Uitslagenmatrix
| AGO | ENS | ENB | GOA | HEN | HER | NEC | QUI | TUB | WAG | |
| AGOVV | * | 0-4 | 1-2 | 2-1 | 2-1 | 0-2 | 1-2 | 2-0 | 3-1 | 0-2 |
| SC Enschede | 4-0 | * | 4-0 | 0-4 | 4-2 | 0-1 | 2-2 | 3-0 | 4-1 | 3-2 |
| Enschedese Boys | 2-0 | 0-1 | * | 1-2 | 3-2 | 0-2 | 2-2 | 3-1 | 1-3 | 7-1 |
| Go Ahead | 1-2 | 1-2 | 3-1 | * | 2-3 | 0-1 | 0-2 | 4-1 | 2-3 | 5-0 |
| Hengelo | 5-1 | 1-1 | 2-4 | 1-0 | * | 0-4 | 3-2 | 2-1 | 1-3 | 4-2 |
| Heracles | 3-0 | 2-2 | 7-2 | 3-0 | 8-2 | * | 5-0 | 1-1 | 4-0 | 5-0 |
| NEC | 8-2 | 5-0 | 1-2 | 3-1 | 6-1 | 1-1 | * | 4-2 | 4-1 | 4-3 |
| Quick | 1-0 | 1-1 | 3-0 | 3-0 | 3-1 | 2-0 | 0-2 | * | 2-2 | 2-2 |
| Tubantia | 1-1 | 4-1 | 3-0 | 6-1 | 6-3 | 2-2 | 1-1 | 3-1 | * | 3-1 |
| Wageningen | 1-4 | 3-1 | 5-1 | 4-0 | 4-3 | 0-2 | 1-3 | 4-0 | 1-1 | * |
Eindstand
| 1 | Heracles * | 18 | 13 | 4 | 1 | 30 | 53 | 12 | 4.41 |
| 2 | NEC | 18 | 11 | 4 | 3 | 26 | 52 | 28 | 1.85 |
| 3 | Tubantia | 18 | 9 | 5 | 4 | 23 | 44 | 33 | 1.33 |
| 4 | SC Enschede | 18 | 9 | 4 | 5 | 22 | 37 | 29 | 1.27 |
| 5 | Enschedese Boys | 18 | 7 | 1 | 10 | 15 | 31 | 43 | 0.72 |
| 6 | Wageningen | 18 | 6 | 2 | 10 | 14 | 36 | 48 | 0.75 |
| 7 | Quick | 18 | 5 | 4 | 9 | 14 | 24 | 34 | 0.70 |
| 8 | Hengelo | 18 | 6 | 1 | 11 | 13 | 37 | 56 | 0.66 |
| 9 | AGOVV | 18 | 6 | 1 | 11 | 13 | 21 | 41 | 0.51 |
| 10 | Go Ahead ^ | 18 | 5 | 0 | 13 | 10 | 27 | 38 | 0.71 |
Wedstrijden om het landskampioenschap
| 04/05/1941 | Heracles | ADO | 3-1 | 10.000 | 1-0 en 2-0 Veldhuis, 2-1 Westhoven, 3-1 Veldhuis |
| 04/05/1941 | VSV | PSV | 1-1 | 8.000 | 1-0 Van der Lugt, 1-1 De Vries (e.d.) |
| 11/05/1941 | ADO | VSV | 1-1 | 13.000 | 1-0 De Heer, 1-1 Van der Kuil |
| 11/05/1941 | PSV | Heracles | 1-5 | 10.000 | 0-1 Jaarsma, 1-1 Roosendaal, 1-2 Veldhuis, 1-3 Van der Veen, 1-4 en 1-5 Veldhuis |
| 18/05/1941 | Be Quick | PSV | 0-0 | 10.000 | |
| 18/05/1941 | Heracles | VSV | 3-1 | 15.000 | 1-0 Jaarsma, 1- Godschalk, 2-1 Jaarsma, 3-1 Veldhuis |
| 22/05/1941 | PSV | Be Quick | 3-0 | 1-0, 2-0 en 3-0 Roosendaal | |
| 22/05/1941 | VSV | ADO | 0-1 | 0-1 De Heer | |
| 25/05/1941 | ADO | Heracles | 3-2 | 13.000 | 0-1 Van der Veen, 1-1 Westhoven, 2-1 .. Eversteijn, 3-1 Westhoven, 3-2 Jaarsma |
| 25/05/1941 | Be Quick | VSV | 3-2 | 8.000 | 1-0 Van Kooijk, 1-1 Stek, 2-1 Wiekens, 2-2 Van der Kuil, 3-2 Boersma |
| 01/06/1941 | ADO | PSV | 2-2 | 10.000 | 1-0 Eversteijn, 1-1 Middel, 2-1 Westhoven, 2-2 Middel |
| 01/06/1941 | Be Quick | Heracles | 0-3 | 13.000 | 0-1 Veldhuis, 0-2 Krabshuis, 0-3 Veldhuis |
| 02/06/1941 | Heracles | Be Quick | 3-0 | 13.000 | 1-0 Dirckinck, 2-0 Veldhuis, 3-0 Van der Veen |
| 02/06/1941 | PSV | ADO | 3-2 | 10.000 | 0-1 Martens, 1-1, 2-1 en 3-1 Roosendaal, 3-2 Choufoer |
| 08/06/1941 | ADO | Be Quick | 2-4 | 0-1 Van Kooijk, 0-2 Blijham, 0-3 Van Kooijk, 1-3 Neuteboom, 2-3 De Heer, 2-4 Blijham |
|
| 08/06/1941 | VSV | Heracles | 2-2 | 1-0 Godschalk, 1-1 Krabshuis, 1-2 Jaarsma, 2-2 Van der Lugt | |
| 15/06/1941 | Be Quick | ADO | 1-1 | 6.000 | 0-1 Tap, 1-1 Van Kooijk |
| 15/06/1941 | PSV | VSV | 1-0 | 1-0 Hunting | |
| 22/06/1941 | Heracles | PSV | 6-1 | 12.000 | 0-1 Middel, 1-1, 2-1 en 3-1 Veldhuis, 4-1 Krabshuis, 5-1 en 6-1 Jaarsma |
| 22/06/1941 | VSV | Be Quick | 5-1 | 0-1 Van Kooijk, 1-1 Godschalk, 2-1 en 3-1 Van der Lugt, 4-1 Godschalk, 5-1 Van der Lugt |
Eindstand