Uitslagenmatrix
| AJA | AZ | EXC | FEY | GRA | GRO | HEE | HER | NAC | NEC | PSV | ROD | SPA | TWE | UTR | VIT | VVV | WIL | |
| Ajax | * | 6 - 1 | 4 - 0 | 3 - 0 | 4 - 1 | 2 - 2 | 3 - 1 | 5 - 1 | 1 - 3 | 0 - 0 | 0 - 2 | 4 - 2 | 6 - 2 | 0 - 0 | 2 - 0 | 4 - 1 | 6 - 1 | 4 - 1 |
| AZ | 2 - 3 | * | 3 - 0 | 0 - 1 | 0 - 0 | 2 - 2 | 0 - 1 | 1 - 0 | 1 - 2 | 4 - 0 | 0 - 2 | 1 - 1 | 1 - 0 | 0 - 0 | 2 - 1 | 2 - 1 | 4 - 0 | 2 - 0 |
| Excelsior | 2 - 1 | 1 - 1 | * | 2 - 1 | 1 - 1 | 1 - 3 | 2 - 5 | 1 - 1 | 0 - 3 | 2 - 0 | 1 - 4 | 1 - 2 | 4 - 3 | 0 - 2 | 0 - 2 | 1 - 2 | 2 - 1 | 0 - 0 |
| Feyenoord | 2 - 2 | 2 - 2 | 1 - 0 | * | 2 - 0 | 1 - 1 | 2 - 0 | 6 - 0 | 5 - 0 | 1 - 3 | 0 - 1 | 3 - 0 | 2 - 0 | 3 - 1 | 3 - 1 | 1 - 0 | 4 - 1 | 2 - 0 |
| De Graafschap | 1 - 8 | 1 - 2 | 1 - 1 | 1 - 3 | * | 1 - 1 | 0 - 3 | 0 - 0 | 0 - 1 | 1 - 1 | 0 - 1 | 2 - 1 | 4 - 0 | 0 - 0 | 1 - 1 | 0 - 3 | 3 - 2 | 1 - 2 |
| FC Groningen | 1 - 2 | 2 - 1 | 3 - 2 | 3 - 2 | 0 - 2 | * | 0 - 1 | 1 - 2 | 1 - 2 | 1 - 3 | 2 - 1 | 1 - 1 | 1 - 0 | 1 - 0 | 3 - 1 | 0 - 0 | 1 - 0 | 1 - 0 |
| sc Heerenveen | 1 - 2 | 4 - 0 | 5 - 0 | 1 - 1 | 2 - 3 | 4 - 2 | * | 9 - 0 | 2 - 0 | 2 - 3 | 2 - 1 | 4 - 3 | 3 - 3 | 1 - 2 | 2 - 3 | 7 - 0 | 5 - 1 | 0 - 0 |
| Heracles Almelo | 0 - 1 | 2 - 1 | 2 - 0 | 3 - 3 | 2 - 0 | 1 - 2 | 2 - 2 | * | 0 - 1 | 0 - 2 | 0 - 2 | 0 - 0 | 2 - 0 | 0 - 3 | 2 - 1 | 2 - 2 | 0 - 0 | 1 - 0 |
| NAC Breda | 2 - 3 | 2 - 3 | 2 - 0 | 3 - 1 | 1 - 0 | 0 - 3 | 2 - 2 | 4 - 1 | * | 0 - 1 | 1 - 1 | 0 - 0 | 3 - 0 | 1 - 5 | 1 - 0 | 1 - 2 | 0 - 0 | 1 - 0 |
| NEC | 1 - 1 | 5 - 2 | 0 - 1 | 0 - 2 | 3 - 1 | 1 - 0 | 0 - 1 | 3 - 0 | 6 - 0 | * | 0 - 0 | 2 - 0 | 4 - 2 | 2 - 2 | 2 - 0 | 1 - 0 | 2 - 2 | 1 - 0 |
| PSV | 0 - 0 | 1 - 1 | 2 - 1 | 4 - 0 | 4 - 1 | 3 - 0 | 1 - 1 | 2 - 0 | 2 - 0 | 5 - 0 | * | 2 - 4 | 3 - 1 | 1 - 1 | 4 - 1 | 1 - 0 | 3 - 1 | 3 - 0 |
| Roda JC | 2 - 1 | 1 - 1 | 3 - 3 | 1 - 3 | 1 - 0 | 5 - 1 | 1 - 0 | 2 - 1 | 0 - 2 | 0 - 2 | 1 - 1 | * | 2 - 3 | 3 - 1 | 1 - 1 | 3 - 2 | 4 - 1 | 1 - 1 |
| Sparta Rotterdam | 2 - 2 | 2 - 2 | 0 - 1 | 3 - 2 | 6 - 1 | 1 - 3 | 4 - 2 | 1 - 1 | 0 - 1 | 1 - 0 | 1 - 4 | 4 - 1 | * | 1 - 1 | 2 - 1 | 1 - 2 | 2 - 0 | 2 - 2 |
| FC Twente | 2 - 1 | 2 - 1 | 1 - 0 | 2 - 0 | 2 - 0 | 3 - 1 | 1 - 0 | 2 - 1 | 3 - 0 | 3 - 0 | 0 - 0 | 0 - 1 | 1 - 2 | * | 2 - 2 | 4 - 3 | 1 - 1 | 2 - 0 |
| FC Utrecht | 0 - 1 | 2 - 2 | 4 - 1 | 0 - 3 | 2 - 2 | 2 - 2 | 2 - 2 | 3 - 1 | 0 - 1 | 3 - 2 | 3 - 1 | 3 - 1 | 7 - 1 | 0 - 1 | * | 2 - 4 | 1 - 4 | 2 - 0 |
| Vitesse | 2 - 2 | 1 - 0 | 3 - 0 | 0 - 1 | 0 - 2 | 2 - 1 | 0 - 1 | 2 - 0 | 3 - 3 | 1 - 0 | 0 - 1 | 1 - 1 | 3 - 0 | 2 - 2 | 2 - 2 | * | 1 - 3 | 1 - 0 |
| VVV-Venlo | 2 - 2 | 2 - 3 | 3 - 1 | 0 - 0 | 3 - 0 | 2 - 5 | 0 - 4 | 0 - 5 | 1 - 3 | 1 - 2 | 1 - 1 | 3 - 5 | 2 - 0 | 0 - 2 | 1 - 2 | 2 - 0 | * | 1 - 1 |
| Willem II | 2 - 3 | 3 - 0 | 6 - 0 | 3 - 1 | 1 - 2 | 1 - 2 | 2 - 3 | 2 - 1 | 0 - 0 | 3 - 0 | 0 - 1 | 1 - 0 | 2 - 2 | 1 - 3 | 1 - 4 | 4 - 0 | 1 - 2 | * |
Eindstand
| 1 | PSV * ** | 34 | 21 | 9 | 4 | 72 | 65 | 24 | 41 |
| 2 | Ajax + *** | 34 | 20 | 9 | 5 | 69 | 94 | 45 | 49 |
| 3 | NAC Breda + | 34 | 19 | 6 | 9 | 63 | 48 | 40 | 8 |
| 4 | FC Twente + ** | 34 | 17 | 11 | 6 | 62 | 52 | 32 | 20 |
| 5 | sc Heerenveen + *** | 34 | 18 | 6 | 10 | 60 | 88 | 48 | 40 |
| 6 | Feyenoord *** | 34 | 18 | 6 | 10 | 60 | 64 | 41 | 23 |
| 7 | FC Groningen + | 34 | 15 | 6 | 13 | 51 | 53 | 54 | -1 |
| 8 | NEC + *** | 34 | 14 | 7 | 13 | 49 | 49 | 50 | -1 |
| 9 | Roda JC | 34 | 12 | 11 | 11 | 47 | 55 | 55 | 0 |
| 10 | FC Utrecht | 34 | 13 | 7 | 14 | 46 | 59 | 55 | 4 |
| 11 | AZ | 34 | 11 | 10 | 13 | 43 | 48 | 53 | -5 |
| 12 | Vitesse | 34 | 12 | 7 | 15 | 43 | 46 | 55 | -9 |
| 13 | Sparta Rotterdam | 34 | 9 | 7 | 18 | 34 | 52 | 76 | -24 |
| 14 | Heracles Almelo | 34 | 8 | 8 | 18 | 32 | 34 | 64 | -30 |
| 15 | Willem II | 34 | 8 | 7 | 19 | 31 | 40 | 49 | -9 |
| 16 | De Graafschap ^^^ | 34 | 7 | 9 | 18 | 30 | 33 | 64 | -31 |
| 17 | VVV-Venlo ^^ | 34 | 7 | 8 | 19 | 29 | 44 | 76 | -32 |
| 18 | Excelsior ^ | 34 | 7 | 6 | 21 | 27 | 32 | 75 | -43 |
Play offs voor Europees voetbal
| CL play off - 1e ronde | |||
| 29/04/2008 | FC Twente | NAC Breda | 3-0 |
| 01/05/2008 | SC Heerenveen | Ajax | 1-2 |
| 03/05/2008 | NAC Breda | FC Twente | 1-5 |
| 05/05/2008 | Ajax | SC Heerenveen | 3-1 |
| CL play off - Finale | |||
| 08/05/2008 | SC Heerenveen | NAC Breda | 2-0 |
| 10/05/2008 | FC Twente | Ajax | 2-1 |
| 12/05/2008 | NAC Breda | SC Heerenveen | 2-2 |
| 18/05/2008 | Ajax | FC Twente | 0-0 |
| UC play off - 1e ronde | |||
| 01/05/2008 | FC Utrecht | FC Groningen | 2-2 |
| 01/05/2008 | Roda JC | NEC | 0-1 |
| 04/05/2008 | FC Groningen | FC Utrecht | 3-1 |
| 04/05/2008 | NEC | Roda JC | 2-0 |
| UC play off - Finale | |||
| 08/05/2008 | NEC | FC Groningen | 1-0 |
| 11/05/2008 | FC Groningen | NEC | 1-3 |
| 15/05/2008 | NEC | NAC Breda | 6-0 |
| 18/05/2008 | NAC Breda | NEC | 0-1 |
FC Twente plaatst zich voor de voorronde van de Champions League
Ajax, sc Heerenveen en NEC plaatsen zich voor de UEFA Cup
Play offs voor promotie en degradatie
| 1e ronde | |||
| 22/04/2008 | Go Ahead Eagles | ADO Den Haag | 1-1 |
| 22/04/2008 | TOP Oss | Helmond Sport | 2-2 |
| 26/04/2008 | ADO Den Haag | Go Ahead Eagles | 3-0 |
| 26/04/2008 | Helmond Sport | TOP Oss | 3-0 |
| 2e ronde | |||
| 01/05/2008 | ADO Den Haag | VVV Venlo | 1-0 |
| 01/05/2008 | Helmond Sport | De Graafschap | 2-3 |
| 01/05/2008 | MVV | RKC Waalwijk | 1-0 |
| 01/05/2008 | FC Zwolle | FC Den Bosch | 0-1 |
| 04/05/2008 | FC Den Bosch | FC Zwolle | 1-2 |
| 04/05/2008 | De Graafschap | Helmond Sport | 3-1 |
| 04/05/2008 | VVV Venlo | ADO Den Haag | 1-0 |
| 04/05/2008 | RKC Waalwijk | MVV | 3-0 |
| 07/05/2008 | ADO Den Haag | VVV Venlo | 2-0 |
| 07/05/2008 | FC Zwolle | FC Den Bosch | 1-0 |
| 07/05/2008 | RKC Waalwijk | MVV | 4-0 |
| Finaleronde | |||
| 11/05/2008 | ADO Den Haag | RKC Waalwijk | 1-1 |
| 11/05/2008 | FC Zwolle | De Graafschap | 1-3 |
| 15/05/2008 | De Graafschap | FC Zwolle | 0-0 |
| 15/05/2008 | RKC Waalwijk | ADO Den Haag | 2-2 |
| 18/05/2008 | ADO Den Haag | RKC Waalwijk | 2-1 |
VVV-Venlo degradeert
De Graafschap handhaaft zich
ADO Den Haag promoveert