Uitslagenmatrix
| AGO | ENS | ENB | GOA | HER | NEC | PEC | QUI | TUB | WAG | |
| AGOVV | * | 1-0 | 3-2 | 2-1 | 3-2 | 2-2 | 2-1 | 1-3 | 5-0 | 7-1 |
| SC Enschede | 2-2 | * | 2-1 | 3-1 | 0-0 | 2-0 | 5-1 | 2-1 | 5-0 | 2-0 |
| Enschedese Boys | 1-3 | 0-2 | * | 3-1 | 1-1 | 1-3 | 1-0 | 1-1 | 3-2 | 2-5 |
| Go Ahead | 2-0 | 1-4 | 2-1 | * | 3-3 | 4-0 | 8-2 | 4-3 | 0-1 | 2-2 |
| Heracles | 4-5 | 0-0 | 2-2 | 1-1 | * | 1-3 | 4-2 | 7-2 | 1-3 | 3-1 |
| NEC | 1-0 | 0-3 | 3-1 | 1-2 | 1-0 | * | 3-2 | 1-0 | 2-3 | 6-0 |
| PEC | 2-4 | 0-2 | 5-2 | 2-5 | 1-3 | 3-0 | * | 1-3 | 4-0 | 2-2 |
| Quick | 1-1 | 0-0 | 4-1 | 6-0 | 3-1 | 2-2 | 3-3 | * | 6-2 | 1-2 |
| Tubantia | 3-1 | 0-1 | 1-3 | 3-6 | 2-3 | 0-3 | 3-2 | 2-3 | * | 3-2 |
| Wageningen | 2-1 | 1-1 | 0-0 | 1-2 | 2-1 | 2-1 | 3-0 | 5-2 | 4-3 | * |
Eindstand
| 1 | SC Enschede * | 18 | 12 | 5 | 1 | 29 | 36 | 9 | 4.00 |
| 2 | AGOVV | 18 | 10 | 3 | 5 | 23 | 43 | 30 | 1.43 |
| 3 | Go Ahead | 18 | 9 | 3 | 6 | 21 | 45 | 38 | 1.18 |
| 4 | NEC | 18 | 9 | 2 | 7 | 20 | 32 | 28 | 1.14 |
| 5 | Wageningen | 18 | 8 | 4 | 6 | 20 | 35 | 39 | 0.89 |
| 6 | Quick | 18 | 7 | 5 | 6 | 19 | 44 | 36 | 1.22 |
| 7 | Heracles | 18 | 5 | 6 | 7 | 16 | 37 | 35 | 1.05 |
| 8 | Enschedse Boys | 18 | 4 | 4 | 10 | 12 | 26 | 40 | 0.65 |
| 9 | Tubantia | 18 | 6 | 0 | 12 | 12 | 31 | 54 | 0.57 |
| 10 | PEC | 18 | 3 | 2 | 13 | 8 | 33 | 53 | 0.62 |
Wedstrijden om het landskampioenschap
| 28/02/1943 | Feijenoord | Willem II | 1-0 | 40.000 | 1-0 Linssen |
| 28/02/1943 | Heerenveen | SC Enschede | 1-5 | 12.000 | 0-1 Ten Duis, 0-2 Gerritsen, 0-3 Wiegerink, 0-4 Kaspers, 1-4 Heins, 1-5 Gerritsen |
| 07/03/1943 | SC Enschede | Feijenoord | 0-0 | 19.000 | |
| 07/03/1943 | Willem II | Heerenveen | 2-6 | 0-1 Lenstra, 0-2 Jonkman, 1-2 Engel, 1-3 Jonkman, 2-3 Engel, 2-4, 2-5 en 2-6 Lenstra, |
|
| 14/03/1943 | SC Enschede | ADO | 1-3 | 19.000 | 0-1 Piet Eversteijn, 1-1 Kaspers, 1-2 Roosenburg, 1-3 Piet Eversteijn |
| 14/03/1943 | Heerenveen | Feijenoord | 1-2 | 14.000 | 0-1 Wilhelm, 1-1 Kuppen (e.d.), 1-2 Vrauwdeunt |
| 04/04/1943 | Heerenveen | Willem II | 4-2 | 11.000 | 1-0 Ploegh, 2-0 Jonkman, 3-0 Lenstra, 3-1 Engel, 4-1 Lenstra, 4-2 Bruens |
| 11/04/1943 | ADO | Feijenoord | 1-1 | 14.000 | 0-1 Wilhelm, 1-1 Joop Eversteijn |
| 11/04/1943 | SC Enschede | Willem II | 2-3 | 15.000 | 1-0 Ten Duis, 2-0 Wiegerink, 2-1 Aarts, 2-2 Engel, 2-3 Schlangen |
| 18/04/1943 | Feijenoord | Heerenveen | 2-1 | 25.000 | 1-0 Vrauwdeunt, 1-1 Lenstra, 2-1 De Vroet Gespeeld in Amsterdam (De Meer) |
| 18/04/1943 | Willem II | ADO | 1-1 | 14.000 | 1-0 Aarts, 1-1 Neuteboom |
| 25/04/1943 | Feijenoord | SC Enschede | 0-1 | 28.000 | 0-1 Wiegerink; Gespeeld in Nijmegen (De Goffert) |
| 26/04/1943 | ADO | Willem II | 1-4 | 14.000 | 1-0 Roosenburg, 1-1 Van Ham, 1-2 Van Loon, 1-3 Van Ham, 1-4 Van Loon |
| 16/05/1943 | Willem II | Feijenoord | 2-2 | 14.000 | 0-1 Wilhelm, 0-2 Linssen, 1-2 Engel, 2-2 Schlangen |
| 23/05/1943 | Heerenveen | ADO | 1-1 | 15.000 | 1-0 Bruinsma, 1-1 Vreken |
| 23/05/1943 | Willem II | SC Enschede | 3-2 | 1-0 en 2-0 Engel, 3-0 Aarts, 3-1 Meierman, 3-2 Wiegerink | |
| 30/05/1943 | ADO | Heerenveen | 8-2 | 1-0 en 2-0 Piet Eversteijn, 3-0 Vreken, 4-0 Piet Eversteijn, 4-1 Ploegh, 4-2 Jonkman, 5-2 De Heer, 6-2 Piet Eversteijn, 7-2 en 8-2 De Heer |
|
| 03/06/1943 | SC Enschede | Heerenveen | 4-2 | 0-1 Haanstra, 1-1 Teutelink, 2-1 Zweers, 3-1 Wiegerink, 4-1 Gerritsen, 4-2 Haanstra |
|
| 06/06/1943 | Feijenoord | ADO | 1-3 | 38.000 | 1-0 Vrauwdeunt, 1-1 Ben Tap, 1-2 Piet Eversteijn, 1-3 De Heer |
| 14/06/1943 | ADO | SC Enschede | 1-0 | 14.000 | 1-0 Vreken |
Eindstand
| 1 | ADO * | 8 | 4 | 3 | 1 | 11 | 19 | 11 | 1.72 |
| 2 | Feijenoord | 8 | 3 | 3 | 2 | 9 | 9 | 9 | 1.00 |
| 3 | Willem II | 8 | 3 | 2 | 3 | 8 | 17 | 19 | 0.89 |
| 4 | SC Enschede | 8 | 3 | 1 | 4 | 7 | 15 | 13 | 1.15 |
| 5 | Heerenveen | 8 | 2 | 1 | 5 | 5 | 18 | 26 | 0.69 |