Uitslagenmatrix
| ACH | BEQ | FRI | GOA | GVA | HEE | HSC | LEE | SNE | VEL | ZWA | ZWO | |
| Achilles | * | 1-4 | 2-1 | 0-1 | 1-1 | 3-5 | 3-2 | 0-2 | 2-0 | 0-1 | 1-1 | 2-1 |
| Be Quick | 5-2 | * | 0-0 | 4-0 | 1-0 | 0-1 | 5-2 | 6-4 | 1-2 | 2-0 | 3-0 | 1-0 |
| Frisia | 2-0 | 1-4 | * | 3-0 | 2-2 | 3-4 | 4-4 | 2-0 | 1-2 | 4-0 | 2-3 | 3-0 |
| Go Ahead | 7-0 | 3-1 | 0-4 | * | 1-1 | 3-1 | 2-1 | 4-4 | 2-9 | 4-0 | 2-0 | 3-0 |
| GVAV | 2-1 | 2-1 | 1-0 | 1-2 | * | 1-2 | 4-0 | 2-3 | 2-1 | 4-0 | 2-2 | 2-0 |
| Heerenveen | 8-2 | 7-0 | 2-3 | 4-1 | 4-2 | * | 8-0 | 6-2 | 2-1 | 7-1 | 9-2 | 8-3 |
| HSC | 2-4 | 0-1 | 0-1 | 0-2 | 1-0 | 0-5 | * | 2-3 | 2-2 | 2-0 | 4-0 | 3-1 |
| Leeuwarden | 4-3 | 4-1 | 9-2 | 3-1 | 5-2 | 3-4 | 6-2 | * | 1-3 | 5-3 | 0-3 | 2-4 |
| Sneek | 0-2 | 2-1 | 1-1 | 0-2 | 3-4 | 3-0 | 3-2 | 0-2 | * | 5-1 | 1-0 | 2-4 |
| Velocitas | 1-1 | 4-4 | 4-2 | 1-1 | 2-5 | 0-2 | 2-2 | 1-2 | 3-2 | * | 2-0 | 1-0 |
| Zwartemeer | 1-4 | 4-2 | 1-0 | 1-2 | 0-2 | 0-5 | 0-2 | 4-2 | 4-0 | 1-1 | * | 0-3 |
| Zwolsche Boys | 3-0 | 0-4 | 3-3 | 2-1 | 0-0 | 0-3 | 2-1 | 2-3 | 1-3 | 3-0 | 5-0 | * |
Eindstand
| 1 | Heerenveen * | 22 | 19 | 0 | 3 | 38 | 97 | 33 | 2.93 |
| 2 | Leeuwarden | 22 | 13 | 1 | 8 | 27 | 69 | 57 | 1.21 |
| 3 | Go Ahead | 22 | 12 | 3 | 7 | 27 | 44 | 40 | 1.10 |
| 4 | Be Quick (Groningen) | 22 | 12 | 2 | 8 | 26 | 51 | 39 | 1.30 |
| 5 | GVAV | 22 | 10 | 5 | 7 | 25 | 42 | 32 | 1.31 |
| 6 | Sneek | 22 | 10 | 2 | 10 | 22 | 45 | 40 | 1.12 |
| 7 | Frisia | 22 | 8 | 5 | 9 | 21 | 44 | 42 | 1.04 |
| 8 | Zwolsche Boys | 22 | 8 | 2 | 12 | 18 | 37 | 45 | 0.82 |
| 9 | Achilles | 22 | 7 | 3 | 12 | 17 | 34 | 54 | 0.62 |
| 10 | Zwartemeer ^ | 22 | 6 | 3 | 13 | 15 | 27 | 54 | 0.50 |
| 11 | Velocitas | 22 | 5 | 5 | 12 | 15 | 28 | 58 | 0.48 |
| 12 | HSC ^ | 22 | 5 | 3 | 14 | 13 | 34 | 58 | 0.58 |
Beslissingswedstrijd voor degradatie:
Velocitas – Zwartemeer 2-1
Wedstrijden om het landskampioenschap
| 29/04/1951 | PSV | Blauw Wit | 3-0 | |
| 03/05/1951 | DWS | PSV | 2-3 | |
| 06/05/1951 | PSV | DWS | 6-1 | |
| 14/05/1951 | Willem II | Heerenveen | 7-2 | |
| 20/05/1951 | Heerenveen | PSV | 2-3 | |
| 23/05/1951 | DWS | Blauw Wit | 3-0 | |
| 27/05/1951 | Blauw Wit | Heerenveen | 3-1 | |
| 27/05/1951 | Willem II | PSV | 2-2 | |
| 03/06/1951 | Heerenveen | DWS | 2-4 | |
| 03/06/1951 | Willem II | Blauw Wit | 2-1 | |
| 09/06/1951 | Blauw Wit | PSV | 3-1 | |
| 10/06/1951 | Heerenveen | Willem II | 0-2 | |
| 13/06/1951 | Blauw Wit | DWS | 3-1 | |
| 16/06/1951 | DWS | Willem II | 4-0 | |
| 17/06/1951 | PSV | Heerenveen | 2-0 | |
| 24/06/1951 | Heerenveen | Blauw Wit | 0-3 | |
| 25/06/1951 | Willem II | DWS | 2-4 | |
| 26/06/1951 | Blauw Wit | Willem II | 1-2 | |
| 30/06/1951 | DWS | Heerenveen | 4-2 | |
| 30/06/1951 | PSV | Willem II | 2-1 |
Eindstand
| 1 | PSV * | 8 | 6 | 1 | 1 | 13 | 22 | 11 | 2.00 |
| 2 | DWS | 8 | 5 | 0 | 3 | 10 | 23 | 18 | 1.27 |
| 3 | Willem II | 8 | 4 | 1 | 3 | 9 | 18 | 16 | 1.12 |
| 4 | Blauw-Wit | 8 | 4 | 0 | 4 | 8 | 14 | 13 | 1.07 |
| 5 | Heerenveen | 8 | 0 | 0 | 8 | 0 | 9 | 28 | 0.32 |