Na zes seizoenen lukt het Sparta Rotterdam onder leiding van trainer Alex Pastoor eindelijk afstand te nemen van de Eerste Divisie. Sparta was zeker niet de gedoodverfde titelkandidaat, maar neemt in de loop van het seizoen een geruststellende voorsprong. Op het laatst wordt daarvan nog aardig wat afgeknabbeld, maar de titel komt niet in gevaar.
NAC Breda, verrassend gedegradeerd, kan de favorietenrol niet waarmaken en verspeeld al vroeg in het seizoen veel punten. Uiteindelijk strandt de ploeg in de finale van de play offs, uitgerekend tegen aartsrivaal Willem II. Ook de nummers twee (VVV Venlo) en vier (FC Eindhoven) redden het niet in de nacompetitie. Dat geldt wel voor nummer vijf Go Ahead Eagles (winst op De Graafschap) dat daardoor na één seizoen, ondanks een aantal zeer moeizame periodes gedurende het seizoen, onder Hans de Koning terugkeert in de Eredivisie.
Het is het laatste seizoen dat er geen degradant is. Met de komst van de Tweede Divisie kan de nummer laatst (dit keer FC Oss) komend seizoen niet zonder gevolgen twintigste worden.
Uitslagenmatrix
| ACH | ALM | DBO | DOR | EIN | EMM | FOR | GOA | HEL | AJA | PSV | MVV | NAC | OSS | RKC | SPA | TEL | VOL | VVV | |
| Achilles '29 | * | 1-3 | 0-1 | 2-1 | 2-1 | 1-2 | 3-0 | 1-0 | 1-2 | 2-1 | 3-2 | 1-2 | 1-2 | 1-0 | 0-0 | 0-3 | 1-3 | 0-0 | 1-3 |
| Almere City FC | 2-1 | * | 1-1 | 3-0 | 1-2 | 4-0 | 0-3 | 3-4 | 2-2 | 2-1 | 7-0 | 0-3 | 0-1 | 0-1 | 3-1 | 1-0 | 0-2 | 2-2 | 3-3 |
| FC Den Bosch | 1-2 | 1-2 | * | 2-0 | 3-1 | 3-0 | 2-2 | 2-4 | 2-1 | 3-0 | 0-0 | 2-2 | 3-6 | 4-2 | 1-1 | 1-2 | 5-0 | 0-0 | 0-1 |
| FC Dordrecht | 3-3 | 3-1 | 1-2 | * | 3-1 | 0-2 | 1-3 | 1-1 | 0-2 | 0-1 | 4-0 | 1-0 | 0-2 | 1-0 | 1-2 | 0-3 | 2-2 | 1-3 | 0-0 |
| FC Eindhoven | 0-1 | 3-2 | 0-0 | 1-1 | * | 1-1 | 3-1 | 0-0 | 1-4 | 2-1 | 2-0 | 4-1 | 2-1 | 4-0 | 1-0 | 1-1 | 2-1 | 1-0 | 2-0 |
| FC Emmen | 3-1 | 5-6 | 1-0 | 1-0 | 4-2 | * | 1-2 | 4-1 | 0-1 | 4-2 | 1-1 | 2-3 | 1-0 | 0-2 | 6-1 | 1-3 | 1-0 | 1-0 | 1-4 |
| Fortuna Sittard | 2-4 | 0-2 | 1-1 | 0-5 | 2-1 | 2-2 | * | 0-1 | 3-0 | 1-2 | 1-1 | 1-2 | 1-2 | 3-0 | 1-0 | 1-4 | 0-3 | 0-6 | 0-5 |
| Go Ahead Eagles | 3-2 | 4-1 | 0-0 | 3-0 | 1-2 | 0-0 | 0-2 | * | 1-1 | 2-0 | 1-2 | 0-0 | 4-1 | 5-0 | 1-0 | 2-0 | 5-0 | 3-2 | 0-3 |
| Helmond Sport | 2-2 | 0-2 | 0-0 | 1-2 | 1-2 | 3-2 | 0-2 | 0-4 | * | 2-3 | 4-2 | 1-0 | 1-1 | 4-0 | 1-0 | 1-1 | 4-1 | 0-2 | 1-4 |
| Jong Ajax | 3-1 | 2-2 | 3-1 | 4-1 | 0-0 | 2-0 | 3-0 | 2-2 | 1-1 | * | 1-2 | 0-1 | 2-1 | 2-2 | 0-0 | 1-1 | 4-1 | 2-0 | 2-2 |
| Jong PSV | 1-1 | 3-4 | 2-1 | 1-4 | 2-0 | 0-0 | 0-1 | 1-0 | 3-1 | 3-3 | * | 2-0 | 0-3 | 3-1 | 3-1 | 0-3 | 4-3 | 2-2 | 1-5 |
| MVV Maastricht | 1-1 | 0-0 | 1-0 | 2-2 | 0-2 | 4-1 | 1-3 | 1-2 | 1-4 | 0-0 | 2-3 | * | 1-1 | 4-2 | 6-2 | 1-3 | 1-0 | 3-1 | 1-3 |
| NAC Breda | 3-1 | 1-1 | 3-0 | 7-0 | 3-1 | 2-2 | 5-0 | 0-1 | 1-0 | 3-0 | 5-2 | 1-1 | * | 5-0 | 1-1 | 4-0 | 2-1 | 1-4 | 0-1 |
| FC Oss | 1-1 | 1-2 | 3-1 | 2-3 | 0-4 | 0-3 | 4-0 | 3-0 | 2-2 | 1-2 | 0-0 | 1-3 | 1-6 | * | 0-0 | 1-2 | 3-3 | 1-2 | 2-1 |
| RKC Waalwijk | 1-1 | 3-1 | 1-1 | 0-1 | 1-2 | 0-1 | 1-1 | 0-2 | 2-2 | 3-5 | 1-2 | 1-3 | 2-0 | 3-2 | * | 1-1 | 2-1 | 2-1 | 2-1 |
| Sparta Rotterdam | 3-0 | 3-2 | 5-2 | 2-3 | 3-0 | 3-2 | 1-1 | 3-1 | 2-1 | 3-1 | 1-0 | 6-0 | 1-1 | 3-1 | 5-2 | * | 2-1 | 3-1 | 3-1 |
| Telstar | 3-0 | 2-2 | 1-0 | 3-0 | 1-2 | 2-1 | 3-0 | 1-2 | 1-0 | 4-2 | 1-1 | 4-0 | 1-4 | 1-1 | 1-1 | 1-3 | * | 1-1 | 2-2 |
| FC Volendam | 0-0 | 3-1 | 2-0 | 2-2 | 1-2 | 0-2 | 1-0 | 1-0 | 2-1 | 1-1 | 3-0 | 0-1 | 1-2 | 1-1 | 3-0 | 2-0 | 3-0 | * | 1-1 |
| VVV-Venlo | 3-0 | 4-0 | 2-1 | 3-0 | 1-0 | 1-0 | 4-1 | 2-1 | 4-1 | 3-0 | 1-2 | 3-0 | 4-3 | 1-2 | 4-3 | 1-1 | 1-2 | 3-0 | * |
Eindstand
| 1 | Sparta Rotterdam * ♦ | 36 | 24 | 7 | 5 | 79 | 83 | 40 | +43 | 7.934 |
| 2 | VVV-Venlo + | 36 | 23 | 6 | 7 | 75 | 85 | 39 | +46 | 3.903 |
| 3 | NAC Breda + | 36 | 20 | 7 | 9 | 67 | 84 | 42 | +42 | 13.959 |
| 4 | FC Eindhoven + | 36 | 19 | 6 | 11 | 63 | 55 | 44 | +11 | 2.499 |
| 5 | Go Ahead Eagles + ♦ | 36 | 18 | 7 | 11 | 61 | 61 | 41 | +20 | 8.491 |
| 6 | FC Volendam + | 36 | 14 | 10 | 12 | 52 | 54 | 40 | +14 | 3.467 |
| 7 | FC Emmen + | 36 | 15 | 6 | 15 | 51 | 58 | 57 | +1 | 3.248 |
| 8 | Almere City FC + | 36 | 14 | 8 | 14 | 50 | 68 | 66 | +2 | 1.183 |
| 9 | Jong Ajax | 36 | 13 | 11 | 12 | 50 | 59 | 57 | +2 | 542 |
| 10 | MVV Maastricht + | 36 | 14 | 8 | 14 | 50 | 52 | 60 | -8 | 4.229 |
| 11 | Jong PSV | 36 | 13 | 9 | 14 | 48 | 51 | 71 | -20 | 603 |
| 12 | Telstar | 36 | 12 | 8 | 16 | 44 | 57 | 64 | -7 | 1.928 |
| 13 | Helmond Sport | 36 | 11 | 9 | 16 | 42 | 52 | 59 | -7 | 1.896 |
| 14 | FC Dordrecht | 36 | 11 | 7 | 18 | 40 | 47 | 67 | -20 | 1.902 |
| 15 | Achilles '29 | 36 | 10 | 9 | 17 | 39 | 43 | 61 | -18 | 1.373 |
| 16 | Fortuna Sittard | 36 | 11 | 6 | 19 | 39 | 41 | 74 | -33 | 1.937 |
| 17 | FC Den Bosch | 36 | 9 | 11 | 16 | 38 | 47 | 53 | -6 | 2.591 |
| 18 | RKC Waalwijk | 36 | 7 | 11 | 18 | 32 | 41 | 66 | -25 | 2.142 |
| 19 | FC Oss | 36 | 7 | 8 | 21 | 29 | 43 | 80 | -37 | 1.563 |
Wedstrijden
| R: | Datum: | Thuis: | Uit: | Sc: | Ts: | Ar: | Details: |
|---|---|---|---|---|---|---|---|
| 1 | 07/08/2015 | Almere City FC | VVV Venlo | 3-3 | 1.066 | Vd Kerkhof | 1-0 Kip, 1-1 Seuntjens (pen), 1-2 Resida, 2-2 Boldewijn, 2-3 Post, 3-3 Quasten |
| 1 | 07/08/2015 | FC Dordrecht | FC Eindhoven | 3-1 | 2.361 | Braamhaar | 0-1 Deschilder, 1-1 Lima, 2-1 Daniëls, 3-1 Touré |
| 1 | 07/08/2015 | NAC Breda | FC Volendam | 1-4 | 14.230 | Mulder | 0-1 Tuyp, 0-2 Kwakman, 1-2 Pedro, 1-3 Steltenpool, 1-4 Philips; R: Naah (NAC) |
| 1 | 07/08/2015 | Achilles'29 | Jong Ajax | 2-1 | 2.500 | Gerrets | 0-1 Cerny, 1-1 Thoone (pen), 2-1 Deckers |
| 1 | 07/08/2015 | FC Den Bosch | Fortuna Sittard | 2-2 | 2.586 | Bax | 1-0 Belterman, 1-1 Hutten, 1-2 Maatsen (ed), 2-2 Hofstede |
| 1 | 07/08/2015 | FC Oss | FC Emmen | 0-3 | 1.987 | Lindhout | 0-1 Deul, 0-2 Kolder (pen), 0-3 Danso R: Ket (Oss) |
| 1 | 07/08/2015 | Helmond Sport | MVV Maastricht | 1-0 | 2.533 | Oostrom | 1-0 Elbers |
| 1 | 10/08/2015 | Jong PSV | Go Ahead Eagles | 1-0 | 1.074 | Otto | 1-0 Rommens |
| 1 | 10/08/2015 | Telstar | RKC Waalwijk | 1-1 | 2.099 | Berben | 0-1 Valpoort, 1-1 Van Essen; R: Uiterloo (Tel) |
| 2 | 14/08/2015 | RKC Waalwijk | Sparta Rotterdam | 1-1 | 2.200 | Blank | 0-1 Verhaar, 1-1 Valpoort |
| 2 | 14/08/2015 | MVV Maastricht | Jong PSV | 2-3 | 2.500 | Martens | 1-0 Peeters, 1-1 Heesakkers, 1-2 Leemans (pen), 1-3 Boljevic, 2-3 Nys |
| 2 | 14/08/2015 | FC Eindhoven | NAC Breda | 2-1 | 3.376 | Liesveld | 0-1 Brands, 1-1 Koç, 2-1 Van den Hurk |
| 2 | 14/08/2015 | Fortuna Sittard | Achilles'29 | 2-4 | 2.780 | Oostrom | 1-0 en 2-0 Lekesiz, 1-1 Thoone, 2-2 Raja Boeaan, 2-3 Van Riel, 2-4 Penterman |
| 2 | 14/08/2015 | VVV Venlo | FC Oss | 1-2 | 3.050 | Pérez | 0-1 Conneh (pen), 1-1 Resida, 1-2 Fortes R: Bourdouxhe (VVV) |
| 2 | 14/08/2015 | FC Emmen | FC Dordrecht | 1-0 | 4.142 | Bax | 1-0 Danso |
| 2 | 14/08/2015 | FC Volendam | FC Den Bosch | 2-0 | 3.000 | Van de Graaf | 1-0 Tuyp, 2-0 Van Kippersluis; R: El Hamdi (Vol) |
| 2 | 16/08/2015 | Go Ahead Eagles | Telstar | 5-0 | 9.016 | Vd Heuvel | 1-0 en 2-0 (pen) De Kogel, 3-0 Hamdaoui, 4-0 Dzepar, 5-0 Teijsse; R: Korpershoek (Tel) |
| 2 | 17/08/2015 | Jong Ajax | Helmond Sport | 1-1 | 591 | Manschot | 1-0 Muric, 1-1 Edwards |
| 3 | 21/08/2015 | Telstar | Almere City FC | 2-2 | 1.889 | Martens | 1-0 Ajnane, 1-1 Braken, 2-1 Ajnane, 2-2 Braken |
| 3 | 21/08/2015 | Sparta Rotterdam | FC Eindhoven | 3-0 | 8.300 | Mulder | 1-0 Brogno, 2-0 Van Moorsel, 3-0 Verhaar R: N'Toko (Ein) |
| 3 | 21/08/2015 | FC Dordrecht | FC Volendam | 1-3 | 2.882 | Vd Kerkhof | 0-1 en 0-2 Tuyp, 1-2 Lumu, 1-3 Kwakman |
| 3 | 21/08/2015 | NAC Breda | Jong Ajax | 3-0 | 13.900 | Lindhout | 1-0 Seuntjens, 2-0 Brands, 3-0 Ars |
| 3 | 21/08/2015 | Jong PSV | VVV Venlo | 1-5 | 1.200 | Berben | 0-1 Nijholt, 0-2 Opoku, 0-3 Loof (e.d.), 1-3 Lammers, 1-4 Buwalda, 1-5 Opoku |
| 3 | 21/08/2015 | Achilles'29 | RKC Waalwijk | 0-0 | 2.189 | Otto | |
| 3 | 21/08/2015 | FC Den Bosch | FC Emmen | 3-0 | 2.500 | Dieperink | 1-0 Thomassen, 2-0 Havar, 3-0 Esajas (pen) |
| 3 | 21/08/2015 | FC Oss | MVV Maastricht | 1-3 | 1.639 | Vd Heuvel | 0-1 Croux, 0-2 Rajcomar, 1-2 Kamaci, 1-3 Peeters |
| 3 | 21/08/2015 | Helmond Sport | Fortuna Sittard | 0-2 | 2.171 | Blank | 0-1 Hutten, 0-2 Lekesiz |
| 4 | 24/08/2015 | RKC Waalwijk | Almere City FC | 3-1 | 2.300 | Bax | 1-0 Valpoort, 1-1 Mamedov, 2-1 (pen) en 3-1 Valpoort |
| 4 | 24/08/2015 | NAC Breda | FC Dordrecht | 7-0 | 13.600 | Kuipers | 1-0 en 2-0 Brands, 3-0 Seuntjens, 4-0 Verbeek, 5-0 Hooi, 6-0 Matic, 7-0 Seuntjens: R: Lima (Dor) |
| 4 | 24/08/2015 | MVV Maastricht | Telstar | 1-0 | 4.200 | Manschot | 1-0 Nys |
| 4 | 24/08/2015 | Achilles'29 | FC Oss | 1-0 | 1.912 | Kooij | 1-0 Penterman |
| 4 | 24/08/2015 | FC Den Bosch | Go Ahead Eagles | 2-4 | 3.452 | Kamphuis | 1-0 Havar, 1-1 Van Ewijk, 1-2 Vriends, 1-3 De Kogel (pen), 1-4 Dzepar, 2-4 Zeldenrust |
| 4 | 24/08/2015 | Fortuna Sittard | FC Volendam | 0-6 | 2.500 | Lindhout | 0-1 Kwakman, 0-2 Schroyen (e.d.), 0-3 Tuyp, 0-4 Schroyen (e.d.), 0-5 Van Son, 0-6 Kwakman |
| 4 | 24/08/2015 | VVV Venlo | Sparta Rotterdam | 1-1 | 3.300 | Makkelie | 0-1 Brogno, 1-1 Seuntjens |
| 4 | 24/08/2015 | Jong Ajax | FC Eindhoven | 0-0 | 435 | Otto | |
| 4 | 24/08/2015 | FC Emmen | Helmond Sport | 0-1 | 3.150 | Vd Kerkhof | 0-1 Van Nuland |
| 5 | 28/08/2015 | Almere City FC | Fortuna Sittard | 0-3 | 994 | Dieperink | 0-1 Schroyen, 0-2 Mert, 0-3 Hutten |
| 5 | 28/08/2015 | FC Volendam | VVV Venlo | 1-1 | 4.000 | Bax | 0-1 Van Crooy, 1-1 Evers |
| 5 | 28/08/2015 | FC Dordrecht | FC Oss | 1-0 | 1.641 | Gözübüyük | 1-0 Lumu |
| 5 | 28/08/2015 | FC Eindhoven | MVV Maastricht | 4-1 | 2.631 | Gerrets | 0-1 Polizzi, 1-1 en 2-1 Van Hout, 3-1 Van den Hurk, 4-1 N'Toko |
| 5 | 28/08/2015 | Telstar | FC Emmen | 2-1 | 1.500 | Kooij | 1-0 Lilipaly, 2-0 Ajnane, 2-1 Danso |
| 5 | 28/08/2015 | Helmond Sport | NAC Breda | 1-1 | 3.151 | Van de Graaf | 1-0 Bjelica, 1-1 Brands |
| 5 | 29/08/2015 | RKC Waalwijk | Jong PSV | 1-2 | 3.400 | Oostrom | 0-1 Bergwijn, 0-2 Vloet, 1-2 Nieuwendaal |
| 5 | 30/08/2015 | Sparta Rotterdam | FC Den Bosch | 5-2 | 6.300 | Perez | 1-0 Langedijk, 2-0 Stokkers, 2-1 Thomassen, 3-1 en 4-1 (pen) Verhaar, 5-1 Brogno, 5-2 Zeldenrust |
| 5 | 30/08/2015 | Go Ahead Eagles | Achilles'29 | 3-2 | 9.056 | Mulder | 1-0 De Kogel, 2-0 Schenk, 3-0 De Kogel (pen), 3-1 en 3-2 (pen) Penterman; R: Dingil (Ach) |
| 6 | 11/09/2015 | FC Eindhoven | Almere City FC | 3-2 | 2.217 | Vd Heuvel | 1-0 Van Hout, 2-0 Van den Hurk, 2-1 en 2-2 Braken, 3-2 Caenepeel |
| 6 | 11/09/2015 | Sparta Rotterdam | Achilles'29 | 3-0 | 7.110 | Bax | 1-0 Van Steen (ed), 2-0 Verhaar (pen), 3-0 Beijer (ed) |
| 6 | 11/09/2015 | FC Volendam | Jong PSV | 3-0 | 3.500 | Blank | 1-0, 2-0 en 3-0 Steltenpool |
| 6 | 11/09/2015 | FC Den Bosch | Helmond Sport | 2-1 | 2.500 | Gerrets | 1-0 Beekmans, 1-1 Van de Sande, 2-1 Havar R: Vicento (Hel) |
| 6 | 11/09/2015 | Fortuna Sittard | FC Dordrecht | 0-5 | 2.500 | Boterberg | 0-1 Lumu, 0-2 Aktaou (pen), 0-3 Daniëls, 0-4 en 0-5 Janga |
| 6 | 11/09/2015 | VVV Venlo | Go Ahead Eagles | 2-1 | 3.900 | Vd Graaf | 1-0 Seuntjens, 1-1 Van Overbeek, 2-1 V. Crooy |
| 6 | 11/09/2015 | FC Emmen | RKC Waalwijk | 6-1 | 3.054 | Mulder | 1-0 Gyasi, 2-0 Kolder, 3-0 Ten Voorde, 3-1 Valpoort, 4-1 Kolder, 5-1 Olijve, Streutker |
| 6 | 13/09/2015 | MVV Maastricht | NAC Breda | 1-1 | 4.558 | Janssen | 1-0 Croux, 1-1 Naah |
| 6 | 14/09/2015 | Jong Ajax | Telstar | 4-1 | 300 | Dieperink | 1-0 Mijnders, 2-0 Younes, 3-0 Hendriks, 3-1 Maletic, 4-1 Hendriks; R: Vd Beek (Aja) |
| 7 | 18/09/2015 | Almere City FC | MVV Maastricht | 0-3 | 1.000 | Berben | 0-1 Polizzi, 0-2 Santiago, 0-3 Peeters (pen) |
| 7 | 18/09/2015 | FC Dordrecht | VVV Venlo | 0-0 | 2.339 | Manschot | |
| 7 | 18/09/2015 | NAC Breda | FC Emmen | 2-2 | 13.500 | Higler | 1-0 Ars, 1-1 Rozema, 1-2 Ten Voorde, 2-2 Seuntjens (pen) |
| 7 | 18/09/2015 | Jong PSV | Sparta Rotterdam | 0-3 | 500 | Kooij | 0-1 Verhaar, 0-2 Brogno, 0-3 Verhaar (pen) |
| 7 | 18/09/2015 | Go Ahead Eagles | Jong Ajax | 2-0 | 8.337 | Martens | 1-0 en 2-0 Ten Den |
| 7 | 18/09/2015 | FC Oss | FC Eindhoven | 0-4 | 1.679 | Blank | 0-1 Van den Hurk, 0-2 Mandiangu, 0-3 Deschilder, 0-4 Van Imschoot |
| 7 | 18/09/2015 | Telstar | Fortuna Sittard | 3-0 | 1.748 | Gerrets | 1-0 Tissoudali, 2-0 Van Berkel, 3-0 Maletic |
| 7 | 18/09/2015 | Helmond Sport | FC Volendam | 0-2 | 1.500 | Vd Heuvel | 0-1 Mertens, 0-2 Van Velzen |
| 7 | 20/09/2015 | Achilles'29 | FC Den Bosch | 0-1 | 800 | Alen | 0-1 Elders (e.d.) |
| 8 | 25/09/2015 | FC Volendam | Almere City FC | 3-1 | 3.500 | Manschot | 1-0, 2-0 en 3-0 Steltenpool, 3-1 Boldewijn |
| 8 | 25/09/2015 | Sparta Rotterdam | Telstar | 2-1 | 6.124 | Van Damme | 1-0 Brogno, 1-1 Tissoudali, 2-1 Verhaar |
| 8 | 27/09/2015 | RKC Waalwijk | Go Ahead Eagles | 0-2 | 1.500 | Otto | 0-1 en 0-2 Van Ewijk; R; Cecilia (RKC) |
| 8 | 25/09/2015 | MVV Maastricht | FC Dordrecht | 2-2 | 3.976 | Bax | 1-0 Pereira, 1-1 Janga, 2-1 Nys, 2-2 Lumu |
| 8 | 27/09/2015 | Fortuna Sittard | NAC Breda | 1-2 | 2.109 | Kamphuis | 0-1 Ars, 1-1 Janssen, 1-2 Ars |
| 8 | 27/09/2015 | VVV Venlo | Helmond Sport | 4-1 | 3.800 | Dieperink | 0-1 De Reuver, 1-1 Resida, 2-1 Van Crooy, 3-1 (pen) en 4-1 Seuntjens; R: Edwards (Hel) |
| 8 | 25/09/2015 | FC Emmen | Jong PSV | 1-1 | 3.380 | Oostrom | 1-0 Ten Voorde, 1-1 Bergwijn |
| 8 | 27/09/2015 | FC Eindhoven | FC Den Bosch | 0-0 | 1.855 | Lindhout | |
| 8 | 28/09/2015 | Jong Ajax | FC Oss | 2-2 | 387 | Perez | 0-1 Kamaci (pen.), 0-2 Zschusschen, 1-2 Hendriks (pen), 2-2 El Azzouzi R: De Vogel (Oss) |
| 9 | 02/10/2015 | Almere City FC | FC Emmen | 4-0 | 750 | Martens | 1-0 Van Amersfoort, 2-0 Metalsi, 3-0 Van Amersfoort, 4-0 Braken; R: Kwee (Emm) |
| 9 | 02/10/2015 | FC Dordrecht | Jong Ajax | 0-1 | 2.632 | Vd Graaf | 0-1 Muric |
| 9 | 02/10/2015 | NAC Breda | VVV Venlo | 0-1 | 12.940 | Bax | 0-12 Ralf Seuntjens |
| 9 | 02/10/2015 | Jong PSV | Achilles'29 | 1-1 | 585 | Gerrets | 0-1 Penterman (pen), 1-1 Paal |
| 9 | 02/10/2015 | Go Ahead Eagles | Sparta Rotterdam | 2-0 | 9.496 | Mulder | 1-0 De Kogel, 2-0 Van Ewijk |
| 9 | 02/10/2015 | FC Den Bosch | MVV Maastricht | 2-2 | 3.067 | Blank | 1-0 Havar, 1-1 Santiago, 1-2 Croux, 2-2 Zeldenrust |
| 9 | 02/10/2015 | FC Oss | Fortuna Sittard | 4-0 | 1.239 | Kooij | 1-0 Zschusschen, 2-0 Kamaci, 3-0 Conneh, 4-0 Zschusschen; R: Bakx (Oss) |
| 9 | 02/10/2015 | Telstar | FC Eindhoven | 1-2 | 1.953 | Perez | 1-0 Tissoudali, 1-1 Van Hout (pen), 1-2 Caenepeel; R: Lilypaly (Tel) |
| 9 | 02/10/2015 | Helmond Sport | RKC Waalwijk | 1-0 | 2.000 | Oostrom | 1-0 Vicento |
| 10 | 16/10/2015 | RKC Waalwijk | FC Dordrecht | 0-1 | 2.220 | Gerrets | 0-1 Van Weert (e.d.); R: Curiël (Dor) |
| 10 | 16/10/2015 | FC Eindhoven | Helmond Sport | 1-4 | 3.316 | Vd Graaf | 0-1 Kerk, 0-2 Visser, 1-2 Mandiangu, 1-3 Justiana, 1-3 Markiet |
| 10 | 16/10/2015 | Fortuna Sittard | Jong PSV | 1-1 | 1.500 | Put | 0-1 De Wijs, 1-1 De Regt |
| 10 | 16/10/2015 | VVV Venlo | Telstar | 1-2 | 3.300 | Vd Kerkhof | 0-1 Maletic, 1-1 Nijholt, 1-2 Serrarens |
| 10 | 16/10/2015 | FC Emmen | Go Ahead Eagles | 4-1 | 3.820 | Blank | 1-0 Mannes, 2-0 Kolder, 2-1 De Kogel, 3-1 Jallo, 4-1 Kolder; R: Zwarthoed (GoA) |
| 10 | 18/10/2015 | Sparta Rotterdam | FC Oss | 3-1 | 6.885 | Bax | 1-0 en 2-0 Brogno, 2-1 Zschusschen, 3-1 Van Moorsel |
| 10 | 18/10/2015 | MVV Maastricht | FC Volendam | 3-1 | 4.885 | Braamhaar | 1-0 en 2-0 Santiago, 2-1 El Hamdi, 3-1 Guvenç |
| 10 | 18/10/2015 | Achilles'29 | NAC Breda | 1-2 | 2.041 | Otto | 1-0 Van Steen, 1-1 Suk, 1-2 Ars R: Ramezani (Ach) |
| 10 | 19/10/2015 | Jong Ajax | Almere City FC | 2-2 | 751 | Vd Kerkhof | 0-1 Rosario, 0-2 Warmerdam (e.d.), 1-2 Van der Hoorn, 2-2 Hendriks (pen) R: Acolatse (Aja) |
| 11 | 23/10/2015 | Go Ahead Eagles | Almere City FC | 4-1 | 8.587 | Vd Graaf | 1-0 David, 2-0 en 3-0 De Kogel, 3-1 Mamedov, 4-1 Wolters; R: Metalsi (Alm) |
| 11 | 23/10/2015 | FC Volendam | FC Emmen | 0-2 | 4.214 | Mulder | 0-1 Ten Voorde, 0-2 Deul |
| 11 | 23/10/2015 | NAC Breda | Sparta Rotterdam | 4-0 | 15.470 | Lindhout | 1-0 Ars, 2-0 Van de Weg, 3-0 Ars (p), 4-0 Brands |
| 11 | 23/10/2015 | FC Eindhoven | RKC Waalwijk | 1-0 | 2.000 | Bax | 1-0 Caenepeel |
| 11 | 23/10/2015 | FC Den Bosch | VVV Venlo | 0-1 | 3.504 | Kooij | 0-1 Seuntjens |
| 11 | 23/10/2015 | Jong Ajax | Fortuna Sittard | 3-0 | 303 | Oostrom | 1-0 (pen), 2-0 en 3-0 Hendriks; R: Mert (For) |
| 11 | 23/10/2015 | FC Oss | Jong PSV | 0-0 | 1.639 | Vd Vrande | |
| 11 | 23/10/2015 | Telstar | Achilles'29 | 3-0 | 1.831 | Berben | 1-0 Maletic (pen), 2-0 en 3-0 Tissoudali |
| 11 | 23/10/2015 | Helmond Sport | FC Dordrecht | 1-2 | 1.250 | Verboomen | 1-0 Justitiana, 1-1 en 1-2 Janga |
| 12 | 30/10/2015 | Almere City FC | Achilles'29 | 2-1 | 906 | Vd Vrande | 0-1 Van de Beek, 1-1 Tadmine, 2-1 Kip |
| 12 | 30/10/2015 | FC Volendam | FC Eindhoven | 1-2 | 4.000 | Lindhout | 1-0 Van Velzen, 1-1 en 1-2 Caenepeel |
| 12 | 30/10/2015 | FC Dordrecht | FC Den Bosch | 1-2 | 2.003 | Martens | 0-1 Havar, 1-1 Fortes, 1-2 Pozder |
| 12 | 30/10/2015 | MVV Maastricht | Go Ahead Eagles | 1-2 | 4.809 | Bax | 0-1 De Kogel (pen), 1-1 Peters (pen), 1-2 Wolters |
| 12 | 30/10/2015 | Fortuna Sittard | RKC Waalwijk | 1-0 | 1.592 | Van Herk | 1-0 Loen; R: Dengering (For) |
| 12 | 30/10/2015 | VVV Venlo | Jong Ajax | 3-0 | 5.803 | Otto | 1-0 en 2-0 Seuntjens, 3-0 Opoku |
| 12 | 30/10/2015 | FC Oss | NAC Breda | 1-6 | 1.798 | Vd Graaf | 1-0 Bakx, 1-1 Suk, 1-2 Seuntjens, 1-3 Ars, 1-4 Seuntjens, 1-5 Brands (pen), 1-6 Suk |
| 12 | 01/11/2015 | FC Emmen | Sparta Rotterdam | 1-3 | 4.089 | Van Boekel | 0-1 Van Moorsel, 1-1 Danso, 1-2 Brogno, 1-3 Bergkamp |
| 12 | 02/11/2015 | Jong PSV | Telstar | 4-3 | 500` | Dieperink | 1-0 Vloet (pen), 1-1 Knol, 2-1 Paal, 2-2 Maletic, 2-3 Tissoudali, 3-3 en 4-3 Vloet |
| 13 | 06/11/2015 | Sparta Rotterdam | Almere City FC | 3-2 | 10.051 | Vd Kerkhof | 1-0 Bergkamp, 2-0 Boldewijn (e.d.), 2-1 Mamedov, 3-1 Bergkamp, 3-2 Oost |
| 13 | 06/11/2015 | RKC Waalwijk | VVV Venlo | 2-1 | 2,200 | Vd Graaf | 0-1 Verkoelen (e.d.), 1-1 Yildirim, 2-1 Verkoelen |
| 13 | 06/11/2015 | Achilles'29 | FC Emmen | 1-2 | 750 | Van Herk | 1-0 Van Steen, 1-1 ten Voorde (pen), 1-2 Danso R: Van Steen (Ach) |
| 13 | 06/11/2015 | FC Eindhoven | Fortuna Sittard | 3-1 | 2.000 | Perez | 0-1 Lekesiz, 1-1 Koç, 2-1 Boere, 3-1 Caenepeel |
| 13 | 06/11/2015 | Go Ahead Eagles | FC Dordrecht | 3-0 | 9.111 | Lindhout | 1-0 Rijsdijk, 2-0 en 3-0 De Kogel |
| 13 | 06/11/2015 | Jong Ajax | MVV Maastricht | 0-1 | 302 | Berben | 0-1 Verheijdt |
| 13 | 06/11/2015 | Telstar | FC Volendam | 1-1 | 2.580 | Bax | 1-0 Serrarens, 1-1 Schouten (pen) |
| 13 | 06/11/2015 | Helmond Sport | Jong PSV | 4-2 | 1.500 | C. Mulder | 1-0 Bjelica (pen), 2-0 Kerk, 2-1 en 2-2 Bergwijn, 3-2 Kerk, 4-2 Bjelica (pen) |
| 13 | 08/11/2015 | FC Den Bosch | FC Oss | 4-2 | 2.669 | S. Mulder | 1-0 Zeldenrust (pen), 2-0 Pozder, 2-1 Zschusschen, 2-2 Kamaci, 3-2 Pozder, 4-2 Boddaert; R: Hengelman (Oss) |
| 14 | 20/11/2015 | Almere City FC | Helmond Sport | 2-2 | 600 | Kooij | 1-0 Tadmine, 2-0 Van Amersfoort, 2-1 Schilders, 2-2 Justitiana |
| 14 | 20/11/2015 | FC Volendam | RKC Waalwijk | 3-0 | 3.000 | Manschot | 1-0 Schouten, 2-0 Laghmouchi, 3-0 Ben Moussa |
| 14 | 20/11/2015 | FC Dordrecht | Telstar | 2-2 | 1.783 | Blank | 1-0 Roorda, 1-1 Tissoudali, 1-2 Serrarens, 2-2 Janga |
| 14 | 20/11/2015 | NAC Breda | FC Den Bosch | 3-0 | 15.860 | Blom | 1-0 Ars, 2-0 Suk, 3-0 Ars |
| 14 | 20/11/2015 | MVV Maastricht | Achilles'29 | 1-1 | 4.144 | Oostrom | 1-0 Nys, 1-1Boogers |
| 14 | 20/11/2015 | Fortuna Sittard | Sparta Rotterdam | 1-4 | 1.492 | Dieperink | 0-1 Van Moorsel, 0-2 Bergkamp, 0-3 Brogno, 0-4 Verhaar, 1-4 De Regt |
| 14 | 20/11/2015 | VVV Venlo | FC Eindhoven | 1-0 | 3.601 | Vd Heuvel | 1-0 Massop (e.d.) |
| 14 | 20/11/2015 | FC Oss | Go Ahead Eagles | 3-0 | 1.735 | Smeets | 1-0 Kamaci, 2-0 Bakx, 3-0 Kamaci |
| 14 | 23/11/2015 | Jong PSV | Jong Ajax | 3-3 | 700 | Van Herk | 1-0 Boljevic, 1-1 El Mahdioui, 1-2 Van Rhijn, 2-2 Blummel, 2-3 Hendriks, 3-3 Sanoh |
| 15 | 27/11/2015 | Almere City FC | FC Oss | 0-1 | 400 | C. Mulder | 0-1 Zschusschen |
| 15 | 27/11/2015 | Sparta Rotterdam | Helmond Sport | 2-1 | 6.330 | Vd Graaf | 0-1 Van der Sande, 1-1 (pen) en 2-1 Verhaar |
| 15 | 27/11/2015 | RKC Waalwijk | NAC Breda | 2-0 | 4.100 | Bax | 1-0 Cicilia, 2-0 Valpoort; R: Van Weert (RKC) |
| 15 | 27/11/2015 | Jong PSV | FC Dordrecht | 1-4 | 500 | Berben | 0-1 Van Vlerken (e.d.), 0-2 Janga, 0-3 Lumu, 1-3 Sanoh, 1-4 Van Wermeskerken |
| 15 | 27/11/2015 | Achilles'29 | FC Volendam | 0-0 | 500 | Gerrets | |
| 15 | 27/11/2015 | Go Ahead Eagles | FC Eindhoven | 1-2 | 8.907 | Janssen | 0-1 Caenepeel, 1-1 Wolters, 1-2 Boere |
| 15 | 27/11/2015 | VVV Venlo | MVV Maastricht | 3-0 | 4.300 | Lindhout | 1-0 Van Crooy, 2-0 Seuntjens, 3-0 Van Crooy |
| 15 | 27/11/2015 | Telstar | FC Den Bosch | 1-0 | 1.534 | Oostrom | 1-0 Maletic |
| 15 | 27/11/2015 | FC Emmen | Jong Ajax | 4-2 | 3.000 | Vd Vrande | 1-0 Ten Voorde, 1-1 Bakker, 2-1 Danso, 2-2 Hendriks, 3-2 Deul, 4-2 Gyasi |
| 16 | 30/11/2015 | FC Dordrecht | Almere City FC | 3-1 | 1.252 | S. Mulder | 1-0 Janga, 2-0 Curiël, 2-1 Mamedov, 3-1 Roorda |
| 16 | 30/11/2015 | FC Volendam | Go Ahead Eagles | 1-0 | 2.500 | Nijhuis | 1-0 Schouten |
| 16 | 30/11/2015 | NAC Breda | Telstar | 2-1 | 11.460 | Vd Kerkhof | 1-0 Suk, 2-0 Seuntjens, 2-1 Tissoudali |
| 16 | 30/11/2015 | MVV Maastricht | Fortuna Sittard | 1-3 | 5.781 | Gözübüyük | 1-0 Janssen (e.d.), 1-1 Hutten, 1-2 Mert, 1-3 De Regt; R: Verheijdt (MVV) |
| 16 | 30/11/2015 | FC Eindhoven | FC Emmen | 1-1 | 1.000 | Kooij | 0-1 Danso, 1-1 Koç; R: Swinnen (Ein) |
| 16 | 30/11/2015 | FC Den Bosch | Jong PSV | 0-0 | 1.000 | Vd Heuvel | |
| 16 | 30/11/2015 | Jong Ajax | Sparta Rotterdam | 1-1 | 532 | Blank | 0-1 Van Rhijn (e.d.), 1-1 El Azzouzi |
| 16 | 30/11/2015 | FC Oss | RKC Waalwijk | 0-0 | 1.724 | Martens | |
| 16 | 30/11/2015 | Helmond Sport | Achilles'29 | 2-2 | 951 | Otto | 0-1 Boogers, 1-1 Bjelica, 1-2 Van de Beek, 2-2 De Reuver |
| 17 | 04/12/2015 | Almere City FC | FC Den Bosch | 1-1 | 750 | Van Herk | 0-1 Havar, 1-1 Oost; R: Burgzorg (Alm) |
| 17 | 04/12/2015 | Sparta Rotterdam | FC Volendam | 3-1 | 7.186 | Braamhaar | 0-1 Laghmouchi, 1-1 Van Moorsel, 2-1 en 3-1 (pen) Verhaar |
| 17 | 04/12/2015 | RKC Waalwijk | Jong Ajax | 3-5 | 2.000 | Otto | 0-1 Clement, 0-2 Cerny, 0-3 El Azzouzi, 0-4 Muric, 1-4, 2-4 en 3-4 Cicilia, 3-5 El Azzouzi |
| 17 | 04/12/2015 | Achilles'29 | FC Eindhoven | 2-1 | 750 | Vd Vrande | 1-0 Sürmeli, 1-1 Caenepeel, 2-1 Thoone |
| 17 | 04/12/2015 | Go Ahead Eagles | Helmond Sport | 1-1 | 8.024 | Kamphuis | 0-1 Bjelica, 1-1 De Kogel (pen) |
| 17 | 04/12/2015 | Fortuna Sittard | VVV Venlo | 0-5 | 1.892 | Bax | 0-1 Dengering (e.d.), 0-2 Van Crooy, 0-3 Nijholt, 0-4 (pen) en 0-5 Seuntjens |
| 17 | 04/12/2015 | Telstar | FC Oss | 1-1 | 1.734 | Gerrets | 0-1 Van Eijma, 1-1 Keurntjes |
| 17 | 04/12/2015 | FC Emmen | MVV Maastricht | 2-3 | 3.164 | Martens | 0-1 en 0-2 Polizzi, 1-2 Santiago (e.d.), 1-3 Peeters, 2-3 Danso |
| 17 | 07/12/2015 | Jong PSV | NAC Breda | 0-3 | 1.000 | C. Mulder | 0-1 Suk, 0-2 Seuntjens, 0-3 Brands (pen) |
| 18 | 11/12/2015 | Jong PSV | Almere City FC | 3-4 | 306 | Vd Vrande | 0-1 Van Amersfoort, 1-1 Leemans, 1-2 Oost, 2-2 Alberto, 2-3 Boldewijn, 3-3 Vloet (pen), 3-4 Loof (e.d.) |
| 18 | 11/12/2015 | FC Volendam | FC Oss | 1-1 | 4.000 | Vd Heuvel | 1-0 Schouten (pen), 1-1 Kamaci |
| 18 | 11/12/2015 | FC Dordrecht | Sparta Rotterdam | 0-3 | 3.399 | Nijhuis | 0-1 Verhaar, 0-2 en 0-3 Stokkers |
| 18 | 11/12/2015 | NAC Breda | Go Ahead Eagles | 0-1 | 17.800 | Mulder | 0-1 De Kogel; R: Daemen (GoA) |
| 18 | 11/12/2015 | MVV Maastricht | RKC Waalwijk | 6-2 | 4.088 | Kooij | 1-0 Santiago, 2-0 Nys, 3-0 Croux, 3-1 Yildirim, 4-1 Croux, 5-1 Verheijdt, 5-2 Valpoort, 6-2 Verheijdt; R: Engberink (RKC) |
| 18 | 11/12/2015 | FC Den Bosch | Jong Ajax | 3-0 | 3.869 | Perez | 1-0 Havar, 2-0 Zeldenrust (pen), 3-0 Belterman |
| 18 | 11/12/2015 | Fortuna Sittard | FC Emmen | 2-2 | 1.278 | Mulder | 1-0 Lekesiz, 1-1 Kolder, 2-1 Mert, 2-2 Siekman |
| 18 | 11/12/2015 | VVV Venlo | Achilles'29 | 3-0 | 3.402 | Dieperink | 1-0 Seuntjens, 2-0 Resida, 3-0 Hunte |
| 18 | 11/12/2015 | Helmond Sport | Telstar | 4-1 | 1.971 | Berben | 1-0 Cortie, 2-0 El Allouchi, 2-1 Lilipaly, 3-1 Visser, 4-1 Schilders |
| 19 | 18/12/2015 | Almere City FC | NAC Breda | 0-1 | 1.634 | Lindhout | 0-1 Pedro |
| 19 | 18/12/2015 | Sparta Rotterdam | MVV Maastricht | 6-0 | 6.625 | Kamphuis | 1-0, 2-0 en 3-0 Van Moorsel, 4-0 Brogno, 5-0 Verhaar, 6-0 Sanusi |
| 19 | 18/12/2015 | RKC Waalwijk | FC Den Bosch | 1-1 | 2.000 | Berben | 0-1 Pozder, 1-1 Van Hoof |
| 19 | 19/12/2015 | Achilles'29 | FC Dordrecht | 2-1 | 1.000 | Vd Kerkhof | 0-1 Janga, 1-1 Van Steen, 2-1 Thoone |
| 19 | 18/12/2015 | FC Eindhoven | Jong PSV | 2-0 | 3.354 | Martens | 1-0 Caenepeel, 2-0 Van den Hurk |
| 19 | 18/12/2015 | Go Ahead Eagles | Fortuna Sittard | 0-2 | 8.817 | Vd Graaf | 0-1 Schroyen, 0-2 Hutten |
| 19 | 18/12/2015 | FC Oss | Helmond Sport | 2-2 | 1.636 | Dieperink | 0-1 Cortie, 1-1 Zschusschen, 2-1 Van der Steen (e.d.), 2-2 El Allouchi |
| 19 | 18/12/2015 | FC Emmen | VVV Venlo | 1-4 | 3.156 | Perez | 0-1 Seuntjens, 1-1 Kolder, 1-2 Opoku, 1-3 Hunte, 1-4 Seuntjens; R: Siekman (Emm) |
| 19 | 21/12/2015 | Jong Ajax | FC Volendam | 2-0 | 1.052 | C. Mulder | 1-0 Muric, 2-0 Hendriks (pen) |
| 20 | 15/01/2016 | VVV Venlo | Almere City FC | 4-0 | 3.509 | Bax | 1-0 Hunte, 2-0, 3-0 (pen) en 4-0 (pen) Seuntjens R: Ramsteijn (Alm) |
| 20 | 15/01/2016 | FC Volendam | NAC Breda | 1-2 | 4.000 | Liesveld | 0-1 Seuntjens, 0-2 Suk, 1-2 Mertens |
| 20 | 15/01/2016 | RKC Waalwijk | Telstar | 2-1 | 1.600 | Blank | 1-0 Nieuwendaal, 1-1 Knol, 2-1 Kindermans |
| 20 | 15/01/2016 | MVV Maastricht | Helmond Sport | 1-4 | 4.139 | Gerrets | 0-1 Edwards, 0-2 Kerk, 0-3 Van de Sande, 0-4 Cortie, 1-4 Guvenç |
| 20 | 15/01/2016 | FC Eindhoven | FC Dordrecht | 1-1 | 2.136 | Manschot | 0-1 Fortes, 1-1 Koç |
| 20 | 15/01/2016 | Go Ahead Eagles | Jong PSV | 1-2 | 8.075 | Perez | 1-0 De Kogel, 1-1 Bergwijn, 1-2 Vloet |
| 20 | 15/01/2016 | Fortuna Sittard | FC Den Bosch | 1-1 | 1.582 | Vd Vrande | 0-1 Pozder, 1-1 Schroyen |
| 20 | 15/01/2016 | Jong Ajax | Achilles'29 | 3-1 | 189 | Martens | 1-0 Bakker, 1-1 T. Hendriks, 2-1 El Mahdioui, 3-1 S. Hendriks |
| 20 | 15/01/2016 | FC Emmen | FC Oss | 0-2 | 2.860 | Nijhuis | 0-1 Van der Venne, 0-2 Zschuschen |
| 21 | 18/01/2016 | Sparta Rotterdam | RKC Waalwijk | 5-2 | 5.854 | Janssen | 1-0 Dumfries, 2-0 Bergkamp, 3-0 Verhaar, 3-1 Kindermans, 3-2 Nieuwendaal, 4-2 Breuer, 5-2 Brogno |
| 21 | 18/01/2016 | FC Dordrecht | FC Emmen | 0-2 | 1.166 | Berben | 0-1 Deul, 0-2 Ten Voorde |
| 21 | 18/01/2016 | NAC Breda | FC Eindhoven | 3-1 | 12.100 | Gözübüyük | 1-0 en 2-0 Pedro, 3-0 Brands, 3-1 Caenepeel (p) R: Pedro (NAC) |
| 21 | 18/01/2016 | Jong PSV | MVV Maastricht | 2-0 | 417 | Van Herk | 1-0 De Wijs, 2-0 Bergwijn |
| 21 | 18/01/2016 | FC Den Bosch | FC Volendam | 0-0 | 1.500 | S. Mulder | |
| 21 | 18/01/2016 | Telstar | Go Ahead Eagles | 1-2 | 1.500 | Oostrom | 0-1 De Kogel, 1-1 Lilypaly, 1-2 Schenk |
| 21 | 18/01/2016 | FC Oss | VVV-Venlo | 2-1 | 1.503 | Kooij | 1-0 Kamaci, 1-1 Hunte, 2-1 Van der Venne |
| 21 | 18/01/2016 | Helmond Sport | Jong Ajax | 2-3 | 1.899 | Dieperink | 1-0 Strijbosch, 1-1 El Azzouzi, 2-1 Kerk, 2-2 Edwards (e.d.), 2-3 El Azzouzi |
| 22 | 22/01/2016 | Almere City FC | Telstar | 0-2 | 1.156 | Otto | 0-1 Van den Broek, 0-2 Tissoudali |
| 22 | 22/01/2016 | FC Volendam | FC Dordrecht | 2-2 | 3.000 | Vd Graaf | 0-1 Janga, 1-1 Laghmouchi, 1-2 Daniëls, 2-2 Steltenpool; R: Fortes (Dor) |
| 22 | 22/01/2016 | RKC Waalwijk | Achilles'29 | 1-1 | 1.400 | Smeets | 0-1 Thoone (pen), 1-1 Langedijk |
| 22 | 22/01/2016 | MVV Maastricht | FC Oss | 4-2 | 3.794 | Berben | 1-0 Nys, 2-0 Koca (e.d.), 3-0 Croux, 3-1 Kamaci, 4-1 Nys, 4-2 Van der Venne |
| 22 | 22/01/2016 | FC Eindhoven | Sparta Rotterdam | 1-1 | 2.269 | Higler | 0-1 Van Moorsel, 1-1 Caenepeel (pen) |
| 22 | 22/01/2016 | VVV Venlo | Jong PSV | 1-2 | 3.753 | Vd Vrande | 0-1 Boljevic, 1-1 Opoku, 1-2 Vloet |
| 22 | 22/01/2016 | FC Emmen | FC Den Bosch | 1-0 | 2.740 | Perez | 1-0 Siekman |
| 22 | 25/01/2016 | Jong Ajax | NAC Breda | 2-1 | 1.500 | Bax | 1-0 Cerny, 2-0 De Jong, 2-1 Brands (pen) Gespeeld in Almere (stadion Almere City) |
| 21 | 25/01/2016 | Achilles'29 | Fortuna Sittard | 3-0 | 1.335 | C. Mulder | 1-0 Thoone (pen), 2-0 Hendriks, 3-0 Boogers |
| 23 | 29/01/2016 | Fortuna Sittard | Almere City FC | 0-2 | 1.202 | Van Herk | 0-1 Boldewijn, 0-2 Kip |
| 23 | 29/01/2016 | NAC Breda | Helmond Sport | 1-0 | 14.015 | Martens | 1-0 Van der Weg |
| 23 | 29/01/2016 | MVV Maastricht | FC Eindhoven | 0-2 | 4.083 | Bax | 0-1 en 0-2 Koç |
| 23 | 29/01/2016 | VVV Venlo | FC Volendam | 3-0 | 3.519 | Kamphuis | 1-0, 2-0 en 3-0 Seuntjens |
| 23 | 29/01/2016 | FC Oss | FC Dordrecht | 2-3 | 1.508 | Dieperink | 1-0 Zschuschen, 1-1 en 1-2 Janga, 2-2 Zschuschen, 2-3 Bunjaku |
| 23 | 29/01/2016 | FC Emmen | Telstar | 1-0 | 3.210 | Kooij | 1-0 Danso |
| 23 | 31/01/2016 | Achilles'29 | Go Ahead Eagles | 1-0 | 1.463 | Lindhout | 1-0 Hendriks |
| 23 | 31/01/2016 | FC Den Bosch | Sparta Rotterdam | 1-2 | 2.698 | Blom | 0-1 Van Moorsel, 1-1 Biemans, 1-2 Ketting |
| 23 | 01/02/2016 | Jong PSV | RKC Waalwijk | 3-1 | 800 | C. Mulder | 0-1 Langedijk, 1-1 Boljevic, 2-1 Bergwijn, 3-1 Da Silva |
| 22 | 01/02/2016 | Fortuna Sittard | Helmond Sport | 3-0 | 1.032 | Vd Heuvel | 1-0 Hutten, 2-0 Janssen (pen), 3-0 Schroyen |
| 24 | 05/02/2016 | Almere City FC | RKC Waalwijk | 3-1 | 1.060 | Dieperink | 1-0 Kip, 1-1 Yildirim, 2-1 Boldewijn, 3-1 Ahannach; R: Van Buuren (Alm) |
| 24 | 05/02/2016 | FC Volendam | Fortuna Sittard | 1-0 | 3.854 | Berben | 1-0 Van Kippersluis |
| 24 | 05/02/2016 | FC Dordrecht | NAC Breda | 0-2 | 2.892 | Vd Kerkhof | 0-1 en 0-2 Ars |
| 24 | 05/02/2016 | FC Eindhoven | Jong Ajax | 2-1 | 1.800 | Otto | 1-0 Van den Hurk (pen), 2-0 Caenepeel, 2-1 Muric |
| 24 | 05/02/2016 | FC Oss | Achilles'29 | 1-1 | 1.111 | Oostrom | 1-0 Bakx, 1-1 Balk (e.d.) |
| 24 | 05/02/2016 | Telstar | MVV Maastricht | 4-0 | 2.063 | C. Mulder | 1-0 en 2-0 Maletic, 3-0 Tissoudali, 4-0 Uiterloo (pen); R: Peeters (MVV) |
| 24 | 05/02/2016 | Helmond Sport | FC Emmen | 3-2 | 1.000 | Alen | 0-1 Warmolts (e.d.), 1-1 Warmolts, 1-2 Danso, 2-2 Strijbosch, 3-2 Van de Sande |
| 24 | 07/02/2016 | Sparta Rotterdam | VVV Venlo | 3-2 | 9.607 | Manschot | 1-0 Verhaar, 1-1 Van Crooy, 2-1 Sanusi, 3-1 Verhaar |
| 24 | 08/02/2016 | Go Ahead Eagles | FC Den Bosch | 0-0 | 6.666 | Bax | R: Wolters (GoA) |
| 25 | 12/02/2016 | Almere City FC | FC Eindhoven | 1-2 | 1.358 | Oostrom | 0-1 Caenepeel (pen), 1-1 Oost, 1-2 Van den Hurk |
| 25 | 12/02/2016 | FC Dordrecht | Fortuna Sittard | 1-3 | 2.142 | Perez | 1-0 Janga, 1-1 Janssen (pen), 1-2 Hutten, 1-3 Briels; R: Vleugels (Dor) |
| 25 | 12/02/2016 | NAC Breda | MVV Maastricht | 1-1 | 14.400 | Makkelie | 0-1 Güvenç, 1-1 Suk; R: Seuntjens (NAC) |
| 25 | 12/02/2016 | RKC Waalwijk | FC Emmen | 0-1 | 1.800 | Van Herk | 0-1 Ten Voorde (pen) |
| 25 | 12/02/2016 | Jong PSV | FC Volendam | 2-2 | 601 | Otto | 0-1 Van Velzen, 0-2 Schouten, 1-2 Boljevic, 2-2 Leemans (pen) |
| 25 | 12/02/2016 | Achilles'29 | Sparta Rotterdam | 0-3 | 2.362 | Kamphuis | 0-1 Brogno, 0-2 Verhaar, 0-3 Klaasen |
| 25 | 12/02/2016 | Go Ahead Eagles | VVV Venlo | 0-3 | 8.464 | Vd Kerkhof | 0-1 en 0-2 Van Crooy, 0-3 Resida |
| 25 | 12/02/2016 | Telstar | Jong Ajax | 4-2 | 2.563 | Martens | 1-0 Tissoudali, 2-0 Ajnane, 3-0 Keurntjes, 3-1 Van Berkel (e.d.), 3-2 El Mahdioui, 4-2 Tissoudali |
| 25 | 12/02/2016 | Helmond Sport | FC Den Bosch | 0-0 | 1.773 | Berben | |
| 26 | 15/02/2016 | MVV Maastricht | Almere City FC | 0-0 | 3.470 | Gerrets | |
| 26 | 15/02/2016 | Sparta Rotterdam | Jong PSV | 1-0 | 6.455 | Vd Heuvel | 1-0 Van Moorsel |
| 26 | 15/02/2016 | FC Volendam | Helmond Sport | 2-1 | 2.500 | Higler | 1-0 Hooi, 2-0 Schouten, 2-1 Heerings |
| 26 | 15/02/2016 | FC Eindhoven | FC Oss | 4-0 | 2.000 | Blank | 1-0 Boere, 2-0 Vandeputte, 3-0 Kastaneer, 4-0 Van Hout |
| 26 | 15/02/2016 | FC Den Bosch | Achilles'29 | 1-2 | 1.000 | Kooij | 0-1 Dingil, 0-2 Popalzay, 1-2 Esajas |
| 26 | 15/02/2016 | Fortuna Sittard | Telstar | 0-3 | 711 | Bax | 0-1 Serrarens, 0-2 Lilypaly, 0-3 Keurntjes (pen) |
| 26 | 15/02/2016 | VVV Venlo | FC Dordrecht | 3-0 | 3.150 | Lindhout | 1-0 Opoku, 2-0 Van Crooy, 3-0 Gravenberch (e.d.) |
| 26 | 15/02/2016 | Jong Ajax | Go Ahead Eagles | 2-2 | 591 | C. Mulder | 0-1 Schenk, 1-1 Muric, 1-2 Van Eeuwijk, 2-2 Hendriks (pen) |
| 26 | 15/02/2016 | FC Emmen | NAC Breda | 1-0 | 3.044 | Vd Graaf | 1-0 Kolder; R: Van der Weg (NAC) |
| 27 | 19/02/2016 | Almere City FC | FC Volendam | 2-2 | 956 | Perez | 0-1 Tuyp, 0-2 Steltenpool, 1-2 Kip, 2-2 Van Amersfoort |
| 27 | 19/02/2016 | FC Dordrecht | MVV Maastricht | 1-0 | 1.541 | Blank | 1-0 Janga (pen) |
| 27 | 19/02/2016 | NAC Breda | Fortuna Sittard | 5-0 | 12.700 | Kamphuis | 1-0 Naah, 2-0 Seuntjens, 3-0 Damen, 4-0 Verbeek, 5-0 Ünal; R: Janssen (For) |
| 27 | 19/02/2016 | Jong PSV | FC Emmen | 0-0 | 550 | Gerrets | |
| 27 | 19/02/2016 | Go Ahead Eagles | RKC Waalwijk | 1-0 | 8.418 | Oostrom | 1-0 De Kogel |
| 27 | 19/02/2016 | FC Den Bosch | FC Eindhoven | 3-1 | 2.588 | Dieperink | 0-1 Kastaneer, 1-1 Slivka, 2-1 en 3-1 Zeldenrust |
| 27 | 19/02/2016 | FC Oss | Jong Ajax | 1-2 | 2.532 | Vd Vrande | 0-1 Acolatse, 0-2 Cerny, 1-2 Kamaci R: Owusu (Aja) |
| 27 | 19/02/2016 | Telstar | Sparta Rotterdam | 1-3 | 2.763 | Vd Graaf | 0-1 Brogno, 1-1 Lilypaly, 1-2 Verhaar, 1-3 Sanusi |
| 27 | 19/02/2016 | Helmond Sport | VVV Venlo | 1-4 | 2.391 | Bax | 1-0 Justiana, 1-1 Seuntjens, 1-2 en 1-3 Buwalda, 1-4 Opoku |
| 28 | 26/02/2016 | FC Emmen | Almere City FC | 5-6 | 2.618 | Bax | 0-1 Kip, 1-1 (pen) en 2-1 Kolder, 2-2 Kip, 2-3 en 2-4 Van Amersfoort, 3-4 Gyasi, 3-5 Kip, 4-5 Danso, 5-5 Deul, 5-6 Ahannach R: Ramsteijn (Alm), Streutker (Emm) |
| 28 | 26/02/2016 | RKC Waalwijk | Helmond Sport | 2-2 | 1.840 | Otto | 1-0 Thomassen, 1-1 Justiana, 2-1 Thomassen, 2-2 Markiet |
| 28 | 26/02/2016 | Achilles'29 | Jong PSV | 3-2 | 1.485 | C. Mulder | 1-0 Popalzay, 1-1 Lammers, 2-1 Thoone, 3-1 Dingil, 3-2 Lokovic |
| 28 | 26/02/2016 | FC Eindhoven | Telstar | 2-1 | 2.872 | Kamphuis | 0-1 Tissoudali, 1-1 Van den Hurk, 2-1 N'Toko |
| 28 | 26/02/2016 | Fortuna Sittard | FC Oss | 3-0 | 3.555 | Van Damme | 1-0 en 2-0 Hutten, 3-0 Van Son |
| 28 | 26/02/2016 | VVV Venlo | NAC Breda | 4-3 | 6.183 | Janssen | 0-1 Ars, 1-1 en 2-1 Haagen, 3-1 Nijholt, 3-2 Ars, 4-2 Opoku, 4-3 Haagen (e.d.) |
| 28 | 28/02/2016 | Sparta Rotterdam | Go Ahead Eagles | 3-1 | 9.395 | Nijhuis | 1-0 Breuer, 2-0 Brogno, 2-1 De Kogel, 3-1 Verhaar; R: Duits (goA) |
| 28 | 28/02/2016 | MVV Maastricht | FC Den Bosch | 1-0 | 3.879 | Manschot | 1-0 Peeters |
| 28 | 29/02/2016 | Jong Ajax | FC Dordrecht | 4-1 | 554 | Blank | 1-0 Fischer, 2-0 Muric, 3-0 Zivkovic, 4-0 Van de Beek, 4-1 Janga |
| 29 | 04/03/2016 | Almere City FC | Jong Ajax | 2-1 | 1.489 | Van Herk | 1-0 Kip (pen), 2-0 Van Amersfoort, 2-1 Zivkovic |
| 29 | 04/03/2016 | FC Dordrecht | RKC Waalwijk | 2-1 | 1.331 | Berben | 1-0 Bunjaku, 1-1 Langedijk, 1-2 Cicilia R: Lumu (Dor) |
| 29 | 04/03/2016 | NAC Breda | Achilles'29 | 3-1 | 11.600 | S. Mulder | 1-0 Van Diermen, 2-0 Ter Wielen (e.d.), 2-1 Hendriks, 3-1 Matic |
| 29 | 04/03/2016 | Go Ahead Eagles | FC Emmen | 0-0 | 8.147 | Otto | |
| 29 | 04/03/2016 | FC Oss | Sparta Rotterdam | 1-2 | 1.916 | Perez | 0-1 Bergkamp, 1-1 Vd Venne, 1-2 Verhaar (pen) |
| 29 | 04/03/2016 | Telstar | VVV Venlo | 2-2 | 1.463 | Dieperink | 1-0 Tissoudali, 1-1 Nijholt, 1-2 Opoku, 2-2 Deekman; R: Van Berkel (Tel) |
| 29 | 04/03/2016 | Helmond Sport | FC Eindhoven | 1-2 | 2.890 | Gerrets | 1-0 El Allouchi, 1-1 en 1-2 Van den Hurk R: Heerings (Hel) |
| 29 | 06/03/2016 | FC Volendam | MVV Maastricht | 0-1 | 3.250 | Oostrom | 0-1 Peeters (pen) |
| 29 | 07/03/2016 | Jong PSV | Fortuna Sittard | 0-1 | 500 | Vd Vrande | 0-1 Janssen (pen) |
| 30 | 11/03/2016 | Achilles'29 | Almere City FC | 1-3 | 1.384 | Martens | 0-1 Kip, 0-2 Ahannach, 0-3 Kip, 1-3 Van Steen; R: Salasiwa (Alm) |
| 30 | 11/03/2016 | Sparta Rotterdam | FC Emmen | 3-2 | 9.400 | Manschot | 1-0 Breuer, 1-1 Deul, 2-1 MacDonald, 2-2 Kwee, 3-2 Sanusi |
| 30 | 11/03/2016 | NAC Breda | FC Oss | 5-0 | 13.800 | Blom | 1-0 Van Diermen, 2-0 Ünal, 3-0 Ars, 4-0 Matic, 5-0 Brands |
| 30 | 11/03/2016 | RKC Waalwijk | Fortuna Sittard | 1-1 | 1.850 | Gerrets | 0-1 De Regt, 1-1 Cicilia |
| 30 | 11/03/2016 | FC Eindhoven | FC Volendam | 1-0 | 3.150 | Vd Kerkhof | 1-0 Caenepeel (pen) |
| 30 | 11/03/2016 | Go Ahead Eagles | MVV Maastricht | 0-0 | 8.176 | Bax | |
| 30 | 11/03/2016 | FC Den Bosch | FC Dordrecht | 2-0 | 2.000 | Put | 1-0 Pozder, 2-0 Carlone |
| 30 | 11/03/2016 | Jong Ajax | VVV Venlo | 2-2 | 445 | Oostrom | 1-0 Zivkovic, 1-1 Seuntjens(pen), 2-1 Zivkovic, 2-2 Hunte; R: Van Bruggen (Aja) |
| 30 | 11/03/2016 | Telstar | Jong PSV | 1-1 | 1.663 | Van Herk | 1-0 Lilipaly, 1-1 Gudmundsson R: Smiljanic (PSV) |
| 31 | 14/03/2016 | Almere City FC | Sparta Rotterdam | 1-0 | 1.648 | Higler | 1-0 Floranus (e.d) |
| 31 | 14/03/2016 | FC Volendam | Telstar | 3-0 | 3.579 | Lindhout | 1-0 Steltenpool, 2-0 Tuyp, 3-0 Essenboom |
| 31 | 14/03/2016 | FC Dordrecht | Go Ahead Eagles | 1-1 | 1.201 | Kooij | 0-1 Bunjaku (e.d.), 1-1 Janga |
| 31 | 14/03/2016 | Jong PSV | Helmond Sport | 3-1 | 550 | Dieperink | 1-0 Laursen, 2-0 Paal, 2-1 Strijbosch, 3-1 Da Silva |
| 31 | 14/03/2016 | MVV Maastricht | Jong Ajax | 0-0 | 3.841 | Otto | |
| 31 | 14/03/2016 | Fortuna Sittard | FC Eindhoven | 2-1 | 1.691 | C. Mulder | 0-1 Van den Buijs, 1-1 (pen) en 2-1 Janssen |
| 31 | 14/03/2016 | VVV Venlo | RKC Waalwijk | 4-3 | 3.515 | Perez | 0-1 Langedijk, 1-1 Van Crooy, 1-2 Thomassen, 1-3 Langedijk, 2-3 Opoku, 3-3 Seuntjens, 4-3 Opoku |
| 31 | 14/03/2016 | FC Oss | FC Den Bosch | 3-1 | 2.168 | Nijhuis | 1-0 Van der Venne, 1-1 Havar, 2-1 Van der Sluys, 3-1 Bakx3-1 |
| 31 | 14/03/2016 | FC Emmen | Achilles'29 | 3-1 | 2.640 | Vd Kerkhof | 1-0 en 2-0 Gyasi, 3-0 Ten Voorde, 3-1 Sürmeli |
| 32 | 18/03/2016 | Helmond Sport | Almere City FC | 0-2 | 1.000 | Gözübüyük | 0-1 Ahannach, 0-2 Oost; R: Cortie (Hel) |
| 32 | 18/03/2016 | Sparta Rotterdam | Fortuna Sittard | 1-1 | 7.705 | Van Boekel | 1-0 Van Moorsel, 1-1 Fafiani |
| 32 | 18/03/2016 | RKC Waalwijk | FC Volendam | 2-1 | 1.952 | Vd Vrande | 1-0 Nieuwendaal, 2-0 Langedijk, 2-1 Steltenpool |
| 32 | 18/03/2016 | FC Eindhoven | VVV Venlo | 2-0 | 3.168 | Martens` | 1-0 Caenepeel, 2-0 Vandeputte |
| 32 | 18/03/2016 | Go Ahead Eagles | FC Oss | 5-0 | 8.300 | Blank | 1-0 Duits, 2-0 en 3-0 Ten Den, 4-0 en 5-0 De Kogel |
| 32 | 18/03/2016 | FC Den Bosch | NAC Breda | 3-6 | 4.167 | Bax | 1-0 en 2-0 Biemans, 2-1 Ünal, 2-2 Ars (pen), 2-3 Ünal, 3-3 Pozder, 3-4 Ars (pen), 3-5 Seuntjens, 3-6 Heemskerk (e.d.) R: Havar (DBo) |
| 32 | 18/03/2016 | Jong Ajax | Jong PSV | 1-2 | 642 | Perez | 1-0 De Jong, 1-1 De Wijs, 1-2 Koch |
| 32 | 18/03/2016 | Telstar | FC Dordrecht | 3-0 | 1.463 | Mulder | 1-0 en 2-0 Tissoudali, 3-0 Van den Broek |
| 32 | 20/03/2016 | Achilles'29 | MVV Maastricht | 1-2 | 1.000 | Kooij | 0-1 en 0-2 Peeters, 1-2 Thoone R: Martina (MVV) |
| 33 | 01/04/2016 | Almere City FC | Go Ahead Eagles | 3-4 | 2.100 | Kamphuis | 1-0 Kip, 1-1 Schenk, 1-2 Wolters, 1-3 De Kogel, 2-3 Kip (pen), 2-4 ten Den, 3-4 Rosario R: Maatsen (GoA) |
| 33 | 01/04/2016 | Sparta Rotterdam | NAC Breda | 1-1 | 10.599 | Janssen | 0-1 Ars, 1-1 Sanusi |
| 33 | 01/04/2016 | FC Dordrecht | Helmond Sport | 0-2 | 1.224 | Manschot | 0-1 Markiet, 0-2 El Allouchi (pen) |
| 33 | 01/04/2016 | RKC Waalwijk | FC Eindhoven | 1-2 | 2.200 | Bax | 0-1 en 0-2 Kastaneer, 1-2 Langedijk (pen) |
| 33 | 01/04/2016 | Achilles'29 | Telstar | 1-3 | 1.000 | Gerrets | 0-1 Serrarens, 0-2 Ajnane, 0-3 Serrarens (pen), 1-3 Boogers |
| 33 | 01/04/2016 | Fortuna Sittard | Jong Ajax | 1-2 | 1.962 | Berben | 1-0 Van Son, 1-1 Muric, 1-2 Cerny |
| 33 | 01/04/2016 | VVV Venlo | FC Den Bosch | 2-1 | 4.200 | Vink | 1-0 Paulissen, 2-0 Van Crooy, 2-1 Khalouta R: Haagen (VVV) |
| 33 | 01/04/2016 | FC Emmen | FC Volendam | 1-0 | 3.523 | Dieperink | 1-0 Ten Voorde |
| 33 | 04/04/2016 | Jong PSV | FC Oss | 3-1 | 369 | Vdrboomen | 1-0 en 2-0 Bergwijn, 3-0 Koch, 3-1 Zschuschen |
| 34 | 08/04/2016 | FC Oss | Almere City FC | 1-2 | 1.822 | Bax | 0-1 Boldewijn, 0-2 Oost, 1-2 Schet |
| 34 | 08/04/2016 | FC Volendam | Achilles'29 | 0-0 | 3.500 | Oostrom | |
| 34 | 08/04/2016 | FC Dordrecht | Jong PSV | 4-0 | 1.223 | Gerrets | 1-0 en 2-0 Janga, 3-0 Bijl, 4-0 Daniëls |
| 34 | 08/04/2016 | NAC Breda | RKC Waalwijk | 1-1 | 15.150 | Kooij | 0-1 Van Arnhem, 1-1 Ars R: Nieuwendaal, Verkoelen (RKC) |
| 34 | 08/04/2016 | MVV Maastricht | VVV Venlo | 1-3 | 5.103 | Vd Graaf | 0-1 en 0-2 Seuntjens, 1-2 Croux, 1-3 Van Crooy |
| 34 | 08/04/2016 | FC Eindhoven | Go Ahead Eagles | 0-0 | 3.100 | Perez | |
| 34 | 08/04/2016 | FC Den Bosch | Telstar | 5-0 | 3.279 | Dieperink | 1-0 Khalouta, 2-0 Boddaert, 3-0 Vossebelt, 4-0 Slivka, 5-0 Zeldenrust |
| 34 | 08/04/2016 | Jong Ajax | FC Emmen | 2-0 | 423 | Vd Vrande | 1-0 Zivkovic, 2-0 Hendriks; R: Rozema (Hee) |
| 34 | 08/04/2016 | Helmond Sport | Sparta Rotterdam | 1-1 | 3.654 | Makkelie | 1-0 Kerk, 1-1 Brogno |
| 35 | 11/04/2016 | Almere City FC | FC Dordrecht | 3-0 | 1.222 | Liesveld | 1-0 Rosario, 2-0 Boldewijn, 3-0 Kip |
| 35 | 11/04/2016 | Sparta Rotterdam | Jong Ajax | 3-1 | 11.000 | Lindhout | 1-0 Brogno, 1-1 Sinkgraven, 2-1 Breuer, 3-1 MacDonald |
| 35 | 11/04/2016 | RKC Waalwijk | FC Oss | 3-2 | 2.000 | Berben | 1-0 Anderson, 2-0 Thomassen, 2-1 Van Eijma, 2-2 Bakx, 3-2 Van Weert |
| 35 | 11/04/2016 | Jong PSV | FC Den Bosch | 2-1 | 350 | Martens | 1-0 Leemans, 1-1 Khalouta, 2-1 Maher |
| 35 | 11/04/2016 | Achilles'29 | Helmond Sport | 1-2 | Blank | 1-0 Van de Beek, 1-1 Kerk, 1-2 Edwards R: Van de Beek (Ach) |
|
| 35 | 11/04/2016 | Go Ahead Eagles | FC Volendam | 3-2 | 7.583 | Vd Kerkhof | 1-0 De Kogel, 1-1 Van Kippersluis, 2-1 Van Ewijk, 2-2 Laghmouchi, 3-2 Teijsse |
| 35 | 11/04/2016 | Fortuna Sittard | MVV Maastricht | 1-2 | 3.813 | Van Boekel | 0-1 Nys, 1-1 De Regt, 1-2 Werker |
| 35 | 11/04/2016 | Telstar | NAC Breda | 1-4 | 1.763 | Higler | 0-1 Ünal, 1-1 Tissoudali, 1-2 en 1-3 Ünal, 1-4 Suk |
| 35 | 11/04/2016 | FC Emmen | FC Eindhoven | 4-2 | 2.840 | S. Mulder | 1-0 Olijve, 1-1 Van den Hurk, 2-1 Danso, 3-1 Gyasi, 4-1 Danso, 4-2 Mitrovic (pen) |
| 36 | 15/04/2016 | FC Den Bosch | Almere City FC | 1-2 | 1.250 | Gerrets | 0-1 Nieuwpoort, 0-2 Oost, 1-2 Biemans |
| 36 | 15/04/2016 | FC Volendam | Sparta Rotterdam | 2-0 | 3.500 | Kamphuis | 1-0 Hilterman, 2-0 Steltenpool |
| 36 | 15/04/2016 | NAC Breda | Jong PSV | 5-2 | 14.500 | Blank | 1-0 Seuntjens, 2-0 Loof (e.d.), 3-0 Ars, 3-1 Boljevic, 3-2 Leemans, 4-2 Seuntjens, 5-2 Loof (e.d.) |
| 36 | 15/04/2016 | MVV Maastricht | FC Emmen | 4-1 | 4.272 | Van Herk | 1-0 Güvenç, 1-1 Deul, 2-1 Verheijdt, 3-1 Peeters (pen), 3-1 Güvenç |
| 36 | 15/04/2016 | FC Eindhoven | Achilles'29 | 0-1 | 2.735 | Mulder | 0-1 Beijer |
| 36 | 15/04/2016 | VVV Venlo | Fortuna Sittard | 4-1 | 4.411 | D'Hondt | 1-0 Opoku, 2-0 Resida, 3-0 Hunte, 3-1 Loen, 4-1 Promes |
| 36 | 15/04/2016 | Jong Ajax | RKC Waalwijk | 0-0 | 283 | Oostrom | |
| 36 | 15/04/2016 | FC Oss | Telstar | 3-3 | 750 | Vd Vrande | 0-1 Zschusschen, 1-1 Maletic, 1-2 Tissoudali, 1-3 Serrarens, 2-3 Stuy vd Herik, 3-3 Kamaci |
| 36 | 15/04/2016 | Helmond Sport | Go Ahead Eagles | 0-4 | 1.000 | Kooij | 0-1 en 0-2 Teijsse, 0-3 en 0-4 Maatsen |
| 37 | 22/04/2016 | MVV Maastricht | Sparta | 1-3 | 4.602 | Kooij | 1-0 Croux, 1-1 Van Drongelen, 1-2 en 1-3 Verhaar |
| 37 | 22/04/2016 | Jong PSV | FC Eindhoven | 2-0 | 900 | Berben | 1-0 en 2-0 Cmiljanic |
| 37 | 22/04/2016 | NAC Breda | Almere City FC | 1-1 | 14.240 | Dieperink | 1-0 Ünal, 1-1 Ahannach |
| 37 | 22/04/2016 | FC Dordrecht | Achilles '29 | 3-3 | 1.232 | Perez | 1-0 Bijl, 1-1 Boogers, 1-2 Popalzay, 2-2 Janga, 2-3 Poalzay, 3-3 Janga |
| 37 | 22/04/2016 | FC Volendam | Jong Ajax | 1-1 | 3.500 | Van Herk | 0-1 Nouri, 1-1 Hooi |
| 37 | 22/04/2016 | Helmond Sport | FC Oss | 4-0 | 1.489 | C. Mulder | 1-0 Edwards, 2-0 Justiana, 3-0 El Allouchi, 4-0 Van de Sande |
| 37 | 22/04/2016 | VVV Venlo | FC Emmen | 1-0 | 3.552 | Bax | 1-0 Opoku |
| 37 | 22/04/2016 | Fortuna Sittard | Go Ahead Eagles | 0-1 | 1.666 | Oostrom | 0-1 De Kogel |
| 37 | 22/04/2016 | FC Den Bosch | RKC Waalwijk | 1-1 | 3.000 | Vd Vrande | 1-0 Yildirim, 1-1 Khalouta |
| 38 | 29/04/2016 | FC Emmen | Fortuna Sittard | 1-2 | 4.032 | Gerrets | 1-0 Danso, 1-1 en 1-2 Hutten |
| 38 | 29/04/2016 | Telstar | Helmond Sport | 1-0 | 2.602 | Oostrom | 1-0 Lilipaly |
| 38 | 29/04/2016 | Almere City FC | Jong PSV | 7-0 | 2.197 | Kooij | 1-0 Ahannach, 2-0 (p) en 3-0 Oost, 4-0 Kip (p), 5-0 en 6-0 Van der Water, 7-0 Ahannach R: Rommens, De Wijs (PSV) |
| 38 | 29/04/2016 | FC Oss | FC Volendam | 1-2 | 1.250 | Vd Graaf | 1-0 Van der Venne, 1-1 Tuyp, 1-2 Hooi |
| 38 | 29/04/2016 | Jong Ajax | FC Den Bosch | 3-1 | 473 | Blank | 1-0 Zivkovic, 1-1 Van der Sande, 2-1 Hendriks, 3-1 Van de Beek |
| 38 | 29/04/2016 | Go Ahead Eagles | NAC Breda | 3-1 | 9.306 | Wiedemeijer | 1-0 Maatsen, 2-0 en 3-0 De Kogel, 3-1 Van der Weg, 4-1 Van Overbeek |
| 38 | 29/04/2016 | Achilles '29 | VVV Venlo | 1-3 | 1.250 | Liesveld | 0-1 Seuntjens, 0-2 Paulissen, 0-3 Seuntjens, 1-3 Van de Groes |
| 38 | 29/04/2016 | RKC Waalwijk | MVV Maastricht | 1-3 | 2.000 | S. Mulder | 0-1 Fernandes, 0-2 Nys, 1-2 Langedijk, 1-3 Polizzi; R: Coster (RKC) |
| 38 | 29/04/2016 | Sparta | FC Dordrecht | 2-3 | 7.888 | Van Boekel | 0-1 Janga, 0-2 Daniëls, 1-2 Spierings, 2-2 Sanusi, 2-3 Fortes |
Play-offs voor promotie/degradatie
| 1e ronde | ||||||
| 02/05/2016 | Almere City FC | FC Emmen | 4-1 | 2.200 | Vd Kerkhof | 1-0 Kip, 2-0 Ahannach, 2-1 Van Buuren (e.d.), 3-1 Boldewijn, 4-1 Ahannach |
| 02/05/2016 | MVV Maastricht | FC Volendam | 2-1 | 4.362 | Lindhout | 1-0 Peeters, 1-1 Van Kippersluis (pen), 2-1 Werker |
| 06/05/2016 | FC Emmen | Almere City FC | 1-4 | 2.580 | Manschot | 1-0 Danso, 1-1, 1-2 en 1-3 Oost, 1-4 Ahannach; R: Siekman (Emm) |
| 06/05/2016 | FC Volendam | MVV Maastricht | 1-2 | 3.590 | Nijhuis | 0-1 en 0-2 Croux, 1-2 Van Kippersluis |
| 2e ronde | ||||||
| 13/05/2016 | MVV Maastricht | De Graafschap | 0-1 | 7.753 | Makkelie | 0-1 Smeets |
| 13/05/2016 | Go Ahead Eagles | VVV-Venlo | 1-0 | 10.000 | Vd Graaf | 1-0 De Kogel (pen); R: Rutten (VVV) |
| 13/05/2016 | FC Eindhoven | NAC Breda | 1-0 | 4.711 | S. Mulder | 1-0 Kastaneer |
| 13/05/2016 | Almere City FC | Willem II | 0-1 | 3.200 | Lindhout | 0-1 Falkenburg; R: Wuytens (Wil) |
| 16/05/2016 | De Graafschap | MVV Maastricht | 2-1 | 11.306 | S. Mulder | 0-1 Nys, 1-1 Vida, 2-1 Tarfi |
| 16/05/2016 | VVV-Venlo | Go Ahead Eagles | 2-2 | 6.799 | Vink | 0-1 De Kogel, 1-1 Seuntjens (pen), 2-1 Nijholt, 2-2 Wolters |
| 16/05/2016 | NAC Breda | FC Eindhoven | 2-0 | 17.400 | Manschot | 1-0 Matic, 2-0 Ars; R: Ünal, Stam (NAC) |
| 16/05/2016 | Willem II | Almere City FC | 5-2 | 12.250 | Nijhuis | 1-0 Andersen, 2-0 Peters, 2-1 Kip, 3-1 Falkenburg, 4-1 en 5-1 Andersen, 5-2 Van Amersfoort |
| 3e ronde | ||||||
| 19/05/2016 | NAC Breda | Willem II | 2-1 | 17.500 | Higler | 0-1 Hupperts, 1-1 Brands, 2-1 Seuntjens |
| 19/05/2016 | Go Ahead Eagles | De Graafschap | 4-1 | 9.689 | Nijhuis | 1-0 Wolters, 2-0 Duits (pen), 2-1 Bannink, 3-1 Teijsse, 4-1 Wolters; R: Van de Pavert (Gra) |
| 22/05/2016 | Willem II | NAC Breda | 3-1 | 13.800 | Makkelie | 1-0 Heerkens, 2-0 en 3-0 Falkenburg, 3-1 Naah |
| 22/05/2016 | De Graafschap | Go Ahead Eagles | 1-1 | 12.381 | Blom | 1-0 Parzyszek, 1-1 De Kogel |
Willem II handhaaft zich, De Graafschap gedegradeerd, Go Ahead Eagles gepromoveerd
Topscorers
| 1 | Ralf Seuntjens | VVV-Venlo | 28 |
| 2 | Leon de Kogel | Go Ahead Eagles | 25 |
| 3 | Thomas Verhaar | Sparta Rotterdam | 24 |
| 4 | Sjoerd Ars | NAC Breda | 21 |
| Rangelo Janga | FC Dordrecht | 21 | |
| 6 | Tarik Tissoudali | Telstar | 19 |
| 7 | Loris Brogno | Sparta Rotterdam | 16 |
| 8 | Jinty Caenepeel | FC Eindhoven | 15 |
| Ricardo Kip | Almere City FC | 15 | |
| 10 | Erixon Danso | FC Emmen | 14 |
| Sam Hendriks | Jong Ajax | 14 |