Het seizoen 2017-2018 wordt uiteindelijk het jaar van de wederopstanding van Fortuna Sittard. Na de degradatie uit de Eredivisie in 2001 ging de club door diepe dalen, hing het voortbestaan regelmatig aan een zijden draadje, maar keert het dit jaar terug aan de top met promotie als gevolg. Dat het kampioenschap uiteindelijk niet wordt behaald (dat gaat naar de beloften van Ajax) is uiteindelijk niet meer dan een voetnootje bij de feestvreugde.
Daarnaast is er nog een heuse primeur met de promotie van FC Emmen via de nacompetitie. Sinds de entree in de Eerste Divisie in 1985, lukte het nooit om te promoveren, maar verrassenderwijs lukt het dit jaar wel, door in de play-offs NEC en Sparta te verslaan. Een derde grote stunt – promotie van Almere City – zit er net niet in. De laatste promotieplek gaat naar De Graafschap, de club die de heen en veer van FC Volendam heeft overgenomen.
Onderin wil het nog altijd niet vlotten met de doorstroom tussen Eerste en Tweede Divisie. In het najaar wordt besloten promotie- en degradatie maar weer eens op te schorten, omdat de KNVB en de clubs het niet eens kunnen worden over de voorwaarden, waaronder dat moet gebeurden. In het rechterrijtje gaat de competitie daarom wederom als een nachtkaars uit.
Uitslagenmatrix
| ALM | CAM | DBO | DOR | EIN | EMM | FOR | GOA | GRA | HEL | AJA | JAZ | PSV | UTR | MVV | NEC | OSS | RKC | TEL | VOL | |
| Almere City FC | * | 1-1 | 1-1 | 1-2 | 5-1 | 2-2 | 1-4 | 2-0 | 2-1 | 3-1 | 1-2 | 3-2 | 2-1 | 2-1 | 3-2 | 3-2 | 2-2 | 3-2 | 2-3 | 2-0 |
| SC Cambuur | 2-1 | * | 2-2 | 3-0 | 3-2 | 1-1 | 1-0 | 2-1 | 3-2 | 4-1 | 1-2 | 3-2 | 0-1 | 2-2 | 0-2 | 1-1 | 1-3 | 1-1 | 2-1 | 2-2 |
| FC Den Bosch | 1-3 | 1-2 | * | 4-1 | 4-0 | 1-2 | 2-4 | 3-0 | 1-1 | 2-2 | 2-5 | 1-3 | 5-0 | 1-0 | 2-1 | 3-0 | 0-0 | 0-0 | 3-2 | 3-1 |
| FC Dordrecht | 1-1 | 0-3 | 0-3 | * | 4-3 | 2-2 | 3-0 | 1-2 | 1-1 | 3-2 | 2-3 | 3-2 | 2-3 | 2-1 | 2-4 | 3-3 | 2-0 | 1-0 | 2-3 | 2-2 |
| FC Eindhoven | 3-2 | 2-1 | 0-1 | 0-1 | * | 2-1 | 1-3 | 3-2 | 2-4 | 3-2 | 2-3 | 1-3 | 1-2 | 5-2 | 3-2 | 3-2 | 1-3 | 3-1 | 2-2 | 1-0 |
| FC Emmen | 2-2 | 2-0 | 2-2 | 1-3 | 1-1 | * | 0-0 | 0-0 | 5-2 | 0-0 | 2-2 | 0-2 | 3-1 | 0-0 | 2-1 | 1-0 | 1-1 | 2-1 | 2-3 | 2-3 |
| Fortuna Sittard | 2-1 | 3-2 | 2-0 | 5-1 | 2-2 | 1-2 | * | 2-1 | 1-1 | 3-0 | 2-1 | 5-1 | 1-0 | 3-1 | 3-0 | 1-2 | 4-0 | 6-0 | 1-1 | 1-0 |
| Go Ahead Eagles | 2-1 | 1-3 | 1-2 | 0-3 | 1-3 | 0-1 | 0-1 | * | 0-4 | 3-1 | 4-1 | 2-1 | 1-1 | 0-0 | 3-1 | 1-1 | 2-1 | 0-0 | 1-1 | 1-1 |
| De Graafschap | 4-2 | 2-0 | 2-1 | 0-1 | 4-0 | 2-2 | 2-0 | 1-1 | * | 1-0 | 2-4 | 1-0 | 2-3 | 7-0 | 1-2 | 1-3 | 1-1 | 1-0 | 1-0 | 2-1 |
| Helmond Sport | 1-2 | 3-0 | 3-1 | 1-2 | 0-0 | 3-1 | 1-3 | 1-1 | 0-2 | * | 1-4 | 3-0 | 1-2 | 2-0 | 2-3 | 1-2 | 2-1 | 2-2 | 1-2 | 1-4 |
| Jong Ajax | 3-0 | 3-2 | 1-0 | 3-0 | 4-0 | 3-2 | 4-2 | 0-2 | 0-5 | 2-0 | * | 0-1 | 0-3 | 2-1 | 2-1 | 1-0 | 2-0 | 1-1 | 1-1 | 7-0 |
| Jong AZ | 4-1 | 0-1 | 1-1 | 3-1 | 1-2 | 2-1 | 2-0 | 0-0 | 2-2 | 1-3 | 4-2 | * | 2-1 | 1-3 | 3-1 | 2-7 | 3-1 | 2-1 | 2-2 | 0-2 |
| Jong PSV | 3-2 | 1-1 | 2-1 | 4-2 | 4-1 | 1-1 | 2-3 | 6-0 | 2-2 | 1-2 | 0-3 | 1-2 | * | 2-0 | 1-0 | 3-3 | 5-1 | 3-2 | 6-0 | 2-1 |
| Jong Utrecht | 2-4 | 1-3 | 1-1 | 0-2 | 1-2 | 1-2 | 0-1 | 1-0 | 1-4 | 0-0 | 2-1 | 1-0 | 1-4 | * | 2-1 | 0-2 | 0-3 | 5-2 | 0-1 | 2-1 |
| MVV Maastricht | 3-0 | 1-1 | 3-0 | 1-0 | 2-0 | 0-1 | 1-2 | 4-3 | 1-3 | 3-1 | 0-4 | 3-0 | 0-0 | 3-1 | * | 4-1 | 1-1 | 0-0 | 0-0 | 2-1 |
| NEC | 3-1 | 3-1 | 1-0 | 6-0 | 2-1 | 1-1 | 1-1 | 5-1 | 1-1 | 1-1 | 2-1 | 2-0 | 2-0 | 3-1 | 4-1 | * | 2-1 | 2-0 | 3-0 | 3-0 |
| FC Oss | 5-1 | 2-1 | 1-1 | 3-1 | 1-1 | 2-3 | 1-2 | 1-6 | 1-4 | 0-0 | 0-3 | 2-1 | 0-3 | 2-0 | 1-0 | 3-0 | * | 3-1 | 0-0 | 1-0 |
| RKC Waalwijk | 0-4 | 0-0 | 1-1 | 1-0 | 0-1 | 0-2 | 1-1 | 2-1 | 0-0 | 1-0 | 2-4 | 1-0 | 3-2 | 2-2 | 1-1 | 0-2 | 2-1 | * | 4-1 | 1-3 |
| Telstar | 4-0 | 0-1 | 3-2 | 3-0 | 4-1 | 0-0 | 0-6 | 3-1 | 3-2 | 2-3 | 3-3 | 2-1 | 0-0 | 1-0 | 0-0 | 3-2 | 3-3 | 0-0 | * | 5-2 |
| FC Volendam | 1-1 | 0-1 | 1-0 | 4-1 | 3-2 | 2-3 | 2-0 | 4-3 | 0-0 | 2-2 | 1-2 | 4-1 | 1-0 | 2-1 | 2-2 | 0-2 | 3-1 | 0-1 | 3-4 | * |
Eindstand
| 1 | Jong Ajax * | 38 | 25 | 4 | 9 | 79 | 89 | 54 | +35 | 951 |
| 2 | Fortuna Sittard ♦ | 38 | 24 | 6 | 8 | 78 | 81 | 41 | +40 | 4.851 |
| 3 | NEC + | 38 | 22 | 8 | 8 | 74 | 82 | 46 | +36 | 9.636 |
| 4 | De Graafschap + ♦ | 38 | 18 | 11 | 9 | 65 | 78 | 47 | +31 | 8.387 |
| 5 | Jong PSV | 38 | 19 | 7 | 12 | 64 | 76 | 54 | +22 | 644 |
| 6 | Telstar + | 38 | 16 | 13 | 9 | 61 | 66 | 63 | +3 | 2.753 |
| 7 | FC Emmen + ♦ | 38 | 14 | 16 | 8 | 58 | 58 | 50 | +8 | 3.112 |
| 8 | SC Cambuur + | 38 | 16 | 10 | 12 | 58 | 58 | 53 | +5 | 7.286 |
| 9 | Almere City FC + | 38 | 15 | 7 | 16 | 52 | 70 | 76 | -6 | 1.648 |
| 10 | MVV Maastricht + | 38 | 14 | 8 | 16 | 50 | 57 | 56 | +1 | 4.857 |
| 11 | FC Den Bosch | 38 | 12 | 11 | 15 | 47 | 59 | 55 | +4 | 2.790 |
| 12 | FC Eindhoven | 38 | 14 | 5 | 19 | 47 | 61 | 83 | _22 | 2.227 |
| 13 | FC Dordrecht + | 38 | 14 | 5 | 19 | 47 | 57 | 81 | -24 | 1.543 |
| 14 | FC Volendam | 38 | 13 | 7 | 18 | 46 | 59 | 67 | -8 | 2.836 |
| 15 | FC Oss | 38 | 12 | 10 | 16 | 46 | 53 | 65 | -12 | 1.991 |
| 16 | Jong AZ | 38 | 14 | 4 | 20 | 46 | 57 | 70 | -13 | 691 |
| 17 | Go Ahead Eagles | 38 | 9 | 10 | 19 | 37 | 48 | 68 | -20 | 6.901 |
| 18 | RKC Waalwijk | 38 | 8 | 13 | 17 | 37 | 37 | 61 | -24 | 2.143 |
| 19 | Helmond Sport | 38 | 9 | 9 | 20 | 36 | 50 | 67 | -17 | 1.649 |
| 20 | Jong FC Utrecht | 38 | 7 | 6 | 25 | 27 | 37 | 76 | -39 | 679 |
Wedstrijden
| R: | Datum: | Thuis: | Uit: | Sc.: | Ts.: | Ar.: | Details: |
|---|---|---|---|---|---|---|---|
| 1 | 18/08/2017 | SC Cambuur | Jong Ajax | 1-2 | 7.334 | Blank | 0-1 Sidioel, 0-2 Cassierra, 1-2 Steenvoorden R: Peersman (Cam) |
| 1 | 18/08/2017 | FC Volendam | Helmond Sport | 2-2 | 2.581 | Bax | 1-0 Runderkamp, 2-0 Ten Den, 2-1 Naudts, 2-2 Janzen |
| 1 | 18/08/2017 | RKC Waalwijk | FC Emmen | 0-2 | 1.931 | Vd Kerkhof | 0-1 Peters (pen), 0-2 Loen |
| 1 | 18/08/2017 | MVV Maastricht | Go Ahead Eagles | 4-3 | 4.915 | Manschot | 0-1 Hendriks, 1-1 Janssen, 1-2 Hendriks, 2-2 Okita, 2-3 Langedijk, 3-3 Ogunjimi, 4-3 Okita |
| 1 | 18/08/2017 | FC Eindhoven | Telstar | 2-2 | 2.408 | Van Herk | 0-1 Júnior, 1-1 Kabangu, 1-2 Rodrigues, 2-2 Kabangu; R: Platje (Tel) |
| 1 | 18/08/2017 | FC Den Bosch | Jong AZ | 1-3 | 2.882 | Oostrom | 1-0 Mert, 1-1 El Hasnaoui, 1-2 Helmer (pen), 1-3 Einarsson |
| 1 | 18/08/2017 | Fortuna Sittard | FC Dordrecht | 5-1 | 3.165 | Perez | 1-0 Semedo, 2-0 en 3-0 Stokkers, 3-1 Hamer, 4-1 Vidigal, 5-1 Askovski; R: V. Wermeskerken (Dor) |
| 1 | 18/08/2017 | NEC | Almere City FC | 3-1 | 9.502 | Janssen | 1-0 Larsson, 1-1 Valpoort, 2-1 Groeneveld, 3-1 Larsson |
| 1 | 21/08/2017 | Jong FC Utrecht | FC Oss | 0-3 | 892 | Gerrets | 0-1 Quekel, 0-2 Van der Venne, 0-3 Kamaci |
| 1 | 21/08/2017 | Jong PSV | De Graafschap | 2-2 | 1.104 | Mulder | 0-1 Serrarens, 1-1 Van Vlerken, 2-1 De Wijs, 2-2 Van den Hurk |
| 2 | 25/08/2017 | FC Dordrecht | Jong FC Utrecht | 2-1 | 1.203 | Kooij | 1-0 Mutzers, 2-0 Mahmudov (pen), 2-1 Hilterman |
| 2 | 25/08/2017 | Go Ahead Eagles | NEC | 1-1 | 8.324 | S. Mulder | 0-1 Braken, 1-1 Hendriks |
| 2 | 25/08/2017 | De Graafschap | SC Cambuur | 2-0 | 8.014 | Vd Graaf | 1-0 Serrarens, 2-0 Van Mieghem |
| 2 | 25/08/2017 | Jong Ajax | Fortuna Sittard | 4-2 | 799 | Dieperink | 1-0 Cassierra, 2-0 en 3-0 Muric, 3-1 Schuurs, 3-2 Semedo, 4-2 Johnsen |
| 2 | 25/08/2017 | FC Oss | FC Volendam | 1-0 | 1.455 | Vd Eijk | 1-0 Van Pol |
| 2 | 25/08/2017 | Almere City FC | FC Den Bosch | 1-1 | 1.500 | Lindhout | 1-0 Salasiwa, 1-1 Blummel |
| 2 | 25/08/2017 | Telstar | MVV Maastricht | 0-0 | 1.400 | Perez | |
| 2 | 25/08/2017 | Helmond Sport | Jong PSV | 1-2 | 2.211 | Van Herk | 1-0 Zeldenrust, 1-1 en 1-2 Laursen |
| 2 | 25/08/2017 | FC Emmen | FC Eindhoven | 1-1 | 2.540 | Bax | 0-1 Lieder, 1-1 Bakker |
| 2 | 25/08/2017 | Jong AZ | RKC Waalwijk | 2-1 | 1.000 | Martens | 1-0 Jacobs, 1-1 De Graauw, 2-1 Helmer |
| 3 | 01/09/2017 | Jong FC Utrecht | Jong AZ | 1-0 | 533 | Van Herk | 1-0 Hatzidiakos (e.d.) |
| 3 | 01/09/2017 | FC Dordrecht | FC Emmen | 2-2 | 1.375 | Vd Eijk | 0-1 Siekman, 1-1 Calcan, 2-1 Mutzers, 2-2 Loen |
| 3 | 01/09/2017 | Jong PSV | Jong Ajax | 0-3 | 2.278 | Oostrom | 0-1 Cassiera, 0-2 Neres, 0-3 Flemming |
| 3 | 01/09/2017 | MVV Maastricht | FC Den Bosch | 3-0 | 4.987 | Vd Graaf | 1-0 Okita, 2-0 Nys, 3-0 Yildirim |
| 3 | 01/09/2017 | Fortuna Sittard | Almere City FC | 2-1 | 3.162 | Bax | 1-0 en 2-0 Askovski, 3-0 Valpoort |
| 3 | 01/09/2017 | NEC | FC Eindhoven | 2-1 | 8.489 | Lindhout | 1-0 Braken, 1-1 De Silva, 2-1 Braken |
| 3 | 01/09/2017 | Telstar | FC Oss | 3-3 | 1.963 | C. Mulder | 0-1 Van der Venne, 0-2 Bax, 1-3, 2-3 en 3-3 Hamdaoui, 3-3 Schouten (e.d.) |
| 3 | 01/09/2017 | Helmond Sport | Go Ahead Eagles | 1-1 | 1.993 | Vd Kerkhof | 0-1 De Kogel, 1-1 Thomassen |
| 3 | 02/09/2017 | RKC Waalwijk | De Graafschap | 0-0 | 1.948 | Gerrets | R: Receveur (Gra) |
| 3 | 03/09/2017 | FC Volendam | SC Cambuur | 0-1 | 3.259 | Manschot | 0-1 Houtkoop |
| 4 | 08/09/2017 | SC Cambuur | Jong FC Utrecht | 2-2 | 6.732 | Oostrom | 1-0 Daniels, 1-1 Venema, 2-1 Steenvoorden, 2-2 Peijnenburg; R: Schils (Cam), Ould Chikh (Utr, |
| 4 | 08/09/2017 | FC Eindhoven | Jong PSV | 1-2 | 2.700 | Vd Eijk | 0-1 Lammers, 1-1 Lieder, 1-2 Junior |
| 4 | 08/09/2017 | Go Ahead Eagles | FC Volendam | 1-1 | 7.331 | Van Boekel | 1-0 Beltrame, 1-1 Ten Den |
| 4 | 08/09/2017 | FC Den Bosch | NEC | 3-0 | 3.188 | Kamphuis | 1-0 Kaars, 2-0 Vossebelt, 3-0 Mert |
| 4 | 08/09/2017 | De Graafschap | MVV Maastricht | 1-2 | 8.023 | Vd Kerkhof | 0-1 Badnarek (e.d.), 0-2 Mmaee, 1-2 Diemers |
| 4 | 08/09/2017 | FC Oss | FC Dordrecht | 3-1 | 1.881 | Dieperink | 0-1 Mahmudov, 1-1 Kamaci, 2-1 Van der Venne, 3-1 Kamaci; R: Hamer (Dor) |
| 4 | 08/09/2017 | Almere City FC | Helmond Sport | 3-1 | 1.300 | Martens | 1-0 Mirani, 2-0 en 3-0 Valpoort, 3-1 Zeldenrust (pen) |
| 4 | 08/09/2017 | FC Emmen | Fortuna Sittard | 0-0 | 2.267 | C. Mulder | R: Peters |
| 4 | 11/09/2017 | Jong Ajax | RKC Waalwijk | 1-1 | 703 | Perez | 1-0 Eiting, 1-1 Drost |
| 4 | 12/09/2017 | Jong AZ | Telstar | 2-2 | 1.647 | Kooij | 1-0 Koopmeiners, 1-1 Novakovich, 2-1 Friday, 2-2 Van Iperen |
| 5 | 15/09/2017 | Jong FC Utrecht | De Graafschap | 1-4 | 660 | Dieperink | 1-0 Venema, 1-1 Van Mieghem, 1-2 Ars, 1-3 Diemers, 1-4 Van den Hurk |
| 5 | 15/09/2017 | FC Dordrecht | Almere City FC | 1-1 | 1.403 | Oostrom | 1-0 Calcan, 1-1 Valpoort |
| 5 | 15/09/2017 | RKC Waalwijk | FC Eindhoven | 0-1 | 1.987 | Vd Graaf | 0-1 Carlone |
| 5 | 15/09/2017 | MVV Maastricht | Jong PSV | 0-0 | 5.083 | Bax | |
| 5 | 15/09/2017 | Go Ahead Eagles | SC Cambuur | 3-1 | 7.859 | Janssen | 0-1 Matieu, 1-1 Hendriks, 2-1 Rossi, 3-1 Barto |
| 5 | 15/09/2017 | Fortuna Sittard | FC Volendam | 1-0 | 2.750 | Martens | 1-0 Ospitalieri |
| 5 | 15/09/2017 | NEC | FC Emmen | 1-1 | 9.550 | Blom | 1-0 Schuurman, 1-1 Bakker |
| 5 | 15/09/2017 | Telstar | FC Den Bosch | 3-2 | 1.815 | Vd Eijk | 1-0 Rodrigues, 1-1 Blummel, 2-1 Platje, 2-2 Kaars, 3-2 Novakovich |
| 5 | 15/09/2017 | Helmond Sport | Jong Ajax | 1-4 | 1.911 | Gerrets | 0-1 Eiting, 1-1 Zeldenrust (pen), 1-2 en 1-3 Cassierra, 1-4 Johnsen |
| 6 | 22/09/2017 | FC Volendam | De Graafschap | 0-0 | 3.202 | Bax | |
| 6 | 22/09/2017 | RKC Waalwijk | Jong FC Utrecht | 2-2 | 1.339 | Blank | 1-0 Rienstra, 1-1 Sow, 2-1 Bergkamp, 2-2 Loukili |
| 6 | 22/09/2017 | MVV Maastricht | SC Cambuur | 1-1 | 4.903 | Higler | 1-0 Okita, 1-1 Barto; R: Pereira (MVV) |
| 6 | 22/09/2017 | FC Eindhoven | FC Den Bosch | 0-1 | 2.263 | d'Hondt | 0-1 Blummel |
| 6 | 22/09/2017 | Fortuna Sittard | Jong AZ | 5-1 | 2.822 | Gerrets | 1-0 en 2-0 (pen) Dianessy, 2-1 Reijnders, 3-1 Semedo, 4-1 Schuurs, 5-1 Semedo |
| 6 | 22/09/2017 | Almere City FC | FC Oss | 2-2 | 1.000 | Perez | 0-1 Bakx, 0-2 Vd Venne, 1-2 en 2-2 Vd Heijden |
| 6 | 22/09/2017 | Helmond Sport | FC Dordrecht | 1-2 | 1.731 | Vd Graaf | 1-0 Zeldenrust (pen), 1-1 Arias, 1-2 Misidjan R: Warmolts (Hel) |
| 6 | 22/09/2017 | FC Emmen | Go Ahead Eagles | 0-0 | 3.045 | Lindhout | |
| 6 | 25/09/2017 | Jong PSV | NEC | 3-3 | 1.463 | Kooij | 1-0 Gudmundsson, 1-1 Joppen, 1-2 Van de Pavert, 1-3 Golla, 2-3 en 3-3 Lammers; R: Paal (PSV) |
| 6 | 25/09/2017 | Jong Ajax | Telstar | 1-1 | 1.750 | Martens | 0-1 Van Huizen, 1-1 Bijleveld |
| 7 | 29/09/2017 | SC Cambuur | RKC Waalwijk | 1-1 | 7.355 | Vd Kerkhof | 0-1 Voskamp, 1-1 Kallon; R: Mezghrani (RKC) |
| 7 | 29/09/2017 | Jong FC Utrecht | Helmond Sport | 0-0 | 565 | Vd Eijk | |
| 7 | 29/09/2017 | FC Dordrecht | FC Volendam | 2-2 | 1.434 | Ruperti | 0-1 Visser, 1-1 Arias, 1-2 Veerman, 2-2 Stankov |
| 7 | 29/09/2017 | Go Ahead Eagles | Almere City FC | 2-1 | 7.673 | Kooij | 1-0 Hendriks, 1-1 Brands, 2-1 Hendriks |
| 7 | 29/09/2017 | FC Den Bosch | Jong PSV | 5-0 | 2.875 | Van Herk | 1-0 Vossebelt (pen), 2-0 Kaars, 3-0 (pen) en 4-0 Vossebelt, 5-0 Sirani |
| 7 | 29/09/2017 | De Graafschap | FC Emmen | 2-2 | 7.671 | Martens | 0-1 Bannink, 0-2 Haydary, 1-2 Ars, 2-2 Van den Hurk |
| 7 | 29/09/2017 | NEC | MVV Maastricht | 4-1 | 9.106 | Vd Graaf | 1-0 Golla, 1-1 Gölpek, 2-1 Rayhi, 3-1 Kadioglu, 4-1 Groeneveld |
| 7 | 29/09/2017 | FC Oss | Jong Ajax | 1-2 | 3.321 | Blank | 0-1 De Wit, 0-2 Cassierra, 0-3 Mazraoui |
| 7 | 29/09/2017 | Telstar | Fortuna Sittard | 0-6 | 1.982 | Oostrom | 0-1 Schuurs, 0-2 Vidigal, 0-3 Dammers, 0-4 Vidigal, 0-5 Stokkers, 0-6 Vidigal |
| 7 | 29/09/2017 | Jong AZ | FC Eindhoven | 1-2 | 573 | Dieperink | 0-1 Lider, 1-1 Garcia, 1-2 Lieder |
| 8 | 06/10/2017 | FC Volendam | Telstar | 3-4 | 3.189 | Blank | 1-0 Veerman, 1-1 Hamdaoui, 1-2 (p) en 1-3 Novakovich, 2-3 Veerman (pen), 2-4 Korpershoek, 3-4 Stroo |
| 8 | 06/10/2017 | FC Dordrecht | FC Eindhoven | 4-3 | 1.159 | C. Mulder | 1-0 Mutzers, 2-0 Mahmudov (pen), 3-0 Arias, 3-1 Lieder (pen), 4-1 Mutzers, 4-2 V. Vaerenbergh, 4-3 Matthys |
| 8 | 08/10/2017 | RKC Waalwijk | FC Den Bosch | 1-1 | 2.705 | Bax | 0-1 Deijl, 1-1 Van Weert |
| 8 | 06/10/2017 | Jong PSV | Jong AZ | 1-2 | 468 | Ruperti | 0-1 en 0-2 Friday, 1-2 Verreth |
| 8 | 06/10/2017 | Fortuna Sittard | NEC | 1-2 | 4.567 | Perez | 1-0 Stokkers, 1-1 Rayhi, 1-2 Joppen R: Joppen (NEC) |
| 8 | 06/10/2017 | Jong Ajax | Jong FC Utrecht | 2-1 | 776 | Van Herk | 1-0 S. de Jong, 1-1 Sow, 2-1 Cassierra |
| 8 | 06/10/2017 | FC Oss | Go Ahead Eagles | 1-6 | 2.001 | Martens | 0-1 Langedijk, 0-2 en 0-3 (pen) Hendriks, 0-4 Werkhoven, 1-4 Kamaci (pen), 1-5 Maneschijn, 1-6 Suk |
| 8 | 06/10/2017 | Almere City FC | MVV Maastricht | 3-2 | 1.537 | Dieperink | 0-1 Yildirim, 1-1 en 2-1 Valpoort, 3-1 Walian, 3-2 Yildirim |
| 8 | 06/10/2017 | Helmond Sport | De Graafschap | 0-2 | 2.047 | Vermeiren | 0-1 Van Mieghem, 0-2 Diemers |
| 8 | 06/10/2017 | FC Emmen | SC Cambuur | 2-0 | 4.018 | Vd Graaf | 1-0 Peters, 2-0 Haydary |
| 9 | 13/10/2017 | SC Cambuur | FC Oss | 1-3 | 7.072 | Vd Eijk | 0-1 Dogan, 0-2 Kamaci, 1-2 Boerlage, 1-3 Adarabioyo |
| 9 | 13/10/2017 | MVV Maastricht | Fortuna Sittard | 1-2 | 8.152 | Janssen | 1-0 Okita, 1-1 Semedo, 1-2 Vidigal R: Semedo (For) |
| 9 | 13/10/2017 | FC Eindhoven | FC Volendam | 1-0 | 1.987 | Perez | 1-0 Kabangu |
| 9 | 13/10/2017 | FC Den Bosch | Jong FC Utrecht | 1-0 | 2.688 | Kooij | 1-0 Blummel |
| 9 | 13/10/2017 | NEC | RKC Waalwijk | 2-0 | 9.016 | Kamphuis | 1-0 Braken, 2-0 Rayhi |
| 9 | 13/10/2017 | Telstar | FC Dordrecht | 3-0 | 2.249 | Teuben | 1-0 Novakovich (pen), 2-0 Osman, 3-0 Van Huizen R: Rodrigues (Tel) |
| 9 | 13/10/2017 | FC Emmen | Jong PSV | 3-1 | 3.043 | Blank | 1-0- Bannink, 1-1 Lammers, 2-1 Peters, 3-1 Haydary |
| 9 | 15/10/2017 | De Graafschap | Go Ahead Eagles | 1-1 | 9.311 | Nijhuis | 0-1 Langedijk, 1-1 Ars |
| 9 | 16/10/2017 | Jong Ajax | Almere City FC | 3-0 | 1.396 | Bax | 1-0 Cassierra, 2-0 Cerny, 3-0 Mazraoui |
| 9 | 16/10/2017 | Jong AZ | Helmond Sport | 1-3 | 713 | Gerrets | 0-1 Braber, 1-1 Friday, 1-2 Damen, 1-3 Naudts |
| 10 | 20/10/2017 | Jong FC Utrecht | MVV Maastricht | 2-1 | 692 | Gerrets | 0-1 Yildirim, 1-1 en 2-1 Venema |
| 10 | 20/10/2017 | FC Volendam | NEC | 0-2 | 2.480 | Dieperink | 0-1 Groeneveld, 0-2 Braken |
| 10 | 20/10/2017 | FC Dordrecht | De Graafschap | 1-1 | 1.824 | Kooij | 0-1 Nieuwpoort, 1-1 Duarte Lopes |
| 10 | 20/10/2017 | Jong PSV | RKC Waalwijk | 3-2 | 428 | Van Damme | 1-0 Ritzmaier, 2-0 Gudmundsson, 2-1 Bergkamp, 2-2 Voskamp (pen), 3-2 Gudmundson |
| 10 | 20/10/2017 | Go Ahead Eagles | Jong Ajax | 4-1 | 8.452 | Vd Eijk | 0-1 Johnsen, 1-1 Hendriks, 2-1 Suk, 3-1 Schenk, 4-1 De Kogel; R: Zeefuik (Aja) |
| 10 | 20/10/2017 | Fortuna Sittard | FC Eindhoven | 2-2 | 5.266 | Teuben | 1-0 Dianessy, 1-1 Lieder (pen), 2-1 Askovski, 2-2 Deschilder |
| 10 | 20/10/2017 | FC Oss | FC Den Bosch | 1-1 | 3.341 | Higler | 0-1 Vossebelt (pen), 1-1 Dogan |
| 10 | 20/10/2017 | Almere City FC | SC Cambuur | 1-1 | 1.400 | Martens | 1-0 Van der Heijden, 1-1 Boerlage |
| 10 | 20/10/2017 | Helmond Sport | Telstar | 1-2 | 1.579 | Ruperti | 0-1 Novakovich, 1-1 Naudts, 1-2 Hamdaoui |
| 10 | 20/10/2017 | Jong AZ | FC Emmen | 2-1 | 587 | C. Mulder | 1-0 Dos Santos, 2-0 Jacobs, 2-1 Hemmen |
| 5 | 23/10/2017 | FC Oss | Jong AZ | 2-1 | 1.232 | Van Herk | 1-0 Church (e.d.), 2-0 Kamaci, 2-1 Friday |
| 11 | 27/10/2017 | SC Cambuur | Jong PSV | 0-1 | 7.245 | Gerrets | 0-1 Duarte |
| 11 | 27/10/2017 | RKC Waalwijk | FC Dordrecht | 0-1 | 2.301 | Manschot | 0-1 Seys |
| 11 | 29/10/2017 | MVV Maastricht | FC Volendam | 2-1 | 4.563 | Kamphuis | 1-0 Gölpek, 1-1 Doodeman, 2-1 Ciranni |
| 11 | 27/10/2017 | FC Eindhoven | Jong Ajax | 2-3 | 2.913 | Oostrom | 1-0 Lieder, 1-1 De Wit, 1-2 Eiting, 1-3 De Wit, 2-3 Lieder |
| 11 | 27/10/2017 | Go Ahead Eagles | Jong AZ | 2-1 | 7.398 | Teuben | 0-1 Friday, 1-1 Langedijk, 2-1 Hendriks |
| 11 | 27/10/2017 | FC Den Bosch | Helmond Sport | 2-2 | 2.659 | Van Herk | 1-0 Kaars, 1-1 Naudts, 1-2 Vicento, 2-2 Biemans |
| 11 | 27/10/2017 | De Graafschap | Fortuna Sittard | 2-0 | 9.201 | Vd Kerkhof | 1-0 Van Mieghem, 2-0 Serrarens |
| 11 | 27/10/2017 | NEC | Jong FC Utrecht | 3-1 | 8.768 | Blank | 1-0 Braken, 2-0 Groeneveld, 2-1 Ould-Chikh, 3-1 Van de Pavert |
| 11 | 29/10/2017 | Telstar | Almere City FC | 4-0 | 2.549 | Vd Eijk | 1-0 Platje, 2-0 Novakovich, 3-0 Platje, 4-0 Osman (pen) |
| 11 | 27/10/2017 | FC Emmen | FC Oss | 1-1 | 3.369 | Kooij | 1-0 Peters, 1-1 Stuy van den Herik |
| 12 | 03/11/2017 | Jong FC Utrecht | FC Eindhoven | 1-2 | 685 | Ruperti | 1-0 Hilterman, 1-1 en 1-2 Lieder |
| 12 | 03/11/2017 | FC Volendam | Jong PSV | 1-0 | 2.886 | Mulder | 1-0 Schilder |
| 12 | 03/11/2017 | FC Dordrecht | FC Den Bosch | 0-3 | 1.352 | Blank | 0-1 Bouyaghlafen, 0-2 Blummel, 0-3 Mert |
| 12 | 03/11/2017 | MVV Maastricht | RKC Waalwijk | 0-0 | 4.637 | Teuben | |
| 12 | 03/11/2017 | Fortuna Sittard | FC Oss | 4-0 | 3.103 | Vergoote | 1-0 Semedo, 2-0 Askovski, 3-0 Stokkers, 4-0 Dianessy |
| 12 | 03/11/2017 | NEC | SC Cambuur | 3-1 | 9.163 | Bax | 0-1 Van Kippersluis, 1-1 en 2-1 Rayhi, 3-1 Langil |
| 12 | 03/11/2017 | Jong Ajax | De Graafschap | 0-5 | 1.103 | Vd Graaf | 0-1 El Jebli, 0-2 Ars, 0-3 Van den Hurk (pen), 0-4 Van Mieghem, 0-5 Receveur; R: Sierhuis (Aja) |
| 12 | 03/11/2017 | Almere City FC | Jong AZ | 3-2 | 1.301 | Oostrom | 1-0 Salasiwa (pen), 1-1 Wijndal, 2-1 Walian, 2-2 Friday, 3-2 Van der Heijden (pen) |
| 12 | 03/11/2017 | Telstar | Go Ahead Eagles | 3-1 | 2.756 | S. Mulder | 1-0 Schouten, 2-0 Osman, 2-1 Hendriks, 3-1 Osman |
| 12 | 03/11/2017 | Helmond Sport | FC Emmen | 3-1 | 1.331 | Martens | 0-1 Loen, 1-1 Naudts, 2-1 en 3-1 Edwards |
| 13 | 17/11/2017 | SC Cambuur | Fortuna Sittard | 1-0 | 7.094 | Van Boekel | 1-0 Peersman; R: Smeets (Cam) |
| 13 | 17/11/2017 | RKC Waalwijk | Telstar | 4-1 | 1.576 | Vd Kerkhof | 1-0 Bakari, 2-0 Mulder, 3-0 De Boer (e.d.), 3-1 Rodrigues, 4-1 Greene |
| 13 | 17/11/2017 | FC Eindhoven | MVV Maastricht | 3-2 | 2.265 | S. Mulder | 1-0, 2-0 en 3-0 Lieder, 3-1 Okita, 3-2 Loshaj |
| 13 | 17/11/2017 | Go Ahead Eagles | FC Dordrecht | 0-3 | 7.762 | Janssen | 0-1 Bliek, 0-2 Duarte Lopes, 0-3 Hamer |
| 13 | 17/11/2017 | FC Den Bosch | FC Volendam | 3-1 | 2.836 | Vd Eijk | 1-0 Vossebelt, 1-1 Stroo, 2-1 Van der Sande, 3-1 Blummel |
| 13 | 17/11/2017 | De Graafschap | NEC | 1-3 | 11.228 | Gözübüyük | 0-1 Groeneveld, 1-1 Van Mieghem, 1-2 Braken, 1-3 Golla |
| 13 | 17/11/2017 | FC Oss | Helmond Sport | 0-0 | 1.923 | Gerrets | R: Fecunda (Hel) |
| 13 | 17/11/2017 | FC Emmen | Almere City FC | 2-2 | 2.517 | Dieperink | 1-0 Peters, 2-0 Bijl, 2-1 Mirani, 2-2 Van der Water |
| 13 | 20/11/2017 | Jong PSV | Jong FC Utrecht | 2-0 | 344 | Kooij | 1-0 Lammers, 2-0 Gudmundsson |
| 13 | 20/11/2017 | Jong AZ | Jong Ajax | 4-2 | 2.471 | Ruperti | 0-1 Mazraoui, 0-2 Cassierra, 1-2 Helmer, 2-2 Reijnders, 3-2 Seuntjens, 4-2 Garcia |
| 14 | 24/11/2017 | SC Cambuur | FC Den Bosch | 2-2 | 7.044 | Manschot | 1-0 Van Kippersluis, 1-1 Mert, 2-1 Steenvoorden, 2-2 Schilder (e.d.) |
| 14 | 24/11/2017 | Jong FC Utrecht | Almere City FC | 2-4 | 511 | Teuben | 1-0 Sow, 1-1 Valpoort, 2-1 Venema, 2-2 Walian, 2-3 Valpoort, 2-4 MacDonald |
| 14 | 24/11/2017 | FC Volendam | FC Emmen | 2-3 | 1.500 | Van Herk | 0-1 Peters (pen), 1-1 Doodeman, 2-1 Stroo, 2-2 Veldmate, 2-3 Hemmen |
| 14 | 24/11/2017 | FC Dordrecht | Jong AZ | 3-2 | 1.234 | Van Damme | 1-0 Calcan, 1-1 Reijnders, 1-2 Hoedemakers, 2-2 Duarte Lopes, 3-2 Mahmudov |
| 14 | 24/11/2017 | RKC Waalwijk | FC Oss | 2-1 | 2.378 | Ruperti | 0-1 Kamaci, 1-1 Mulder, 2-1 Greene |
| 14 | 24/11/2017 | Jong PSV | Telstar | 6-0 | 506 | Dieperink | 1-0 Gudmundsson, 2-0 Verreth, 3-0 en 4-0 Malen, 5-0 Rigo, 6-0 Laursen; R: Lopes Cabral (Tel) |
| 14 | 24/11/2017 | MVV Maastricht | Helmond Sport | 3-1 | 4.429 | Bax | 1-0 Okita, 2-0 Kostons, 2-1 Naudts, 3-1 Koolhof |
| 14 | 24/11/2017 | Fortuna Sittard | Go Ahead Eagles | 2-1 | 3.186 | Higler | 0-1 Hendriks, 1-1 en 2-1 Dammers |
| 14 | 24/11/2017 | De Graafschap | FC Eindhoven | 4-0 | 8.245 | Blank | 1-0 Van Mieghem, 2-0 Nieuwpoort, 3-0 Van den Hurk (pen), 4-0 Receveur R: Matthys (Ein) |
| 14 | 24/11/2017 | NEC | Jong Ajax | 2-1 | 11.037 | Martens | 0-1 Mazraoui, 1-1 Rayhi, 2-1 Joppen |
| 15 | 27/11/2017 | FC Eindhoven | SC Cambuur | 2-1 | 1.335 | C. Mulder | 1-0 Van de Velde, 1-1 Barto, 2-1 Lieder (pen) |
| 15 | 27/11/2017 | Go Ahead Eagles | Jong FC Utrecht | 0-0 | 6.118 | Oostrom | |
| 15 | 27/11/2017 | FC Den Bosch | De Graafschap | 1-1 | 2.653 | Bax | 1-0 Blummel, 1-1 Ars |
| 15 | 27/11/2017 | Jong Ajax | FC Dordrecht | 3-0 | 580 | Gerrets | 1-0 Johnsen, 2-0 De Wit, 3-0 Nunnely |
| 15 | 27/11/2017 | FC Oss | Jong PSV | 0-3 | 1.106 | Blank | 0-1 Laursen, 0-2 Lammers, 0-3 Malen |
| 15 | 27/11/2017 | Almere City FC | RKC Waalwijk | 3-2 | 1.503 | Van Herk | 1-0 VAlpoort (pen), 1-1 Lammers, 2-1 Walian, 3-1 Van de Water, 3-2 Seys |
| 15 | 27/11/2017 | Telstar | NEC | 3-2 | 2.563 | Vd Graaf | 1-0 Van Huizen, 2-0 Osman, 2-1 Achahbar, 2-2 Braken, 3-2 Platje |
| 15 | 27/11/2017 | Helmond Sport | Fortuna Sittard | 1-3 | 1.031 | Manschot | 0-1 Vidigal, 1-1 Naudts, 1-2 Vidigal, 1-3 Askovski |
| 15 | 27/11/2017 | FC Emmen | MVV Maastricht | 2-1 | 2.163 | Blom | 1-0 en 2-0 Peters, 2-1 Gölpek |
| 15 | 27/11/2017 | Jong AZ | FC Volendam | 0-2 | 1.366 | Perez | 0-1 Veerman, 0-2 Antwi |
| 16 | 01/12/2017 | SC Cambuur | Telstar | 2-1 | 6.769 | Kooij | 0-1 Hamdaoui, 1-1 Narsingh, 2-1 Kip (pen) |
| 16 | 01/12/2017 | FC Volendam | Almere City FC | 1-1 | 2.000 | Blank | 0-1 Valpoort, 1-1 Antwi; R; Schilder (Vol) |
| 16 | 01/12/2017 | RKC Waalwijk | Helmond Sport | 1-0 | 2.411 | C. Mulder | 1-0 Greene |
| 16 | 01/12/2017 | MVV Maastricht | Jong Ajax | 0-4 | 4.861 | Perez | 0-1 en 0-2 Sierhuis, 0-3 en 0-4 Flemming |
| 16 | 01/12/2017 | FC Eindhoven | FC Oss | 1-3 | 1.962 | Teuben | 1-0 Lieder, 1-1 Van der Venne, 1-2 Van Pol, 1-3 Van der Sluys; R: Matthys (Ein) |
| 16 | 01/12/2017 | FC Den Bosch | Go Ahead Eagles | 3-0 | 3.173 | Vd Graaf | 1-0 en 2-0 Van der Sande, 3-0 Vossebelt |
| 16 | 01/12/2017 | De Graafschap | Jong AZ | 1-0 | 7.508 | Van Herk | 1-0 Van Mieghem |
| 16 | 01/12/2017 | NEC | FC Dordrecht | 6-0 | 9.038 | Lindhout | 1-0 Larsson, 2-0 (pen) en 3-0 Langil, 4-0 Kadioglu, 5-0 Langil (pen), 6-0 Achahbar |
| 16 | 04/12/2017 | Jong FC Utrecht | FC Emmen | 1-2 | 698 | Ruperti | 1-0 David, 1-1 Bannink, 1-2 Hemmen |
| 16 | 04/12/2017 | Jong PSV | Fortuna Sittard | 2-3 | 603 | Oostrom | 1-0 Malen, 2-0 Lammers, 2-1 Askovski, 2-2 Semedo (p), 2-3 Askovski R: Gudmundsson (PSV) |
| 17 | 08/12/2017 | FC Volendam | Jong FC Utrecht | 2-1 | 1.000 | Gerrets | 1-0 Doodeman, 2-0 Stroo, 2-1 Peijnenburg R: Ten Den (Vol) |
| 17 | 08/12/2017 | FC Dordrecht | MVV Maastricht | 2-4 | 1.245 | Oostrom | 1-0 Mmaee (e.d.), 1-1 Ciranni, 2-1 Arias (pen), 2-2 Koolhof, 2-3 Mmaee, 2-4 Alkan (e.d.) |
| 17 | 12/12/2017 | Go Ahead Eagles | Jong PSV | 1-1 | 4.318 | Bax | 0-1 Malen, 1-1 Beltrame |
| 17 | 08/12/2017 | Fortuna Sittard | RKC Waalwijk | 6-0 | 2.887 | Kooij | 1-0 en 2-0 Schuurs, 3-0 Askovski, 4-0 Stokkers, 5-0 Dianessy (pen), 6-0 Hutten R: Quasten, Greene (RKC) |
| 17 | 08/12/2017 | Almere City FC | De Graafschap | 2-1 | 1.845 | Vd Kerkhof | 0-1 Van den Hurk, 1-1 Van der Water, 2-1 Van der Heijden |
| 17 | 08/12/2017 | Telstar | FC Emmen | 0-0 | 2.142 | C. Mulder | |
| 17 | 18/12/2017 | Helmond Sport | FC Eindhoven | 0-0 | 2.891 | Van Herk | |
| 17 | 18/12/2017 | Jong Ajax | FC Den Bosch | 1-0 | 400 | Dieperink | 1-0 Nunnely |
| 18 | 15/12/2017 | SC Cambuur | FC Dordrecht | 3-0 | 6.912 | Ruperti | 1-0 Kallon, 2-0 Houtkoop, 3-0 Kip |
| 18 | 15/12/2017 | Jong FC Utrecht | Telstar | 0-1 | 431 | Blank | 0-1 Platje |
| 18 | 15/12/2017 | RKC Waalwijk | FC Volendam | 1-3 | 1.918 | Vermeire | 1-0 Seys, 1-1 Kwakman, 1-2 en 1-3 Stroo |
| 18 | 15/12/2017 | MVV Maastricht | Jong AZ | 3-0 | 4.278 | Martens | 1-0 Koolhof, 2-0 Yildirim, 3-0 Houben |
| 18 | 15/12/2017 | FC Eindhoven | Go Ahead Eagles | 3-2 | 1.843 | Kooij | 0-1 Hendriks, 1-1 Kabangu, 2-1 Lieder, 2-2 Beltrame, 3-2 Kabangu |
| 18 | 15/12/2017 | Jong PSV | Almere City FC | 3-2 | 305 | Gerrets | 1-0 Obispo, 1-1 Van der Water, 1-2 Valpoort, 2-2 en 3-2 Malen |
| 18 | 15/12/2017 | FC Den Bosch | Fortuna Sittard | 2-4 | 3.586 | Perez | 0-1 Saddiki, 0-2 Dianessy, 1-2 Vossebelt, 1-3 Semedo, 2-3 Kaars, 2-4 Dianessy |
| 18 | 15/12/2017 | De Graafschap | FC Oss | 1-1 | 8.102 | Vd Graaf | 1-0 Van Mieghem, 1-1 Grotenbreg |
| 18 | 15/12/2017 | NEC | Helmond Sport | 1-1 | 9.251 | Van Boekel | 1-0 Larsson, 1-1 Hiwat |
| 18 | 15/12/2017 | FC Emmen | Jong Ajax | 2-2 | 4.766 | Oostrom | 0-1 Veendorp (e.d.), 1-1 Peters, 2-1 Hemmen, 2-2 Lang |
| 19 | 22/12/2017 | FC Dordrecht | Jong PSV | 2-3 | 1.333 | Teuben | 0-1 Statia (e.d.), 0-2 Lonwijk, 1-2 Duarte Lopes, 1-3 Malen, 2-3 Duarte Lopes |
| 19 | 22/12/2017 | Go Ahead Eagles | RKC Waalwijk | 0-0 | 6.278 | Vd Kerkhof | |
| 19 | 23/12/2017 | Fortuna Sittard | Jong FC Utrecht | 3-1 | 7.032 | Dieperink | 1-0 en 2-0 Stokkers, 2-1 Mallahi, 3-1 Stokkers |
| 19 | 22/12/2017 | Jong Ajax | FC Volendam | 7-0 | 931 | C. Mulder | 1-0 en 2-0 Cassierra, 3-0 Nunnely, 4-0 Cassierra, 5-0 Mazraoui (pen), 6-0 en 7-0 Sierhuis |
| 19 | 22/12/2017 | FC Oss | MVV Maastricht | 1-0 | 1.521 | Ruperti | 1-0 Van der Venne |
| 19 | 22/12/2017 | Almere City FC | FC Eindhoven | 5-1 | 1.364 | Gözübüyük | 1-0 Valpoort, 1-1 Van Landschoot, 2-1 Overtoom, 3-1 Salasiwa, 4-1 en 5-1 Overtoom |
| 19 | 22/12/2017 | Telstar | De Graafschap | 3-2 | 2.736 | Perez | 0-1 Van den Hurk, 1-1 en 2-1 Novakovich, 2-2 Serrarens, 3-2 Platje |
| 19 | 22/12/2017 | Helmond Sport | SC Cambuur | 3-0 | 1.163 | Vd Graaf | 1-0 Bourdouxhe, 2-0 Braber, 3-0 Thomassen R: Peersman (Cam) |
| 19 | 22/12/2017 | FC Emmen | FC Den Bosch | 2-2 | 2.408 | Kooij | 0-1 Mert, 1-1 Peters, 1-2 Vossebelt (pen), 2-2 Peters (pen) |
| 19 | 22/12/2017 | Jong AZ | NEC | 2-7 | 475 | Oostrom | 0-1 en 0-2 Achahbar, 0-3 Breinburg, 1-3 Duin, 1-4 Heinloth, 1-5 Achahbar, 1-6 Kadioglu, 2-6 Bakker, 2-7 Braken |
| 20 | 12/01/2018 | SC Cambuur | De Graafschap | 3-2 | 7.277 | Kamphuis | 0-1 Ars, 1-1 Robertha, 2-1 Houtkoop, 3-1 Robertha, 3-2 Schilder (e.d.) R: S. Nieuwpoort (Gra) |
| 20 | 12/01/2018 | Jong FC Utrecht | FC Dordrecht | 0-2 | 406 | Mulder | 0-1 Mutzers, 0-2 Arias (pen) |
| 20 | 12/01/2018 | FC Volendam | FC Oss | 3-1 | 2.000 | Martens | 1-0 Doodeman, 2-0 Stroo, 3-0 Runderkamp, 3-1 Van der Sluys |
| 20 | 12/01/2018 | RKC Waalwijk | Jong AZ | 1-0 | 2.018 | Gerrets | 1-0 Greene |
| 20 | 12/01/2018 | Jong PSV | Helmond Sport | 1-2 | 528 | Dieperink | 1-0 Verreth, 1-1 Thomassen, 1-2 Edwards |
| 20 | 12/01/2018 | MVV Maastricht | Telstar | 0-0 | 4.419 | Vd Kerkhof | |
| 20 | 12/01/2018 | FC Eindhoven | FC Emmen | 2-1 | 2.216 | Blank | 1-0 Kabangu, 2-0 Van den Boomen, 2-1 Haydari |
| 20 | 12/01/2018 | FC Den Bosch | Almere City FC | 1-3 | 2.525 | Oostrom | 1-0 Blummel, 1-1 Overtoom, 1-2 Van der Heijden, 1-3 Van der Water; R: Salasiwa (Alm) |
| 20 | 12/01/2018 | Fortuna Sittard | Jong Ajax | 2-1 | 7.143 | Vd Graaf | 1-0 en 2-0 Dianessy, 2-1 De Wit |
| 20 | 12/01/2018 | NEC | Go Ahead Eagles | 5-1 | 10.097 | Bax | 1-0 Achahbar, 1-1 Nemane, 2-1 Kadioglu, 3-1 Schuurman, 4-1 en 5-1 Achahbar |
| 17 | 15/01/2018 | FC Oss | NEC | 3-0 | 2.234 | Wiedemeijer | 1-0 Sturing (e.d.), 2-0 Bakx, 3-0 Van Pol R: Grotenbreg (Oss) |
| 17 | 15/01/2018 | Jong AZ | SC Cambuur | 0-1 | 290 | Teuben | 0-1 Houtkoop |
| 21 | 19/01/2018 | FC Dordrecht | Fortuna Sittard | 3-0 | 1.505 | Perez | 1-0 Arias, 2-0 Mutzers, 3-0 Arias |
| 21 | 19/01/2018 | Go Ahead Eagles | MVV Maastricht | 3-1 | 7.684 | Manschot | 1-0 en 2-0 Hendriks, 3-0 Beltrame, 3-1 Okita |
| 21 | 19/01/2018 | De Graafschap | Jong PSV | 2-3 | 8.072 | Ruperti | 1-0 Nieuwpoort, 2-0 El Jebli, 2-1 Gakpo, 2-2 Rigo (pen), 2-3 Gakpo |
| 21 | 19/01/2018 | FC Oss | Jong FC Utrecht | 2-0 | 1.451 | Van Damme | 1-0 Kamaci, 2-0 Oratmangoen |
| 21 | 19/01/2018 | Almere City FC | NEC | 3-2 | 1.750 | Blom | 1-0 Hoefdraad, 2-0 Ahannach, 2-1 Braken, 3-1 Van de Water, 3-2 Braken; R: Romeny (NEC) |
| 21 | 19/01/2018 | Telstar | FC Eindhoven | 4-1 | 2.489 | S. Mulder | 1-0 Novakovich, 1-1 Lieder, 2-1 Platje, 3-1 Novakovich, 4-1 Osman |
| 21 | 19/01/2018 | Helmond Sport | FC Volendam | 1-4 | 1.367 | Kooij | 0-1 Stroo, 0-2 Veerman, 0-3 Visser, 1-3 Thomassen, 1-4 Antwi |
| 21 | 19/01/2018 | FC Emmen | RKC Waalwijk | 2-1 | 3.019 | Teuben | 0-1 Voskamp, 1-1 en 2-1 Jansen; R: Ndefe (RKC) |
| 21 | 22/01/2018 | Jong Ajax | SC Cambuur | 3-2 | 485 | Martens | 1-0 Cassierra, 2-0 Lang, 3-0 Eiting, 3-1 en 3-2 Robertha |
| 21 | 22/01/2018 | Jong AZ | FC Den Bosch | 1-1 | 400 | Bijl | 1-0 Druijf, 1-1 Blummel |
| 22 | 26/01/2018 | FC Dordrecht | FC Oss | 2-0 | 1.272 | Bax | 1-0 Arias, 2-0 Mahmudov R: Janssen (Oss), Groothusen (Dor) |
| 22 | 26/01/2018 | RKC Waalwijk | Jong Ajax | 2-4 | 3.246 | D'Hondt | 0-1 De Wit, 0-2 Sierehuis, 1-2 Seys, 1-3 en 1-4 De Wit, 2-4 Seys |
| 22 | 26/01/2018 | MVV Maastricht | De Graafschap | 1-3 | 4.658 | Van Boekel | 0-1 (pen) en 0-2 Ars, 1-2 Okita, 1-3 Serrarens |
| 22 | 26/01/2018 | Fortuna Sittard | FC Emmen | 1-2 | 3.604 | Lindhout | 0-1 Jansen, 0-2 Bannink,1-2 Stokkers |
| 22 | 26/01/2018 | NEC | FC Den Bosch | 1-0 | 9.539 | Kamphuis | 1-0 Langil (pen) |
| 22 | 26/01/2018 | Telstar | Jong AZ | 2-1 | 2.838 | Oostrom | 0-1 Druijf, 1-1 Osman, 2-1 Platje |
| 22 | 26/01/2018 | Helmond Sport | Almere City FC | 1-2 | 1.176 | Vd Kerkhof | 1-0 Hiwat, 1-1 Van der Heijden, 1-2 Mac-Intosch R: VAn Heugten (Hel) |
| 22 | 28/01/2018 | FC Volendam | Go Ahead Eagles | 4-3 | 3.301 | Vd Graaf | 1-0 Visser, 2-0 Stroo, 2-1 Hendriks, 2-2 Evers (e.d.), 2-3 Beltrame, 3-3 Antwi, 4-3 Stroo |
| 22 | 29/01/2018 | Jong FC Utrecht | SC Cambuur | 1-3 | 500 | Bijl | 0-1 Robertha, 0-2 Barto, 1-2 Venema (pen), 1-3 Rosheuvel |
| 22 | 29/01/2018 | Jong PSV | FC Eindhoven | 4-1 | 803 | C. Mulder | 1-0 Geze, 2-0 Gakpo, 3-0 Lundqvist, 4-0 Gudmundsson, 4-1 Lieder |
| 23 | 02/02/2018 | SC Cambuur | Go Ahead Eagles | 2-1 | 7.954 | Vd Kerkhof | 1-0 en 2-0 Barto, 2-1 Andrade |
| 23 | 02/02/2018 | FC Volendam | Fortuna Sittard | 2-0 | 2.939 | Dieperink | 1-0 Pedro, 2-0 Smal |
| 23 | 02/02/2018 | FC Eindhoven | RKC Waalwijk | 3-1 | 2.036 | Martens | 1-0 Lieder, 1-1 Seys, 2-1 Lieder, 3-1 Van Landschoot |
| 23 | 02/02/2018 | FC Den Bosch | Telstar | 3-2 | 2.565 | Blank | 0-1 Platje (pen), 1-1 Vossebelt, 2-1 Vd Winden, 2-2 Schouten, 3-2 Kaars; R: Van Iperen (Tel) |
| 23 | 02/02/2018 | De Graafschap | Jong FC Utrecht | 7-0 | 7.711 | Perez | 1-0 en 2-0 Diemers, 3-0 Van Mieghem, 4-0 Serrarens (pen), 5-0 Diemers, 6-0 El Jebli, 7-0 Tissoudali |
| 23 | 02/02/2018 | Almere City FC | FC Dordrecht | 1-2 | 1.497 | Vd Graaf | 0-1 Arias (pen), 1-1 Van der Water, 1-2 Calcan |
| 23 | 02/02/2018 | FC Emmen | NEC | 1-0 | 3.788 | S. Mulder | 1-0 Bannink |
| 23 | 05/02/2018 | Jong PSV | MVV Maastricht | 1-0 | 501 | Gerrets | 1-0 Duarte |
| 23 | 05/02/2018 | Jong Ajax | Helmond Sport | 2-0 | 398 | Ruperti | 1-0 Younes, 2-0 Jensen |
| 23 | 05/02/2018 | Jong AZ | FC Oss | 3-1 | 315 | C. Mulder | 1-0 Druijf, 2-0 Kaandorp, 3-0 Koreniuk, 3-1 Kamaci (pen) |
| 24 | 08/02/2018 | NEC | Jong PSV | 2-0 | 8.815 | Martens | 1-0 Abels (e.d.), 2-0 Groeneveld; R: Abels (PSV) |
| 24 | 09/02/2018 | SC Cambuur | MVV Maastricht | 0-2 | 7.476 | Kooij | 0-1 Houben, 0-2 Mmaee |
| 24 | 09/02/2018 | FC Dordrecht | Helmond Sport | 3-2 | 1.143 | De Cremer | 1-0 Mahmudov, 1-1 Thomassen, 2-1 Mutzers, 3-1 Hamer, 3-2 Thomassen |
| 24 | 12/02/2018 | Go Ahead Eagles | FC Emmen | 0-1 | 4.177 | Kamphuis | 0-1 Bannink; R: Bijl (Emm) |
| 24 | 09/02/2018 | FC Den Bosch | FC Eindhoven | 4-0 | 2.211 | Teuben | 1-0 Van der Winden 2-0 Vossebelt, 3-0 Blummel, 4-0 Vossebelt |
| 24 | 09/02/2018 | De Graafschap | FC Volendam | 2-1 | 7.746 | Bax | 1-0 en 2-0 Diemers, 2-1 Veerman |
| 24 | 09/02/2018 | FC Oss | Almere City FC | 5-1 | 1.376 | Blank | 1-0 Bakx, 1-1 Valpoort, 2-1 Van der Venne, 3-1 Dogan, 4-1 en 5-1 Van der Venne |
| 24 | 09/02/2018 | Telstar | Jong Ajax | 3-3 | 3.223 | Dieperink | 1-0 Hamdaoui, 2-0 Novakovich, 2-1 Cassierra, 2-2 Flemming, 2-3 Orejuela, 3-3 Schouten |
| 24 | 09/02/2018 | Jong FC Utrecht | RKC Waalwijk | 5-2 | 378 | Oostrom | 0-1 Van Weert, 1-1 Sow, 2-1 Mallahi, 3-1 Sow, 4-1 Mallahi, 5-1 Sow, 5-2 Van Weert |
| 24 | 12/02/2018 | Jong AZ | Fortuna Sittard | 2-0 | 445 | Gerrets | 1-0 Druijf, 2-0 Wijndal; R: Schuurs (For) |
| 25 | 16/02/2018 | FC Volendam | FC Dordrecht | 4-1 | 2.876 | Vd Kerkhof | 1-0 Visser, 2-0 Stroo, 3-0 Vlak, 4-0 Vissers, 4-1 Mutzers |
| 25 | 16/02/2018 | RKC Waalwijk | SC Cambuur | 0-0 | 1.701 | C. Mulder | R: Van Weert (RKC) |
| 25 | 16/02/2018 | MVV Maastricht | NEC | 4-1 | 4.844 | Makkelie | 1-0 Yildirim, 2-0 Nys, 2-1 Rayhi (pen), 3-1 Schroyen, 4-1 Okita |
| 25 | 16/02/2018 | FC Eindhoven | Jong AZ | 1-3 | 1.986 | Alen | 0-1 Druijf (pen), 1-1 Van den Boomen, 1-2 Druijf, 1-3 Koreniuk; R: Kramer (AZ) |
| 25 | 16/02/2018 | Fortuna Sittard | Telstar | 1-1 | 3.019 | Bax | 0-1 Hamdaoui, 1-1 Semedo (pen) |
| 25 | 16/02/2018 | Almere City FC | Go Ahead Eagles | 2-0 | 1.588 | S. Mulder | 1-0 en 2-0 Salasiwa |
| 25 | 16/02/2018 | Helmond Sport | Jong FC Utrecht | 2-0 | 1.131 | Blank | 1-0 Vicento, 2-0 Van Heugten R: Hoogenhout (Utr) |
| 25 | 16/02/2018 | FC Emmen | De Graafschap | 5-2 | 3.889 | Wiedemeijer | 1-0 Bannink, 1-1 Van Mieghem, 1-2 Tissoudali, 2-2 Nieuwpoort (e.d.), 3-2 Bakker, 4-2 Bannink, 5-2 Aslanyan |
| 25 | 19/02/2018 | Jong PSV | FC Den Bosch | 2-1 | 264 | Perez | 1-0 Gudmundsson (pen), 1-1 Mert, 2-1 Lammers |
| 25 | 19/02/2018 | Jong Ajax | FC Oss | 2-0 | 601 | Bijl | 1-0 en 2-0 De Wit |
| 26 | 23/02/2018 | SC Cambuur | FC Emmen | 1-1 | 7.476 | Vd Graaf | 1-0 Daniëls (pen), 1-1 Peters |
| 26 | 23/02/2018 | MVV Maastricht | Almere City FC | 3-0 | 4.364 | Boterberg | 1-0 Nys, 2-0 Okita, 3-0 Yildirim |
| 26 | 23/02/2018 | FC Eindhoven | FC Dordrecht | 0-1 | 1.936 | Kooij | 0-1 Mahmudov |
| 26 | 23/02/2018 | Go Ahead Eagles | FC Oss | 2-1 | 4.868 | Vd Eijk | 0-1 Oratmangoen, 1-1 Dekker, 2-1 Ketting R: Stuy van den Herik (Oss) |
| 26 | 23/02/2018 | FC Den Bosch | RKC Waalwijk | 0-0 | 2.788 | Van Herk | R: Van der Winden (DBo), Greene, Mulder (RKC) |
| 26 | 23/02/2018 | De Graafschap | Helmond Sport | 1-0 | 7.411 | Oostrom | 1-0 Diemers |
| 26 | 23/02/2018 | NEC | Fortuna Sittard | 1-1 | 10.920 | Vd Kerkhof | 0-1 Cantwell, 1-1 Groeneveld |
| 26 | 23/02/2018 | Telstar | FC Volendam | 5-2 | 2.850 | Lindhout | 1-0 en 2-0 Hamdaoui, 3-0 Sno, 4-0 Platje, 5-0 Novakovich, 5-1 Stroo, 5-2 Smal |
| 26 | 26/02/2018 | Jong FC Utrecht | Jong Ajax | 2-1 | 404 | Teuben | 1-0 Joosten, 1-1 Sierhuis, 2-1 Sow |
| 26 | 26/02/2018 | Jong AZ | Jong PSV | 2-1 | 400 | Ruperti | 1-0 Jacobs, 2-0 Reijnders, 2-1 Gakpo |
| 27 | 02/03/2018 | FC Volendam | FC Eindhoven | 3-2 | 2.910 | Vermeire | 1-0 Stroo, 1-1 Schilder (e.d.), 1-2 Thomas (pen), 2-2 Doodeman, 3-2 Veerman |
| 27 | 02/03/2018 | FC Dordrecht | Telstar | 2-3 | 1.048 | Martens | 1-0 Breedijk, 1-1 en 1-2 Novakovich, 1-3 Hamdaoui, 2-3 Mutzers |
| 27 | 02/03/2018 | RKC Waalwijk | NEC | 0-2 | 1.813 | Vd Graaf | 0-1 Sturing, 0-2 Achahbar; R: Ndefe (RKC) |
| 27 | 05/03/2018 | Fortuna Sittard | MVV Maastricht | 3-0 | 7.283 | Higler | 1-0 Dianessy, 2-0 Semedo (pen), 3-0 Askovski R: Martina (MVV) |
| 27 | 02/03/2018 | FC Oss | SC Cambuur | 2-1 | 1.432 | S. Mulder | 1-0 Van der Venne, 1-1 Boerlage, 2-1 Nieveld |
| 27 | 02/03/2018 | Almere City FC | Jong Ajax | 1-2 | 2.323 | Bax | 1-0 Van der Water, 1-1 en 1-2 Flemming |
| 27 | 02/03/2018 | Helmond Sport | Jong AZ | 3-0 | 833 | Vd Eijk | 1-0 Van Koesveld, 2-0 en 3-0 Thomassen |
| 27 | 04/03/2018 | Go Ahead Eagles | De Graafschap | 0-4 | 9.180 | Dieperink | 0-1 Van Mieghem, 0-2 Olijve, 0-3 Tissoudali, 0-4 Serrarens |
| 27 | 05/03/2018 | Jong FC Utrecht | FC Den Bosch | 1-1 | 633 | Gerrets | 1-0 Joosten, 1-1 Mert |
| 27 | 05/03/2018 | Jong PSV | FC Emmen | 1-1 | 313 | Vd Kerkhof | 0-1 Jansen, 1-1 Lammers |
| 28 | 09/03/2018 | SC Cambuur | Almere City FC | 2-1 | 7.036 | Perez | 0-1 Van der Water, 1-1 Barto, 2-1 Mathieu |
| 28 | 09/03/2018 | RKC Waalwijk | Jong PSV | 3-2 | 2.223 | Teuben | 0-1 Laursen, 1-1 Voskamp, 1-2 Laursen, 2-2 Mezghrani, 3-2 Voskamp |
| 28 | 09/03/2018 | MVV Maastricht | Jong FC Utrecht | 3-1 | 4.266 | Ruperti | 1-0 en 2-0 Nwakali, 2-1 Venema, 3-1 Yildirim |
| 28 | 09/03/2018 | FC Eindhoven | Fortuna Sittard | 1-3 | 2.230 | Vd Graaf | 0-1 Dianessy, 0-2 Cantwell, 1-2 Kortstam, 1-3 Askovski |
| 28 | 09/03/2018 | FC Den Bosch | FC Oss | 0-0 | 3.214 | Dieperink | |
| 28 | 09/03/2018 | De Graafschap | FC Dordrecht | 0-1 | 8.311 | Gözübüyük | 0-1 Mahmudov (pen) |
| 28 | 09/03/2018 | NEC | FC Volendam | 3-0 | 9.695 | Van Boekel | 1-0 Groeneveld, 2-0 Verdonk, 3-0 Joppen |
| 28 | 09/03/2018 | Jong Ajax | Go Ahead Eagles | 0-2 | 700 | Van Herk | 0-1 Ketting, 0-2 Langedijk; R: Matusiwa (Aja) |
| 28 | 09/03/2018 | Telstar | Helmond Sport | 2-3 | 2.874 | Vd Kerkhof | 1-0 Platje, 1-1 en 1-2 Thomassen, 2-2 Platje, 2-3 Janzen; R: De Braal (Hel) |
| 28 | 09/03/2018 | FC Emmen | Jong AZ | 0-2 | 4.213 | Bax | 0-1 Klok (e.d.), 0-2 Duijn (pen) |
| 29 | 12/03/2018 | Jong FC Utrecht | NEC | 0-2 | 890 | Vd Eijk | 0-1 Kadioglu, 0-2 Verdonk |
| 29 | 12/03/2018 | FC Volendam | MVV Maastricht | 2-2 | 2.760 | Wiedemeijer | 0-1 Okita, 0-2 Martina, 1-2 Stroo, 2-2 Doodeman |
| 29 | 12/03/2018 | FC Dordrecht | RKC Waalwijk | 1-0 | 3.148 | Blank | 1-0 Mahmudov |
| 29 | 12/03/2018 | Jong PSV | SC Cambuur | 1-1 | 321 | Gerrets | 1-0 Gakpo, 1-1 Kip |
| 29 | 12/03/2018 | Fortuna Sittard | De Graafschap | 1-1 | 3.642 | S. Mulder | 0-1 Tissoudali, 1-1 Schuurs; R: Serrarens (Gra) |
| 29 | 12/03/2018 | Jong Ajax | FC Eindhoven | 4-0 | 408 | Oostrom | 1-0 Johnsen, 2-0 Mazraoui, 3-0 en 4-0 De Wit |
| 29 | 12/03/2018 | FC Oss | FC Emmen | 2-3 | 1.432 | Manschot | 0-1 Bilate, 1-1 Kamaci, 1-2 Bijl, 2-2 Van der Venne, 2-3 Peters (pen) |
| 29 | 12/03/2018 | Almere City FC | Telstar | 2-3 | 1.250 | Vd Graaf | 0-1 Mirani (e.d.), 0-2 en 0-3 Novakovich, 1-3 Kvida, 2-3 Van der Water |
| 29 | 12/03/2018 | Helmond Sport | FC Den Bosch | 3-1 | 1.476 | C. Mulder | 0-1 Vossebelt (pen), 1-1 Braber, 2-1 Thomassen, 3-1 Zeldenrust |
| 29 | 12/03/2018 | Jong AZ | Go Ahead Eagles | 0-0 | 480 | Teuben | |
| 30 | 16/03/2018 | SC Cambuur | NEC | 1-1 | 7.262 | Kamphuis | 0-1 Achahbar, 1-1 Van Deelen |
| 30 | 16/03/2018 | RKC Waalwijk | MVV Maastricht | 1-1 | 1.938 | Bijl | 1-0 Janssens, 1-1 Okita |
| 30 | 16/03/2018 | Jong PSV | FC Volendam | 2-1 | 298 | Blank | 1-0 Malen, 2-0 Verreth, 2-1 Tol; R: Evers (Vol) |
| 30 | 16/03/2018 | FC Eindhoven | Jong FC Utrecht | 5-2 | 2.346 | Van Herk | 1-0 Lieder, 2-0 Kabangu, 2-1 Venema, 3-1 Lieder (pen), 4-1 Swinnen, 5-1 Lieder, 5-2 Venema |
| 30 | 16/03/2018 | Go Ahead Eagles | Telstar | 1-1 | 6.788 | Perez | 1-0 Werkhoven, 1-1 Novakovich |
| 30 | 16/03/2018 | FC Den Bosch | FC Dordrecht | 4-1 | 2.186 | Bax | 1-0 en 2-0 Vossebelt (pen), 3-0 Blummel, 3-1 Boumediene, 4-1 Felida |
| 30 | 16/03/2018 | De Graafschap | Jong Ajax | 2-4 | 9.114 | Vd Graaf | 0-1 Sierhuis, 1-1 Van Mieghem, 1-2 Sierhuis, 2-2 El Jebli, 2-3 Sierhuis (pen), 2-4 Nunnely R: Nieuwpoort, Abena (Gra) |
| 30 | 16/03/2018 | FC Oss | Fortuna Sittard | 1-2 | 1.472 | Kooij | 1-0 Van der Venne, 1-1 Schuurs, 1-2 Askovski |
| 30 | 16/03/2018 | FC Emmen | Helmond Sport | 0-0 | 2.850 | Dieperink | |
| 30 | 16/03/2018 | Jong AZ | Almere City FC | 4-1 | 300 | C. Mulder | 1-0 Einarsson, 2-0 Jacobs, 2-1 MacDonald, 3-1 Hoedemakers, 4-1 Fase |
| 31 | 23/03/2018 | Jong FC Utrecht | Jong PSV | 1-4 | 250 | C. Mulder | 0-1 Van der Moot, 0-2 Ritzmaier, 0-3 Verreth, 1-3 Zwartjens, 1-4 Verreth |
| 31 | 25/03/2018 | FC Dordrecht | Go Ahead Eagles | 1-2 | 1.721 | Gerrets | 0-1 Stans, 1-1 Mahmudov, 1-2 Schenk |
| 31 | 23/03/2018 | MVV Maastricht | FC Eindhoven | 2-0 | 5.011 | Bax | 1-0 Ciranni, 2-0 Nwakali (pen) |
| 31 | 23/03/2018 | Fortuna Sittard | SC Cambuur | 3-2 | 3.520 | Dieperink | 0-1 Steenvoorden, 0-2 Kip, 1-2, 2-2 (pen) en 3-2 (pen) Semedo |
| 31 | 23/03/2018 | NEC | De Graafschap | 1-1 | 11.402 | Nijhuis | 1-0 Achahbar, 1-1 El Jabli |
| 31 | 25/03/2018 | Jong Ajax | Jong AZ | 0-1 | 1.353 | Perez | 0-1 Reijnders |
| 31 | 25/03/2018 | Almere City FC | FC Emmen | 2-2 | 1.420 | Kooij | 1-0 Van der Water, 2-0 Valpoort, 2-1 Bilate, 2-2 Mirani (e.d.) |
| 31 | 24/03/2018 | Telstar | RKC Waalwijk | 0-0 | 2.663 | Vd Eijk | |
| 31 | 23/03/2018 | Helmond Sport | FC Oss | 2-1 | 1.791 | Ruperti | 1-0 Janzen, 2-0 Hiwat, 2-1 Dogan |
| 31 | 25/03/2018 | FC Volendam | FC Den Bosch | 1-0 | 3.423 | Martens | 1-0 Antwi |
| 32 | 30/03/2018 | SC Cambuur | FC Volendam | 2-2 | 7.283 | Vd Graaf | 1-0 Houtkoop, 1-1 Antwi, 2-1 Crowley, 2-2 Berenstein |
| 32 | 30/03/2018 | FC Eindhoven | NEC | 3-2 | 2.487 | Mulder | 1-0 en 2-0 Kabangu, 3-0 De Silva, 3-1 Achahbar, 3-2 Golla |
| 32 | 30/03/2018 | Go Ahead Eagles | Helmond Sport | 3-1 | 7.173 | Blank | 1-0 Suk, 1-1 Zeldenrust, 2-1 en 3-1 Werkhoven R: Warmolts (Hel) |
| 32 | 30/03/2018 | FC Den Bosch | MVV Maastricht | 2-1 | 2.889 | Dieperink | 1-0 en 2-0 Van der Sande, 2-1 Okita; R: Nys (MVV) |
| 32 | 30/03/2018 | De Graafschap | RKC Waalwijk | 1-0 | 8.233 | Martens | 1-0 Tissoudali |
| 32 | 30/03/2018 | Jong Ajax | Jong PSV | 0-3 | 1.351 | Ruperti | 0-1 Verreth, 0-2 Daneels, 0-3 Laursen |
| 32 | 30/03/2018 | FC Oss | Telstar | 0-0 | 2.921 | Bijl | |
| 32 | 30/03/2018 | Almere City FC | Fortuna Sittard | 1-4 | 2.332 | Vd Kerkhof | 0-1, 0-2 en 0-3 (pen) Vidigal, 0-4 Stokkers, 1-4 Mac-Intosch |
| 32 | 30/03/2018 | FC Emmen | FC Dordrecht | 1-3 | 2.661 | Perez | 0-1 Mahmudov, 0-2 en 0-3 Mutzers, 1-3 Loen |
| 32 | 30/03/2018 | Jong AZ | Jong FC Utrecht | 1-3 | 390 | Teuben | 0-1, 0-2 (pen) en 0-3 Venema, 1-3 Reijnders |
| 33 | 02/04/2018 | SC Cambuur | FC Eindhoven | 3-2 | 7.796 | Nijhuis | 0-1 Lieder, 1-1 en 2-1 Barto, 2-2 Lieder,3-2 Crowley |
| 33 | 02/04/2018 | Jong FC Utrecht | Go Ahead Eagles | 1-0 | 566 | Oostrom | 1-0 Özbozkurt |
| 33 | 02/04/2018 | FC Volendam | Jong AZ | 4-1 | 3.530 | Ruperti | 0-1 Druijf, 1-1 Berenstein, 2-1 Ten Den, 3-1 Visser, 4-1 Ten Den |
| 33 | 02/04/2018 | FC Dordrecht | Jong Ajax | 2-3 | 1.642 | Teuben | 1-0 Mutzers, 1-1 Nunnely, 1-2 Cassierra, 2-2 Mahmudov, 2-3 Bijleveld |
| 33 | 02/04/2018 | RKC Waalwijk | Almere City FC | 0-4 | 2.039 | Van Herk | 0-1 Hoefdraad, 0-2 Overtoom, 0-3 Salasiwa, 0-4 Owusu |
| 33 | 02/04/2018 | Jong PSV | FC Oss | 4-1 | 700 | Perez | 1-0 Malen, 1-1 Van der Venne, 2-1 Lammers, 3-1 Gakpo, 4-1 en 5-1 Malen |
| 33 | 02/04/2018 | MVV Maastricht | FC Emmen | 0-1 | 4.426 | Blank | 0-1 Peters |
| 33 | 02/04/2018 | Fortuna Sittard | Helmond Sport | 3-0 | 6.012 | Vd Eijk | 1-0 Hutten, 2-0 Pinto, 3-0 Semedo |
| 33 | 02/04/2018 | De Graafschap | FC Den Bosch | 2-1 | 8.911 | Vd Kerkhof | 1-0 Serrarens, 2-0 Van Mieghem, 2-1 Bouyaghlafen |
| 33 | 02/04/2018 | NEC | Telstar | 3-0 | 10.538 | Bax | 1-0 Heinloth, 2-0 Golla, 3-0 Kadiaglu R: Sno (Tel) |
| 34 | 06/04/2018 | FC Eindhoven | De Graafschap | 2-4 | 2.480 | Vd Eijk | 0-1 Van Mieghem, 0-2 El Jebli, 1-2 Van de Velde, 2-2 Kabangu, 2-3 en 2-4 Serrarens R: Tutuarima (Gra) |
| 34 | 06/04/2018 | Go Ahead Eagles | Fortuna Sittard | 0-1 | 7.563 | Lindhout | 0-1 Schuurs |
| 34 | 06/04/2018 | FC Den Bosch | SC Cambuur | 1-2 | 2.657 | Perez | 0-1 Schils, 0-2 Van Kippersluis, 1-2 Fernandes |
| 34 | 06/04/2018 | FC Oss | RKC Waalwijk | 3-1 | 2.287 | Gerrets | 0-1 Kökcü, 1-1 Bakx, 2-1 en 3-1 Kamaci |
| 34 | 06/04/2018 | Almere City FC | Jong FC Utrecht | 2-1 | 1.592 | Blank | 1-0 MacDonald, 1-1 Sow, 2-1 MacDonald |
| 34 | 06/04/2018 | Telstar | Jong PSV | 0-0 | 2.863 | Martens | |
| 34 | 06/04/2018 | Helmond Sport | MVV Maastricht | 2-3 | 1.981 | Oostrom | 0-1 en 0-2 Okita, 1-2 Naudts, 2-2 Thomassen, 2-3 Okita |
| 34 | 06/04/2018 | FC Emmen | FC Volendam | 2-3 | 2.875 | Vd Kerkhof | 0-1 Smal, 1-1 Veldmate, 1-2 Vlak, 2-2 Peters, 2-3 Stroo |
| 34 | 06/04/2018 | Jong AZ | FC Dordrecht | 3-1 | 400 | Bijl | 1-0 Church, 2-0 en 3-0 Jacobs, 3-1 Mahmudov |
| 35 | 09/04/2018 | SC Cambuur | Jong AZ | 3-2 | 7.083 | Van Herk | 1-0 Van Kippersluis, 1-1 Jacobs, 2-1 Van Kippersluis, 2-2 Jacobs, 3-2 Mathieu |
| 35 | 09/04/2018 | Jong FC Utrecht | FC Volendam | 2-1 | 667 | Bijl | 1-0 Troupée, 1-1 Ten Den, 2-1 Loukili R: Mulder (Utr) |
| 35 | 09/04/2018 | RKC Waalwijk | Fortuna Sittard | 1-1 | 2.618 | Perez | 1-0 Seys, 1-1 Hutten |
| 35 | 09/04/2018 | MVV Maastricht | FC Dordrecht | 1-0 | 4.419 | Mulder | 1-0 Schroijen |
| 35 | 09/04/2018 | FC Eindhoven | Helmond Sport | 3-2 | 2.419 | Dieperink | 0-1 Naudts, 1-1 en 2-1 Van de Velde, 2-2 Naudts, 3-2 Swinnen |
| 35 | 09/04/2018 | FC Den Bosch | Jong Ajax | 2-5 | 3.217 | Blank | 1-0 Van der Sande, 1-1 Johnsen, 1-2 Cassierra, 2-2 Van der Sande, 2-3 Ekkelenkamp, 2-4 CAssierra (pen), 2-5 Sierhuis |
| 35 | 09/04/2018 | De Graafschap | Almere City FC | 4-2 | 7.712 | Bax | 1-0 en 2-0 Tissoudali, 2-1 Valpoort, 2-2 Van Hilten, 3-2 Tissoudsali, 4-2 Diemers |
| 35 | 09/04/2018 | NEC | FC Oss | 2-1 | 8.667 | Martens | 0-1 Kamaci, 1-1 Groeneveld, 2-1 Kadioglu |
| 35 | 09/04/2018 | FC Emmen | Telstar | 2-3 | 2.359 | Kamphuis | 0-1 Platje (pen), 1-1 Peters (pen), 1-2 Schouten, 1-3 Novakovich, 2-3 Dallinga; R: Loen (Emm) |
| 35 | 10/04/2018 | Jong PSV | Go Ahead Eagles | 6-0 | 544 | Teuben | 1-0 en 2-0 Laursen, 3-0 Lammers, 4-0 Groenbast (ed), 5-0 (p) en 6-0 Gudmundsson |
| 36 | 13/04/2018 | FC Volendam | RKC Waalwijk | 0-1 | 3.654 | C. Mulder | 0-1 Van Eijma |
| 36 | 13/04/2018 | FC Dordrecht | SC Cambuur | 0-3 | 2.135 | Vd Eijk | 0-1 Crowley, 0-2 en 0-3 Barto |
| 36 | 13/04/2018 | Go Ahead Eagles | FC Eindhoven | 1-3 | 5.312 | Ruperti | 1-0 Schenk, 1-1 Van Landschoot, 1-2 en 1-3 Lieder R: Werkhoven (GoA) |
| 36 | 13/04/2018 | Fortuna Sittard | FC Den Bosch | 2-0 | 8.214 | S. Mulder | 1-0 Semedo, 2-0 Stokkers |
| 36 | 13/04/2018 | Jong Ajax | FC Emmen | 3-2 | 714 | Martens | 1-0 Sierhuis, 2-0 Nunnely, 3-0 Sierhuis, 3-1 en 3-2 Bannink |
| 36 | 13/04/2018 | FC Oss | De Graafschap | 1-4 | 2.891 | Oostrom | 1-0 Kamaci, 1-1 El Jebli, 1-2 Van Mieghem, 1-3 Tissoudali, 1-4 Serrarens |
| 36 | 13/04/2018 | Almere City FC | Jong PSV | 2-1 | 2.185 | Vd Graaf | 1-0 Salasiwa, 1-1 Konings, 2-1 Mirani |
| 36 | 13/04/2018 | Telstar | Jong FC Utrecht | 1-0 | 2.514 | Van Herk | 1-0 Platje (pen) |
| 36 | 13/04/2018 | Helmond Sport | NEC | 1-2 | 1.938 | Vd Kerkhof | 0-1 Groeneveld, 0-2 Heinloth, 1-2 Braber R: Janzen (Hel) |
| 36 | 13/04/2018 | Jong AZ | MVV Maastricht | 3-1 | 270 | Gerrets | 0-1 Schroijen. 1-1 Kaandorp, 2-1 Jacobs, 3-1 Goudmijn |
| 34 | 16/04/2018 | Jong Ajax | NEC | 1-0 | 1.829 | Vd Graaf | 1-0 Johnsen |
| 37 | 20/04/2018 | SC Cambuur | Helmond Sport | 4-1 | 8.233 | Rupereti | 1-0 Steenvoorden, 1-1 Braber, 2-1 Mathieu, 3-1 Van Kippersluis, 4-1 Kip |
| 37 | 20/04/2018 | Jong FC Utrecht | Fortuna Sittard | 0-1 | 2.547 | Bax | 0-1 Hutten |
| 37 | 20/04/2018 | FC Volendam | Jong Ajax | 1-2 | 4.396 | Gerrets | 0-1 De Wit, 1-1 Vlak, 1-2 Sierhuis |
| 37 | 20/04/2018 | RKC Waalwijk | Go Ahead Eagles | 2-1 | 2.623 | Bijl | 0-1 Schets, 1-1 Seys, 2-1 Van Eijma |
| 37 | 20/04/2018 | Jong PSV | FC Dordrecht | 4-2 | 458 | Oostrom | 1-0 Gakpo, 2-0 Obispo, 3-0 Laursen, 3-1 Mahmudov, 4-1 Malen, 4-2 Arias (pen) |
| 37 | 20/04/2018 | MVV Maastricht | FC Oss | 1-1 | 5.073 | Teuben | 1-0 Okita, 1-1 Verrips (e.d.) |
| 37 | 20/04/2018 | FC Eindhoven | Almere City FC | 3-2 | 2.509 | Martens | 0-1 MacDonald, 1-1 en 2-1 Lieder, 2-2 Hoefdraad, 3-2 Lieder (pen) |
| 37 | 23/04/2018 | FC Den Bosch | FC Emmen | 1-2 | 2.213 | Dieperink | 0-1 Peters (pen), 1-1 Van der Sande, 1-2 Gronsveld |
| 37 | 20/04/2018 | De Graafschap | Telstar | 1-0 | 8.822 | Blank | 1-0 El Jebli |
| 37 | 20/04/2018 | NEC | Jong AZ | 2-0 | 10.496 | Dieperink | 1-0 Achahbar, 2-0 Groeneveld |
| 38 | 28/04/2018 | FC Dordrecht | NEC | 3-3 | 2.134 | Lindhout | 1-0 Calcan, 2-0 Mahmudov, 2-1 en 2-2 Achahbar, 2-3 Golla, 3-3 Calcan; R: Bliek (Dor) |
| 38 | 28/04/2018 | Go Ahead Eagles | FC Den Bosch | 1-2 | 6.869 | Vd Graaf | 0-1 en 0-2 Blummel, 1-2 Namane |
| 38 | 28/04/2018 | Fortuna Sittard | Jong PSV | 1-0 | 11.787 | Janssen | 1-0 Stokkers |
| 38 | 28/04/2018 | Jong Ajax | MVV Maastricht | 2-1 | 1.800 | Bax | 0-1 Nwakali (pen), 1-1 Sierhuis, 2-1 Cassierra |
| 38 | 28/04/2018 | FC Oss | FC Eindhoven | 1-1 | 2.560 | C. Mulder | 1-0 Kamaci, 1-1 Thomas |
| 38 | 28/04/2018 | Almere City FC | FC Volendam | 2-0 | 2.629 | S. Mulder | 1-0 Van der Water, 2-0 Overtoom |
| 38 | 28/04/2018 | Telstar | SC Cambuur | 0-1 | 2.663 | Bijl | 0-1 Mathieu (pen); R: Lopes Cabral (Tel) |
| 38 | 28/04/2018 | Helmond Sport | RKC Waalwijk | 2-2 | 1.741 | Manschot | 1-0 Braber, 1-1 Van Koesveld (e.d.), 2-1 Naudts, 2-2 Van Eijma |
| 38 | 28/04/2018 | FC Emmen | Jong FC Utrecht | 0-0 | 3.329 | Vd Eijk | |
| 38 | 28/04/2018 | Jong AZ | De Graafschap | 2-2 | 600 | Teuben | 1-0 Hoedemakers, 1-1 Serrarens, 1-2 Diemers, 2-2 Kaandorp |
Play offs voor promotie/degradatie
| 1e ronde | ||||||
| 01/05/2018 | MVV Maastricht | Almere City FC | 1-3 | 4.264 | Janssen | 0-1 Mirani, 1-1 Ciranni, 1-2 en 1-3 Mirani |
| 01/05/2018 | FC Dordrecht | SC Cambuur | 1-4 | 2.412 | Bax | 0-1 Crowley, 0-2 Mathieu, 1-2 Bliek, 1-3 en 1-4 Barto |
| 05/05/2018 | Almere City FC | MVV Maastricht | 3-2 | 1.792 | Gözübüyük | 0-1 Janssen, 1-1 Van der Water, 1-2 Okita, 2-2 en 3-2 MacDonald |
| 05/05/2018 | SC Cambuur | FC Dordrecht *** | 1-4 | 7.542 | 1-0 Kallon, 1-1 Cijntje, 1-2 Arias, 1-3 (pen) en 1-4 Mahmudov | |
| 2e ronde | ||||||
| 10/05/2018 | Telstar | De Graafschap | 3-2 | 4.663 | Kamphuis | 1-0 Platje, 2-0 Navokovich, 1-1 Van Mieghem, 2-2 Serrarens, 3-2 Hamdaoui; R: Nieuwpoort (Gra), Van Huizen (Tel) |
| 10/05/2018 | FC Emmen | NEC | 4-0 | 5.378 | Vd Kerkhof | 1-0 Veldmate, 2-0 Bakker, 3-0 Loen, 4-0 Bijl |
| 10/05/2018 | FC Dordrecht | Sparta Rotterdam | 1-2 | 4.235 | S. Mulder | 0-1 Brogno, 1-1 Spierings (e.d.), 1-2 Muhren |
| 10/05/2018 | Almere City FC | Roda JC Kerkrade | 0-0 | 2.826 | Nijhuis | |
| 13/05/2018 | De Graafschap | Telstar | 4-2 | 11.083 | Van Boekel | 1-0 Nieuwpoort, 2-0 El Jebli, 2-1 Hamdaoui, 3-1 Serrarens, 3-2 Novakovich (pen), 4-2 Van Mieghem |
| 13/05/2018 | NEC | FC Emmen | 4-1 | 5.321 | Nijhuis | 1-0 en 2-0 Achahbar, 2-1 Bannink, 3-1 Sturing, 4-1 Romeny |
| 13/05/2018 | Sparta Rotterdam | FC Dordrecht | 2-2 | 10.132 | Manschot | 0-1 Mahmudov, 0-2 Cijntje, 1-2 Duarte, 2-2 Mühren |
| 13/05/2018 | Roda JC Kerkrade | Almere City FC | 1-2 | 12.489 | Lindhout | 0-1 Van der Water, 1-1 Schahin, 1-2 Hammouti |
| 3e ronde | ||||||
| 17/05/2018 | FC Emmen | Sparta Rotterdam | 0-0 | 8.301 | Lindhout | |
| 17/05/2018 | Almere City FC | De Graafschap | 1-1 | 3.430 | Blom | 1-0 Van der Water, 1-1 Serrarens (pen); R: Overtoom (Alm) |
| 20/05/2018 | Sparta Rotterdam | FC Emmen | 1-3 | 10.606 | Higler | 1-0 Sp[ierings, 1-1 Chacon, 1-2 Jansen, 1-3 Bannink R: Dougall (Spa) |
| 20/05/2018 | De Graafschap | Almere City FC | 2-1 | 12.600 | Makkelie | 0-1 Hoefdraad, 1-1 Tissoudali, 2-1 Serrarens |
FC Emmen en De Graafschap gepromoveerd, Sparta en Roda JC gedegradeerd.
Topscorers
| 1 | Mart Lieder | FC Eindhoven | 30 |
| 2 | Andrija Novakovich | Telstar | 19 |
| 3 | Mateo Cassierra | Jong Ajax | 18 |
| 4 | Jonathan Okita | MVV Maastricht | 18 |
| 5 | Cas Peters | FC Emmen | 17 |
| 6 | Sam Hendriks | Go Ahead Eagles | 16 |
| 7 | Daryl van Mieghem | De Graafschap | 16 |
| 8 | Arsenio Valpoort | Almere City FC | 16 |
| 9 | Anass Achahbar | NEC | 15 |
| 10 | Fatih Kamaci | FC Oss | 15 |
| 11 | Denis Mahmudov | FC Dordrecht | 15 |
| 12 | Lisandro Semedo | Fortuna Sittard | 15 |
| 13 | Enzo Stroo | FC Volendam | 15 |
| 14 | Niek Vossebelt | FC Den Bosch | 15 |