mieghem, 2-1 Bouyaghlafen |
| 33 | 02/04/2018 | NEC | Telstar | 3-0 | 10.538 | Bax | 1-0 Heinloth, 2-0 Golla, 3-0 Kadiaglu R: Sno (Tel) |
| 34 | 06/04/2018 | FC Eindhoven | De Graafschap | 2-4 | 2.480 | Vd Eijk | 0-1 Van Mieghem, 0-2 El Jebli, 1-2 Van de Velde, 2-2 Kabangu, 2-3 en 2-4 Serrarens R: Tutuarima (Gra) |
| 34 | 06/04/2018 | Go Ahead Eagles | Fortuna Sittard | 0-1 | 7.563 | Lindhout | 0-1 Schuurs |
| 34 | 06/04/2018 | FC Den Bosch | SC Cambuur | 1-2 | 2.657 | Perez | 0-1 Schils, 0-2 Van Kippersluis, 1-2 Fernandes |
| 34 | 06/04/2018 | FC Oss | RKC Waalwijk | 3-1 | 2.287 | Gerrets | 0-1 Kökcü, 1-1 Bakx, 2-1 en 3-1 Kamaci |
| 34 | 06/04/2018 | Almere City FC | Jong FC Utrecht | 2-1 | 1.592 | Blank | 1-0 MacDonald, 1-1 Sow, 2-1 MacDonald |
| 34 | 06/04/2018 | Telstar | Jong PSV | 0-0 | 2.863 | Martens | |
| 34 | 06/04/2018 | Helmond Sport | MVV Maastricht | 2-3 | 1.981 | Oostrom | 0-1 en 0-2 Okita, 1-2 Naudts, 2-2 Thomassen, 2-3 Okita |
| 34 | 06/04/2018 | FC Emmen | FC Volendam | 2-3 | 2.875 | Vd Kerkhof | 0-1 Smal, 1-1 Veldmate, 1-2 Vlak, 2-2 Peters, 2-3 Stroo |
| 34 | 06/04/2018 | Jong AZ | FC Dordrecht | 3-1 | 400 | Bijl | 1-0 Church, 2-0 en 3-0 Jacobs, 3-1 Mahmudov |
| 35 | 09/04/2018 | SC Cambuur | Jong AZ | 3-2 | 7.083 | Van Herk | 1-0 Van Kippersluis, 1-1 Jacobs, 2-1 Van Kippersluis, 2-2 Jacobs, 3-2 Mathieu |
| 35 | 09/04/2018 | Jong FC Utrecht | FC Volendam | 2-1 | 667 | Bijl | 1-0 Troupée, 1-1 Ten Den, 2-1 Loukili R: Mulder (Utr) |
| 35 | 09/04/2018 | RKC Waalwijk | Fortuna Sittard | 1-1 | 2.618 | Perez | 1-0 Seys, 1-1 Hutten |
| 35 | 09/04/2018 | MVV Maastricht | FC Dordrecht | 1-0 | 4.419 | Mulder | 1-0 Schroijen |
| 35 | 09/04/2018 | FC Eindhoven | Helmond Sport | 3-2 | 2.419 | Dieperink | 0-1 Naudts, 1-1 en 2-1 Van de Velde, 2-2 Naudts, 3-2 Swinnen |
| 35 | 09/04/2018 | FC Den Bosch | Jong Ajax | 2-5 | 3.217 | Blank | 1-0 Van der Sande, 1-1 Johnsen, 1-2 Cassierra, 2-2 Van der Sande, 2-3 Ekkelenkamp, 2-4 CAssierra (pen), 2-5 Sierhuis |
| 35 | 09/04/2018 | De Graafschap | Almere City FC | 4-2 | 7.712 | Bax | 1-0 en 2-0 Tissoudali, 2-1 Valpoort, 2-2 Van Hilten, 3-2 Tissoudsali, 4-2 Diemers |
| 35 | 09/04/2018 | NEC | FC Oss | 2-1 | 8.667 | Martens | 0-1 Kamaci, 1-1 Groeneveld, 2-1 Kadioglu |
| 35 | 09/04/2018 | FC Emmen | Telstar | 2-3 | 2.359 | Kamphuis | 0-1 Platje (pen), 1-1 Peters (pen), 1-2 Schouten, 1-3 Novakovich, 2-3 Dallinga; R: Loen (Emm) |
| 35 | 10/04/2018 | Jong PSV | Go Ahead Eagles | 6-0 | 544 | Teuben | 1-0 en 2-0 Laursen, 3-0 Lammers, 4-0 Groenbast (ed), 5-0 (p) en 6-0 Gudmundsson |
| 36 | 13/04/2018 | FC Volendam | RKC Waalwijk | 0-1 | 3.654 | C. Mulder | 0-1 Van Eijma |
| 36 | 13/04/2018 | FC Dordrecht | SC Cambuur | 0-3 | 2.135 | Vd Eijk | 0-1 Crowley, 0-2 en 0-3 Barto |
| 36 | 13/04/2018 | Go Ahead Eagles | FC Eindhoven | 1-3 | 5.312 | Ruperti | 1-0 Schenk, 1-1 Van Landschoot, 1-2 en 1-3 Lieder R: Werkhoven (GoA) |
| 36 | 13/04/2018 | Fortuna Sittard | FC Den Bosch | 2-0 | 8.214 | S. Mulder | 1-0 Semedo, 2-0 Stokkers |
| 36 | 13/04/2018 | Jong Ajax | FC Emmen | 3-2 | 714 | Martens | 1-0 Sierhuis, 2-0 Nunnely, 3-0 Sierhuis, 3-1 en 3-2 Bannink |
| 36 | 13/04/2018 | FC Oss | De Graafschap | 1-4 | 2.891 | Oostrom | 1-0 Kamaci, 1-1 El Jebli, 1-2 Van Mieghem, 1-3 Tissoudali, 1-4 Serrarens |
| 36 | 13/04/2018 | Almere City FC | Jong PSV | 2-1 | 2.185 | Vd Graaf | 1-0 Salasiwa, 1-1 Konings, 2-1 Mirani |
| 36 | 13/04/2018 | Telstar | Jong FC Utrecht | 1-0 | 2.514 | Van Herk | 1-0 Platje (pen) |
| 36 | 13/04/2018 | Helmond Sport | NEC | 1-2 | 1.938 | Vd Kerkhof | 0-1 Groeneveld, 0-2 Heinloth, 1-2 Braber R: Janzen (Hel) |
| 36 | 13/04/2018 | Jong AZ | MVV Maastricht | 3-1 | 270 | Gerrets | 0-1 Schroijen. 1-1 Kaandorp, 2-1 Jacobs, 3-1 Goudmijn |
| 34 | 16/04/2018 | Jong Ajax | NEC | 1-0 | 1.829 | Vd Graaf | 1-0 Johnsen |
| 37 | 20/04/2018 | SC Cambuur | Helmond Sport | 4-1 | 8.233 | Rupereti | 1-0 Steenvoorden, 1-1 Braber, 2-1 Mathieu, 3-1 Van Kippersluis, 4-1 Kip |
| 37 | 20/04/2018 | Jong FC Utrecht | Fortuna Sittard | 0-1 | 2.547 | Bax | 0-1 Hutten |
| 37 | 20/04/2018 | FC Volendam | Jong Ajax | 1-2 | 4.396 | Gerrets | 0-1 De Wit, 1-1 Vlak, 1-2 Sierhuis |
| 37 | 20/04/2018 | RKC Waalwijk | Go Ahead Eagles | 2-1 | 2.623 | Bijl | 0-1 Schets, 1-1 Seys, 2-1 Van Eijma |
| 37 | 20/04/2018 | Jong PSV | FC Dordrecht | 4-2 | 458 | Oostrom | 1-0 Gakpo, 2-0 Obispo, 3-0 Laursen, 3-1 Mahmudov, 4-1 Malen, 4-2 Arias (pen) |
| 37 | 20/04/2018 | MVV Maastricht | FC Oss | 1-1 | 5.073 | Teuben | 1-0 Okita, 1-1 Verrips (e.d.) |
| 37 | 20/04/2018 | FC Eindhoven | Almere City FC | 3-2 | 2.509 | Martens | 0-1 MacDonald, 1-1 en 2-1 Lieder, 2-2 Hoefdraad, 3-2 Lieder (pen) |
| 37 | 23/04/2018 | FC Den Bosch | FC Emmen | 1-2 | 2.213 | Dieperink | 0-1 Peters (pen), 1-1 Van der Sande, 1-2 Gronsveld |
| 37 | 20/04/2018 | De Graafschap | Telstar | 1-0 | 8.822 | Blank | 1-0 El Jebli |
| 37 | 20/04/2018 | NEC | Jong AZ | 2-0 | 10.496 | Dieperink | 1-0 Achahbar, 2-0 Groeneveld |
| 38 | 28/04/2018 | FC Dordrecht | NEC | 3-3 | 2.134 | Lindhout | 1-0 Calcan, 2-0 Mahmudov, 2-1 en 2-2 Achahbar, 2-3 Golla, 3-3 Calcan; R: Bliek (Dor) |
| 38 | 28/04/2018 | Go Ahead Eagles | FC Den Bosch | 1-2 | 6.869 | Vd Graaf | 0-1 en 0-2 Blummel, 1-2 Namane |
| 38 | 28/04/2018 | Fortuna Sittard | Jong PSV | 1-0 | 11.787 | Janssen | 1-0 Stokkers |
| 38 | 28/04/2018 | Jong Ajax | MVV Maastricht | 2-1 | 1.800 | Bax | 0-1 Nwakali (pen), 1-1 Sierhuis, 2-1 Cassierra |
| 38 | 28/04/2018 | FC Oss | FC Eindhoven | 1-1 | 2.560 | C. Mulder | 1-0 Kamaci, 1-1 Thomas |
| 38 | 28/04/2018 | Almere City FC | FC Volendam | 2-0 | 2.629 | S. Mulder | 1-0 Van der Water, 2-0 Overtoom |
| 38 | 28/04/2018 | Telstar | SC Cambuur | 0-1 | 2.663 | Bijl | 0-1 Mathieu (pen); R: Lopes Cabral (Tel) |
| 38 | 28/04/2018 | Helmond Sport | RKC Waalwijk | 2-2 | 1.741 | Manschot | 1-0 Braber, 1-1 Van Koesveld (e.d.), 2-1 Naudts, 2-2 Van Eijma |
| 38 | 28/04/2018 | FC Emmen | Jong FC Utrecht | 0-0 | 3.329 | Vd Eijk | |
| 38 | 28/04/2018 | Jong AZ | De Graafschap | 2-2 | 600 | Teuben | 1-0 Hoedemakers, 1-1 Serrarens, 1-2 Diemers, 2-2 Kaandorp |
Play offs voor promotie/degradatie
| 1e ronde | ||||||
| 01/05/2018 | MVV Maastricht | Almere City FC | 1-3 | 4.264 | Janssen | 0-1 Mirani, 1-1 Ciranni, 1-2 en 1-3 Mirani |
| 01/05/2018 | FC Dordrecht | SC Cambuur | 1-4 | 2.412 | Bax | 0-1 Crowley, 0-2 Mathieu, 1-2 Bliek, 1-3 en 1-4 Barto |
| 05/05/2018 | Almere City FC | MVV Maastricht | 3-2 | 1.792 | Gözübüyük | 0-1 Janssen, 1-1 Van der Water, 1-2 Okita, 2-2 en 3-2 MacDonald |
| 05/05/2018 | SC Cambuur | FC Dordrecht *** | 1-4 | 7.542 | 1-0 Kallon, 1-1 Cijntje, 1-2 Arias, 1-3 (pen) en 1-4 Mahmudov | |
| 2e ronde | ||||||
| 10/05/2018 | Telstar | De Graafschap | 3-2 | 4.663 | Kamphuis | 1-0 Platje, 2-0 Navokovich, 1-1 Van Mieghem, 2-2 Serrarens, 3-2 Hamdaoui; R: Nieuwpoort (Gra), Van Huizen (Tel) |
| 10/05/2018 | FC Emmen | NEC | 4-0 | 5.378 | Vd Kerkhof | 1-0 Veldmate, 2-0 Bakker, 3-0 Loen, 4-0 Bijl |
| 10/05/2018 | FC Dordrecht | Sparta Rotterdam | 1-2 | 4.235 | S. Mulder | 0-1 Brogno, 1-1 Spierings (e.d.), 1-2 Muhren |
| 10/05/2018 | Almere City FC | Roda JC Kerkrade | 0-0 | 2.826 | Nijhuis | |
| 13/05/2018 | De Graafschap | Telstar | 4-2 | 11.083 | Van Boekel | 1-0 Nieuwpoort, 2-0 El Jebli, 2-1 Hamdaoui, 3-1 Serrarens, 3-2 Novakovich (pen), 4-2 Van Mieghem |
| 13/05/2018 | NEC | FC Emmen | 4-1 | 5.321 | Nijhuis | 1-0 en 2-0 Achahbar, 2-1 Bannink, 3-1 Sturing, 4-1 Romeny |
| 13/05/2018 | Sparta Rotterdam | FC Dordrecht | 2-2 | 10.132 | Manschot | 0-1 Mahmudov, 0-2 Cijntje, 1-2 Duarte, 2-2 Mühren |
| 13/05/2018 | Roda JC Kerkrade | Almere City FC | 1-2 | 12.489 | Lindhout | 0-1 Van der Water, 1-1 Schahin, 1-2 Hammouti |
| 3e ronde | ||||||
| 17/05/2018 | FC Emmen | Sparta Rotterdam | 0-0 | 8.301 | Lindhout | |
| 17/05/2018 | Almere City FC | De Graafschap | 1-1 | 3.430 | Blom | 1-0 Van der Water, 1-1 Serrarens (pen); R: Overtoom (Alm) |
| 20/05/2018 | Sparta Rotterdam | FC Emmen | 1-3 | 10.606 | Higler | 1-0 Sp[ierings, 1-1 Chacon, 1-2 Jansen, 1-3 Bannink R: Dougall (Spa) |
| 20/05/2018 | De Graafschap | Almere City FC | 2-1 | 12.600 | Makkelie | 0-1 Hoefdraad, 1-1 Tissoudali, 2-1 Serrarens |
FC Emmen en De Graafschap gepromoveerd, Sparta en Roda JC gedegradeerd.
Topscorers
| 1 | Mart Lieder | FC Eindhoven | 30 |
| 2 | Andrija Novakovich | Telstar | 19 |
| 3 | Mateo Cassierra | Jong Ajax | 18 |
| 4 | Jonathan Okita | MVV Maastricht | 18 |
| 5 | Cas Peters | FC Emmen | 17 |
| 6 | Sam Hendriks | Go Ahead Eagles | 16 |
| 7 | Daryl van Mieghem | De Graafschap | 16 |
| 8 | Arsenio Valpoort | Almere City FC | 16 |
| 9 | Anass Achahbar | NEC | 15 |
| 10 | Fatih Kamaci | FC Oss | 15 |
| 11 | Denis Mahmudov | FC Dordrecht | 15 |
| 12 | Lisandro Semedo | Fortuna Sittard | 15 |
| 13 | Enzo Stroo | FC Volendam | 15 |
| 14 | Niek Vossebelt | FC Den Bosch | 15 |
Na twee seizoenen keerde VVV-Venlo terug in de Eredivisie. De promotie van de Venloërs hing al erg lang in de lucht, omdat de enige serieuze concurrent Jong Ajax niet voor promotie in aanmerking komt. Uiteindelijk sleepte de ploeg ook het kampioenschap overtuigend binnen.
Voor het eerst sinds jaren was er sprake van degradatie uit de Eerste Divisie. Heel lang was Achilles’29 de gedoodverfde kandidaat daarvoor, maar op het eind startten de Groesbekers een inhaalrace en doordat FC Dordrecht nauwelijks nog punten haalde werd het toch nog even spannend. Een late 2-2 van Dordrecht in de onderlinge ontmoeting en de drie punten aftrek die Achilles vlak voor de laatste wedstrijd van de KNVB nog kreeg, beslechtten de degradatiestrijd uiteindelijk.
Via de play-offs bewerkstelligde NAC Breda de fel begeerde promotie ten koste van NEC. Favoriet SC Cambuur verslikte zich in MVV Maastricht dat het uiteindelijk niet kon bolwerken tegen Eredivisie-herkanser Roda JC.
Uitslagenmatrix
| ACH | ALM | CAM | DBO | DOR | EIN | EMM | FOR | GRA | HEL | AJA | PSV | UTR | MVV | NAC | OSS | RKC | TEL | VOL | VVV | |
| Achilles '29 | * | 3-3 | 0-3 | 2-1 | 2-2 | 4-3 | 0-4 | 0-1 | 0-0 | 1-2 | 2-3 | 1-5 | 1-1 | 2-3 | 1-2 | 1-2 | 2-3 | 1-2 | 0-6 | 0-3 |
| Almere City FC | 1-0 | * | 0-1 | 4-1 | 3-0 | 4-0 | 3-1 | 2-0 | 1-2 | 1-0 | 1-4 | 1-0 | 2-1 | 2-1 | 0-2 | 3-3 | 6-2 | 2-0 | 2-2 | 0-2 |
| SC Cambuur | 3-1 | 4-1 | * | 0-1 | 3-0 | 4-1 | 1-0 | 1-1 | 1-1 | 3-0 | 1-3 | 1-1 | 4-2 | 4-0 | 3-1 | 4-2 | 5-0 | 5-1 | 2-1 | 0-2 |
| FC Den Bosch | 2-1 | 1-3 | 3-1 | * | 1-0 | 0-2 | 1-1 | 1-1 | 2-1 | 1-1 | 1-2 | 0-0 | 1-0 | 2-1 | 2-1 | 2-1 | 1-1 | 0-0 | 2-5 | 0-2 |
| FC Dordrecht | 3-0 | 1-4 | 0-1 | 2-2 | * | 1-1 | 0-4 | 2-2 | 0-3 | 1-4 | 0-2 | 2-3 | 3-0 | 0-1 | 1-2 | 1-1 | 1-1 | 0-2 | 1-0 | 5-2 |
| FC Eindhoven | 2-1 | 4-1 | 2-0 | 4-2 | 2-1 | * | 0-1 | 3-1 | 2-1 | 2-2 | 2-1 | 0-5 | 2-1 | 1-1 | 6-2 | 1-2 | 3-0 | 4-2 | 0-1 | 0-0 |
| FC Emmen | 1-0 | 2-0 | 0-1 | 3-0 | 2-1 | 2-0 | * | 2-3 | 2-0 | 1-2 | 0-0 | 1-1 | 0-3 | 0-0 | 0-0 | 2-0 | 1-0 | 0-0 | 3-1 | 1-2 |
| Fortuna Sittard | 2-1 | 2-1 | 3-0 | 0-4 | 3-2 | 1-1 | 2-2 | * | 3-2 | 4-1 | 5-2 | 0-0 | 4-1 | 2-3 | 0-2 | 2-0 | 0-1 | 1-1 | 3-0 | 2-0 |
| De Graafschap | 3-3 | 4-1 | 3-0 | 0-3 | 2-3 | 4-1 | 3-0 | 5-0 | * | 2-4 | 1-0 | 1-1 | 3-1 | 2-0 | 2-1 | 3-5 | 4-0 | 2-1 | 1-1 | 0-2 |
| Helmond Sport | 1-2 | 1-1 | 1-0 | 2-0 | 1-0 | 3-0 | 1-3 | 1-0 | 0-2 | * | 2-4 | 1-0 | 1-1 | 2-2 | 2-1 | 3-1 | 1-1 | 3-4 | 2-0 | 2-1 |
| Jong Ajax | 7-1 | 6-3 | 2-1 | 5-2 | 1-0 | 1-1 | 1-1 | 2-1 | 4-2 | 2-0 | * | 1-0 | 2-0 | 1-1 | 2-1 | 7-0 | 4-1 | 2-1 | 1-1 | 0-4 |
| Jong PSV | 4-0 | 0-1 | 0-2 | 5-4 | 3-2 | 4-1 | 1-0 | 3-0 | 1-0 | 3-0 | 3-1 | * | 2-0 | 0-0 | 2-0 | 2-4 | 4-1 | 1-0 | 2-0 | 2-1 |
| Jong FC Utrecht | 0-1 | 1-1 | 0-2 | 5-0 | 1-1 | 3-1 | 3-1 | 3-0 | 3-2 | 1-0 | 2-2 | 0-2 | * | 1-2 | 0-2 | 2-1 | 1-3 | 2-1 | 2-4 | 0-0 |
| MVV Maastricht | 0-0 | 2-2 | 2-1 | 3-0 | 2-1 | 0-0 | 2-2 | 1-1 | 2-0 | 2-0 | 1-0 | 2-2 | 4-1 | * | 1-1 | 3-0 | 1-1 | 2-1 | 1-2 | 1-2 |
| NAC Breda | 2-0 | 3-1 | 0-2 | 0-0 | 1-0 | 3-3 | 3-1 | 3-1 | 1-0 | 0-0 | 4-3 | 1-1 | 4-1 | 1-2 | * | 4-1 | 2-3 | 1-0 | 1-0 | 0-0 |
| FC Oss | 4-0 | 2-3 | 2-7 | 1-1 | 4-2 | 6-2 | 2-2 | 3-1 | 2-1 | 3-1 | 0-3 | 2-0 | 4-2 | 0-3 | 3-4 | * | 2-5 | 0-2 | 2-2 | 0-3 |
| RKC Waalwijk | 2-0 | 1-1 | 2-2 | 0-2 | 2-1 | 1-2 | 1-1 | 3-0 | 2-1 | 5-2 | 3-2 | 1-1 | 1-2 | 2-0 | 2-4 | 3-0 | * | 1-0 | 1-4 | 1-2 |
| Telstar | 1-1 | 3-6 | 0-3 | 2-0 | 0-0 | 1-4 | 2-2 | 1-1 | 2-1 | 4-2 | 1-3 | 0-0 | 3-1 | 1-1 | 2-0 | 3-1 | 0-4 | * | 0-1 | 1-2 |
| FC Volendam | 1-2 | 1-1 | 1-1 | 2-1 | 1-1 | 3-1 | 0-1 | 3-0 | 2-2 | 1-0 | 1-1 | 1-0 | 2-2 | 3-1 | 2-1 | 3-1 | 1-1 | 3-0 | * | 0-1 |
| VVV-Venlo | 4-0 | 3-2 | 2-1 | 3-1 | 3-1 | 1-0 | 0-0 | 4-1 | 4-1 | 7-0 | 1-4 | 1-2 | 2-0 | 2-1 | 0-4 | 2-0 | 4-0 | 1-1 | 0-1 | * |
Eindstand
| 1 | VVV-Venlo * ♦ | 38 | 25 | 5 | 8 | 80 | 75 | 35 | +40 | 5.151 |
| 2 | Jong Ajax | 38 | 23 | 7 | 8 | 76 | 93 | 54 | +39 | 924 |
| 3 | SC Cambuur + | 38 | 22 | 5 | 11 | 71 | 78 | 42 | +36 | 7.509 |
| 4 | Jong PSV | 38 | 20 | 9 | 9 | 69 | 66 | 35 | +31 | 516 |
| 5 | NAC Breda + ♦ | 38 | 19 | 7 | 12 | 64 | 65 | 50 | +15 | 13.280 |
| 6 | FC Volendam + | 38 | 17 | 11 | 10 | 62 | 63 | 44 | +19 | 4.123 |
| 7 | MVV Maastricht + | 38 | 15 | 14 | 9 | 59 | 55 | 45 | +10 | 4.637 |
| 8 | Almere City FC + | 38 | 17 | 8 | 13 | 59 | 74 | 66 | +8 | 1.748 |
| 9 | FC Emmen + | 38 | 14 | 13 | 11 | 55 | 50 | 40 | +10 | 2.933 |
| 10 | RKC Waalwijk + | 38 | 15 | 9 | 14 | 54 | 62 | 70 | -8 | 2.185 |
| 11 | FC Eindhoven | 38 | 15 | 8 | 15 | 53 | 64 | 71 | -7 | 2.572 |
| 12 | De Graafschap | 38 | 15 | 5 | 18 | 50 | 70 | 63 | +7 | 8.523 |
| 13 | Helmond Sport + | 38 | 14 | 7 | 17 | 49 | 51 | 67 | -16 | 1.825 |
| 14 | FC Den Bosch | 38 | 12 | 9 | 17 | 45 | 48 | 67 | -19 | 2.721 |
| 15 | FC Oss | 38 | 12 | 5 | 21 | 41 | 67 | 95 | -28 | 2.096 |
| 16 | Telstar | 38 | 10 | 10 | 18 | 40 | 46 | 64 | -18 | 1.835 |
| 17 | Fortuna Sittard ² | 38 | 13 | 9 | 16 | 39 | 54 | 67 | -13 | 1.829 |
| 18 | Jong FC Utrecht | 38 | 10 | 7 | 21 | 37 | 50 | 71 | -21 | 810 |
| 19 | FC Dordrecht | 38 | 5 | 9 | 24 | 24 | 42 | 72 | -30 | 1.529 |
| 20 | Achilles '29 ^ ¹ | 38 | 5 | 7 | 26 | 19 | 37 | 92 | -55 | 1.475 |
¹ Achilles’29 drie punten in mindering
² Fortuna Sittard negen punten in mindering
Wedstrijden
| R: | Datum: | Thuis: | Uit: | Sc.: | Ts.: | Ar.: | Details: |
|---|---|---|---|---|---|---|---|
| 1 | 05/08/2016 | Helmond Sport | MVV Maastricht | 2-2 | 1.800 | Bax | 1-0 Edwards (pen), 1-1 Kuipers, 2-1 Thomassen, 2-2 Güvenç |
| 1 | 05/08/2016 | NAC Breda | Jong FC Utrecht | 4-1 | 12.285 | Perez | 1-0 Stans, 2-0 Dessers, 2-1 Antwi, 3-1 Brusselers, 4-1 Nijholt |
| 1 | 05/08/2016 | FC Dordrecht | FC Oss | 1-1 | 1.952 | Blank | 1-0 Alkan, 1-1 Lazic |
| 1 | 05/08/2016 | Fortuna Sittard | Achilles'29 | 2-1 | 1.541 | Oostrom | 0-1 Boogers, 1-1 Briels, 2-1 Khalouta; R: Briels (For) |
| 1 | 05/08/2016 | VVV-Venlo | SC Cambuur | 2-1 | 4.422 | Kooij | 0-1 Van de Streek, 1-1 Van Crooy, 2-1 Seuntjens |
| 1 | 05/08/2016 | De Graafschap | FC Eindhoven | 4-1 | 7.463 | Wiedemeijer | 1-0 Smeets, 2-0 Nieuwpoort, 2-1 Lieder, 3-1 Koolhof, 4-1 Parzyszek |
| 1 | 05/08/2016 | FC Volendam | Almere City FC | 1-1 | 3.525 | Vd Kerkhof | 0-1 Salasiwa, 1-1 Hilterman |
| 1 | 08/08/2016 | RKC Waalwijk | Telstar | 1-0 | 2.100 | Vd Graaf | 1-0 Anderson |
| 1 | 08/08/2016 | Jong Ajax | FC Emmen | 1-1 | 1.098 | Gerrets | 0-1 Krohne, 1-1 Muric |
| 1 | 08/08/2016 | Jong PSV | FC Den Bosch | 5-4 | 400 | Van Herk | 1-0, 2-0, 3-0 en 4-0 Lammers, 4-1 Rommens, 4-2 Azizov, 4-3 Regales (pen), 4-4 Biemans, 5-4 Lammers; R: Fernandes (DBo) |
| 2 | 12/08/2016 | MVV Maastricht | VVV-Venlo | 1-2 | 4.704 | Liesveld | 0-1 Post, 1-1 Kuipers, 1-2 Rutten |
| 2 | 12/08/2016 | FC Den Bosch | De Graafschap | 2-1 | 2.953 | Higler | 0-1 Koolhof, 1-1 Regales (pen), 2-1 Havar |
| 2 | 12/08/2016 | SC Cambuur | Jong PSV | 1-1 | 7.042 | Dieperink | 0-1 Lammers, 1-1 Bakker |
| 2 | 12/08/2016 | Achilles'29 | NAC Breda | 1-2 | 2.000 | Vd Graaf | 0-1 Smith-Brown, 0-2 Dessers, 1-2 Van de Beek |
| 2 | 12/08/2016 | FC Eindhoven | FC Volendam | 0-1 | 1.703 | Lindhout | 0-1 Tuyp |
| 2 | 12/08/2016 | FC Emmen | RKC Waalwijk | 1-0 | 2.740 | Vd Vrande | 1-0 Krohne |
| 2 | 12/08/2016 | FC Oss | Helmond Sport | 3-1 | 1.900 | Martens | 0-1 Bourdouxhe, 1-1 El Aisatti, 2-1 (pen) en 3-1 Boere |
| 2 | 12/08/2016 | Almere City FC | Jong Ajax | 1-3 | 1.300 | Mulder | 0-1 en 0-2 Zivkovic, 0-3 Cerny, 0-4 Zivokovic, 1-4 Salasiwa |
| 2 | 12/08/2016 | Telstar | Fortuna Sittard | 1-1 | 1.763 | Bax | 0-1 Dianessy, 1-1 Van Iperen |
| 2 | 15/08/2016 | Jong FC Utrecht | FC Dordrecht | 1-1 | 1.181 | Van Herk | 1-0 Rosheuvel, 1-1 Arias |
| 3 | 19/08/2016 | De Graafschap | Jong FC Utrecht | 3-1 | 8.514 | Oostrom | 0-1 Cakmak, 1-1 (p), 2-1 en 3-1 (p) Parzyszek |
| 3 | 19/08/2016 | Jong Ajax | FC Den Bosch | 5-2 | 462 | Blank | 0-1 Santermans, 1-1 Cerny, 2-1 Nouri (pen), 2-2 Regales, 3-2 Cerny, 4-2 Heymans (e.d.), 5-2 Cerny |
| 3 | 19/08/2016 | RKC Waalwijk | FC Eindhoven | 1-2 | 2.100 | Vd Kerkhof | 0-1 Lieder, 0-2 Da Silva, 1-2 Langedijk |
| 3 | 19/08/2016 | NAC Breda | MVV Maastricht | 1-2 | 12.556 | Kamphuis | 0-1 Verheijdt, 1-1 Van Diermen, 1-2 Ciranni R: Verschueren (NAC) |
| 3 | 19/08/2016 | VVV-Venlo | FC Oss | 2-0 | 3.911 | Bax | 1-0 Seuntjens, 2-0 Hunte |
| 3 | 19/08/2016 | Helmond Sport | Achilles'29 | 1-2 | 1.000 | Dieperink | 0-1 Popalzay, 1-1 Hiwat, 1-2 Hendriks |
| 3 | 19/08/2016 | Fortuna Sittard | Almere City FC | 2-1 | 1.806 | Gerrets | 0-1 Van der Water, 1-1 De Regt, 2-1 Khalouta R: Ramsteijn, Overtoom (Alm) |
| 3 | 19/08/2016 | FC Dordrecht | SC Cambuur | 0-1 | 1.742 | Wiedemeijer | 0-1 Van de Streek; R: Amevor (Dor) |
| 3 | 19/08/2016 | Jong PSV | FC Emmen | 1-0 | 350 | Mulder | 1-0 Gudmundsson |
| 3 | 19/08/2016 | FC Volendam | Telstar | 3-0 | 2.718 | Manschot | 1-0 Meulens, 2-0 Tuyp, 3-0 Van Velzen |
| 4 | 22/08/2016 | SC Cambuur | De Graafschap | 1-1 | 7.206 | S. Mulder | 1-0 Hoefdraad, 1-1 Parzyszek |
| 4 | 22/08/2016 | FC Den Bosch | FC Volendam | 2-5 | 2.000 | Perez | 0-1 Meulens, 1-1 Heymans, 1-2 Meulens, 1-3 Van Velzen, 2-3 Regales (pen), 2-4 Van Velzen, 2-5 Tuyp |
| 4 | 22/08/2016 | MVV Maastricht | FC Oss | 3-0 | 4.013 | Kooij | 1-0 Verheijdt, 2-0 Gijzen, 3-0 Croux |
| 4 | 22/08/2016 | FC Dordrecht | NAC Breda | 1-2 | 2.106 | Lindhout | 0-1 Dessers, 1-1 Van Haaren, 1-2 Demon |
| 4 | 22/08/2016 | Jong Ajax | Fortuna Sittard | 2-1 | 653 | Van Herk | 1-0 Nouri, 2-0 Clement, 2-1 Mares R: El Idrissi (Aja) |
| 4 | 22/08/2016 | FC Eindhoven | Achilles'29 | 2-1 | 1.200 | Martens | 1-0 Boelens (e.d.), 2-0 Lieder, 2-1 Hendriks (pen) |
| 4 | 22/08/2016 | Jong FC Utrecht | RKC Waalwijk | 1-3 | 500 | Vd Eijk | 0-1 en 0-2 Voskamp, 1-2 Barazite, 1-3 Sanoh |
| 4 | 22/08/2016 | FC Emmen | Almere City FC | 2-0 | 3.450 | Bax | 1-0 Peters, 2-0 Krohne |
| 4 | 22/08/2016 | Telstar | Helmond Sport | 4-2 | 1.299 | Vd Vrande | 1-0 Van Berkel, 2-0 Zamouri, 3-0 Serrarens, 3-1 en 3-2 Thomassen (pen), 4-2 Ajnane |
| 4 | 22/08/2016 | VVV-Venlo | Jong PSV | 1-2 | 4.277 | Oostrom | 1-0 Leemans, 1-1 Lammers, 1-2 De Wijs; R: Leemans (VVV) |
| 5 | 26/08/2016 | Jong PSV | Jong FC Utrecht | 2-0 | 700 | Kooij | 1-0 Verreth, 2-0 Rosario |
| 5 | 26/08/2016 | De Graafschap | VVV-Venlo | 0-2 | 8.230 | Manschot | 0-1 Röseler, 0-2 Sleegers |
| 5 | 26/08/2016 | Almere City FC | FC Eindhoven | 4-0 | 1.800 | Dieperink | 1-0 Salasiwa, 2-0 Rijsdijk, 3-0 Ahannach, 4-0 Arica |
| 5 | 26/08/2016 | FC Oss | Telstar | 0-2 | 1.989 | Vd Eijk | 0-1 Ajnane (pen), 0-2 Lilipaly; R: Kodalak (Tel) |
| 5 | 26/08/2016 | NAC Breda | FC Den Bosch | 0-0 | 12.058 | S. Mulder | |
| 5 | 26/08/2016 | Helmond Sport | SC Cambuur | 1-0 | 1.331 | Vd Graaf | 1-0 Höcher |
| 5 | 26/08/2016 | RKC Waalwijk | Jong Ajax | 3-2 | 2.450 | Berben | 1-0 Anderson, 2-0 Greene, 2-1 Van de Beek, 2-2 Nouri (pen), 3-2 Anderson |
| 5 | 26/08/2016 | Fortuna Sittard | FC Dordrecht | 3-2 | 1.776 | Martens | 0-1 Daniëls, 1-1 Khalouta, 1-2 Arias, 2-2 Van Hout, 3-2 Torunarigha |
| 5 | 26/08/2016 | FC Volendam | FC Emmen | 0-1 | 2.871 | Kamphuis | 0-1 Peters |
| 5 | 28/08/2016 | Achilles'29 | MVV Maastricht | 2-3 | 1.262 | Janssen | 0-1 Kuipers, 0-2 Güvenç, 1-2 Van de Beek, 1-3 Croux (pen), 2-3 Raterink |
| 6 | 09/09/2016 | FC Den Bosch | FC Oss | 2-1 | 2.641 | Van Boekel | 0-1 Bakx, 1-1 Regales (pen), 2-1 Robinson |
| 6 | 09/09/2016 | FC Eindhoven | MVV Maastricht | 1-1 | 1.050 | Vd Graaf | 1-0 De Silva, 1-1 Schroyen |
| 6 | 09/09/2016 | NAC Breda | Jong PSV | 1-1 | 14.864 | Vd Kerkhof | 0-1 Siem de Jong, 1-1 Dessers |
| 6 | 09/09/2016 | Telstar | De Graafschap | 2-1 | 2.363 | Martens | 0-1 Parzyszek, 1-1 Zamouri, 2-1 Lilypali |
| 6 | 09/09/2016 | FC Dordrecht | RKC Waalwijk | 1-1 | 1.684 | Bax | 1-0 Chacon, 1-1 Benson |
| 6 | 09/09/2016 | FC Emmen | Helmond Sport | 1-2 | 3.244 | Lindhout | 0-1 Edwards, 0-2 Bourdouxhe, 1-2 Warmolts (e.d.) |
| 6 | 09/09/2016 | SC Cambuur | Almere City FC | 4-1 | 7.032 | Blank | 1-0 Anderson, 2-0 Hoefdraad, 2-1 Arica, 3-1 Barto, 4-1 Bakker |
| 6 | 09/09/2016 | VVV-Venlo | FC Volendam | 0-1 | 4.400 | Nijhuis | 0-1 Tuyp |
| 6 | 12/09/2016 | Jong FC Utrecht | Fortuna Sittard | 3-0 | 891 | Dieperink | 1-0 en 2-0 Kerk, 3-0 Peijnenburg |
| 6 | 12/09/2016 | Jong Ajax | Achilles'29 | 7-1 | 700 | Perez | 0-1 Beijer, 1-1 Van de Beek,2-1, 3-1 en 4-1 Cassierra, 4-1 Cerny, 6-1 Cassierra, 7-1 Nouri (p) |
| 7 | 16/09/2016 | Helmond Sport | VVV-Venlo | 2-1 | 2.397 | Vd Kerkhof | 1-0 Ten Den (pen), 1-1 Van Crooy (pen), 2-1 Zeldenrust |
| 7 | 16/09/2016 | Achilles'29 | Telstar | 1-2 | 1.000 | Bax | 0-1 Lilipaly, 0-2 Philips, 1-2 Versteegen |
| 7 | 16/09/2016 | Almere City FC | FC Den Bosch | 4-1 | 1.500 | Vd Graaf | 1-0 en 2-0 Braken, 3-0 Arica, 4-0 Ten Voorde, 4-1 Van der Winden |
| 7 | 16/09/2016 | FC Volendam | Jong FC Utrecht | 2-2 | 2.952 | Vd Vrande | 1-0 Tuyp, 1-1 Peterson, 2-1 Tuyp, 2-2 Rosheuvel (pen); R: Kwakman (Vol) |
| 7 | 16/09/2016 | Fortuna Sittard | SC Cambuur | 3-0 | 1.837 | Gerrets | 1-0 Hadzhiev, 2-0 Van Hout, 3-0 Saddiki |
| 7 | 16/09/2016 | De Graafschap | FC Emmen | 3-0 | 8.324 | Kooij | 1-0 Parzyszek, 2-0 Van den Hurk, 3-0 Bannink |
| 7 | 16/09/2016 | MVV Maastricht | Jong Ajax | 1-0 | 4.767 | D'Hondt | 1-0 Schroyen |
| 7 | 16/09/2016 | Jong PSV | FC Dordrecht | 3-2 | 700 | Mulder | 1-0 Rosario, 1-1 Chacon, 1-2 Arias, 2-2 en 3-2 Lammers; R: Rigo (PSV) |
| 7 | 16/09/2016 | FC Oss | FC Eindhoven | 6-2 | 1.915 | Lindhout | 0-1 Deschilder, 1-1 Kamaci, 2-1 Boere, 2-2 Lieder, 3-2 Boere, 4-2 Kamaci, 5-2 Boere (pen), 6-2 Van der Venne |
| 7 | 16/09/2016 | RKC Waalwijk | NAC Breda | 2-4 | 3.442 | Wiedemeijer | 0-1 El Allouchi, 1-1 Langedijk (pen), 1-2 Dessers, 2-2 Benson, 2-3 O'Neill, 2-4 Adarabioyo |
| 8 | 23/09/2016 | NAC Breda | De Graafschap | 1-0 | 14.016 | Vd Graaf | 1-0 Korte |
| 8 | 23/09/2016 | Almere City FC | MVV Maastricht | 2-1 | 1.300 | Gerrets | 1-0 en 2-0 Braken, 2-1 Gijzen |
| 8 | 24/09/2016 | FC Dordrecht | FC Volendam | 1-0 | 2.492 | Lindhout | 1-0 Da Cruz |
| 8 | 23/09/2016 | Helmond Sport | RKC Waalwijk | 1-1 | 1.812 | Daemen | 1-0 Thomassen, 1-1 Rienstra |
| 8 | 23/09/2016 | Telstar | FC Eindhoven | 1-4 | 1.963 | Kooij | 0-1 Alemao, 1-1 Dzepar, 1-2 Alemao, 1-3 en 1-4 Lieder |
| 8 | 23/09/2016 | VVV-Venlo | Jong FC Utrecht | 2-0 | 3.800 | Mulder | 1-0 Seuntjens, 2-0 Hunte |
| 8 | 23/09/2016 | SC Cambuur | Achilles'29 | 3-1 | 6.872 | Oostrom | 1-0 Bakker (pen), 1-1 Sürmeli, 2-1 Kip, 3-1 Gouriye; R: Beijer (Ach) |
| 8 | 23/09/2016 | FC Emmen | FC Den Bosch | 3-0 | 3.423 | Vd Eijk | 1-0 Kallon, 2-0 Bos, 3-0 Peters |
| 8 | 26/09/2016 | Jong Ajax | FC Oss | 7-0 | 848 | Mulder | 1-0 Van de Beek, 2-0 Cassierra, 3-0 De Jong, 4-0 en 5-0 Dekker, 6-0 Van de Beek, 7-0 Dekker |
| 8 | 26/09/2016 | Jong PSV | Fortuna Sittard | 3-0 | 250 | Berben | 1-0, 2-0 en 3-0 Gudmundsson |
| 9 | 30/09/2016 | Achilles'29 | VVV-Venlo | 0-3 | 1.640 | Kooij | 0-1 Seuntjens, 0-2 Hunte, 0-3 Opoku |
| 9 | 30/09/2016 | FC Den Bosch | Telstar | 0-0 | 2.296 | Van Herk | |
| 9 | 30/09/2016 | FC Oss | Almere City FC | 2-3 | 1.975 | Vd Vrande | 1-0 Lazic, 2-0 Boere, 2-1 Arica, 2-2 Ramsteijn, 2-3 Braken |
| 9 | 30/09/2016 | MVV Maastricht | SC Cambuur | 2-1 | 4.427 | Lindhout | 0-1 Kip, 1-1 Schroijen, 2-1 Gijzen |
| 9 | 30/09/2016 | De Graafschap | FC Dordrecht | 2-3 | 8.304 | Vd Kerkhof | 1-0 Lammers, 1-1 Chacon (pen), 2-1 Koolhof, 2-2 Van Haaren, 2-3 Da Cruz |
| 9 | 30/09/2016 | FC Eindhoven | Jong Ajax | 2-1 | 3.125 | Bax | 1-0 Van den Buijs (pen), 1-1 Clement, 2-1 Vloet |
| 9 | 30/09/2016 | Fortuna Sittard | FC Emmen | 2-2 | 1.721 | Mulder | 0-1 Peters, 1-1 De Regt, 1-2 Krohne, 2-2 De Regt; R: Wiafe (For) |
| 9 | 30/09/2016 | Jong FC Utrecht | Helmond Sport | 1-0 | 874 | Blank | 1-0 Sow |
| 9 | 30/09/2016 | FC Volendam | NAC Breda | 2-1 | 3.657 | Janssen | 0-1 Dessers, 1-1 Kwakman, 2-1 Van Kippersluis (pen); R: Verhulst (Vol) |
| 9 | 30/09/2016 | RKC Waalwijk | Jong PSV | 1-1 | 2.275 | Manschot | 0-1 Lammers, 1-1 Langedijk (pen) |
| 10 | 14/10/2016 | Fortuna Sittard | VVV-Venlo | 2-0 | 2.450 | S. Mulder | 1-0 Khalouta (p), 2-0 V. Hout; R: Janssen (VVV) |
| 10 | 14/10/2016 | FC Eindhoven | FC Emmen | 0-1 | 2.413 | Blank | 0-1 Siekman |
| 10 | 14/10/2016 | Achilles'29 | Jong FC Utrecht | 1-1 | 1.220 | Berben | 0-1 Sow, 1-1 Hendriks R: Van Steen (Ach), Van Eijk (Utr) |
| 10 | 14/10/2016 | Almere City FC | Jong PSV | 1-0 | 1.662 | Lindhout | 1-0 Arica |
| 10 | 14/10/2016 | Helmond Sport | FC Volendam | 2-0 | 2.562 | Van Herk | 1-0 Zeldenrust, 2-0 Ten Den |
| 10 | 14/10/2016 | FC Oss | RKC Waalwijk | 2-5 | 2.066 | Vd Eijk | 1-0 Bakx, 2-0 Mateiu, 2-1 Landendijk, 2-2 Greene, 2-3 Voskamp, 2-4 Langedijk, 2-5 Voskamp |
| 10 | 14/10/2016 | FC Den Bosch | SC Cambuur | 3-1 | 2.479 | Vd Kerkhof | 0-1 Houtkoop, 1-1 Havar, 2-1 Santermans, 3-1 Beltrame |
| 10 | 14/10/2016 | Telstar | NAC Breda | 2-0 | 2.601 | Manschot | 1-0 Lilipaly, 2-0 Abdulahi |
| 10 | 16/10/2016 | MVV Maastricht | FC Dordrecht | 2-1 | 4.754 | Bax | 1-0 Ippel, 2-0 Verheijdt, 2-1 Van Haaren |
| 10 | 17/10/2016 | Jong Ajax | De Graafschap | 4-2 | 2.068 | Martens | 0-1 Parzyszek, 1-1 en 2-1 Cerny, 3-1 El Idrissi, 4-1 Nouri, 4-2 Van Overbeek |
| 11 | 21/10/2016 | FC Emmen | Telstar | 0-0 | 3.212 | Berben | |
| 11 | 21/10/2016 | SC Cambuur | FC Oss | 4-2 | 7.021 | Bax | 1-0 Van de Streek, 1-1 en 1-2 Boere, 2-2 Vd Streek, 3-2 Bakker, 4-2 Vd Streek |
| 11 | 21/10/2016 | Jong PSV | FC Eindhoven | 4-1 | 750 | Mulder | 0-1 Deschilder, 1-1 Alberto, 2-1 Paal, 3-1 Jozefzoon,4-1 Rosario |
| 11 | 21/10/2016 | De Graafschap | Helmond Sport | 2-4 | 0 | Blank | 0-1 Thomassen, 0-2 Hiwat, 1-2 El Jebli, 1-3 en 1-4 Thomassen, 2-4 Van den Hurk |
| 11 | 21/10/2016 | RKC Waalwijk | Achilles'29 | 2-0 | 2.250 | Vd Graaf | 1-0 Greene, 2-0 Voskamp |
| 11 | 21/10/2016 | FC Volendam | Jong Ajax | 1-1 | 6.345 | Oostrom | 1-0 Van Kippersluis, 1-1 Cerny |
| 11 | 21/10/2016 | FC Dordrecht | Almere City FC | 1-4 | 1.983 | Alen | 0-1 Arica, 1-1 Kramer, 1-2 Overtoom, 1-3 Braken, 1-4 Ahannach; R: Amevor (Dor) |
| 11 | 21/10/2016 | VVV-Venlo | FC Den Bosch | 3-1 | 4.600 | Gerrets | 1-0 Fernandes (e.d.), 1-1 Van der Sande, 2-1 Opoku, 3-1 Leemans (p); R: Heymans (DBo) |
| 11 | 21/10/2016 | NAC Breda | Fortuna Sittard | 3-1 | 14.070 | Nijhuis | 1-0 Dessers, 2-0 Korte, 2-1 De Regt, 3-1 Barker |
| 11 | 21/10/2016 | Jong FC Utrecht | MVV Maastricht | 1-2 | 556 | Pérez | 0-1 Verheijdt, 0-2 N'Koyi, 1-2 Van der Moot (p) R: Pereira (MVV) |
| 12 | 28/10/2016 | MVV Maastricht | FC Volendam | 1-2 | 5.012 | Wiedemeijer | 0-1 Van Son, 1-1 Ciranni, 1-2 Steltenpool |
| 12 | 28/10/2016 | FC Den Bosch | Jong FC Utrecht | 1-0 | 2.572 | Van der Vrande | 1-0 Van der Sande |
| 12 | 28/10/2016 | Almere City FC | Helmond Sport | 1-0 | 1.576 | Martens | 1-0 Ahannach |
| 12 | 28/10/2016 | Fortuna Sittard | RKC Waalwijk | 0-1 | 2.440 | Lindhout | 0-1 Voskamp; R: Nieuwendaal (RKC) |
| 12 | 28/10/2016 | FC Eindhoven | SC Cambuur | 2-0 | 2.100 | Pérez | 1-0 De Wilde, 2-0 Van den Buijs (pen) |
| 12 | 28/10/2016 | FC Emmen | FC Dordrecht | 2-1 | 3.644 | Gerrets | 0-1 Thoams, 1-1 en 2-1 Peters |
| 12 | 28/10/2016 | FC Oss | NAC Breda | 3-4 | 2.009 | Kooij | 0-1 Korte, 0-2 Verschueren, 1-2 (pen) en 2-2 Boere, 3-2 Mathieu, 3-3 Dessers, 3-4 Mathieu (e.d.) |
| 12 | 28/10/2016 | Telstar | Jong PSV | 0-0 | 2.323 | Blank | R: Van den Broek (Tel) |
| 12 | 28/10/2016 | Achilles'29 | De Graafschap | 0-0 | 2.320 | Mulder | |
| 12 | 31/10/2016 | Jong Ajax | VVV-Venlo | 0-4 | 1.183 | Manschot | 0-1 Leemans, 0-2 Opoku, 0-3 Sleegers, 0-4 Opoku |
| 13 | 04/11/2016 | Jong Ajax | NAC Breda | 2-1 | 1.721 | Bax | 1-0 El Ghazi, 2-0 De Ligt, 2-1 Dessers |
| 13 | 04/11/2016 | SC Cambuur | FC Volendam | 2-1 | 7.250 | Blom | 0-1 Van Kippersluis, 1-1 Van de Streek, 2-1 Barto |
| 13 | 04/11/2016 | FC Eindhoven | Jong FC Utrecht | 2-1 | 2.338 | Mulder | 1-0 Vloet, 1-1 Van Rooijen, 2-1 Van de Velde |
| 13 | 04/11/2016 | Helmond Sport | Jong PSV | 1-0 | 2.578 | Vd Kerkhof | 1-0 Höcher |
| 13 | 04/11/2016 | MVV Maastricht | Telstar | 2-1 | 4.380 | Higler | 1-0 Verheijdt, 1-1 Mahmudov, 2-1 Gijzen R: Ottenhof (Tel) |
| 13 | 04/11/2016 | RKC Waalwijk | FC Den Bosch | 0-2 | 2.900 | Dieperink | 0-1 Van der Sande, 0-2 Schet |
| 13 | 04/11/2016 | De Graafschap | Fortuna Sittard | 5-0 | 11.312 | Manschot | 1-0 Parzyszek, 2-0 Van Overbeek, 3-0 Ter Wielen (e.d.), 4-0 Van Overbeek, 5-0 Lammers |
| 13 | 04/11/2016 | Almere City FC | Achilles'29 | 1-0 | 1.530 | Vd Eijk | 1-0 Overtoom |
| 13 | 04/11/2016 | VVV-Venlo | FC Dordrecht | 3-1 | 4.227 | Vd Graaf | 1-0 Van Crooy, 1-1 Chacon (p), 2-1 Leemans (p), 3-1 Seuntjens; R: Receveur (VVV) |
| 13 | 04/11/2016 | FC Oss | FC Emmen | 2-2 | 1.800 | Van Damme | 0-1 Krohne, 1-1 Boere (pen), 1-2 Krohne, 2-2 Boere |
| 14 | 18/11/2016 | Fortuna Sittard | MVV Maastricht | 2-3 | 4.780 | Gözübüyük | 0-1 Verheydt, 1-1 Van Hout, 2-1 Smeets, 2-2 Verheydt, 2-3 Nys |
| 14 | 18/11/2016 | Achilles'29 | FC Oss | 1-2 | 1.430 | Gerrets | 1-0 Van Riel, 1-1 Boere, 1-2 Mathieu R: Gortemaker (Ach) |
| 14 | 18/11/2016 | FC Den Bosch | FC Eindhoven | 0-2 | 2.741 | Bax | 0-1 Deschilder, 0-2 Alemao |
| 14 | 18/11/2016 | FC Dordrecht | Helmond Sport | 1-4 | 1.641 | Oostrom | 0-1 en 0-2 Thomassen, 0-3 Zeldenrust, 1-3 Thomas, 1-4 Höcher |
| 14 | 18/11/2016 | NAC Breda | VVV-Venlo | 0-0 | 16.753 | Makkelie | |
| 14 | 18/11/2016 | FC Emmen | SC Cambuur | 0-1 | 3.710 | Vd Kerkhof | 0-1 Bosz |
| 14 | 18/11/2016 | FC Volendam | RKC Waalwijk | 1-1 | 5.066 | Vd Graaf | 0-1 Langedijk, 1-1 Kok |
| 14 | 18/11/2016 | Telstar | Almere City FC | 3-6 | 1.903 | S. Mulder | 0-1 MacDonald, 1-1 Ahannach, 1-2 Abdulahi, 2-2 Donald, 3-2 Mahmudov, 3-3 Ahannach, 3-4 MacDonald, 3-5 Vd Water, 3-6 Ahannach |
| 14 | 21/11/2016 | Jong PSV | De Graafschap | 1-0 | 500 | Van Herk | 1-0 Rosario |
| 14 | 21/11/2016 | Jong FC Utrecht | Jong Ajax | 2-2 | 1.423 | Dieperink | 1-0 Kerk, 1-1 El Ghazi, 2-1 Peterson, 2-2 El Ghazi |
| 15 | 25/11/2016 | RKC Waalwijk | De Graafschap | 2-1 | 2.100 | Vd Kerkhof | 0-1 Van Overbeek, 1-1 Langedijk, 2-1 Sanoh |
| 15 | 25/11/2016 | Achilles'29 | FC Emmen | 0-4 | 1.220 | C. Mulder | 0-1 Krohne, 0-2 Mannes, 0-3 Kallon, 0-4 Siekman; R: Van Steen (Ach) |
| 15 | 25/11/2016 | Jong Ajax | Telstar | 2-1 | 683 | Gerrets | 1-0 El Ghazi, 2-0 De Jong, 2-1 Mahmudov |
| 15 | 25/11/2016 | Almere City FC | VVV-Venlo | 0-2 | 2.276 | Bax | 0-1 Leemans, 0-2 Van Crooy |
| 15 | 25/11/2016 | SC Cambuur | NAC Breda | 3-1 | 7.258 | Liesveld | 1-0 Van de Streek, 1-1 Faupala, 2-1 Van de Streek, 3-1 Monteiro |
| 15 | 25/11/2016 | FC Oss | Jong FC Utrecht | 4-2 | 3.267 | Oostrom | 0-1 Rosheuvel (pen), 1-1 Stuy van den Herik, 2-1 en 3-1 (pen) Boere, 4-1 Matieu, 4-2 Sow |
| 15 | 25/11/2016 | MVV Maastricht | FC Den Bosch | 3-0 | 5.504 | Vd Graaf | 1-0 Schroyen, 2-0 Verheydt, 3-0 Gijzen |
| 15 | 25/11/2016 | FC Eindhoven | FC Dordrecht | 2-1 | 3.076 | Vd Vrande | 1-0 Vandeputte, 1-1 Daniëls, 2-1 Vd Buijs (pen) |
| 15 | 25/11/2016 | Helmond Sport | Fortuna Sittard | 1-0 | 2.382 | Vd Eijk | 1-0 Verkoelen |
| 15 | 25/11/2016 | FC Volendam | Jong PSV | 1-0 | 4.058 | Pérez | 1-0 Van Kippersluis |
| 16 | 28/11/2016 | De Graafschap | FC Volendam | 1-1 | 8.394 | Dieperink | 0-1 Meulens, 1-1 Parzyszek |
| 16 | 28/11/2016 | FC Emmen | MVV Maastricht | 0-0 | 2.115 | Bax | |
| 16 | 28/11/2016 | Jong PSV | FC Oss | 2-4 | 550 | Vd Eijk | 1-0 De Wijs, 1-1 Boere (pen), 1-2 Mathieu, 1-3 De Wijs (e.d.), 2-3 Poulsen, 2-4 Falkenstein |
| 16 | 28/11/2016 | FC Den Bosch | Achilles'29 | 2-1 | 1.589 | Manschot | 0-1 Hemmink, 1-1 Van der Sande, 2-1 Havar |
| 16 | 28/11/2016 | FC Dordrecht | Jong Ajax | 0-2 | 1.425 | Van Herk | 0-1 Nouri, 0-2 Clement |
| 16 | 28/11/2016 | Jong FC Utrecht | Almere City FC | 1-1 | 741 | Gerrets | 1-0 Kerk, 1-1 Ten Voorde |
| 16 | 28/11/2016 | Telstar | SC Cambuur | 0-3 | 1.563 | C. Mulder | 0-1 Monteiro, 0-2 Barto, 0-3 Van de Streek |
| 16 | 28/11/2016 | Fortuna Sittard | FC Eindhoven | 1-1 | 1.143 | Vd Graaf | 1-0 Torunarigha, 1-1Van den Buijs |
| 16 | 28/11/2016 | NAC Breda | Helmond Sport | 0-0 | 10.435 | Nijhuis | |
| 16 | 28/11/2016 | VVV-Venlo | RKC Waalwijk | 4-0 | 4.239 | Pérez | 1-0 Post, 2-0 Seuntjens, 3-0 Van Crooy, 4-0 Opoku |
| 17 | 02/12/2016 | FC Dordrecht | FC Den Bosch | 2-2 | 1.238 | Kooij | 1-0 Daniels, 1-1 Amevor (e.d.), 1-2 Azizov, 2-2 Thomas |
| 17 | 02/12/2016 | RKC Waalwijk | MVV Maastricht | 2-0 | 1.407 | S. Mulder | 1-0 Voskamp, 2-0 Sanoh |
| 17 | 02/12/2016 | Jong PSV | Achilles'29 | 4-0 | 363 | Martens | 1-0 en 2-0 Da Silva, 3-0 Rosario, 4-0 Lammers (pen) |
| 17 | 02/12/2016 | SC Cambuur | Jong Ajax | 1-3 | 8.321 | Blank | 1-0 Hoefdraad, 1-1 De Jong, 1-2 Clement, 1-3 Kluivert; R: Peersman (Cam) |
| 17 | 02/12/2016 | NAC Breda | Almere City FC | 3-1 | 13.211 | Vd Graaf | 1-0 Barker (pen), 1-1 MacDonald, 2-1 Haemhouts, 3-1 Agyepong |
| 17 | 02/12/2016 | Helmond Sport | FC Eindhoven | 3-0 | 3.195 | Van Herk | 1-0 Edwards, 2-0 Zeldenrust, 3-0 Braber |
| 17 | 02/12/2016 | Jong FC Utrecht | FC Emmen | 3-1 | 387 | Pérez | 1-0 Van Rooijen, 2-0 Abena, 2-1 Peters (pen), 3-1 Boukhari |
| 17 | 02/12/2016 | FC Volendam | Fortuna Sittard | 3-0 | 4.094 | Vd Kerkhof | 1-0 Kwakman, 2-0 Van Kippersluis, 3-0 Steltenpool |
| 17 | 02/12/2016 | VVV-Venlo | Telstar | 1-1 | 4.621 | Oostrom | 1-0 Opoku, 1-1 Van Berkel; R: Zonneveld (Tel) |
| 17 | 02/12/2016 | De Graafschap | FC Oss | 3-5 | 8.602 | Bax | 0-1 Kamaci, 0-2 Mathieu, 1-2 Parzsyzek, 1-3 (pen) en 1-4 Boere, 2-4 Parszyzek, 3-4 Bannink, 3-5 Boere; R: Kaak (Gra) |
| 18 | 09/12/2016 | Achilles'29 | FC Volendam | 0-6 | 1.220 | Bax | 0-1 Van Kippersluis, 0-2 Visser, 0-3 Van Kippersluis, 0-4 Kwakman, 0-5 Van Kippersluis, 0-6 Schilder (p) |
| 18 | 09/12/2016 | Jong Ajax | Jong PSV | 1-0 | 2.154 | C. Mulder | 1-0 Sierhuis |
| 18 | 09/12/2016 | Almere City FC | RKC Waalwijk | 6-2 | 1.837 | Van Herk | 1-0 MacDonald, 2-0 Ten Voorde, 3-0 Ahannach, 3-1 Vd Sande, 4-1 Salasiwa, 4-1 Langedijk (pen), 5-2 Ten Voorde, 6-2 Van de Water |
| 18 | 09/12/2016 | SC Cambuur | Jong FC Utrecht | 4-2 | 7.084 | Vd Eijk | 1-0 Barto, 2-0 Van de Streek, 2-1 Abena, 2-2 Kerk, 3-2 Barto, 4-2 Bakker (pen) |
| 18 | 09/12/2016 | FC Den Bosch | Helmond Sport | 1-1 | 3.567 | Dieperink | 1-0 Havar, 1-1 Justiana |
| 18 | 09/12/2016 | FC Eindhoven | NAC Breda | 6-2 | 3.055 | Martens | 1-0 Caenepeel, 2-0 Lieder, 3-0 Alemao, 3-1 Dessers, 4-1 Vd Buijs (pen), 5-1 Caenepeel, 5-2 Haemhouts, 6-2 Vloet |
| 18 | 09/12/2016 | FC Emmen | VVV-Venlo | 1-2 | 2.866 | S. Mulder | 0-1 Opoku, 0-2 Hunte, 1-2 Siekman |
| 18 | 09/12/2016 | MVV Maastricht | De Graafschap | 2-0 | 4.821 | Manschot | 1-0 Verheydt (pen), 2-0 Nwakali; R: Will (Gra) |
| 18 | 09/12/2016 | Telstar | FC Dordrecht | 0-0 | 1.701 | Pérez | |
| 18 | 09/12/2016 | FC Oss | Fortuna Sittard | 3-1 | 1.996 | Vd Vrande | 1-0 Balk, 1-1 Van Hout, 2-1 Boere, 3-1 Lazic |
| 19 | 16/12/2016 | FC Dordrecht | Achilles'29 | 3-0 | 1.434 | Blank | 1-0 Toure, 2-0 Da Cruz, 3-0 Daniels |
| 19 | 16/12/2016 | Helmond Sport | Jong Ajax | 2-4 | 2.491 | Oostrom | 1-0 Sanniez (e.d.), 1-1 Kluivert, 1-2 Zeefuik, 1-3 Dankerlui, 2-3 Ten Den, 2-4 Mazraoui |
| 19 | 16/12/2016 | De Graafschap | Almere City FC | 4-1 | 8.364 | Gerrets | 1-0 Koolhof, 2-0 El Jebli, 3-0 Parzsyzek, 3-1 Ten Voorde, 4-1 Diemers |
| 19 | 16/12/2016 | Fortuna Sittard | FC Den Bosch | 0-4 | 1.120 | C. Mulder | 0-1 Vossebelt, 0-2 Schet, 0-3 Dautovic (e.d.), 0-4 Van der Winden |
| 19 | 16/12/2016 | VVV-Venlo | FC Eindhoven | 1-0 | 4.722 | Dieperink | 1-0 Sleegers; R: Deschilder (Ein) |
| 19 | 16/12/2016 | NAC Breda | FC Emmen | 3-1 | 12.065 | Manschot | 1-0 Dessers, 2-0 Verschueren, 3-0 Haemhouts, 3-1 Loen |
| 19 | 16/12/2016 | FC Volendam | FC Oss | 3-1 | 4.207 | S. Mulder | 1-0 Tuyp, 2-0 Van Kippersluis, 3-0 Kwakman, 3-1 Mahieu (pen) |
| 19 | 18/12/2016 | RKC Waalwijk | SC Cambuur | 2-2 | 1.800 | Janssen | 1-0 Langedijk (pen), 1-1 Barto, 2-1 Voskamp, 2-2 Van de Streek |
| 19 | 19/12/2016 | Jong PSV | MVV Maastricht | 0-0 | 549 | Kooij | |
| 19 | 19/12/2016 | Jong FC Utrecht | Telstar | 2-1 | 915 | Vd Vrande | 1-0 Kerk, 2-0 Sow, 2-1 Zamouri |
| 20 | 13/01/2017 | Achilles'29 | Fortuna Sittard | 0-1 | 800 | Martens | 0-1 Vlijter |
| 20 | 13/01/2017 | FC Den Bosch | Jong PSV | 0-0 | 2.986 | Dieperink | |
| 20 | 13/01/2017 | SC Cambuur | VVV-Venlo | 0-2 | 7.420 | Manschot | 0-1 Opoku, 0-2 Röseler |
| 20 | 13/01/2017 | FC Eindhoven | De Graafschap | 2-1 | 2.836 | Blank | 1-0 Van der Velde, 2-0 Uiterloo, 2-1 Parzsyzek |
| 20 | 13/01/2017 | Almere City FC | FC Volendam | 2-2 | 1.538 | Lindhout | 1-0 Salasiwa, 1-1 Visser, 1-2 Steltenpool, 2-2 Rijsdijk |
| 20 | 13/01/2017 | MVV Maastricht | Helmond Sport | 2-0 | 4.188 | Vd Kerkhof | 1-0 Ciranni, 2-0 Schroyen |
| 20 | 13/01/2017 | FC Oss | FC Dordrecht | 4-2 | 2.012 | Vd Vrande | 1-0 Boere, 1-1 Daniëls, 2-1 Lazic, 3-1 en 4-1 Boere, 4-2 Da Cruz |
| 20 | 13/01/2017 | FC Emmen | Jong Ajax | 0-0 | 3.150 | Mulder | |
| 20 | 13/01/2017 | Telstar | RKC Waalwijk | 0-4 | 1.001 | Gerrets | 0-1 Voskamp, 0-2 Sanoh, 0-3 Voskamp, 0-4 Lazic (pen); R: Lilipaly (Tel) |
| 20 | 16/01/2017 | Jong FC Utrecht | NAC Breda | 0-2 | 1.612 | Vd Eijk | 0-1 Verschueren, 0-2 Haemhouts |
| 21 | 20/01/2017 | Helmond Sport | FC Oss | 3-1 | 1.231 | Vd Eijk | 1-0 Ten Den, 1-1 Boere, 2-1 Justitiana, 3-1 Ten Den; R: Warmolts (Hel) |
| 21 | 20/01/2017 | FC Dordrecht | Jong FC Utrecht | 3-0 | 1.133 | Oostrom | 1-0 Godee, 2-0 Daniels, 3-0 Godee |
| 21 | 20/01/2017 | Fortuna Sittard | Telstar | 1-1 | 1.444 | Pérez | 0-1 Van Huizen, 1-1 De Regt; R: Van Berkel (Tel) |
| 21 | 20/01/2017 | NAC Breda | Achilles'29 | 2-0 | 12.335 | Lindhout | 1-0 Dessers, 2-0 Rommens |
| 21 | 20/01/2017 | FC Volendam | FC Eindhoven | 3-1 | 4.155 | Vd Kerkhof | 0-1 Uiterloo, 1-1 Visser, 2-1 en 3-1 Veerman |
| 21 | 20/01/2017 | RKC Waalwijk | FC Emmen | 1-1 | 2.268 | Van Herk | 0-1 Peters, 1-1 Langedijk (pen); R: Lima (Emm) |
| 21 | 20/01/2017 | De Graafschap | FC Den Bosch | 0-3 | 8.416 | Mulder | 0-1 Smeets (e.d.), 0-2 Beltrame, 0-3 Schet |
| 21 | 22/01/2017 | VVV-Venlo | MVV Maastricht | 2-1 | 8.000 | Gözübüyük | 1-0 Opoku, 1-1 Ippel, 2-1 Seuntjens |
| 21 | 23/01/2017 | Jong PSV | SC Cambuur | 0-2 | 419 | Martens | 0-1 Van de Streek, 0-2 Tissoudali |
| 22 | 27/01/2017 | FC Eindhoven | RKC Waalwijk | 3-0 | 2.500 | Oostrom | 1-0 Lieder, 2-0 Van den Buijs (pen), 3-0 Lieder |
| 22 | 27/01/2017 | MVV Maastricht | NAC Breda | 1-1 | 4.977 | Higler | 1-0 Nkoyi, 1-1 Labylle |
| 22 | 27/01/2017 | FC Oss | VVV-Venlo | 0-3 | 2.225 | S. Mulder | 0-1 Sleegers, 0-2 en 0-3 Van Crooy |
| 22 | 27/01/2017 | Achilles'29 | Helmond Sport | 1-2 | 1.000 | Vd Vrande | 0-1 Braber, 1-1 V. Koesveld (e.d.), 1-2 V. Koesveld R: Van Steen (Ach) |
| 22 | 27/01/2017 | Almere City FC | Fortuna Sittard | 2-0 | 1.486 | Vd Eijk | 1-0 Overtoom, 2-0 Valpoort |
| 22 | 27/01/2017 | FC Emmen | Jong PSV | 1-1 | 2.580 | Gerrets | 0-1 Rosario, 1-1 Peters; R: Scamacca (PSV) |
| 22 | 27/01/2017 | Telstar | FC Volendam | 0-1 | 2.275 | C. Mulder | 0-1 Veerman |
| 22 | 27/01/2017 | FC Den Bosch | Jong Ajax | 1-2 | 3.579 | Put | 1-0 Beltrame, 1-1 De Jong, 1-2 Mazraoui |
| 22 | 28/01/2017 | SC Cambuur | FC Dordrecht | 3-0 | 7.197 | Lindhout | 1-0 Tissoudali, 2-0 Hoefdraad, 3-0 Bakker (pen) R: De Nooijer, Chacon (Dor) |
| 22 | 30/01/2017 | Jong FC Utrecht | De Graafschap | 3-2 | 829 | Van Herk | 1-0 Venema, 2-0 Koch, 3-0 Sow, 3-1 Smeets, 3-2 Abena (e.d.) |
| 21 | 30/01/2017 | Jong Ajax | Almere City FC | 6-3 | 772 | Dieperink | 1-0 Mazraoui, 2-0 Nouri, 3-0 (pen) en 4-0 Van de Beek, 5-0 Casierra, 5-1 Ahannach, 5-2 MacDonald, 5-3 Overtoom, 6-3 Dankerlui |
| 23 | 03/02/2017 | FC Den Bosch | NAC Breda | 2-1 | 3.494 | v. Boekel | 1-0 Carlone, 2-0 Azizov, 2-1 Oosterwijk (pen) |
| 23 | 03/02/2017 | SC Cambuur | Helmond Sport | 3-0 | 8.083 | Bax | 1-0 Van Deelen, 2-0 Lilipaly, 3-0 Monteiro |
| 23 | 03/02/2017 | Jong Ajax | RKC Waalwijk | 4-1 | 650 | Martens | 1-0 De Jong, 1-1 Langedijk (pen), 2-1 en 3-1 Eiting, 4-1 Mazraoui |
| 23 | 03/02/2017 | FC Dordrecht | Fortuna Sittard | 2-2 | 1.135 | Blank | 1-0 Daniels, 2-0 Kramer, 2-1 Stokkers, 2-2 Van Hout |
| 23 | 03/02/2017 | FC Emmen | FC Volendam | 3-1 | 2.630 | Perez | 1-0 Klok, 2-0 Olijve, 2-1 Steltenpool, 3-1 Peters (pen) |
| 23 | 03/02/2017 | MVV Maastricht | Achilles'29 | 0-0 | 4.031 | Kooij | |
| 23 | 03/02/2017 | Jong FC Utrecht | Jong PSV | 0-2 | 503 | C. Mulder | 0-1 Rommens, 0-2 Lammers |
| 23 | 03/02/2017 | VVV-Venlo | De Graafschap | 4-1 | 5.105 | Janssen | 1-0 V. van Crooy, 2-0 Janssen, 3-0 Leemans (pen), 4-0 Opoku, 4-1 Parzyszek |
| 23 | 03/02/2017 | FC Eindhoven | Almere City FC | 4-1 | 2.423 | Manschot | 1-0 De Wilde, 1-1 Valpoort, 2-1 Alemao, 3-1 Lieder, 4-1 Vandeputte; R: Quasten (Alm) |
| 23 | 03/02/2017 | Telstar | FC Oss | 3-1 | 1.850 | Oostrom | 0-1 Çelik, 1-1 (p) en 2-1 Ajnane 3-1 Van der Linden |
| 24 | 06/02/2017 | Achilles'29 | FC Eindhoven | 4-3 | 1.243 | Gerrets | 1-0 Thoone (pen), 1-1 Vloet, 2-1 Oulad Omar, 3-1 Smajic, 3-2 Vloet, 3-3 Vandeputte, 4-3 Smajic; R: Uiterloo (Ein) |
| 24 | 06/02/2017 | RKC Waalwijk | Jong FC Utrecht | 1-2 | 900 | Vd Vrande | 0-1 Kerk, 1-1 Langedijk, 1-2 Velanas |
| 24 | 06/02/2017 | Almere City FC | FC Emmen | 3-1 | 1.589 | Martens | 0-1 Bos, 1-1 Bakker (e.d.), 2-1 Ahannach, 3-1 Van der Water |
| 24 | 06/02/2017 | Helmond Sport | Telstar | 3-4 | 1.286 | Blank | 0-1 Van den Broek, 1-1 Thomassen, 2-1 Zeldenrust, 2-2 Serrarens, 2-3 Van den Broek, 2-4 Serrarens, 3-4 Thomassen, |
| 24 | 06/02/2017 | Jong PSV | VVV-Venlo | 2-1 | 750 | Vd Kerkhof | 0-1 Seuntjens, 1-1 Promes (e.d.), 2-1 Lammers |
| 24 | 06/02/2017 | De Graafschap | SC Cambuur | 3-0 | 8.064 | Perez | 1-0 Van den Hurk, 2-0 El Jebli, 3-0 Straalman |
| 24 | 06/02/2017 | FC Volendam | FC Den Bosch | 2-1 | 4.075 | Kooij | 1-0 Kwakman, 1-1 Regales, 2-1 Van Kippersluis |
| 24 | 06/02/2017 | FC Oss | MVV Maastricht | 0-3 | 1.087 | Bax | 0-1 Verheijdt, 0-2 Schroyen, 0-3 Verheijdt |
| 24 | 06/02/2017 | NAC Breda | FC Dordrecht | 1-0 | 11.456 | Blom | 1-0 Garcia |
| 24 | 06/02/2017 | Fortuna Sittard | Jong Ajax | 5-2 | 1.412 | Oostrom | 0-1 Cerny, 0-2 Cassiera, 1-2 Stokkers, 2-2 Schuurs, 3-2 Vlijter, 4-2 en 5-2 Dianessy |
| 25 | 10/02/2017 | SC Cambuur | Fortuna Sittard | 1-1 | 7.133 | S. Mulder | 0-1 Stokkers, 1-1 Barto |
| 25 | 10/02/2017 | FC Emmen | De Graafschap | 2-0 | 2.630 | Lindhout | 1-0 Loen, 2-0 Peters |
| 25 | 10/02/2017 | FC Dordrecht | Jong PSV | 2-3 | 1.303 | Van Herk | 1-0 Daniels, 1-1 Lammers, 1-2 Verreth, 2-2 Thomas, 2-3 Lammers |
| 25 | 10/02/2017 | FC Eindhoven | FC Oss | 1-2 | 2.826 | Kooij | 0-1 (pen) en 0-2 Boere, 1-2 Lieder |
| 25 | 10/02/2017 | NAC Breda | RKC Waalwijk | 2-3 | 13.826 | Bax | 0-1 Anderson, 1-1 Dessers, 1-2 Sanoh, 2-2 Oosterwijk, 2-3 Rienstra R: Verbeek (NAC), Williams (RKC) |
| 25 | 10/02/2017 | VVV-Venlo | Helmond Sport | 7-0 | 5.011 | Kamphuis | 1-0 Van Crooy, 2-0 Sleegers, 3-0 Promes, 4-0 Seuntjens, 5-0 Leemans, 6-0 Post, 7-0 Zelalem |
| 25 | 10/02/2017 | Telstar | Achilles'29 | 1-1 | 1.499 | Dieperink | 0-1 Stankov, 1-1 Ajnane; R: Elders (Ach) |
| 25 | 10/02/2017 | FC Den Bosch | Almere City FC | 1-3 | 2.373 | Vd Graaf | 0-1 Overtoom, 0-2 Ten Voorde, 0-3 Ahannach, 1-3 Vossebelt |
| 25 | 13/02/2017 | Jong FC Utrecht | FC Volendam | 2-4 | 770 | Blank | 0-1 Van der Heijden, 1-1 Venema, 1-2 Steltenpool, 2-2 Kerk, 2-3 Schilder (pen), 2-4 Steltenpool |
| 25 | 13/02/2017 | Jong Ajax | MVV Maastricht | 1-1 | 514 | C. Mulder | 1-0 Mazraoui, 1-1 Ciranni |
| 26 | 17/02/2017 | Fortuna Sittard | Jong FC Utrecht | 4-1 | 1.734 | Gerrets | 1-0 Bassan, 2-0 Stokkers (pen), 2-1 Loukili, 3-1 Dianessy, 4-1 Torunarigha |
| 26 | 17/02/2017 | Achilles'29 | Jong Ajax | 2-3 | 2.113 | Vd Eijk | 1-0 Kortstam, 1-1 Walian, 1-2 en 1-3 Sierhuis, 2-3 Versteegen; R: Kortstam (Ach) |
| 26 | 17/02/2017 | Almere City FC | SC Cambuur | 0-1 | 1.807 | Vd Kerkhof | 0-1 Tissoudali |
| 26 | 17/02/2017 | FC Volendam | VVV-Venlo | 0-1 | 4.582 | Vd Graaf | 0-1 Rutten; R: Kok (Vol) |
| 26 | 17/02/2017 | FC Oss | FC Den Bosch | 1-1 | 2.889 | Manschot | 1-0- Kamaci, 1-1 Bilate |
| 26 | 17/02/2017 | De Graafschap | Telstar | 2-1 | 8.714 | Bax | 0-1 Van Berkel, 1-1 (pen) en 2-1 Parzyszek |
| 26 | 17/02/2017 | RKC Waalwijk | FC Dordrecht | 2-1 | 2.267 | Alen | 0-1 Daniels, 1-1 en 2-1 Van Eijma |
| 26 | 17/02/2017 | Helmond Sport | FC Emmen | 1-3 | 1.516 | Oostrom | 0-1 Kallon, 0-2 Peters, 0-3 Olijve, 1-3 Zeldenrust |
| 26 | 19/02/2017 | MVV Maastricht | FC Eindhoven | 0-0 | 4.681 | Perez | R: Ippel (MVV) |
| 26 | 20/02/2017 | Jong PSV | NAC Breda | 2-0 | 641 | Martens | 1-0 en 2-0 Gudmundsson |
| 27 | 24/02/2017 | Almere City FC | FC Oss | 3-3 | 1.964 | Bax | 0-1 Boere (pen), 0-2 Kivuvu, 1-2 Rijsdijk, 2-2 MacDonald, 3-2 Ahannach, 3-3 Boere R: Mathieu (Oss) |
| 27 | 24/02/2017 | SC Cambuur | MVV Maastricht | 4-0 | 7.511 | Vd Graaf | 1-0 Van de Streek, 2-0 Monteiro, 3-0 Barto, 4-0 Lilipaly |
| 27 | 24/02/2017 | FC Dordrecht | De Graafschap | 0-3 | 1.638 | Vd Eijk | 0-1 en 0-2 Diemers, 0-3 Parzyszek; R: Godee (Dor) |
| 27 | 24/02/2017 | Jong Ajax | FC Eindhoven | 1-1 | 744 | Vd Vrande | 1-0 Sierhuis, 1-1 Uiterloo |
| 27 | 24/02/2017 | FC Emmen | Fortuna Sittard | 2-3 | 2.113 | Kooij | 0-1 Schuurs, 1-1 Bannink, 2-1 Lima, 2-2 en 2-3 (pen) Stokkers |
| 27 | 24/02/2017 | Helmond Sport | Jong FC Utrecht | 1-1 | 1.028 | Dieperink | 1-0 Thomassen, 1-1 Peijnenburg |
| 27 | 24/02/2017 | NAC Breda | FC Volendam | 1-0 | 13.805 | Lindhout | 1-0 El Allouchi |
| 27 | 24/02/2017 | Jong PSV | RKC Waalwijk | 4-1 | 407 | Blank | 0-1 Van Bruggen, 1-1, 2-1 en 3-1 Gudmundsson, 4-1 Lammers |
| 27 | 24/02/2017 | VVV-Venlo | Achilles'29 | 4-0 | 4.411 | Manschot | 1-0 Van Crooy, 2-0 Sleegers, 3-0 Seuntjens, 4-0 Van Crooy |
| 27 | 24/02/2017 | Telstar | FC Den Bosch | 2-0 | 2.222 | Van Herk | 1-0 Abdulahi, 2-0 Serrarens; R: Santermans (DBo) |
| 28 | 03/03/2017 | FC Eindhoven | Telstar | 4-2 | 2.430 | Oostrom | 0-1 Dzepar, 1-1 Sprockel, 2-1 Vloet, 3-1 VAn den Buijs (pen), 3-2 Serrarens, 4-2 Van den Buijs (pen); R: Ajnane (Tel) |
| 28 | 03/03/2017 | Fortuna Sittard | Jong PSV | 0-0 | 1.680 | Perez | |
| 28 | 03/03/2017 | FC Den Bosch | FC Emmen | 1-1 | 2.268 | Bax | 0-1 Bannink, 1-1 Vossbelt (pen) |
| 28 | 03/03/2017 | FC Oss | Jong Ajax | 0-3 | 3.004 | Gerrets | 0-1 Nouri, 0-2 Cassierra, 0-3 Tete |
| 28 | 03/03/2017 | MVV Maastricht | Almere City FC | 2-2 | 3.997 | D'hondt | 0-1 Ten Voorde, 1-1 Guvenc, 1-2 MacIntosch, 2-2 Schroyen |
| 28 | 03/03/2017 | FC Volendam | FC Dordrecht | 1-1 | 4.248 | S. Mulder | 1-0 Tuyp, 1-1 Thomas |
| 28 | 03/03/2017 | RKC Waalwijk | Helmond Sport | 5-2 | 1.996 | Manschot | 0-1 Ten Den, 1-1 Benson, 1-2 Ten Den, 2-2 Rienstra, 3-2 Voskamp, 4-2 en 5-2 (p) Langedijk |
| 28 | 03/03/2017 | De Graafschap | NAC Breda | 2-1 | 9.124 | Vd Kerkhof | 1-0 Parzyszek, 2-0 Van Mieghem, 2-1 Oosterwijk |
| 28 | 05/03/2017 | Achilles'29 | SC Cambuur | 0-3 | 1.185 | Martens | 0-1 en 0-2 Barto, 0-3 Lilipaly |
| 28 | 06/03/2017 | Jong FC Utrecht | VVV-Venlo | 0-0 | 771 | ||
| 29 | 10/03/2017 | SC Cambuur | FC Den Bosch | 0-1 | 7.368 | Lindhout | 0-1 Vossebelt |
| 29 | 10/03/2017 | FC Dordrecht | MVV Maastricht | 0-1 | 1.123 | Dieperink | 0-1 Loshaj |
| 29 | 10/03/2017 | NAC Breda | Telstar | 1-0 | 12.283 | Janssen | 1-0 Dessers; R: Ottenhoff (Tel) |
| 29 | 10/03/2017 | VVV-Venlo | Fortuna Sittard | 4-1 | 6.123 | Higler | 1-0 Seuntjens, 1-1 Bassan, 2-1 Van Crooy, 3-1 en 4-1 Seuntjens; R: Hadzhiev (For) |
| 29 | 10/03/2017 | FC Emmen | FC Eindhoven | 2-0 | 3.014 | Blank | 1-0 Bannink, 2-0 Zeefuik |
| 29 | 10/03/2017 | De Graafschap | Jong Ajax | 3-2 | 10.043 | Vd Graaf | 1-0 Van den Hurk, 1-1 Cerny, 1-2 De Jong, 2-2 en 3-2 Van den Hurk |
| 29 | 10/03/2017 | Jong FC Utrecht | Achilles'29 | 0-1 | 500 | Oostrom | 0-1 Sürmeli |
| 29 | 10/03/2017 | Jong PSV | Almere City FC | 0-1 | 463 | Kooij | 0-1 MacIntosch |
| 29 | 10/03/2017 | FC Volendam | Helmond Sport | 1-0 | 4.446 | Martens | 1-0 Stroo |
| 29 | 10/03/2017 | RKC Waalwijk | FC Oss | 3-0 | 2.131 | Van Herk | 1-0 Benson, 2-0 en 3-0 Voskamp |
| 30 | 13/03/2017 | FC Eindhoven | Jong PSV | 0-5 | 3.156 | C. Mulder | 0-1, 0-2 en 0-3 Gudmundsson, 0-4 Locadia, 0-5 Lonwijk |
| 30 | 13/03/2017 | Helmond Sport | De Graafschap | 0-2 | 1.011 | Gerrets | 0-1 Smeets, 0-2 Van den Hurk |
| 30 | 13/03/2017 | Achilles'29 | RKC Waalwijk | 2-3 | 1.533 | S. Mulder | 0-1 Anderson, 1-1 Oulad Omar, 1-2 Langedijk, 1-3 Sno, 2-3 Smajic |
| 30 | 13/03/2017 | Jong Ajax | FC Volendam | 1-1 | 1.007 | Perez | 1-0 Nouri, 1-1 Van Kippersluis |
| 30 | 13/03/2017 | Almere City FC | FC Dordrecht | 3-0 | 1.430 | Blank | 1-0 Ahannach, 2-0 en 3-0 MacDonald |
| 30 | 13/03/2017 | FC Den Bosch | VVV-Venlo | 0-2 | 2.058 | Kooij | 0-1 Van Crooy, 0-2 Leemans (pen) |
| 30 | 13/03/2017 | Fortuna Sittard | NAC Breda | 0-2 | 1.290 | Gözübüyük | 0-1 Meijers, 0-2 Horsfield; R: Ospitalieri (For) |
| 30 | 13/03/2017 | MVV Maastricht | Jong FC Utrecht | 4-1 | 3.782 | Martens | 1-0 N'Koyi, 1-0 Schroyen, 2-1 Tesselaar, 3-1 Nys, 4-1 Güvenç |
| 30 | 13/03/2017 | Telstar | FC Emmen | 2-2 | 1.263 | Manschot | 1-0 Yamazaki, 2-0 Mahmudov, 2-1 Loen, 2-2 Kallon |
| 30 | 13/03/2017 | FC Oss | SC Cambuur | 2-7 | 921 | Vd Eijk | 1-0 Çelik, 1-1 en 1-2 Van de Streek, 2-2 Mathieu, 2-3 Van de Streek, 2-4 Van Deelen, 2-5 en 2-6 Lilipaly, 2-7 Barto |
| 31 | 17/03/2017 | FC Den Bosch | RKC Waalwijk | 1-1 | 3.452 | Martens | 0-1 Anderson, 1-1 Regales (DBo); R: Benson (RKC) |
| 31 | 17/03/2017 | Fortuna Sittard | De Graafschap | 3-2 | 1.512 | Lindhout | 0-1 Parzyszek (pen), 1-1 Dianessy, 2-1 en 3-1 Bassan, 3-2 Diemers; R: Will (Gra) |
| 31 | 17/03/2017 | Achilles'29 | Almere City FC | 3-3 | 1.333 | Gerrets | 0-1 Ahannach, 1-1 Sürmeli, 1-2 Ahannach, 2-2 Smajic, 3-2 Van Steen, 3-3 MacIntosch |
| 31 | 17/03/2017 | FC Dordrecht | VVV-Venlo | 5-2 | 1.109 | Vd Kerkhof | 0-1 Van Crooy, 1-1 Thomas, 1-2 Sleegers, 2-2 Vleugels, 3-2 Pisas, 4-2 Da Cruz, 5-2 Thomas (p) |
| 31 | 17/03/2017 | FC Emmen | FC Oss | 2-0 | 2.280 | Gözübüyük | 1-0 Siekman, 2-0 Zeefuik |
| 31 | 17/03/2017 | NAC Breda | Jong Ajax | 4-3 | 15.054 | Manschot | 0-1 Neres, 1-1 Dessers, 1-2 Mazraoui, 2-2 Garcia, 3-2 Dessers, 4-2 Verschueren, 4-3 Cassierra |
| 31 | 17/03/2017 | Jong FC Utrecht | FC Eindhoven | 3-1 | 654 | Van Herk | 1-0 Van der Moot, 2-0 Velanas, 2-1 Vloet, 3-1 Venema |
| 31 | 17/03/2017 | Jong PSV | Helmond Sport | 3-0 | 604 | Vd Eijk | 1-0 Gudmundsson, 2-0 Lammers, 3-0 Piroe |
| 31 | 17/03/2017 | Telstar | MVV Maastricht | 1-1 | 1.200 | Kooij | 0-1 Pedro, 1-1 Tutuarima |
| 31 | 19/03/2017 | FC Volendam | SC Cambuur | 1-1 | 5.269 | Kamphuis | 0-1 Van de Streek, 1-1 Van Kippersluis |
| 32 | 31/03/2017 | Almere City FC | Telstar | 2-0 | 2.150 | Van Herk | 1-0 Nieuwpoort, 2-0 Ahannach |
| 32 | 31/03/2017 | SC Cambuur | FC Emmen | 1-0 | 7.735 | Vd Graaf | 1-0 Barto |
| 32 | 31/03/2017 | RKC Waalwijk | FC Volendam | 1-4 | 2.756 | Bax | 0-1 Stroo, 1-1 Anderson, 1-2 Van der Heijden, 1-3 Stroo, 1-4 Van der Heijden |
| 32 | 31/03/2017 | De Graafschap | Jong PSV | 2-1 | 9.311 | Martens | 1-0 Parzyszek, 2-0 El Jebli, 2-1 Lammers |
| 32 | 31/03/2017 | FC Oss | Achilles'29 | 4-0 | 2.221 | Kooij | 1-0 Boere, 2-0 Çelik, 3-0 (pen) en 4-0 Boere |
| 32 | 31/03/2017 | FC Eindhoven | FC Den Bosch | 4-2 | 3.513 | Perez | 1-0 Vloet, 2-0 Van de Velde, 2-1 Bilate, 2-2 Azizov, 3-2 Lieder, 4-2 Vloet |
| 32 | 31/03/2017 | Helmond Sport | FC Dordrecht | 1-0 | 1.837 | Oostrom | 1-0 Ten Den |
| 32 | 31/03/2017 | VVV-Venlo | NAC Breda | 0-4 | 6.634 | Nijhuis | 0-1 Dessers, 0-2 Haemhouts, 0-3 Korte, 0-4 Dessers (pen) |
| 32 | 02/04/2017 | MVV Maastricht | Fortuna Sittard | 1-1 | 7.004 | S. Mulder | 1-0 N'Koyi, 1-1 Bassan; R: Briels (For) |
| 32 | 03/04/2017 | Jong Ajax | Jong FC Utrecht | 2-0 | 675 | Dieperink | 1-0 en 2-0 Walian |
| 33 | 07/04/2017 | FC Den Bosch | MVV Maastricht | 2-1 | 2.782 | Blank | 0-1 Nwakali, 1-1 Fernandes, 2-1 Brouwers |
| 33 | 07/04/2017 | FC Dordrecht | FC Eindhoven | 1-1 | 1.156 | Vd Eijk | 1-0 Pisas, 1-1 Vloet |
| 33 | 07/04/2017 | Fortuna Sittard | Helmond Sport | 4-1 | 1.623 | Van Damme | 1-0 Dianessy, 2-0 Stokkers, 3-0 Braun, 3-1 Hiwat, 4-1 Bassan |
| 33 | 07/04/2017 | De Graafschap | RKC Waalwijk | 4-0 | 10.110 | Perez | 1-0 Van den Hurk, 2-0 Parzyszek, 3-0 Diemers, 4-0 Parzyszek |
| 33 | 07/04/2017 | FC Emmen | Achilles'29 | 1-0 | 2.468 | Van Herk | 1-0 Peters |
| 33 | 07/04/2017 | Telstar | Jong Ajax | 1-3 | 2.963 | Oostrom | 0-1, 0-2 en 0-3 Cerny, 1-3 Philips |
| 33 | 07/04/2017 | VVV-Venlo | Almere City FC | 3-2 | 5.183 | Bax | 0-1 Ahannach, 1-1 Seuntjens, 1-2 Mirani, 2-2 Seuntjens, 3-2 Sleegers |
| 33 | 07/04/2017 | NAC Breda | SC Cambuur | 0-2 | 14.285 | S. Mulder | 0-1 Van de Streek, 0-2 Lilipaly |
| 33 | 10/04/2017 | Jong PSV | FC Volendam | 2-0 | 491 | Gerrets | 1-0 en 2-0 Bergwijn |
| 33 | 10/04/2017 | Jong FC Utrecht | FC Oss | 2-1 | 604 | C. Mulder | 1-0 Venema, 1-1 Boere, 2-1 Venema |
| 34 | 14/04/2017 | FC Oss | Jong PSV | 2-0 | 2.756 | Blanl | 1-0 Mathieu, 2-0 Boere |
| 34 | 14/04/2017 | Achilles'29 | FC Den Bosch | 2-1 | 1.235 | C. Mulder | 0-1 Bilate, 1-1 Van de Beek, 2-1 Versteegen |
| 34 | 14/04/2017 | Jong Ajax | FC Dordrecht | 1-0 | 500 | Martens | 1-0 Bergsma |
| 34 | 14/04/2017 | Almere City FC | Jong FC Utrecht | 2-1 | 2.388 | Vd Eijk | 1-0 Ahannach, 1-1 Van der Moot, 2-1 Ahannach |
| 34 | 14/04/2017 | SC Cambuur | Telstar | 5-1 | 7.610 | Bax | 1-0 Van de Streek, 2-0 Tissoudali, 3-0 Bakker (pen), 4-0 Houtkoop, 4-1 Yamazaki, 5-1 Barto |
| 34 | 14/04/2017 | FC Eindhoven | Fortuna Sittard | 3-1 | 2.871 | Dieperink | 1-0 Lieder, 1-1 Hadzhiev, 2-1 Lieder, 3-1 Swinnen |
| 34 | 14/04/2017 | Helmond Sport | NAC Breda | 2-1 | 2.211 | Vd Graaf | 1-0 Edwards, 2-0 Ten Den, 2-1 Dessers |
| 34 | 14/04/2017 | RKC Waalwijk | VVV-Venlo | 1-2 | 3.089 | Kamphuis | 0-1 Leemans (pen), 1-1 Voskamp (pen), 1-2 Leemans |
| 34 | 14/04/2017 | FC Volendam | De Graafschap | 2-2 | 4.475 | Van Boekel | 1-0 Stroo, 1-1 Straalman, 1-2 Parzyszek (pen), 2-2 Stroo; R: Schouten (Vol) |
| 34 | 14/04/2017 | MVV Maastricht | FC Emmen | 2-2 | 4.370 | Lindhout | 0-1 Peters, 0-2 Huisman, 1-2 N'Koyi, 2-2 Schroyen |
| 35 | 17/04/2017 | FC Dordrecht | Telstar | 0-2 | 1.226 | Vd Graaf | 0-1 Philips, 0-2 Serrarens; R: Daniels (Dor) |
| 35 | 17/04/2017 | Fortuna Sittard | FC Oss | 2-0 | 1.875 | Gerrets | 1-0 Dianessy, 2-0 Vlijter; R: Piqué (Oss) |
| 35 | 17/04/2017 | FC Volendam | Achilles'29 | 1-2 | 4.301 | Perez | 1-0 Kortstam (e.d.), 1-1 Van de Beek, 1-2 Versteegen |
| 35 | 17/04/2017 | Jong PSV | Jong Ajax | 3-1 | 400 | Van Herk | 0-1 Cerny, 1-1 Rosario, 2-1 Gudmundsson, 3-1 Bergsma (e.d.) |
| 35 | 17/04/2017 | RKC Waalwijk | Almere City FC | 1-1 | 1.540 | C. Mulder | 0-1 Ten Voorde, 1-1 Langedijk |
| 35 | 17/04/2017 | Jong FC Utrecht | SC Cambuur | 0-2 | 791 | Kooij | 0-1 Van de Streek, 0-2 Tissoudali |
| 35 | 17/04/2017 | Helmond Sport | FC Den Bosch | 2-0 | 1.471 | Kamphuis | 1-0 Hiwat, 2-0 Ten Den |
| 35 | 17/04/2017 | NAC Breda | FC Eindhoven | 3-3 | 13.821 | Lindhout | 1-0 El Allouchi, 1-1 Vloet, 2-1 en 3-1 (pen) Dessers, 3-2 Van den Buys (pen), 3-3 Vloet |
| 35 | 17/04/2017 | VVV-Venlo | FC Emmen | 0-0 | 7.803 | S. Mulder | |
| 35 | 17/04/2017 | De Graafschap | MVV Maastricht | 2-0 | 10.623 | Bax | 1-0 Parzyszek, 2-0 Van Mieghem |
| 36 | 21/04/2017 | MVV Maastricht | Jong PSV | 2-2 | 4.290 | Perez | 1-0 Nkoyi, 1-1 Alberto, 2-1 Ciranni, 2-2 Gunmundsson |
| 36 | 21/04/2017 | Achilles'29 | FC Dordrecht | 2-2 | 2.322 | Janssen | 1-0 Versteegen, 1-1 Godee (pen), 2-1 Beijer, 2-2 Alkan |
| 36 | 21/04/2017 | Jong Ajax | Helmond Sport | 2-0 | 500 | Vd Eijk | 1-0 Nouri (pen), 2-0 Clement |
| 36 | 21/04/2017 | Almere City FC | De Graafschap | 1-2 | 2.130 | Nijhuis | 1-0 Van Buuren, 1-1 Van Mieghem, 1-2 Van den Hurk |
| 36 | 21/04/2017 | SC Cambuur | RKC Waalwijk | 5-0 | 9.142 | Lindhout | 1-0 Van de Streek, 2-0 en 3-0 Tissoudali, 4-0 Lilipaly, 5-0 E. Bakker |
| 36 | 21/04/2017 | FC Den Bosch | Fortuna Sittard | 1-1 | 2.173 | Oostrom | 0-1 Bassan, 1-1 Vossebelt |
| 36 | 21/04/2017 | FC Eindhoven | VVV-Venlo | 0-0 | 3.496 | Manschot | R: Van den Buijs (Ein) |
| 36 | 21/04/2017 | FC Emmen | NAC Breda | 0-0 | 2.850 | Vd Kerkhof | |
| 36 | 21/04/2017 | FC Oss | FC Volendam | 2-2 | 1.512 | Dieperink | 1-0 Van der Sluys, 1-1 Kwakman, 2-1 Van der Venne, 2-2 Tuyp |
| 36 | 21/04/2017 | Telstar | Jong FC Utrecht | 3-1 | 1.444 | Blank | 1-0 Philips, 2-0 Serrarens (pen), 2-1 Sow, 3-1 Yamazaki |
| 37 | 28/04/2017 | SC Cambuur | FC Eindhoven | 4-1 | 8.388 | Vd Graaf | 1-0 Hoefdraad, 2-0 E. Bakker (p), 3-0 Van de Streek, 3-1 Lieder, 4-1 Lilipaly |
| 37 | 28/04/2017 | FC Dordrecht | FC Emmen | 0-4 | 1.525 | Kooij | 0-1 Bakker, 0-2 en 0-3 Siekman, 0-4 Bakker |
| 37 | 28/04/2017 | NAC Breda | FC Oss | 4-1 | 13.148 | Manschot | 0-1 Van der Venne, 1-1 Dessers, 2-1 Korte, 3-1 El Allouchi, 4-1 Korte |
| 37 | 28/04/2017 | Jong PSV | Telstar | 1-0 | 520 | Dieperink | 1-0 Gudmundsson |
| 37 | 28/04/2017 | De Graafschap | Achilles'29 | 3-3 | 10.033 | Lindhout | 1-0 Diemers, 1-1 Van Steen, 2-1 Van den Hurk, 2-2 Stankov, 3-2 Van den Hurk, 3-3 Versteegen |
| 37 | 28/04/2017 | FC Volendam | MVV Maastricht | 3-1 | 3.295 | Van Herk | 1-0 Stroo, 1-1 Nkoyi, 2-1 Kwakman, 3-1 Van Kippersluis (pen) |
| 37 | 25/04/2017 | Jong FC Utrecht | FC Den Bosch | 5-0 | 881 | Martens | 1-0 Rosheuvel, 2-0 en 3-0 Boukhari, 4-0 Van Rooijen, 5-0 Braafheid |
| 37 | 28/04/2017 | VVV-Venlo | Jong Ajax | 1-4 | 6.379 | C. Mulder | 0-1 Cassierra, 0-2 Tete, 0-3 Neres, 1-3 Leemans (p), 1-4 Cerny; R: Zeefuik (Aja), Post (VVV) |
| 37 | 28/04/2017 | Helmond Sport | Almere City FC | 1-1 | 1.533 | Vd Kerkhof | 0-1 Ten Voorde, 1-1 Braber |
| 37 | 28/04/2017 | RKC Waalwijk | Fortuna Sittard | 3-0 | 1.738 | S. Mulder | 1-0 Voskamp, 2-0 Langedijk, 3-0 Benson |
| 38 | 05/05/2017 | FC Den Bosch | FC Dordrecht | 1-0 | 3.687 | S. Mulder | 1-0 Regales (pen) |
| 38 | 05/05/2017 | MVV Maastricht | RKC Waalwijk | 1-1 | 4.402 | Vd Kerkhof | 0-1 Benson, 1-1 N'Koyi (pen); R: Kuipers (MVV) |
| 38 | 05/05/2017 | FC Oss | De Graafschap | 2-1 | 2.278 | Vd Hurk | 1-0 Bakx, 1-1 Van den Hurk, 2-1 Mathieu |
| 38 | 05/05/2017 | Achilles'29 | Jong PSV | 1-5 | 1.943 | Manschot | 0-1 Gudmundsson, 0-2 Piroe, 0-3 Gudmundsson, 1-3 Stankov, 1-4 Paal, 1-5 Lonwijk |
| 38 | 05/05/2017 | Jong Ajax | SC Cambuur | 2-1 | 616 | Perez | 1-0 Eiting, 2-0 Cassierra, 2-1 Bakker (pen) |
| 38 | 05/05/2017 | Almere City FC | NAC Breda | 0-2 | 1.953 | Bax | 0-1 Agyepong, 0-2 Korte |
| 38 | 05/05/2017 | FC Eindhoven | Helmond Sport | 2-2 | 2.750 | Martens | 0-1 Thomassen, 1-1 Leonardo, 2-1 Vandeputte, 2-2 Justitiana |
| 38 | 05/05/2017 | FC Emmen | Jong FC Utrecht | 0-3 | 3.608 | Dieperink | 0-1 en 0-2 Venema, 0-3 Sow |
| 38 | 05/05/2017 | Fortuna Sittard | FC Volendam | 3-0 | 1.560 | Kooij | 1-0 Smeets, 2-0 De Regt, 3-0 Van Hout |
| 38 | 05/05/2017 | Telstar | VVV-Venlo | 1-2 | 1.663 | Gerrets | 1-0 Serrarens, 1-1 Seuntjens, 1-2 Leemans |
Play-offs voor promotie/degradatie
| 1e ronde | ||||||
| 08/05/2017 | Helmond Sport | Almere City FC | 4-2 | 2.031 | Manschot | 0-1 Salasiwa, 0-2 Ten Voorde, 1-2 Ten Den, 2-2 Braber, 3-2 Thomassen, 4-2 Edwards |
| 08/05/2017 | RKC Waalwijk | FC Emmen | 1-5 | 4.223 | Bax | 0-1 Loen, 0-2 Kallon, 0-3 Bannink, 0-4 Olijve, 0-5 Huisman, 1-5 Voskamp |
| 12/05/2017 | Almere City FC | Helmond Sport | 0-2 | 1.420 | Lindhout | 0-1 Thomassen, 0-2 Ten Den |
| 12/05/2017 | FC Emmen | RKC Waalwijk | 0-1 | 2.856 | Vd Graaf | 0-1 Voskamp; R: Van de Sande (RKC) |
| 2e ronde | ||||||
| 18/05/2017 | Helmond Sport | Roda JC Kerkrade | 0-1 | 3.431 | Vd Kerkhof | 0-1 Schahin; R: Auassar (Rod) |
| 18/05/2017 | MVV Maastricht | SC Cambuur | 1-1 | 5.642 | S. Mulder | 1-0 Nwakali, 1-1 Van de Streek |
| 18/05/2017 | FC Volendam | NAC Breda | 2-2 | 3.687 | Vd Graaf | 0-1 Agyepong, 1-1 Van Son, 2-1 Runderkamp, 2-2 Dessers |
| 18/05/2017 | FC Emmen | NEC | 1-3 | 4.969 | Lindhout | 1-0 Bannink, 1-1 Breinburg, 1-2 Grot, 1-3 Awoniyi |
| 21/05/2017 | Roda JC Kerkrade | Helmond Sport | 1-1 | 12.449 | S. Mulder | 0-1 Zeldenrust, 1-1 Van Velzen; R: Rosheuvel (Rod) |
| 21/05/2017 | SC Cambuur | MVV Maastricht | 1-2 | 9.640 | Kamphuis | 1-0 Barto, 1-1 Pereira, 1-2 Verheydt |
| 21/05/2017 | NAC Breda | FC Volendam | 2-0 | 16.554 | Janssen | 1-0 en 2-0 Dessers |
| 21/05/2017 | NEC | FC Emmen | 1-0 | 9.500 | Nijhuis | 1-0 Mayi |
| 3e ronde | ||||||
| 25/05/2017 | NAC Breda | NEC | 1-0 | 19.000 | Higler | 1-0 Dessers |
| 25/05/2017 | MVV Maastricht | Roda JC Kerkrade | 0-0 | 8.500 | Van Boekel | |
| 28/05/2017 | NEC | NAC Breda | 1-4 | 12.500 | Blom | 0-1 Dessers (pen), 1-1 Breinburg (pen), 1-2 Dessers, 1-3 Korte, 1-4 Dessers; R: Rayhi (NEC) |
| 28/05/2017 | Roda JC Kerkrade | MVV Maastricht | 1-0 | 16.019 | Janssen | 1-0 Werker; R: Kuipers (MVV) |
NAC Breda promoveert, NEC degradeert
Topscorers
| 1 | Tom Boere | FC Oss | 33 |
| 2 | Piotr Parzyszek | De Graafschap | 25 |
| 3 | Cyriel Dessers | NAC Breda | 22 |
| Sander van de Streek | SC Cambuur | 22 | |
| 5 | Soufyan Ahannach | Almere City FC | 18 |
| Albert Gudmundsson | Jong PSV | 18 | |
| 7 | Sam Lammers | Jong PSV | 17 |
| Pieter Langedijk | RKC Waalwijk | 17 | |
| 9 | Ralf Seuntjens | VVV-Venlo | 16 |
| 10 | Vaclav Cerny | Jong Ajax | 15 |
| Mart Lieder | FC Eindhoven | 15 | |
| Johan Voskamp | RKC Waalwijk | 15 |
Na zes seizoenen lukt het Sparta Rotterdam onder leiding van trainer Alex Pastoor eindelijk afstand te nemen van de Eerste Divisie. Sparta was zeker niet de gedoodverfde titelkandidaat, maar neemt in de loop van het seizoen een geruststellende voorsprong. Op het laatst wordt daarvan nog aardig wat afgeknabbeld, maar de titel komt niet in gevaar.
NAC Breda, verrassend gedegradeerd, kan de favorietenrol niet waarmaken en verspeeld al vroeg in het seizoen veel punten. Uiteindelijk strandt de ploeg in de finale van de play offs, uitgerekend tegen aartsrivaal Willem II. Ook de nummers twee (VVV Venlo) en vier (FC Eindhoven) redden het niet in de nacompetitie. Dat geldt wel voor nummer vijf Go Ahead Eagles (winst op De Graafschap) dat daardoor na één seizoen, ondanks een aantal zeer moeizame periodes gedurende het seizoen, onder Hans de Koning terugkeert in de Eredivisie.
Het is het laatste seizoen dat er geen degradant is. Met de komst van de Tweede Divisie kan de nummer laatst (dit keer FC Oss) komend seizoen niet zonder gevolgen twintigste worden.
Uitslagenmatrix
| ACH | ALM | DBO | DOR | EIN | EMM | FOR | GOA | HEL | AJA | PSV | MVV | NAC | OSS | RKC | SPA | TEL | VOL | VVV | |
| Achilles '29 | * | 1-3 | 0-1 | 2-1 | 2-1 | 1-2 | 3-0 | 1-0 | 1-2 | 2-1 | 3-2 | 1-2 | 1-2 | 1-0 | 0-0 | 0-3 | 1-3 | 0-0 | 1-3 |
| Almere City FC | 2-1 | * | 1-1 | 3-0 | 1-2 | 4-0 | 0-3 | 3-4 | 2-2 | 2-1 | 7-0 | 0-3 | 0-1 | 0-1 | 3-1 | 1-0 | 0-2 | 2-2 | 3-3 |
| FC Den Bosch | 1-2 | 1-2 | * | 2-0 | 3-1 | 3-0 | 2-2 | 2-4 | 2-1 | 3-0 | 0-0 | 2-2 | 3-6 | 4-2 | 1-1 | 1-2 | 5-0 | 0-0 | 0-1 |
| FC Dordrecht | 3-3 | 3-1 | 1-2 | * | 3-1 | 0-2 | 1-3 | 1-1 | 0-2 | 0-1 | 4-0 | 1-0 | 0-2 | 1-0 | 1-2 | 0-3 | 2-2 | 1-3 | 0-0 |
| FC Eindhoven | 0-1 | 3-2 | 0-0 | 1-1 | * | 1-1 | 3-1 | 0-0 | 1-4 | 2-1 | 2-0 | 4-1 | 2-1 | 4-0 | 1-0 | 1-1 | 2-1 | 1-0 | 2-0 |
| FC Emmen | 3-1 | 5-6 | 1-0 | 1-0 | 4-2 | * | 1-2 | 4-1 | 0-1 | 4-2 | 1-1 | 2-3 | 1-0 | 0-2 | 6-1 | 1-3 | 1-0 | 1-0 | 1-4 |
| Fortuna Sittard | 2-4 | 0-2 | 1-1 | 0-5 | 2-1 | 2-2 | * | 0-1 | 3-0 | 1-2 | 1-1 | 1-2 | 1-2 | 3-0 | 1-0 | 1-4 | 0-3 | 0-6 | 0-5 |
| Go Ahead Eagles | 3-2 | 4-1 | 0-0 | 3-0 | 1-2 | 0-0 | 0-2 | * | 1-1 | 2-0 | 1-2 | 0-0 | 4-1 | 5-0 | 1-0 | 2-0 | 5-0 | 3-2 | 0-3 |
| Helmond Sport | 2-2 | 0-2 | 0-0 | 1-2 | 1-2 | 3-2 | 0-2 | 0-4 | * | 2-3 | 4-2 | 1-0 | 1-1 | 4-0 | 1-0 | 1-1 | 4-1 | 0-2 | 1-4 |
| Jong Ajax | 3-1 | 2-2 | 3-1 | 4-1 | 0-0 | 2-0 | 3-0 | 2-2 | 1-1 | * | 1-2 | 0-1 | 2-1 | 2-2 | 0-0 | 1-1 | 4-1 | 2-0 | 2-2 |
| Jong PSV | 1-1 | 3-4 | 2-1 | 1-4 | 2-0 | 0-0 | 0-1 | 1-0 | 3-1 | 3-3 | * | 2-0 | 0-3 | 3-1 | 3-1 | 0-3 | 4-3 | 2-2 | 1-5 |
| MVV Maastricht | 1-1 | 0-0 | 1-0 | 2-2 | 0-2 | 4-1 | 1-3 | 1-2 | 1-4 | 0-0 | 2-3 | * | 1-1 | 4-2 | 6-2 | 1-3 | 1-0 | 3-1 | 1-3 |
| NAC Breda | 3-1 | 1-1 | 3-0 | 7-0 | 3-1 | 2-2 | 5-0 | 0-1 | 1-0 | 3-0 | 5-2 | 1-1 | * | 5-0 | 1-1 | 4-0 | 2-1 | 1-4 | 0-1 |
| FC Oss | 1-1 | 1-2 | 3-1 | 2-3 | 0-4 | 0-3 | 4-0 | 3-0 | 2-2 | 1-2 | 0-0 | 1-3 | 1-6 | * | 0-0 | 1-2 | 3-3 | 1-2 | 2-1 |
| RKC Waalwijk | 1-1 | 3-1 | 1-1 | 0-1 | 1-2 | 0-1 | 1-1 | 0-2 | 2-2 | 3-5 | 1-2 | 1-3 | 2-0 | 3-2 | * | 1-1 | 2-1 | 2-1 | 2-1 |
| Sparta Rotterdam | 3-0 | 3-2 | 5-2 | 2-3 | 3-0 | 3-2 | 1-1 | 3-1 | 2-1 | 3-1 | 1-0 | 6-0 | 1-1 | 3-1 | 5-2 | * | 2-1 | 3-1 | 3-1 |
| Telstar | 3-0 | 2-2 | 1-0 | 3-0 | 1-2 | 2-1 | 3-0 | 1-2 | 1-0 | 4-2 | 1-1 | 4-0 | 1-4 | 1-1 | 1-1 | 1-3 | * | 1-1 | 2-2 |
| FC Volendam | 0-0 | 3-1 | 2-0 | 2-2 | 1-2 | 0-2 | 1-0 | 1-0 | 2-1 | 1-1 | 3-0 | 0-1 | 1-2 | 1-1 | 3-0 | 2-0 | 3-0 | * | 1-1 |
| VVV-Venlo | 3-0 | 4-0 | 2-1 | 3-0 | 1-0 | 1-0 | 4-1 | 2-1 | 4-1 | 3-0 | 1-2 | 3-0 | 4-3 | 1-2 | 4-3 | 1-1 | 1-2 | 3-0 | * |
Eindstand
| 1 | Sparta Rotterdam * ♦ | 36 | 24 | 7 | 5 | 79 | 83 | 40 | +43 | 7.934 |
| 2 | VVV-Venlo + | 36 | 23 | 6 | 7 | 75 | 85 | 39 | +46 | 3.903 |
| 3 | NAC Breda + | 36 | 20 | 7 | 9 | 67 | 84 | 42 | +42 | 13.959 |
| 4 | FC Eindhoven + | 36 | 19 | 6 | 11 | 63 | 55 | 44 | +11 | 2.499 |
| 5 | Go Ahead Eagles + ♦ | 36 | 18 | 7 | 11 | 61 | 61 | 41 | +20 | 8.491 |
| 6 | FC Volendam + | 36 | 14 | 10 | 12 | 52 | 54 | 40 | +14 | 3.467 |
| 7 | FC Emmen + | 36 | 15 | 6 | 15 | 51 | 58 | 57 | +1 | 3.248 |
| 8 | Almere City FC + | 36 | 14 | 8 | 14 | 50 | 68 | 66 | +2 | 1.183 |
| 9 | Jong Ajax | 36 | 13 | 11 | 12 | 50 | 59 | 57 | +2 | 542 |
| 10 | MVV Maastricht + | 36 | 14 | 8 | 14 | 50 | 52 | 60 | -8 | 4.229 |
| 11 | Jong PSV | 36 | 13 | 9 | 14 | 48 | 51 | 71 | -20 | 603 |
| 12 | Telstar | 36 | 12 | 8 | 16 | 44 | 57 | 64 | -7 | 1.928 |
| 13 | Helmond Sport | 36 | 11 | 9 | 16 | 42 | 52 | 59 | -7 | 1.896 |
| 14 | FC Dordrecht | 36 | 11 | 7 | 18 | 40 | 47 | 67 | -20 | 1.902 |
| 15 | Achilles '29 | 36 | 10 | 9 | 17 | 39 | 43 | 61 | -18 | 1.373 |
| 16 | Fortuna Sittard | 36 | 11 | 6 | 19 | 39 | 41 | 74 | -33 | 1.937 |
| 17 | FC Den Bosch | 36 | 9 | 11 | 16 | 38 | 47 | 53 | -6 | 2.591 |
| 18 | RKC Waalwijk | 36 | 7 | 11 | 18 | 32 | 41 | 66 | -25 | 2.142 |
| 19 | FC Oss | 36 | 7 | 8 | 21 | 29 | 43 | 80 | -37 | 1.563 |
Wedstrijden
| R: | Datum: | Thuis: | Uit: | Sc: | Ts: | Ar: | Details: |
|---|---|---|---|---|---|---|---|
| 1 | 07/08/2015 | Almere City FC | VVV Venlo | 3-3 | 1.066 | Vd Kerkhof | 1-0 Kip, 1-1 Seuntjens (pen), 1-2 Resida, 2-2 Boldewijn, 2-3 Post, 3-3 Quasten |
| 1 | 07/08/2015 | FC Dordrecht | FC Eindhoven | 3-1 | 2.361 | Braamhaar | 0-1 Deschilder, 1-1 Lima, 2-1 Daniëls, 3-1 Touré |
| 1 | 07/08/2015 | NAC Breda | FC Volendam | 1-4 | 14.230 | Mulder | 0-1 Tuyp, 0-2 Kwakman, 1-2 Pedro, 1-3 Steltenpool, 1-4 Philips; R: Naah (NAC) |
| 1 | 07/08/2015 | Achilles'29 | Jong Ajax | 2-1 | 2.500 | Gerrets | 0-1 Cerny, 1-1 Thoone (pen), 2-1 Deckers |
| 1 | 07/08/2015 | FC Den Bosch | Fortuna Sittard | 2-2 | 2.586 | Bax | 1-0 Belterman, 1-1 Hutten, 1-2 Maatsen (ed), 2-2 Hofstede |
| 1 | 07/08/2015 | FC Oss | FC Emmen | 0-3 | 1.987 | Lindhout | 0-1 Deul, 0-2 Kolder (pen), 0-3 Danso R: Ket (Oss) |
| 1 | 07/08/2015 | Helmond Sport | MVV Maastricht | 1-0 | 2.533 | Oostrom | 1-0 Elbers |
| 1 | 10/08/2015 | Jong PSV | Go Ahead Eagles | 1-0 | 1.074 | Otto | 1-0 Rommens |
| 1 | 10/08/2015 | Telstar | RKC Waalwijk | 1-1 | 2.099 | Berben | 0-1 Valpoort, 1-1 Van Essen; R: Uiterloo (Tel) |
| 2 | 14/08/2015 | RKC Waalwijk | Sparta Rotterdam | 1-1 | 2.200 | Blank | 0-1 Verhaar, 1-1 Valpoort |
| 2 | 14/08/2015 | MVV Maastricht | Jong PSV | 2-3 | 2.500 | Martens | 1-0 Peeters, 1-1 Heesakkers, 1-2 Leemans (pen), 1-3 Boljevic, 2-3 Nys |
| 2 | 14/08/2015 | FC Eindhoven | NAC Breda | 2-1 | 3.376 | Liesveld | 0-1 Brands, 1-1 Koç, 2-1 Van den Hurk |
| 2 | 14/08/2015 | Fortuna Sittard | Achilles'29 | 2-4 | 2.780 | Oostrom | 1-0 en 2-0 Lekesiz, 1-1 Thoone, 2-2 Raja Boeaan, 2-3 Van Riel, 2-4 Penterman |
| 2 | 14/08/2015 | VVV Venlo | FC Oss | 1-2 | 3.050 | Pérez | 0-1 Conneh (pen), 1-1 Resida, 1-2 Fortes R: Bourdouxhe (VVV) |
| 2 | 14/08/2015 | FC Emmen | FC Dordrecht | 1-0 | 4.142 | Bax | 1-0 Danso |
| 2 | 14/08/2015 | FC Volendam | FC Den Bosch | 2-0 | 3.000 | Van de Graaf | 1-0 Tuyp, 2-0 Van Kippersluis; R: El Hamdi (Vol) |
| 2 | 16/08/2015 | Go Ahead Eagles | Telstar | 5-0 | 9.016 | Vd Heuvel | 1-0 en 2-0 (pen) De Kogel, 3-0 Hamdaoui, 4-0 Dzepar, 5-0 Teijsse; R: Korpershoek (Tel) |
| 2 | 17/08/2015 | Jong Ajax | Helmond Sport | 1-1 | 591 | Manschot | 1-0 Muric, 1-1 Edwards |
| 3 | 21/08/2015 | Telstar | Almere City FC | 2-2 | 1.889 | Martens | 1-0 Ajnane, 1-1 Braken, 2-1 Ajnane, 2-2 Braken |
| 3 | 21/08/2015 | Sparta Rotterdam | FC Eindhoven | 3-0 | 8.300 | Mulder | 1-0 Brogno, 2-0 Van Moorsel, 3-0 Verhaar R: N'Toko (Ein) |
| 3 | 21/08/2015 | FC Dordrecht | FC Volendam | 1-3 | 2.882 | Vd Kerkhof | 0-1 en 0-2 Tuyp, 1-2 Lumu, 1-3 Kwakman |
| 3 | 21/08/2015 | NAC Breda | Jong Ajax | 3-0 | 13.900 | Lindhout | 1-0 Seuntjens, 2-0 Brands, 3-0 Ars |
| 3 | 21/08/2015 | Jong PSV | VVV Venlo | 1-5 | 1.200 | Berben | 0-1 Nijholt, 0-2 Opoku, 0-3 Loof (e.d.), 1-3 Lammers, 1-4 Buwalda, 1-5 Opoku |
| 3 | 21/08/2015 | Achilles'29 | RKC Waalwijk | 0-0 | 2.189 | Otto | |
| 3 | 21/08/2015 | FC Den Bosch | FC Emmen | 3-0 | 2.500 | Dieperink | 1-0 Thomassen, 2-0 Havar, 3-0 Esajas (pen) |
| 3 | 21/08/2015 | FC Oss | MVV Maastricht | 1-3 | 1.639 | Vd Heuvel | 0-1 Croux, 0-2 Rajcomar, 1-2 Kamaci, 1-3 Peeters |
| 3 | 21/08/2015 | Helmond Sport | Fortuna Sittard | 0-2 | 2.171 | Blank | 0-1 Hutten, 0-2 Lekesiz |
| 4 | 24/08/2015 | RKC Waalwijk | Almere City FC | 3-1 | 2.300 | Bax | 1-0 Valpoort, 1-1 Mamedov, 2-1 (pen) en 3-1 Valpoort |
| 4 | 24/08/2015 | NAC Breda | FC Dordrecht | 7-0 | 13.600 | Kuipers | 1-0 en 2-0 Brands, 3-0 Seuntjens, 4-0 Verbeek, 5-0 Hooi, 6-0 Matic, 7-0 Seuntjens: R: Lima (Dor) |
| 4 | 24/08/2015 | MVV Maastricht | Telstar | 1-0 | 4.200 | Manschot | 1-0 Nys |
| 4 | 24/08/2015 | Achilles'29 | FC Oss | 1-0 | 1.912 | Kooij | 1-0 Penterman |
| 4 | 24/08/2015 | FC Den Bosch | Go Ahead Eagles | 2-4 | 3.452 | Kamphuis | 1-0 Havar, 1-1 Van Ewijk, 1-2 Vriends, 1-3 De Kogel (pen), 1-4 Dzepar, 2-4 Zeldenrust |
| 4 | 24/08/2015 | Fortuna Sittard | FC Volendam | 0-6 | 2.500 | Lindhout | 0-1 Kwakman, 0-2 Schroyen (e.d.), 0-3 Tuyp, 0-4 Schroyen (e.d.), 0-5 Van Son, 0-6 Kwakman |
| 4 | 24/08/2015 | VVV Venlo | Sparta Rotterdam | 1-1 | 3.300 | Makkelie | 0-1 Brogno, 1-1 Seuntjens |
| 4 | 24/08/2015 | Jong Ajax | FC Eindhoven | 0-0 | 435 | Otto | |
| 4 | 24/08/2015 | FC Emmen | Helmond Sport | 0-1 | 3.150 | Vd Kerkhof | 0-1 Van Nuland |
| 5 | 28/08/2015 | Almere City FC | Fortuna Sittard | 0-3 | 994 | Dieperink | 0-1 Schroyen, 0-2 Mert, 0-3 Hutten |
| 5 | 28/08/2015 | FC Volendam | VVV Venlo | 1-1 | 4.000 | Bax | 0-1 Van Crooy, 1-1 Evers |
| 5 | 28/08/2015 | FC Dordrecht | FC Oss | 1-0 | 1.641 | Gözübüyük | 1-0 Lumu |
| 5 | 28/08/2015 | FC Eindhoven | MVV Maastricht | 4-1 | 2.631 | Gerrets | 0-1 Polizzi, 1-1 en 2-1 Van Hout, 3-1 Van den Hurk, 4-1 N'Toko |
| 5 | 28/08/2015 | Telstar | FC Emmen | 2-1 | 1.500 | Kooij | 1-0 Lilipaly, 2-0 Ajnane, 2-1 Danso |
| 5 | 28/08/2015 | Helmond Sport | NAC Breda | 1-1 | 3.151 | Van de Graaf | 1-0 Bjelica, 1-1 Brands |
| 5 | 29/08/2015 | RKC Waalwijk | Jong PSV | 1-2 | 3.400 | Oostrom | 0-1 Bergwijn, 0-2 Vloet, 1-2 Nieuwendaal |
| 5 | 30/08/2015 | Sparta Rotterdam | FC Den Bosch | 5-2 | 6.300 | Perez | 1-0 Langedijk, 2-0 Stokkers, 2-1 Thomassen, 3-1 en 4-1 (pen) Verhaar, 5-1 Brogno, 5-2 Zeldenrust |
| 5 | 30/08/2015 | Go Ahead Eagles | Achilles'29 | 3-2 | 9.056 | Mulder | 1-0 De Kogel, 2-0 Schenk, 3-0 De Kogel (pen), 3-1 en 3-2 (pen) Penterman; R: Dingil (Ach) |
| 6 | 11/09/2015 | FC Eindhoven | Almere City FC | 3-2 | 2.217 | Vd Heuvel | 1-0 Van Hout, 2-0 Van den Hurk, 2-1 en 2-2 Braken, 3-2 Caenepeel |
| 6 | 11/09/2015 | Sparta Rotterdam | Achilles'29 | 3-0 | 7.110 | Bax | 1-0 Van Steen (ed), 2-0 Verhaar (pen), 3-0 Beijer (ed) |
| 6 | 11/09/2015 | FC Volendam | Jong PSV | 3-0 | 3.500 | Blank | 1-0, 2-0 en 3-0 Steltenpool |
| 6 | 11/09/2015 | FC Den Bosch | Helmond Sport | 2-1 | 2.500 | Gerrets | 1-0 Beekmans, 1-1 Van de Sande, 2-1 Havar R: Vicento (Hel) |
| 6 | 11/09/2015 | Fortuna Sittard | FC Dordrecht | 0-5 | 2.500 | Boterberg | 0-1 Lumu, 0-2 Aktaou (pen), 0-3 Daniëls, 0-4 en 0-5 Janga |
| 6 | 11/09/2015 | VVV Venlo | Go Ahead Eagles | 2-1 | 3.900 | Vd Graaf | 1-0 Seuntjens, 1-1 Van Overbeek, 2-1 V. Crooy |
| 6 | 11/09/2015 | FC Emmen | RKC Waalwijk | 6-1 | 3.054 | Mulder | 1-0 Gyasi, 2-0 Kolder, 3-0 Ten Voorde, 3-1 Valpoort, 4-1 Kolder, 5-1 Olijve, Streutker |
| 6 | 13/09/2015 | MVV Maastricht | NAC Breda | 1-1 | 4.558 | Janssen | 1-0 Croux, 1-1 Naah |
| 6 | 14/09/2015 | Jong Ajax | Telstar | 4-1 | 300 | Dieperink | 1-0 Mijnders, 2-0 Younes, 3-0 Hendriks, 3-1 Maletic, 4-1 Hendriks; R: Vd Beek (Aja) |
| 7 | 18/09/2015 | Almere City FC | MVV Maastricht | 0-3 | 1.000 | Berben | 0-1 Polizzi, 0-2 Santiago, 0-3 Peeters (pen) |
| 7 | 18/09/2015 | FC Dordrecht | VVV Venlo | 0-0 | 2.339 | Manschot | |
| 7 | 18/09/2015 | NAC Breda | FC Emmen | 2-2 | 13.500 | Higler | 1-0 Ars, 1-1 Rozema, 1-2 Ten Voorde, 2-2 Seuntjens (pen) |
| 7 | 18/09/2015 | Jong PSV | Sparta Rotterdam | 0-3 | 500 | Kooij | 0-1 Verhaar, 0-2 Brogno, 0-3 Verhaar (pen) |
| 7 | 18/09/2015 | Go Ahead Eagles | Jong Ajax | 2-0 | 8.337 | Martens | 1-0 en 2-0 Ten Den |
| 7 | 18/09/2015 | FC Oss | FC Eindhoven | 0-4 | 1.679 | Blank | 0-1 Van den Hurk, 0-2 Mandiangu, 0-3 Deschilder, 0-4 Van Imschoot |
| 7 | 18/09/2015 | Telstar | Fortuna Sittard | 3-0 | 1.748 | Gerrets | 1-0 Tissoudali, 2-0 Van Berkel, 3-0 Maletic |
| 7 | 18/09/2015 | Helmond Sport | FC Volendam | 0-2 | 1.500 | Vd Heuvel | 0-1 Mertens, 0-2 Van Velzen |
| 7 | 20/09/2015 | Achilles'29 | FC Den Bosch | 0-1 | 800 | Alen | 0-1 Elders (e.d.) |
| 8 | 25/09/2015 | FC Volendam | Almere City FC | 3-1 | 3.500 | Manschot | 1-0, 2-0 en 3-0 Steltenpool, 3-1 Boldewijn |
| 8 | 25/09/2015 | Sparta Rotterdam | Telstar | 2-1 | 6.124 | Van Damme | 1-0 Brogno, 1-1 Tissoudali, 2-1 Verhaar |
| 8 | 27/09/2015 | RKC Waalwijk | Go Ahead Eagles | 0-2 | 1.500 | Otto | 0-1 en 0-2 Van Ewijk; R; Cecilia (RKC) |
| 8 | 25/09/2015 | MVV Maastricht | FC Dordrecht | 2-2 | 3.976 | Bax | 1-0 Pereira, 1-1 Janga, 2-1 Nys, 2-2 Lumu |
| 8 | 27/09/2015 | Fortuna Sittard | NAC Breda | 1-2 | 2.109 | Kamphuis | 0-1 Ars, 1-1 Janssen, 1-2 Ars |
| 8 | 27/09/2015 | VVV Venlo | Helmond Sport | 4-1 | 3.800 | Dieperink | 0-1 De Reuver, 1-1 Resida, 2-1 Van Crooy, 3-1 (pen) en 4-1 Seuntjens; R: Edwards (Hel) |
| 8 | 25/09/2015 | FC Emmen | Jong PSV | 1-1 | 3.380 | Oostrom | 1-0 Ten Voorde, 1-1 Bergwijn |
| 8 | 27/09/2015 | FC Eindhoven | FC Den Bosch | 0-0 | 1.855 | Lindhout | |
| 8 | 28/09/2015 | Jong Ajax | FC Oss | 2-2 | 387 | Perez | 0-1 Kamaci (pen.), 0-2 Zschusschen, 1-2 Hendriks (pen), 2-2 El Azzouzi R: De Vogel (Oss) |
| 9 | 02/10/2015 | Almere City FC | FC Emmen | 4-0 | 750 | Martens | 1-0 Van Amersfoort, 2-0 Metalsi, 3-0 Van Amersfoort, 4-0 Braken; R: Kwee (Emm) |
| 9 | 02/10/2015 | FC Dordrecht | Jong Ajax | 0-1 | 2.632 | Vd Graaf | 0-1 Muric |
| 9 | 02/10/2015 | NAC Breda | VVV Venlo | 0-1 | 12.940 | Bax | 0-12 Ralf Seuntjens |
| 9 | 02/10/2015 | Jong PSV | Achilles'29 | 1-1 | 585 | Gerrets | 0-1 Penterman (pen), 1-1 Paal |
| 9 | 02/10/2015 | Go Ahead Eagles | Sparta Rotterdam | 2-0 | 9.496 | Mulder | 1-0 De Kogel, 2-0 Van Ewijk |
| 9 | 02/10/2015 | FC Den Bosch | MVV Maastricht | 2-2 | 3.067 | Blank | 1-0 Havar, 1-1 Santiago, 1-2 Croux, 2-2 Zeldenrust |
| 9 | 02/10/2015 | FC Oss | Fortuna Sittard | 4-0 | 1.239 | Kooij | 1-0 Zschusschen, 2-0 Kamaci, 3-0 Conneh, 4-0 Zschusschen; R: Bakx (Oss) |
| 9 | 02/10/2015 | Telstar | FC Eindhoven | 1-2 | 1.953 | Perez | 1-0 Tissoudali, 1-1 Van Hout (pen), 1-2 Caenepeel; R: Lilypaly (Tel) |
| 9 | 02/10/2015 | Helmond Sport | RKC Waalwijk | 1-0 | 2.000 | Oostrom | 1-0 Vicento |
| 10 | 16/10/2015 | RKC Waalwijk | FC Dordrecht | 0-1 | 2.220 | Gerrets | 0-1 Van Weert (e.d.); R: Curiël (Dor) |
| 10 | 16/10/2015 | FC Eindhoven | Helmond Sport | 1-4 | 3.316 | Vd Graaf | 0-1 Kerk, 0-2 Visser, 1-2 Mandiangu, 1-3 Justiana, 1-3 Markiet |
| 10 | 16/10/2015 | Fortuna Sittard | Jong PSV | 1-1 | 1.500 | Put | 0-1 De Wijs, 1-1 De Regt |
| 10 | 16/10/2015 | VVV Venlo | Telstar | 1-2 | 3.300 | Vd Kerkhof | 0-1 Maletic, 1-1 Nijholt, 1-2 Serrarens |
| 10 | 16/10/2015 | FC Emmen | Go Ahead Eagles | 4-1 | 3.820 | Blank | 1-0 Mannes, 2-0 Kolder, 2-1 De Kogel, 3-1 Jallo, 4-1 Kolder; R: Zwarthoed (GoA) |
| 10 | 18/10/2015 | Sparta Rotterdam | FC Oss | 3-1 | 6.885 | Bax | 1-0 en 2-0 Brogno, 2-1 Zschusschen, 3-1 Van Moorsel |
| 10 | 18/10/2015 | MVV Maastricht | FC Volendam | 3-1 | 4.885 | Braamhaar | 1-0 en 2-0 Santiago, 2-1 El Hamdi, 3-1 Guvenç |
| 10 | 18/10/2015 | Achilles'29 | NAC Breda | 1-2 | 2.041 | Otto | 1-0 Van Steen, 1-1 Suk, 1-2 Ars R: Ramezani (Ach) |
| 10 | 19/10/2015 | Jong Ajax | Almere City FC | 2-2 | 751 | Vd Kerkhof | 0-1 Rosario, 0-2 Warmerdam (e.d.), 1-2 Van der Hoorn, 2-2 Hendriks (pen) R: Acolatse (Aja) |
| 11 | 23/10/2015 | Go Ahead Eagles | Almere City FC | 4-1 | 8.587 | Vd Graaf | 1-0 David, 2-0 en 3-0 De Kogel, 3-1 Mamedov, 4-1 Wolters; R: Metalsi (Alm) |
| 11 | 23/10/2015 | FC Volendam | FC Emmen | 0-2 | 4.214 | Mulder | 0-1 Ten Voorde, 0-2 Deul |
| 11 | 23/10/2015 | NAC Breda | Sparta Rotterdam | 4-0 | 15.470 | Lindhout | 1-0 Ars, 2-0 Van de Weg, 3-0 Ars (p), 4-0 Brands |
| 11 | 23/10/2015 | FC Eindhoven | RKC Waalwijk | 1-0 | 2.000 | Bax | 1-0 Caenepeel |
| 11 | 23/10/2015 | FC Den Bosch | VVV Venlo | 0-1 | 3.504 | Kooij | 0-1 Seuntjens |
| 11 | 23/10/2015 | Jong Ajax | Fortuna Sittard | 3-0 | 303 | Oostrom | 1-0 (pen), 2-0 en 3-0 Hendriks; R: Mert (For) |
| 11 | 23/10/2015 | FC Oss | Jong PSV | 0-0 | 1.639 | Vd Vrande | |
| 11 | 23/10/2015 | Telstar | Achilles'29 | 3-0 | 1.831 | Berben | 1-0 Maletic (pen), 2-0 en 3-0 Tissoudali |
| 11 | 23/10/2015 | Helmond Sport | FC Dordrecht | 1-2 | 1.250 | Verboomen | 1-0 Justitiana, 1-1 en 1-2 Janga |
| 12 | 30/10/2015 | Almere City FC | Achilles'29 | 2-1 | 906 | Vd Vrande | 0-1 Van de Beek, 1-1 Tadmine, 2-1 Kip |
| 12 | 30/10/2015 | FC Volendam | FC Eindhoven | 1-2 | 4.000 | Lindhout | 1-0 Van Velzen, 1-1 en 1-2 Caenepeel |
| 12 | 30/10/2015 | FC Dordrecht | FC Den Bosch | 1-2 | 2.003 | Martens | 0-1 Havar, 1-1 Fortes, 1-2 Pozder |
| 12 | 30/10/2015 | MVV Maastricht | Go Ahead Eagles | 1-2 | 4.809 | Bax | 0-1 De Kogel (pen), 1-1 Peters (pen), 1-2 Wolters |
| 12 | 30/10/2015 | Fortuna Sittard | RKC Waalwijk | 1-0 | 1.592 | Van Herk | 1-0 Loen; R: Dengering (For) |
| 12 | 30/10/2015 | VVV Venlo | Jong Ajax | 3-0 | 5.803 | Otto | 1-0 en 2-0 Seuntjens, 3-0 Opoku |
| 12 | 30/10/2015 | FC Oss | NAC Breda | 1-6 | 1.798 | Vd Graaf | 1-0 Bakx, 1-1 Suk, 1-2 Seuntjens, 1-3 Ars, 1-4 Seuntjens, 1-5 Brands (pen), 1-6 Suk |
| 12 | 01/11/2015 | FC Emmen | Sparta Rotterdam | 1-3 | 4.089 | Van Boekel | 0-1 Van Moorsel, 1-1 Danso, 1-2 Brogno, 1-3 Bergkamp |
| 12 | 02/11/2015 | Jong PSV | Telstar | 4-3 | 500` | Dieperink | 1-0 Vloet (pen), 1-1 Knol, 2-1 Paal, 2-2 Maletic, 2-3 Tissoudali, 3-3 en 4-3 Vloet |
| 13 | 06/11/2015 | Sparta Rotterdam | Almere City FC | 3-2 | 10.051 | Vd Kerkhof | 1-0 Bergkamp, 2-0 Boldewijn (e.d.), 2-1 Mamedov, 3-1 Bergkamp, 3-2 Oost |
| 13 | 06/11/2015 | RKC Waalwijk | VVV Venlo | 2-1 | 2,200 | Vd Graaf | 0-1 Verkoelen (e.d.), 1-1 Yildirim, 2-1 Verkoelen |
| 13 | 06/11/2015 | Achilles'29 | FC Emmen | 1-2 | 750 | Van Herk | 1-0 Van Steen, 1-1 ten Voorde (pen), 1-2 Danso R: Van Steen (Ach) |
| 13 | 06/11/2015 | FC Eindhoven | Fortuna Sittard | 3-1 | 2.000 | Perez | 0-1 Lekesiz, 1-1 Koç, 2-1 Boere, 3-1 Caenepeel |
| 13 | 06/11/2015 | Go Ahead Eagles | FC Dordrecht | 3-0 | 9.111 | Lindhout | 1-0 Rijsdijk, 2-0 en 3-0 De Kogel |
| 13 | 06/11/2015 | Jong Ajax | MVV Maastricht | 0-1 | 302 | Berben | 0-1 Verheijdt |
| 13 | 06/11/2015 | Telstar | FC Volendam | 1-1 | 2.580 | Bax | 1-0 Serrarens, 1-1 Schouten (pen) |
| 13 | 06/11/2015 | Helmond Sport | Jong PSV | 4-2 | 1.500 | C. Mulder | 1-0 Bjelica (pen), 2-0 Kerk, 2-1 en 2-2 Bergwijn, 3-2 Kerk, 4-2 Bjelica (pen) |
| 13 | 08/11/2015 | FC Den Bosch | FC Oss | 4-2 | 2.669 | S. Mulder | 1-0 Zeldenrust (pen), 2-0 Pozder, 2-1 Zschusschen, 2-2 Kamaci, 3-2 Pozder, 4-2 Boddaert; R: Hengelman (Oss) |
| 14 | 20/11/2015 | Almere City FC | Helmond Sport | 2-2 | 600 | Kooij | 1-0 Tadmine, 2-0 Van Amersfoort, 2-1 Schilders, 2-2 Justitiana |
| 14 | 20/11/2015 | FC Volendam | RKC Waalwijk | 3-0 | 3.000 | Manschot | 1-0 Schouten, 2-0 Laghmouchi, 3-0 Ben Moussa |
| 14 | 20/11/2015 | FC Dordrecht | Telstar | 2-2 | 1.783 | Blank | 1-0 Roorda, 1-1 Tissoudali, 1-2 Serrarens, 2-2 Janga |
| 14 | 20/11/2015 | NAC Breda | FC Den Bosch | 3-0 | 15.860 | Blom | 1-0 Ars, 2-0 Suk, 3-0 Ars |
| 14 | 20/11/2015 | MVV Maastricht | Achilles'29 | 1-1 | 4.144 | Oostrom | 1-0 Nys, 1-1Boogers |
| 14 | 20/11/2015 | Fortuna Sittard | Sparta Rotterdam | 1-4 | 1.492 | Dieperink | 0-1 Van Moorsel, 0-2 Bergkamp, 0-3 Brogno, 0-4 Verhaar, 1-4 De Regt |
| 14 | 20/11/2015 | VVV Venlo | FC Eindhoven | 1-0 | 3.601 | Vd Heuvel | 1-0 Massop (e.d.) |
| 14 | 20/11/2015 | FC Oss | Go Ahead Eagles | 3-0 | 1.735 | Smeets | 1-0 Kamaci, 2-0 Bakx, 3-0 Kamaci |
| 14 | 23/11/2015 | Jong PSV | Jong Ajax | 3-3 | 700 | Van Herk | 1-0 Boljevic, 1-1 El Mahdioui, 1-2 Van Rhijn, 2-2 Blummel, 2-3 Hendriks, 3-3 Sanoh |
| 15 | 27/11/2015 | Almere City FC | FC Oss | 0-1 | 400 | C. Mulder | 0-1 Zschusschen |
| 15 | 27/11/2015 | Sparta Rotterdam | Helmond Sport | 2-1 | 6.330 | Vd Graaf | 0-1 Van der Sande, 1-1 (pen) en 2-1 Verhaar |
| 15 | 27/11/2015 | RKC Waalwijk | NAC Breda | 2-0 | 4.100 | Bax | 1-0 Cicilia, 2-0 Valpoort; R: Van Weert (RKC) |
| 15 | 27/11/2015 | Jong PSV | FC Dordrecht | 1-4 | 500 | Berben | 0-1 Van Vlerken (e.d.), 0-2 Janga, 0-3 Lumu, 1-3 Sanoh, 1-4 Van Wermeskerken |
| 15 | 27/11/2015 | Achilles'29 | FC Volendam | 0-0 | 500 | Gerrets | |
| 15 | 27/11/2015 | Go Ahead Eagles | FC Eindhoven | 1-2 | 8.907 | Janssen | 0-1 Caenepeel, 1-1 Wolters, 1-2 Boere |
| 15 | 27/11/2015 | VVV Venlo | MVV Maastricht | 3-0 | 4.300 | Lindhout | 1-0 Van Crooy, 2-0 Seuntjens, 3-0 Van Crooy |
| 15 | 27/11/2015 | Telstar | FC Den Bosch | 1-0 | 1.534 | Oostrom | 1-0 Maletic |
| 15 | 27/11/2015 | FC Emmen | Jong Ajax | 4-2 | 3.000 | Vd Vrande | 1-0 Ten Voorde, 1-1 Bakker, 2-1 Danso, 2-2 Hendriks, 3-2 Deul, 4-2 Gyasi |
| 16 | 30/11/2015 | FC Dordrecht | Almere City FC | 3-1 | 1.252 | S. Mulder | 1-0 Janga, 2-0 Curiël, 2-1 Mamedov, 3-1 Roorda |
| 16 | 30/11/2015 | FC Volendam | Go Ahead Eagles | 1-0 | 2.500 | Nijhuis | 1-0 Schouten |
| 16 | 30/11/2015 | NAC Breda | Telstar | 2-1 | 11.460 | Vd Kerkhof | 1-0 Suk, 2-0 Seuntjens, 2-1 Tissoudali |
| 16 | 30/11/2015 | MVV Maastricht | Fortuna Sittard | 1-3 | 5.781 | Gözübüyük | 1-0 Janssen (e.d.), 1-1 Hutten, 1-2 Mert, 1-3 De Regt; R: Verheijdt (MVV) |
| 16 | 30/11/2015 | FC Eindhoven | FC Emmen | 1-1 | 1.000 | Kooij | 0-1 Danso, 1-1 Koç; R: Swinnen (Ein) |
| 16 | 30/11/2015 | FC Den Bosch | Jong PSV | 0-0 | 1.000 | Vd Heuvel | |
| 16 | 30/11/2015 | Jong Ajax | Sparta Rotterdam | 1-1 | 532 | Blank | 0-1 Van Rhijn (e.d.), 1-1 El Azzouzi |
| 16 | 30/11/2015 | FC Oss | RKC Waalwijk | 0-0 | 1.724 | Martens | |
| 16 | 30/11/2015 | Helmond Sport | Achilles'29 | 2-2 | 951 | Otto | 0-1 Boogers, 1-1 Bjelica, 1-2 Van de Beek, 2-2 De Reuver |
| 17 | 04/12/2015 | Almere City FC | FC Den Bosch | 1-1 | 750 | Van Herk | 0-1 Havar, 1-1 Oost; R: Burgzorg (Alm) |
| 17 | 04/12/2015 | Sparta Rotterdam | FC Volendam | 3-1 | 7.186 | Braamhaar | 0-1 Laghmouchi, 1-1 Van Moorsel, 2-1 en 3-1 (pen) Verhaar |
| 17 | 04/12/2015 | RKC Waalwijk | Jong Ajax | 3-5 | 2.000 | Otto | 0-1 Clement, 0-2 Cerny, 0-3 El Azzouzi, 0-4 Muric, 1-4, 2-4 en 3-4 Cicilia, 3-5 El Azzouzi |
| 17 | 04/12/2015 | Achilles'29 | FC Eindhoven | 2-1 | 750 | Vd Vrande | 1-0 Sürmeli, 1-1 Caenepeel, 2-1 Thoone |
| 17 | 04/12/2015 | Go Ahead Eagles | Helmond Sport | 1-1 | 8.024 | Kamphuis | 0-1 Bjelica, 1-1 De Kogel (pen) |
| 17 | 04/12/2015 | Fortuna Sittard | VVV Venlo | 0-5 | 1.892 | Bax | 0-1 Dengering (e.d.), 0-2 Van Crooy, 0-3 Nijholt, 0-4 (pen) en 0-5 Seuntjens |
| 17 | 04/12/2015 | Telstar | FC Oss | 1-1 | 1.734 | Gerrets | 0-1 Van Eijma, 1-1 Keurntjes |
| 17 | 04/12/2015 | FC Emmen | MVV Maastricht | 2-3 | 3.164 | Martens | 0-1 en 0-2 Polizzi, 1-2 Santiago (e.d.), 1-3 Peeters, 2-3 Danso |
| 17 | 07/12/2015 | Jong PSV | NAC Breda | 0-3 | 1.000 | C. Mulder | 0-1 Suk, 0-2 Seuntjens, 0-3 Brands (pen) |
| 18 | 11/12/2015 | Jong PSV | Almere City FC | 3-4 | 306 | Vd Vrande | 0-1 Van Amersfoort, 1-1 Leemans, 1-2 Oost, 2-2 Alberto, 2-3 Boldewijn, 3-3 Vloet (pen), 3-4 Loof (e.d.) |
| 18 | 11/12/2015 | FC Volendam | FC Oss | 1-1 | 4.000 | Vd Heuvel | 1-0 Schouten (pen), 1-1 Kamaci |
| 18 | 11/12/2015 | FC Dordrecht | Sparta Rotterdam | 0-3 | 3.399 | Nijhuis | 0-1 Verhaar, 0-2 en 0-3 Stokkers |
| 18 | 11/12/2015 | NAC Breda | Go Ahead Eagles | 0-1 | 17.800 | Mulder | 0-1 De Kogel; R: Daemen (GoA) |
| 18 | 11/12/2015 | MVV Maastricht | RKC Waalwijk | 6-2 | 4.088 | Kooij | 1-0 Santiago, 2-0 Nys, 3-0 Croux, 3-1 Yildirim, 4-1 Croux, 5-1 Verheijdt, 5-2 Valpoort, 6-2 Verheijdt; R: Engberink (RKC) |
| 18 | 11/12/2015 | FC Den Bosch | Jong Ajax | 3-0 | 3.869 | Perez | 1-0 Havar, 2-0 Zeldenrust (pen), 3-0 Belterman |
| 18 | 11/12/2015 | Fortuna Sittard | FC Emmen | 2-2 | 1.278 | Mulder | 1-0 Lekesiz, 1-1 Kolder, 2-1 Mert, 2-2 Siekman |
| 18 | 11/12/2015 | VVV Venlo | Achilles'29 | 3-0 | 3.402 | Dieperink | 1-0 Seuntjens, 2-0 Resida, 3-0 Hunte |
| 18 | 11/12/2015 | Helmond Sport | Telstar | 4-1 | 1.971 | Berben | 1-0 Cortie, 2-0 El Allouchi, 2-1 Lilipaly, 3-1 Visser, 4-1 Schilders |
| 19 | 18/12/2015 | Almere City FC | NAC Breda | 0-1 | 1.634 | Lindhout | 0-1 Pedro |
| 19 | 18/12/2015 | Sparta Rotterdam | MVV Maastricht | 6-0 | 6.625 | Kamphuis | 1-0, 2-0 en 3-0 Van Moorsel, 4-0 Brogno, 5-0 Verhaar, 6-0 Sanusi |
| 19 | 18/12/2015 | RKC Waalwijk | FC Den Bosch | 1-1 | 2.000 | Berben | 0-1 Pozder, 1-1 Van Hoof |
| 19 | 19/12/2015 | Achilles'29 | FC Dordrecht | 2-1 | 1.000 | Vd Kerkhof | 0-1 Janga, 1-1 Van Steen, 2-1 Thoone |
| 19 | 18/12/2015 | FC Eindhoven | Jong PSV | 2-0 | 3.354 | Martens | 1-0 Caenepeel, 2-0 Van den Hurk |
| 19 | 18/12/2015 | Go Ahead Eagles | Fortuna Sittard | 0-2 | 8.817 | Vd Graaf | 0-1 Schroyen, 0-2 Hutten |
| 19 | 18/12/2015 | FC Oss | Helmond Sport | 2-2 | 1.636 | Dieperink | 0-1 Cortie, 1-1 Zschusschen, 2-1 Van der Steen (e.d.), 2-2 El Allouchi |
| 19 | 18/12/2015 | FC Emmen | VVV Venlo | 1-4 | 3.156 | Perez | 0-1 Seuntjens, 1-1 Kolder, 1-2 Opoku, 1-3 Hunte, 1-4 Seuntjens; R: Siekman (Emm) |
| 19 | 21/12/2015 | Jong Ajax | FC Volendam | 2-0 | 1.052 | C. Mulder | 1-0 Muric, 2-0 Hendriks (pen) |
| 20 | 15/01/2016 | VVV Venlo | Almere City FC | 4-0 | 3.509 | Bax | 1-0 Hunte, 2-0, 3-0 (pen) en 4-0 (pen) Seuntjens R: Ramsteijn (Alm) |
| 20 | 15/01/2016 | FC Volendam | NAC Breda | 1-2 | 4.000 | Liesveld | 0-1 Seuntjens, 0-2 Suk, 1-2 Mertens |
| 20 | 15/01/2016 | RKC Waalwijk | Telstar | 2-1 | 1.600 | Blank | 1-0 Nieuwendaal, 1-1 Knol, 2-1 Kindermans |
| 20 | 15/01/2016 | MVV Maastricht | Helmond Sport | 1-4 | 4.139 | Gerrets | 0-1 Edwards, 0-2 Kerk, 0-3 Van de Sande, 0-4 Cortie, 1-4 Guvenç |
| 20 | 15/01/2016 | FC Eindhoven | FC Dordrecht | 1-1 | 2.136 | Manschot | 0-1 Fortes, 1-1 Koç |
| 20 | 15/01/2016 | Go Ahead Eagles | Jong PSV | 1-2 | 8.075 | Perez | 1-0 De Kogel, 1-1 Bergwijn, 1-2 Vloet |
| 20 | 15/01/2016 | Fortuna Sittard | FC Den Bosch | 1-1 | 1.582 | Vd Vrande | 0-1 Pozder, 1-1 Schroyen |
| 20 | 15/01/2016 | Jong Ajax | Achilles'29 | 3-1 | 189 | Martens | 1-0 Bakker, 1-1 T. Hendriks, 2-1 El Mahdioui, 3-1 S. Hendriks |
| 20 | 15/01/2016 | FC Emmen | FC Oss | 0-2 | 2.860 | Nijhuis | 0-1 Van der Venne, 0-2 Zschuschen |
| 21 | 18/01/2016 | Sparta Rotterdam | RKC Waalwijk | 5-2 | 5.854 | Janssen | 1-0 Dumfries, 2-0 Bergkamp, 3-0 Verhaar, 3-1 Kindermans, 3-2 Nieuwendaal, 4-2 Breuer, 5-2 Brogno |
| 21 | 18/01/2016 | FC Dordrecht | FC Emmen | 0-2 | 1.166 | Berben | 0-1 Deul, 0-2 Ten Voorde |
| 21 | 18/01/2016 | NAC Breda | FC Eindhoven | 3-1 | 12.100 | Gözübüyük | 1-0 en 2-0 Pedro, 3-0 Brands, 3-1 Caenepeel (p) R: Pedro (NAC) |
| 21 | 18/01/2016 | Jong PSV | MVV Maastricht | 2-0 | 417 | Van Herk | 1-0 De Wijs, 2-0 Bergwijn |
| 21 | 18/01/2016 | FC Den Bosch | FC Volendam | 0-0 | 1.500 | S. Mulder | |
| 21 | 18/01/2016 | Telstar | Go Ahead Eagles | 1-2 | 1.500 | Oostrom | 0-1 De Kogel, 1-1 Lilypaly, 1-2 Schenk |
| 21 | 18/01/2016 | FC Oss | VVV-Venlo | 2-1 | 1.503 | Kooij | 1-0 Kamaci, 1-1 Hunte, 2-1 Van der Venne |
| 21 | 18/01/2016 | Helmond Sport | Jong Ajax | 2-3 | 1.899 | Dieperink | 1-0 Strijbosch, 1-1 El Azzouzi, 2-1 Kerk, 2-2 Edwards (e.d.), 2-3 El Azzouzi |
| 22 | 22/01/2016 | Almere City FC | Telstar | 0-2 | 1.156 | Otto | 0-1 Van den Broek, 0-2 Tissoudali |
| 22 | 22/01/2016 | FC Volendam | FC Dordrecht | 2-2 | 3.000 | Vd Graaf | 0-1 Janga, 1-1 Laghmouchi, 1-2 Daniëls, 2-2 Steltenpool; R: Fortes (Dor) |
| 22 | 22/01/2016 | RKC Waalwijk | Achilles'29 | 1-1 | 1.400 | Smeets | 0-1 Thoone (pen), 1-1 Langedijk |
| 22 | 22/01/2016 | MVV Maastricht | FC Oss | 4-2 | 3.794 | Berben | 1-0 Nys, 2-0 Koca (e.d.), 3-0 Croux, 3-1 Kamaci, 4-1 Nys, 4-2 Van der Venne |
| 22 | 22/01/2016 | FC Eindhoven | Sparta Rotterdam | 1-1 | 2.269 | Higler | 0-1 Van Moorsel, 1-1 Caenepeel (pen) |
| 22 | 22/01/2016 | VVV Venlo | Jong PSV | 1-2 | 3.753 | Vd Vrande | 0-1 Boljevic, 1-1 Opoku, 1-2 Vloet |
| 22 | 22/01/2016 | FC Emmen | FC Den Bosch | 1-0 | 2.740 | Perez | 1-0 Siekman |
| 22 | 25/01/2016 | Jong Ajax | NAC Breda | 2-1 | 1.500 | Bax | 1-0 Cerny, 2-0 De Jong, 2-1 Brands (pen) Gespeeld in Almere (stadion Almere City) |
| 21 | 25/01/2016 | Achilles'29 | Fortuna Sittard | 3-0 | 1.335 | C. Mulder | 1-0 Thoone (pen), 2-0 Hendriks, 3-0 Boogers |
| 23 | 29/01/2016 | Fortuna Sittard | Almere City FC | 0-2 | 1.202 | Van Herk | 0-1 Boldewijn, 0-2 Kip |
| 23 | 29/01/2016 | NAC Breda | Helmond Sport | 1-0 | 14.015 | Martens | 1-0 Van der Weg |
| 23 | 29/01/2016 | MVV Maastricht | FC Eindhoven | 0-2 | 4.083 | Bax | 0-1 en 0-2 Koç |
| 23 | 29/01/2016 | VVV Venlo | FC Volendam | 3-0 | 3.519 | Kamphuis | 1-0, 2-0 en 3-0 Seuntjens |
| 23 | 29/01/2016 | FC Oss | FC Dordrecht | 2-3 | 1.508 | Dieperink | 1-0 Zschuschen, 1-1 en 1-2 Janga, 2-2 Zschuschen, 2-3 Bunjaku |
| 23 | 29/01/2016 | FC Emmen | Telstar | 1-0 | 3.210 | Kooij | 1-0 Danso |
| 23 | 31/01/2016 | Achilles'29 | Go Ahead Eagles | 1-0 | 1.463 | Lindhout | 1-0 Hendriks |
| 23 | 31/01/2016 | FC Den Bosch | Sparta Rotterdam | 1-2 | 2.698 | Blom | 0-1 Van Moorsel, 1-1 Biemans, 1-2 Ketting |
| 23 | 01/02/2016 | Jong PSV | RKC Waalwijk | 3-1 | 800 | C. Mulder | 0-1 Langedijk, 1-1 Boljevic, 2-1 Bergwijn, 3-1 Da Silva |
| 22 | 01/02/2016 | Fortuna Sittard | Helmond Sport | 3-0 | 1.032 | Vd Heuvel | 1-0 Hutten, 2-0 Janssen (pen), 3-0 Schroyen |
| 24 | 05/02/2016 | Almere City FC | RKC Waalwijk | 3-1 | 1.060 | Dieperink | 1-0 Kip, 1-1 Yildirim, 2-1 Boldewijn, 3-1 Ahannach; R: Van Buuren (Alm) |
| 24 | 05/02/2016 | FC Volendam | Fortuna Sittard | 1-0 | 3.854 | Berben | 1-0 Van Kippersluis |
| 24 | 05/02/2016 | FC Dordrecht | NAC Breda | 0-2 | 2.892 | Vd Kerkhof | 0-1 en 0-2 Ars |
| 24 | 05/02/2016 | FC Eindhoven | Jong Ajax | 2-1 | 1.800 | Otto | 1-0 Van den Hurk (pen), 2-0 Caenepeel, 2-1 Muric |
| 24 | 05/02/2016 | FC Oss | Achilles'29 | 1-1 | 1.111 | Oostrom | 1-0 Bakx, 1-1 Balk (e.d.) |
| 24 | 05/02/2016 | Telstar | MVV Maastricht | 4-0 | 2.063 | C. Mulder | 1-0 en 2-0 Maletic, 3-0 Tissoudali, 4-0 Uiterloo (pen); R: Peeters (MVV) |
| 24 | 05/02/2016 | Helmond Sport | FC Emmen | 3-2 | 1.000 | Alen | 0-1 Warmolts (e.d.), 1-1 Warmolts, 1-2 Danso, 2-2 Strijbosch, 3-2 Van de Sande |
| 24 | 07/02/2016 | Sparta Rotterdam | VVV Venlo | 3-2 | 9.607 | Manschot | 1-0 Verhaar, 1-1 Van Crooy, 2-1 Sanusi, 3-1 Verhaar |
| 24 | 08/02/2016 | Go Ahead Eagles | FC Den Bosch | 0-0 | 6.666 | Bax | R: Wolters (GoA) |
| 25 | 12/02/2016 | Almere City FC | FC Eindhoven | 1-2 | 1.358 | Oostrom | 0-1 Caenepeel (pen), 1-1 Oost, 1-2 Van den Hurk |
| 25 | 12/02/2016 | FC Dordrecht | Fortuna Sittard | 1-3 | 2.142 | Perez | 1-0 Janga, 1-1 Janssen (pen), 1-2 Hutten, 1-3 Briels; R: Vleugels (Dor) |
| 25 | 12/02/2016 | NAC Breda | MVV Maastricht | 1-1 | 14.400 | Makkelie | 0-1 Güvenç, 1-1 Suk; R: Seuntjens (NAC) |
| 25 | 12/02/2016 | RKC Waalwijk | FC Emmen | 0-1 | 1.800 | Van Herk | 0-1 Ten Voorde (pen) |
| 25 | 12/02/2016 | Jong PSV | FC Volendam | 2-2 | 601 | Otto | 0-1 Van Velzen, 0-2 Schouten, 1-2 Boljevic, 2-2 Leemans (pen) |
| 25 | 12/02/2016 | Achilles'29 | Sparta Rotterdam | 0-3 | 2.362 | Kamphuis | 0-1 Brogno, 0-2 Verhaar, 0-3 Klaasen |
| 25 | 12/02/2016 | Go Ahead Eagles | VVV Venlo | 0-3 | 8.464 | Vd Kerkhof | 0-1 en 0-2 Van Crooy, 0-3 Resida |
| 25 | 12/02/2016 | Telstar | Jong Ajax | 4-2 | 2.563 | Martens | 1-0 Tissoudali, 2-0 Ajnane, 3-0 Keurntjes, 3-1 Van Berkel (e.d.), 3-2 El Mahdioui, 4-2 Tissoudali |
| 25 | 12/02/2016 | Helmond Sport | FC Den Bosch | 0-0 | 1.773 | Berben | |
| 26 | 15/02/2016 | MVV Maastricht | Almere City FC | 0-0 | 3.470 | Gerrets | |
| 26 | 15/02/2016 | Sparta Rotterdam | Jong PSV | 1-0 | 6.455 | Vd Heuvel | 1-0 Van Moorsel |
| 26 | 15/02/2016 | FC Volendam | Helmond Sport | 2-1 | 2.500 | Higler | 1-0 Hooi, 2-0 Schouten, 2-1 Heerings |
| 26 | 15/02/2016 | FC Eindhoven | FC Oss | 4-0 | 2.000 | Blank | 1-0 Boere, 2-0 Vandeputte, 3-0 Kastaneer, 4-0 Van Hout |
| 26 | 15/02/2016 | FC Den Bosch | Achilles'29 | 1-2 | 1.000 | Kooij | 0-1 Dingil, 0-2 Popalzay, 1-2 Esajas |
| 26 | 15/02/2016 | Fortuna Sittard | Telstar | 0-3 | 711 | Bax | 0-1 Serrarens, 0-2 Lilypaly, 0-3 Keurntjes (pen) |
| 26 | 15/02/2016 | VVV Venlo | FC Dordrecht | 3-0 | 3.150 | Lindhout | 1-0 Opoku, 2-0 Van Crooy, 3-0 Gravenberch (e.d.) |
| 26 | 15/02/2016 | Jong Ajax | Go Ahead Eagles | 2-2 | 591 | C. Mulder | 0-1 Schenk, 1-1 Muric, 1-2 Van Eeuwijk, 2-2 Hendriks (pen) |
| 26 | 15/02/2016 | FC Emmen | NAC Breda | 1-0 | 3.044 | Vd Graaf | 1-0 Kolder; R: Van der Weg (NAC) |
| 27 | 19/02/2016 | Almere City FC | FC Volendam | 2-2 | 956 | Perez | 0-1 Tuyp, 0-2 Steltenpool, 1-2 Kip, 2-2 Van Amersfoort |
| 27 | 19/02/2016 | FC Dordrecht | MVV Maastricht | 1-0 | 1.541 | Blank | 1-0 Janga (pen) |
| 27 | 19/02/2016 | NAC Breda | Fortuna Sittard | 5-0 | 12.700 | Kamphuis | 1-0 Naah, 2-0 Seuntjens, 3-0 Damen, 4-0 Verbeek, 5-0 Ünal; R: Janssen (For) |
| 27 | 19/02/2016 | Jong PSV | FC Emmen | 0-0 | 550 | Gerrets | |
| 27 | 19/02/2016 | Go Ahead Eagles | RKC Waalwijk | 1-0 | 8.418 | Oostrom | 1-0 De Kogel |
| 27 | 19/02/2016 | FC Den Bosch | FC Eindhoven | 3-1 | 2.588 | Dieperink | 0-1 Kastaneer, 1-1 Slivka, 2-1 en 3-1 Zeldenrust |
| 27 | 19/02/2016 | FC Oss | Jong Ajax | 1-2 | 2.532 | Vd Vrande | 0-1 Acolatse, 0-2 Cerny, 1-2 Kamaci R: Owusu (Aja) |
| 27 | 19/02/2016 | Telstar | Sparta Rotterdam | 1-3 | 2.763 | Vd Graaf | 0-1 Brogno, 1-1 Lilypaly, 1-2 Verhaar, 1-3 Sanusi |
| 27 | 19/02/2016 | Helmond Sport | VVV Venlo | 1-4 | 2.391 | Bax | 1-0 Justiana, 1-1 Seuntjens, 1-2 en 1-3 Buwalda, 1-4 Opoku |
| 28 | 26/02/2016 | FC Emmen | Almere City FC | 5-6 | 2.618 | Bax | 0-1 Kip, 1-1 (pen) en 2-1 Kolder, 2-2 Kip, 2-3 en 2-4 Van Amersfoort, 3-4 Gyasi, 3-5 Kip, 4-5 Danso, 5-5 Deul, 5-6 Ahannach R: Ramsteijn (Alm), Streutker (Emm) |
| 28 | 26/02/2016 | RKC Waalwijk | Helmond Sport | 2-2 | 1.840 | Otto | 1-0 Thomassen, 1-1 Justiana, 2-1 Thomassen, 2-2 Markiet |
| 28 | 26/02/2016 | Achilles'29 | Jong PSV | 3-2 | 1.485 | C. Mulder | 1-0 Popalzay, 1-1 Lammers, 2-1 Thoone, 3-1 Dingil, 3-2 Lokovic |
| 28 | 26/02/2016 | FC Eindhoven | Telstar | 2-1 | 2.872 | Kamphuis | 0-1 Tissoudali, 1-1 Van den Hurk, 2-1 N'Toko |
| 28 | 26/02/2016 | Fortuna Sittard | FC Oss | 3-0 | 3.555 | Van Damme | 1-0 en 2-0 Hutten, 3-0 Van Son |
| 28 | 26/02/2016 | VVV Venlo | NAC Breda | 4-3 | 6.183 | Janssen | 0-1 Ars, 1-1 en 2-1 Haagen, 3-1 Nijholt, 3-2 Ars, 4-2 Opoku, 4-3 Haagen (e.d.) |
| 28 | 28/02/2016 | Sparta Rotterdam | Go Ahead Eagles | 3-1 | 9.395 | Nijhuis | 1-0 Breuer, 2-0 Brogno, 2-1 De Kogel, 3-1 Verhaar; R: Duits (goA) |
| 28 | 28/02/2016 | MVV Maastricht | FC Den Bosch | 1-0 | 3.879 | Manschot | 1-0 Peeters |
| 28 | 29/02/2016 | Jong Ajax | FC Dordrecht | 4-1 | 554 | Blank | 1-0 Fischer, 2-0 Muric, 3-0 Zivkovic, 4-0 Van de Beek, 4-1 Janga |
| 29 | 04/03/2016 | Almere City FC | Jong Ajax | 2-1 | 1.489 | Van Herk | 1-0 Kip (pen), 2-0 Van Amersfoort, 2-1 Zivkovic |
| 29 | 04/03/2016 | FC Dordrecht | RKC Waalwijk | 2-1 | 1.331 | Berben | 1-0 Bunjaku, 1-1 Langedijk, 1-2 Cicilia R: Lumu (Dor) |
| 29 | 04/03/2016 | NAC Breda | Achilles'29 | 3-1 | 11.600 | S. Mulder | 1-0 Van Diermen, 2-0 Ter Wielen (e.d.), 2-1 Hendriks, 3-1 Matic |
| 29 | 04/03/2016 | Go Ahead Eagles | FC Emmen | 0-0 | 8.147 | Otto | |
| 29 | 04/03/2016 | FC Oss | Sparta Rotterdam | 1-2 | 1.916 | Perez | 0-1 Bergkamp, 1-1 Vd Venne, 1-2 Verhaar (pen) |
| 29 | 04/03/2016 | Telstar | VVV Venlo | 2-2 | 1.463 | Dieperink | 1-0 Tissoudali, 1-1 Nijholt, 1-2 Opoku, 2-2 Deekman; R: Van Berkel (Tel) |
| 29 | 04/03/2016 | Helmond Sport | FC Eindhoven | 1-2 | 2.890 | Gerrets | 1-0 El Allouchi, 1-1 en 1-2 Van den Hurk R: Heerings (Hel) |
| 29 | 06/03/2016 | FC Volendam | MVV Maastricht | 0-1 | 3.250 | Oostrom | 0-1 Peeters (pen) |
| 29 | 07/03/2016 | Jong PSV | Fortuna Sittard | 0-1 | 500 | Vd Vrande | 0-1 Janssen (pen) |
| 30 | 11/03/2016 | Achilles'29 | Almere City FC | 1-3 | 1.384 | Martens | 0-1 Kip, 0-2 Ahannach, 0-3 Kip, 1-3 Van Steen; R: Salasiwa (Alm) |
| 30 | 11/03/2016 | Sparta Rotterdam | FC Emmen | 3-2 | 9.400 | Manschot | 1-0 Breuer, 1-1 Deul, 2-1 MacDonald, 2-2 Kwee, 3-2 Sanusi |
| 30 | 11/03/2016 | NAC Breda | FC Oss | 5-0 | 13.800 | Blom | 1-0 Van Diermen, 2-0 Ünal, 3-0 Ars, 4-0 Matic, 5-0 Brands |
| 30 | 11/03/2016 | RKC Waalwijk | Fortuna Sittard | 1-1 | 1.850 | Gerrets | 0-1 De Regt, 1-1 Cicilia |
| 30 | 11/03/2016 | FC Eindhoven | FC Volendam | 1-0 | 3.150 | Vd Kerkhof | 1-0 Caenepeel (pen) |
| 30 | 11/03/2016 | Go Ahead Eagles | MVV Maastricht | 0-0 | 8.176 | Bax | |
| 30 | 11/03/2016 | FC Den Bosch | FC Dordrecht | 2-0 | 2.000 | Put | 1-0 Pozder, 2-0 Carlone |
| 30 | 11/03/2016 | Jong Ajax | VVV Venlo | 2-2 | 445 | Oostrom | 1-0 Zivkovic, 1-1 Seuntjens(pen), 2-1 Zivkovic, 2-2 Hunte; R: Van Bruggen (Aja) |
| 30 | 11/03/2016 | Telstar | Jong PSV | 1-1 | 1.663 | Van Herk | 1-0 Lilipaly, 1-1 Gudmundsson R: Smiljanic (PSV) |
| 31 | 14/03/2016 | Almere City FC | Sparta Rotterdam | 1-0 | 1.648 | Higler | 1-0 Floranus (e.d) |
| 31 | 14/03/2016 | FC Volendam | Telstar | 3-0 | 3.579 | Lindhout | 1-0 Steltenpool, 2-0 Tuyp, 3-0 Essenboom |
| 31 | 14/03/2016 | FC Dordrecht | Go Ahead Eagles | 1-1 | 1.201 | Kooij | 0-1 Bunjaku (e.d.), 1-1 Janga |
| 31 | 14/03/2016 | Jong PSV | Helmond Sport | 3-1 | 550 | Dieperink | 1-0 Laursen, 2-0 Paal, 2-1 Strijbosch, 3-1 Da Silva |
| 31 | 14/03/2016 | MVV Maastricht | Jong Ajax | 0-0 | 3.841 | Otto | |
| 31 | 14/03/2016 | Fortuna Sittard | FC Eindhoven | 2-1 | 1.691 | C. Mulder | 0-1 Van den Buijs, 1-1 (pen) en 2-1 Janssen |
| 31 | 14/03/2016 | VVV Venlo | RKC Waalwijk | 4-3 | 3.515 | Perez | 0-1 Langedijk, 1-1 Van Crooy, 1-2 Thomassen, 1-3 Langedijk, 2-3 Opoku, 3-3 Seuntjens, 4-3 Opoku |
| 31 | 14/03/2016 | FC Oss | FC Den Bosch | 3-1 | 2.168 | Nijhuis | 1-0 Van der Venne, 1-1 Havar, 2-1 Van der Sluys, 3-1 Bakx3-1 |
| 31 | 14/03/2016 | FC Emmen | Achilles'29 | 3-1 | 2.640 | Vd Kerkhof | 1-0 en 2-0 Gyasi, 3-0 Ten Voorde, 3-1 Sürmeli |
| 32 | 18/03/2016 | Helmond Sport | Almere City FC | 0-2 | 1.000 | Gözübüyük | 0-1 Ahannach, 0-2 Oost; R: Cortie (Hel) |
| 32 | 18/03/2016 | Sparta Rotterdam | Fortuna Sittard | 1-1 | 7.705 | Van Boekel | 1-0 Van Moorsel, 1-1 Fafiani |
| 32 | 18/03/2016 | RKC Waalwijk | FC Volendam | 2-1 | 1.952 | Vd Vrande | 1-0 Nieuwendaal, 2-0 Langedijk, 2-1 Steltenpool |
| 32 | 18/03/2016 | FC Eindhoven | VVV Venlo | 2-0 | 3.168 | Martens` | 1-0 Caenepeel, 2-0 Vandeputte |
| 32 | 18/03/2016 | Go Ahead Eagles | FC Oss | 5-0 | 8.300 | Blank | 1-0 Duits, 2-0 en 3-0 Ten Den, 4-0 en 5-0 De Kogel |
| 32 | 18/03/2016 | FC Den Bosch | NAC Breda | 3-6 | 4.167 | Bax | 1-0 en 2-0 Biemans, 2-1 Ünal, 2-2 Ars (pen), 2-3 Ünal, 3-3 Pozder, 3-4 Ars (pen), 3-5 Seuntjens, 3-6 Heemskerk (e.d.) R: Havar (DBo) |
| 32 | 18/03/2016 | Jong Ajax | Jong PSV | 1-2 | 642 | Perez | 1-0 De Jong, 1-1 De Wijs, 1-2 Koch |
| 32 | 18/03/2016 | Telstar | FC Dordrecht | 3-0 | 1.463 | Mulder | 1-0 en 2-0 Tissoudali, 3-0 Van den Broek |
| 32 | 20/03/2016 | Achilles'29 | MVV Maastricht | 1-2 | 1.000 | Kooij | 0-1 en 0-2 Peeters, 1-2 Thoone R: Martina (MVV) |
| 33 | 01/04/2016 | Almere City FC | Go Ahead Eagles | 3-4 | 2.100 | Kamphuis | 1-0 Kip, 1-1 Schenk, 1-2 Wolters, 1-3 De Kogel, 2-3 Kip (pen), 2-4 ten Den, 3-4 Rosario R: Maatsen (GoA) |
| 33 | 01/04/2016 | Sparta Rotterdam | NAC Breda | 1-1 | 10.599 | Janssen | 0-1 Ars, 1-1 Sanusi |
| 33 | 01/04/2016 | FC Dordrecht | Helmond Sport | 0-2 | 1.224 | Manschot | 0-1 Markiet, 0-2 El Allouchi (pen) |
| 33 | 01/04/2016 | RKC Waalwijk | FC Eindhoven | 1-2 | 2.200 | Bax | 0-1 en 0-2 Kastaneer, 1-2 Langedijk (pen) |
| 33 | 01/04/2016 | Achilles'29 | Telstar | 1-3 | 1.000 | Gerrets | 0-1 Serrarens, 0-2 Ajnane, 0-3 Serrarens (pen), 1-3 Boogers |
| 33 | 01/04/2016 | Fortuna Sittard | Jong Ajax | 1-2 | 1.962 | Berben | 1-0 Van Son, 1-1 Muric, 1-2 Cerny |
| 33 | 01/04/2016 | VVV Venlo | FC Den Bosch | 2-1 | 4.200 | Vink | 1-0 Paulissen, 2-0 Van Crooy, 2-1 Khalouta R: Haagen (VVV) |
| 33 | 01/04/2016 | FC Emmen | FC Volendam | 1-0 | 3.523 | Dieperink | 1-0 Ten Voorde |
| 33 | 04/04/2016 | Jong PSV | FC Oss | 3-1 | 369 | Vdrboomen | 1-0 en 2-0 Bergwijn, 3-0 Koch, 3-1 Zschuschen |
| 34 | 08/04/2016 | FC Oss | Almere City FC | 1-2 | 1.822 | Bax | 0-1 Boldewijn, 0-2 Oost, 1-2 Schet |
| 34 | 08/04/2016 | FC Volendam | Achilles'29 | 0-0 | 3.500 | Oostrom | |
| 34 | 08/04/2016 | FC Dordrecht | Jong PSV | 4-0 | 1.223 | Gerrets | 1-0 en 2-0 Janga, 3-0 Bijl, 4-0 Daniëls |
| 34 | 08/04/2016 | NAC Breda | RKC Waalwijk | 1-1 | 15.150 | Kooij | 0-1 Van Arnhem, 1-1 Ars R: Nieuwendaal, Verkoelen (RKC) |
| 34 | 08/04/2016 | MVV Maastricht | VVV Venlo | 1-3 | 5.103 | Vd Graaf | 0-1 en 0-2 Seuntjens, 1-2 Croux, 1-3 Van Crooy |
| 34 | 08/04/2016 | FC Eindhoven | Go Ahead Eagles | 0-0 | 3.100 | Perez | |
| 34 | 08/04/2016 | FC Den Bosch | Telstar | 5-0 | 3.279 | Dieperink | 1-0 Khalouta, 2-0 Boddaert, 3-0 Vossebelt, 4-0 Slivka, 5-0 Zeldenrust |
| 34 | 08/04/2016 | Jong Ajax | FC Emmen | 2-0 | 423 | Vd Vrande | 1-0 Zivkovic, 2-0 Hendriks; R: Rozema (Hee) |
| 34 | 08/04/2016 | Helmond Sport | Sparta Rotterdam | 1-1 | 3.654 | Makkelie | 1-0 Kerk, 1-1 Brogno |
| 35 | 11/04/2016 | Almere City FC | FC Dordrecht | 3-0 | 1.222 | Liesveld | 1-0 Rosario, 2-0 Boldewijn, 3-0 Kip |
| 35 | 11/04/2016 | Sparta Rotterdam | Jong Ajax | 3-1 | 11.000 | Lindhout | 1-0 Brogno, 1-1 Sinkgraven, 2-1 Breuer, 3-1 MacDonald |
| 35 | 11/04/2016 | RKC Waalwijk | FC Oss | 3-2 | 2.000 | Berben | 1-0 Anderson, 2-0 Thomassen, 2-1 Van Eijma, 2-2 Bakx, 3-2 Van Weert |
| 35 | 11/04/2016 | Jong PSV | FC Den Bosch | 2-1 | 350 | Martens | 1-0 Leemans, 1-1 Khalouta, 2-1 Maher |
| 35 | 11/04/2016 | Achilles'29 | Helmond Sport | 1-2 | Blank | 1-0 Van de Beek, 1-1 Kerk, 1-2 Edwards R: Van de Beek (Ach) |
|
| 35 | 11/04/2016 | Go Ahead Eagles | FC Volendam | 3-2 | 7.583 | Vd Kerkhof | 1-0 De Kogel, 1-1 Van Kippersluis, 2-1 Van Ewijk, 2-2 Laghmouchi, 3-2 Teijsse |
| 35 | 11/04/2016 | Fortuna Sittard | MVV Maastricht | 1-2 | 3.813 | Van Boekel | 0-1 Nys, 1-1 De Regt, 1-2 Werker |
| 35 | 11/04/2016 | Telstar | NAC Breda | 1-4 | 1.763 | Higler | 0-1 Ünal, 1-1 Tissoudali, 1-2 en 1-3 Ünal, 1-4 Suk |
| 35 | 11/04/2016 | FC Emmen | FC Eindhoven | 4-2 | 2.840 | S. Mulder | 1-0 Olijve, 1-1 Van den Hurk, 2-1 Danso, 3-1 Gyasi, 4-1 Danso, 4-2 Mitrovic (pen) |
| 36 | 15/04/2016 | FC Den Bosch | Almere City FC | 1-2 | 1.250 | Gerrets | 0-1 Nieuwpoort, 0-2 Oost, 1-2 Biemans |
| 36 | 15/04/2016 | FC Volendam | Sparta Rotterdam | 2-0 | 3.500 | Kamphuis | 1-0 Hilterman, 2-0 Steltenpool |
| 36 | 15/04/2016 | NAC Breda | Jong PSV | 5-2 | 14.500 | Blank | 1-0 Seuntjens, 2-0 Loof (e.d.), 3-0 Ars, 3-1 Boljevic, 3-2 Leemans, 4-2 Seuntjens, 5-2 Loof (e.d.) |
| 36 | 15/04/2016 | MVV Maastricht | FC Emmen | 4-1 | 4.272 | Van Herk | 1-0 Güvenç, 1-1 Deul, 2-1 Verheijdt, 3-1 Peeters (pen), 3-1 Güvenç |
| 36 | 15/04/2016 | FC Eindhoven | Achilles'29 | 0-1 | 2.735 | Mulder | 0-1 Beijer |
| 36 | 15/04/2016 | VVV Venlo | Fortuna Sittard | 4-1 | 4.411 | D'Hondt | 1-0 Opoku, 2-0 Resida, 3-0 Hunte, 3-1 Loen, 4-1 Promes |
| 36 | 15/04/2016 | Jong Ajax | RKC Waalwijk | 0-0 | 283 | Oostrom | |
| 36 | 15/04/2016 | FC Oss | Telstar | 3-3 | 750 | Vd Vrande | 0-1 Zschusschen, 1-1 Maletic, 1-2 Tissoudali, 1-3 Serrarens, 2-3 Stuy vd Herik, 3-3 Kamaci |
| 36 | 15/04/2016 | Helmond Sport | Go Ahead Eagles | 0-4 | 1.000 | Kooij | 0-1 en 0-2 Teijsse, 0-3 en 0-4 Maatsen |
| 37 | 22/04/2016 | MVV Maastricht | Sparta | 1-3 | 4.602 | Kooij | 1-0 Croux, 1-1 Van Drongelen, 1-2 en 1-3 Verhaar |
| 37 | 22/04/2016 | Jong PSV | FC Eindhoven | 2-0 | 900 | Berben | 1-0 en 2-0 Cmiljanic |
| 37 | 22/04/2016 | NAC Breda | Almere City FC | 1-1 | 14.240 | Dieperink | 1-0 Ünal, 1-1 Ahannach |
| 37 | 22/04/2016 | FC Dordrecht | Achilles '29 | 3-3 | 1.232 | Perez | 1-0 Bijl, 1-1 Boogers, 1-2 Popalzay, 2-2 Janga, 2-3 Poalzay, 3-3 Janga |
| 37 | 22/04/2016 | FC Volendam | Jong Ajax | 1-1 | 3.500 | Van Herk | 0-1 Nouri, 1-1 Hooi |
| 37 | 22/04/2016 | Helmond Sport | FC Oss | 4-0 | 1.489 | C. Mulder | 1-0 Edwards, 2-0 Justiana, 3-0 El Allouchi, 4-0 Van de Sande |
| 37 | 22/04/2016 | VVV Venlo | FC Emmen | 1-0 | 3.552 | Bax | 1-0 Opoku |
| 37 | 22/04/2016 | Fortuna Sittard | Go Ahead Eagles | 0-1 | 1.666 | Oostrom | 0-1 De Kogel |
| 37 | 22/04/2016 | FC Den Bosch | RKC Waalwijk | 1-1 | 3.000 | Vd Vrande | 1-0 Yildirim, 1-1 Khalouta |
| 38 | 29/04/2016 | FC Emmen | Fortuna Sittard | 1-2 | 4.032 | Gerrets | 1-0 Danso, 1-1 en 1-2 Hutten |
| 38 | 29/04/2016 | Telstar | Helmond Sport | 1-0 | 2.602 | Oostrom | 1-0 Lilipaly |
| 38 | 29/04/2016 | Almere City FC | Jong PSV | 7-0 | 2.197 | Kooij | 1-0 Ahannach, 2-0 (p) en 3-0 Oost, 4-0 Kip (p), 5-0 en 6-0 Van der Water, 7-0 Ahannach R: Rommens, De Wijs (PSV) |
| 38 | 29/04/2016 | FC Oss | FC Volendam | 1-2 | 1.250 | Vd Graaf | 1-0 Van der Venne, 1-1 Tuyp, 1-2 Hooi |
| 38 | 29/04/2016 | Jong Ajax | FC Den Bosch | 3-1 | 473 | Blank | 1-0 Zivkovic, 1-1 Van der Sande, 2-1 Hendriks, 3-1 Van de Beek |
| 38 | 29/04/2016 | Go Ahead Eagles | NAC Breda | 3-1 | 9.306 | Wiedemeijer | 1-0 Maatsen, 2-0 en 3-0 De Kogel, 3-1 Van der Weg, 4-1 Van Overbeek |
| 38 | 29/04/2016 | Achilles '29 | VVV Venlo | 1-3 | 1.250 | Liesveld | 0-1 Seuntjens, 0-2 Paulissen, 0-3 Seuntjens, 1-3 Van de Groes |
| 38 | 29/04/2016 | RKC Waalwijk | MVV Maastricht | 1-3 | 2.000 | S. Mulder | 0-1 Fernandes, 0-2 Nys, 1-2 Langedijk, 1-3 Polizzi; R: Coster (RKC) |
| 38 | 29/04/2016 | Sparta | FC Dordrecht | 2-3 | 7.888 | Van Boekel | 0-1 Janga, 0-2 Daniëls, 1-2 Spierings, 2-2 Sanusi, 2-3 Fortes |
Play-offs voor promotie/degradatie
| 1e ronde | ||||||
| 02/05/2016 | Almere City FC | FC Emmen | 4-1 | 2.200 | Vd Kerkhof | 1-0 Kip, 2-0 Ahannach, 2-1 Van Buuren (e.d.), 3-1 Boldewijn, 4-1 Ahannach |
| 02/05/2016 | MVV Maastricht | FC Volendam | 2-1 | 4.362 | Lindhout | 1-0 Peeters, 1-1 Van Kippersluis (pen), 2-1 Werker |
| 06/05/2016 | FC Emmen | Almere City FC | 1-4 | 2.580 | Manschot | 1-0 Danso, 1-1, 1-2 en 1-3 Oost, 1-4 Ahannach; R: Siekman (Emm) |
| 06/05/2016 | FC Volendam | MVV Maastricht | 1-2 | 3.590 | Nijhuis | 0-1 en 0-2 Croux, 1-2 Van Kippersluis |
| 2e ronde | ||||||
| 13/05/2016 | MVV Maastricht | De Graafschap | 0-1 | 7.753 | Makkelie | 0-1 Smeets |
| 13/05/2016 | Go Ahead Eagles | VVV-Venlo | 1-0 | 10.000 | Vd Graaf | 1-0 De Kogel (pen); R: Rutten (VVV) |
| 13/05/2016 | FC Eindhoven | NAC Breda | 1-0 | 4.711 | S. Mulder | 1-0 Kastaneer |
| 13/05/2016 | Almere City FC | Willem II | 0-1 | 3.200 | Lindhout | 0-1 Falkenburg; R: Wuytens (Wil) |
| 16/05/2016 | De Graafschap | MVV Maastricht | 2-1 | 11.306 | S. Mulder | 0-1 Nys, 1-1 Vida, 2-1 Tarfi |
| 16/05/2016 | VVV-Venlo | Go Ahead Eagles | 2-2 | 6.799 | Vink | 0-1 De Kogel, 1-1 Seuntjens (pen), 2-1 Nijholt, 2-2 Wolters |
| 16/05/2016 | NAC Breda | FC Eindhoven | 2-0 | 17.400 | Manschot | 1-0 Matic, 2-0 Ars; R: Ünal, Stam (NAC) |
| 16/05/2016 | Willem II | Almere City FC | 5-2 | 12.250 | Nijhuis | 1-0 Andersen, 2-0 Peters, 2-1 Kip, 3-1 Falkenburg, 4-1 en 5-1 Andersen, 5-2 Van Amersfoort |
| 3e ronde | ||||||
| 19/05/2016 | NAC Breda | Willem II | 2-1 | 17.500 | Higler | 0-1 Hupperts, 1-1 Brands, 2-1 Seuntjens |
| 19/05/2016 | Go Ahead Eagles | De Graafschap | 4-1 | 9.689 | Nijhuis | 1-0 Wolters, 2-0 Duits (pen), 2-1 Bannink, 3-1 Teijsse, 4-1 Wolters; R: Van de Pavert (Gra) |
| 22/05/2016 | Willem II | NAC Breda | 3-1 | 13.800 | Makkelie | 1-0 Heerkens, 2-0 en 3-0 Falkenburg, 3-1 Naah |
| 22/05/2016 | De Graafschap | Go Ahead Eagles | 1-1 | 12.381 | Blom | 1-0 Parzyszek, 1-1 De Kogel |
Willem II handhaaft zich, De Graafschap gedegradeerd, Go Ahead Eagles gepromoveerd
Topscorers
| 1 | Ralf Seuntjens | VVV-Venlo | 28 |
| 2 | Leon de Kogel | Go Ahead Eagles | 25 |
| 3 | Thomas Verhaar | Sparta Rotterdam | 24 |
| 4 | Sjoerd Ars | NAC Breda | 21 |
| Rangelo Janga | FC Dordrecht | 21 | |
| 6 | Tarik Tissoudali | Telstar | 19 |
| 7 | Loris Brogno | Sparta Rotterdam | 16 |
| 8 | Jinty Caenepeel | FC Eindhoven | 15 |
| Ricardo Kip | Almere City FC | 15 | |
| 10 | Erixon Danso | FC Emmen | 14 |
| Sam Hendriks | Jong Ajax | 14 |
Uitslagenmatrix