Het seizoen begint dramatisch voor de Nederlandse topclubs. Ajax en PSV stranden al in de voorronden van het Europese voetbal tegen respectievelijk Rosenborg en Osijek. Opnieuw een duidelijk signaal dat het Nederlandse voetbal er beroerd voor staat. Dat blijkt later ook als Feyenoord geen potten kan breken in de Champions League.
PSV is wel net op tijd in vorm voor de start van de competitie en neemt direct het heft in handen om dat niet meer los te laten. Feyenoord worstelt na de titel met zijn vorm en bij Ajax gaat alles fout na een succesvol seizoen onder Peter Bosz, met als dieptepunt het noodlot dat Abdelhak Nouri treft in een oefenwedstrijd tegen Werder Bremen op 8 juli. Hartfalen zorgt voor blijvende hersenschade bij het dan 20-jarige talent. Het blijft het hele seizoen als een deken over Ajax liggen.
PSV is uiteindelijk al vroeg zeker van de derde landstitel in vier seizoenen. De Eindhovenaren zijn het hele seizoen de meest degelijke en constante ploeg, zonder dat het vaak tot flitsend spel komt. Ondanks het rampseizoen wordt Ajax uiteindelijk tweede. AZ maakt voetballend misschien wel de meeste indruk, maar bouwt een complex op als het gaat om spelen tegen de topclubs: alle zes ontmoetingen met de “PAF”-clubs gaan verloren. Vitesse pakt in de play-offs verrassend het laatste Europese ticket.
Minstens zo verrassend is de degradatie van grootmacht FC Twente. De club, die twee jaar eerder ternauwernood degradatie van achter de grote tafel wist te voorkomen, kent een dramatisch seizoen. Met een onsamenhangende selectie en paniekerig beleid (zowel René Hake als Gert-Jan Verbeek worden ontslagen) presteert het team, dat nog altijd over een subtopbegroting beschikt, ondermaats en eindigt als laatste. Via de play-offs degraderen nog eens twee van oudsher grote clubs (Sparta en Roda JC).
Feyenoord, dat zich opricht in de laatste fase van de competitie pakt met de KNVB-Bekerwinst toch nog een prijs. Dat gaat ten koste van AZ, dat ook de zevende wedstrijd tegen een traditionele topclub verliest.
Uitslagenmatrix
| ADO | AJA | AZ | EXC | FEY | GRO | HEE | HER | NAC | PEC | PSV | ROD | SPA | TWE | UTR | VIT | VVV | WIL | |
| ADO Den Haag | * | 1-1 | 0-3 | 1-2 | 2-2 | 0-3 | 1-2 | 4-1 | 0-2 | 4-0 | 3-3 | 3-2 | 1-0 | 2-1 | 0-3 | 1-0 | 1-1 | 2-1 |
| Ajax | 0-0 | * | 3-0 | 3-1 | 2-0 | 3-1 | 4-1 | 1-0 | 3-1 | 3-0 | 3-0 | 5-1 | 4-0 | 2-1 | 1-2 | 1-2 | 4-1 | 3-1 |
| AZ | 2-0 | 1-2 | * | 0-2 | 0-4 | 3-2 | 3-1 | 5-0 | 2-1 | 6-0 | 2-3 | 2-2 | 2-1 | 2-0 | 3-0 | 4-3 | 0-0 | 3-2 |
| Excelsior | 1-2 | 1-2 | 1-2 | * | 0-1 | 2-0 | 1-2 | 2-2 | 0-0 | 1-2 | 1-2 | 1-0 | 1-1 | 0-0 | 2-2 | 0-3 | 0-2 | 2-1 |
| Feyenoord | 3-1 | 1-4 | 2-1 | 5-0 | * | 3-0 | 1-1 | 1-0 | 0-2 | 0-0 | 1-3 | 5-1 | 3-1 | 2-1 | 3-1 | 1-0 | 1-1 | 5-0 |
| FC Groningen | 0-0 | 1-2 | 1-1 | 4-0 | 0-2 | * | 3-3 | 3-3 | 1-1 | 2-0 | 3-3 | 2-1 | 4-0 | 1-0 | 2-1 | 4-2 | 1-1 | 0-1 |
| sc Heerenveen | 2-0 | 0-4 | 1-2 | 0-1 | 2-3 | 1-1 | * | 1-1 | 1-0 | 1-2 | 2-0 | 1-1 | 2-1 | 1-0 | 2-2 | 0-4 | 2-2 | 2-0 |
| Heracles Almelo | 1-1 | 2-1 | 0-3 | 2-2 | 2-4 | 2-1 | 1-2 | * | 2-1 | 2-1 | 1-2 | 2-1 | 3-2 | 2-1 | 1-1 | 1-1 | 3-0 | 1-0 |
| NAC Breda | 0-1 | 0-8 | 1-3 | 3-1 | 2-1 | 2-1 | 3-0 | 6-1 | * | 0-2 | 1-4 | 0-1 | 2-2 | 1-2 | 3-1 | 1-0 | 0-1 | 1-2 |
| PEC Zwolle | 2-0 | 0-1 | 1-1 | 1-1 | 3-4 | 3-2 | 3-2 | 2-1 | 1-0 | * | 0-1 | 4-2 | 2-0 | 2-0 | 1-1 | 1-2 | 1-1 | 0-1 |
| PSV | 3-0 | 3-0 | 3-2 | 1-0 | 1-0 | 0-0 | 2-2 | 3-0 | 5-1 | 4-0 | * | 2-0 | 1-0 | 4-3 | 3-0 | 2-1 | 3-0 | 4-0 |
| Roda JC | 2-3 | 2-4 | 0-1 | 2-1 | 1-1 | 2-2 | 2-1 | 0-3 | 1-0 | 3-2 | 2-2 | * | 0-2 | 1-1 | 1-4 | 1-3 | 0-1 | 1-3 |
| Sparta | 2-1 | 2-5 | 0-2 | 2-3 | 0-7 | 2-1 | 0-0 | 2-5 | 2-1 | 1-1 | 1-2 | 1-2 | * | 1-0 | 1-3 | 0-1 | 3-2 | 1-0 |
| FC Twente | 2-3 | 3-3 | 0-4 | 1-3 | 1-3 | 1-1 | 0-4 | 2-1 | 1-1 | 2-0 | 0-2 | 3-0 | 1-1 | * | 4-0 | 1-1 | 1-2 | 2-2 |
| FC Utrecht | 3-3 | 0-0 | 1-1 | 3-1 | 1-1 | 1-1 | 3-1 | 1-1 | 2-2 | 2-1 | 1-7 | 2-0 | 1-0 | 3-1 | * | 5-1 | 1-0 | 2-0 |
| Vitesse | 2-0 | 3-2 | 1-2 | 1-2 | 3-1 | 2-0 | 1-1 | 0-0 | 4-1 | 0-0 | 2-4 | 0-3 | 7-0 | 5-0 | 1-1 | * | 1-1 | 2-2 |
| VVV-Venlo | 0-2 | 0-2 | 0-2 | 2-3 | 1-0 | 1-1 | 0-2 | 3-1 | 0-0 | 1-1 | 2-5 | 1-4 | 3-0 | 0-0 | 0-1 | 2-2 | * | 3-3 |
| Willem II | 1-2 | 1-3 | 0-2 | 1-2 | 1-5 | 1-1 | 1-2 | 3-1 | 1-1 | 2-3 | 5-0 | 1-0 | 2-2 | 3-1 | 3-2 | 2-2 | 3-0 | * |
Eindstand
| 1 | PSV * ** | 34 | 26 | 5 | 3 | 83 | 87 | 39 | +48 | 33.132 |
| 2 | Ajax ** | 34 | 25 | 4 | 5 | 79 | 89 | 33 | +56 | 44.453 |
| 3 | AZ *** | 34 | 22 | 5 | 7 | 71 | 72 | 38 | +34 | 14.643 |
| 4 | Feyenoord *** | 34 | 20 | 6 | 8 | 66 | 76 | 39 | +37 | 45.588 |
| 5 | FC Utrecht + | 34 | 14 | 12 | 8 | 54 | 58 | 53 | +5 | 18.971 |
| 6 | Vitesse + *** | 34 | 13 | 10 | 11 | 49 | 63 | 47 | +16 | 15.944 |
| 7 | ADO Den Haag + | 34 | 13 | 8 | 13 | 47 | 45 | 53 | −8 | 11.537 |
| 8 | sc Heerenveen + | 34 | 12 | 10 | 12 | 46 | 48 | 53 | −5 | 19.830 |
| 9 | PEC Zwolle | 34 | 12 | 8 | 14 | 44 | 42 | 54 | −12 | 13.048 |
| 10 | Heracles Almelo | 34 | 11 | 9 | 14 | 42 | 50 | 64 | −14 | 10.580 |
| 11 | Excelsior | 34 | 11 | 7 | 16 | 40 | 41 | 56 | −15 | 4.201 |
| 12 | FC Groningen | 34 | 8 | 14 | 12 | 38 | 50 | 50 | 0 | 17.198 |
| 13 | Willem II | 34 | 10 | 7 | 17 | 37 | 50 | 63 | −13 | 12.420 |
| 14 | NAC Breda | 34 | 9 | 7 | 18 | 34 | 41 | 57 | −16 | 18.404 |
| 15 | VVV-Venlo | 34 | 7 | 13 | 14 | 34 | 35 | 54 | −19 | 6.745 |
| 16 | Roda JC Kerkrade ^^ | 34 | 8 | 6 | 20 | 30 | 42 | 69 | −27 | 12.329 |
| 17 | Sparta Rotterdam ^^ | 34 | 7 | 6 | 21 | 27 | 34 | 75 | −41 | 10.138 |
| 18 | FC Twente ^ | 34 | 5 | 9 | 20 | 24 | 37 | 63 | −26 | 24.394 |
Wedstrijden
| R: | Datum: | Thuis: | Uit: | Sc.: | Ts.: | Ar.: | Details: |
|---|---|---|---|---|---|---|---|
| 1 | 11/08/2017 | ADO Den Haag | FC Utrecht | 0-3 | 12.123 | Janssen | 0-1 Dessers, 0-2 Van de Streek, 0-3 Dessers |
| 1 | 12/08/2017 | VVV-Venlo | Sparta Rotterdam | 3-0 | 5.832 | Kamphuis | 1-0 Leemans, 2-0 Tissoudali, 3-0 Van Crooy R: Chabot (Spa) |
| 1 | 12/08/2017 | PSV | AZ | 3-2 | 30.000 | Kuipers | 0-1 Dos Santos, 1-1 Lozano, 2-1 Pereiro, 3-1 Van Ginkel, 3-2 Weghorst (pen) |
| 1 | 12/08/2017 | Heracles Almelo | Ajax | 2-1 | 12.080 | Blom | 0-1 Ziyech, 1-1 Gladon, 2-1 Kuwas |
| 1 | 12/08/2017 | Vitesse | NAC Breda | 4-1 | 13.921 | Mulder | 1-0 Bruns, 2-0 Linssen, 3-0 Matavz, 3-1 Ambrose, 4-1 Rashica |
| 1 | 13/08/2017 | PEC Zwolle | Roda JC Kerkrade | 4-2 | 13.000 | Nijhuis | 0-1 Gustrafson, 1-1 Marcellis, 2-1 Auassar (e.d.), 2-2 Gustafson (pen), 3-2 Saymak, 4-1 Van Polen |
| 1 | 13/08/2017 | Feyenoord | FC Twente | 2-1 | 47.500 | Gözübüyük | 1-0 Jørgensen, 1-1 F. Jensen, 2-1 Berghuis |
| 1 | 13/08/2017 | Willem II | Excelsior | 1-2 | 12.800 | Manschot | 0-1 Wellenreuther (e.d.), 0-2 El Azouzzi, 1-2 Sol |
| 1 | 13/08/2017 | FC Groningen | sc Heerenveen | 3-3 | 19.255 | Van Boekel | 0-1 Thorsby, 0-2 Ghoochannejhad, 1-2 Veldwijk, 2-2 Mahi (pen), 2-3 Thorsby, 3-3 Mahi (pen) |
| 2 | 18/08/2017 | Roda JC Kerkrade | Vitesse | 1-3 | 12.004 | Kamphuis | 0-1 Matavz, 1-1 Pasveer (e.d.), 1-2 Bruns, 1-3 Kashia |
| 2 | 19/08/2017 | FC Twente | VVV-Venlo | 1-2 | 23.000 | Mulder | 0-1 Van Crooy, 0-2 Promes, 1-2 Boere |
| 2 | 19/08/2017 | sc Heerenveen | Heracles Almelo | 1-1 | 18.300 | Vd Graaf | 0-1 Pröpper, 1-1 Mihajlovic |
| 2 | 20/08/2017 | Ajax | FC Groningen | 3-1 | 45.000 | Higler | 1-0 Huntelaar, 2-0 Ziyech, 1-2 Idrissi, 3-1 Schöne |
| 2 | 19/08/2017 | AZ | ADO Den Haag | 2-0 | 12.749 | Makkelie | 1-0 Weghorst (pen), 2-0 Til; R: Kanon (ADO) |
| 2 | 20/08/2017 | Excelsior | Feyenoord | 0-1 | 4.400 | Kuipers | 0-1 Boëtius |
| 2 | 20/08/2017 | FC Utrecht | Willem II | 2-0 | 16.093 | Gözübüyük | 1-0 Labyad, 2-0 Dessers |
| 2 | 20/08/2017 | Sparta Rotterdam | PEC Zwolle | 1-1 | 10.012 | Lindhout | 0-1 Mokhtar, 1-1 Mühren |
| 2 | 20/08/2017 | NAC Breda | PSV | 1-4 | 18.788 | Van Boekel | 0-1 Bergwijn, 1-1 Ambrose (pen), 1-2 Van Ginkel, 1-3 Lozano, 1-4 Hendrix |
| 3 | 25/08/2017 | NAC Breda | Sparta Rotterdam | 2-2 | 17.912 | Higler | 1-0 Marí, 2-0 Vloet, 2-1 en 2-2 Ache |
| 3 | 26/08/2017 | Vitesse | AZ | 1-2 | 14.500 | Blom | 0-1 Weghorst, 1-1 Matavz, 1-2 Weghorst |
| 3 | 26/08/2017 | ADO Den Haag | sc Heerenveen | 1-2 | 7.902 | Kamphuis | 0-1 en 0-2 Thorsby, 1-2 Johnsen |
| 3 | 26/08/2017 | PEC Zwolle | FC Twente | 2-0 | 12.800 | Janssen | 1-0 Mokhtar, 2-0 Van Polen (pen) |
| 3 | 26/08/2017 | Heracles Almelo | Excelsior | 2-2 | 10.067 | Vd Kerkhof | 1-0 Kuwas, 1-1 Bruins, 2-1 Gladon, 2-2 Caenepeel; R: Hadouir (Exc) |
| 3 | 27/08/2017 | Feyenoord | Willem II | 5-0 | 47.500 | Nijhuis | 1-0 Toornstra, 2-0 Berghuis, 3-0 Toornstra, 4-0 Vilhena, 5-0 Boëtius (pen) |
| 3 | 27/08/2017 | VVV-Venlo | Ajax | 0-2 | 8.000 | Kuipers | 0-1 Van de Beek, 0-2 Neres |
| 3 | 27/08/2017 | PSV | Roda JC Kerkrade | 2-0 | 32.200 | Makkelie | 1-0 Locadia, 2-0 Lozano |
| 3 | 27/08/2017 | FC Groningen | FC Utrecht | 2-1 | 16.032 | Manschot | 1-0 Warmerdam, 2-0 Drost, 2-1 Bahebeck |
| 4 | 09/09/2017 | Willem II | ADO Den Haag | 1-2 | 11.123 | Higler | 0-1 El Khayati (pen), 1-1 Sol, 1-2 El Khayati |
| 4 | 09/09/2017 | Heracles Almelo | Feyenoord | 2-4 | 11.331 | Makkelie | 0-1 en 0-2 Berghuis, 0-3 Boëtius, 1-3 en 2-3 (pen) Niemeijer, 2-4 Larsson |
| 4 | 09/09/2017 | Ajax | PEC Zwolle | 3-0 | 45.000 | Gözübüyük | 1-0 Huntelaar, 2-0 Ziyech, 3-0 Huntelaar |
| 4 | 09/09/2017 | Excelsior | Vitesse | 0-3 | 4.100 | Nijhuis | 0-1 Castaignos, 0-2 Matavz (pen), 0-3 Linssen |
| 4 | 10/09/2017 | sc Heerenveen | PSV | 2-0 | 22.345 | Blom | 1-0 Zeneli, 2-0 Ghoochannejhad; R: Lozano (PSV) |
| 4 | 10/09/2017 | FC Utrecht | Roda JC Kerkrade | 2-0 | 19.042 | S. Mulder | 1-0 Van de Streek, 2-0 Labyad |
| 4 | 10/09/2017 | Sparta Rotterdam | FC Twente | 1-0 | 10.034 | Bax | 1-0 Goodwin; R: Thesker |
| 4 | 10/09/2017 | AZ | NAC Breda | 2-1 | 12.511 | Janssen | 1-0 Helmer, 2-0 Til, 2-1 Korte |
| 4 | 10/09/2017 | FC Groningen | VVV-Venlo | 1-1 | 15.832 | Lindhout | 1-0 Mahi, 1-1 Nwakali |
| 5 | 15/09/2017 | Sparta Rotterdam | AZ | 0-2 | 10.210 | S. Mulder | 0-1 en 0-2 Weghorst |
| 5 | 16/09/2017 | Excelsior | sc Heerenveen | 1-2 | 4.034 | Lindhout | 1-0 Koolwijk, 1-1 Zeneli, 1-2 Rojas |
| 5 | 16/09/2017 | Roda JC Kerkrade | Willem II | 1-3 | 11.668 | Van Boekel | 0-1 Velikonja, 0-2 Sol, 0-3 Velikonja, 1-3 Rosheuvel |
| 5 | 16/09/2017 | NAC Breda | FC Groningen | 2-1 | 18.563 | Makkelie | 1-0 en 2-0 Vloet, 2-1 Mahi |
| 5 | 16/09/2017 | PEC Zwolle | Heracles Almelo | 2-1 | 12.500 | Manschot | 1-0 Mokhtar, 1-1 Monteiro, 2-1 Mokhtar |
| 5 | 17/09/2017 | Vitesse | VVV-Venlo | 1-1 | 15.000 | Higler | 1-0 Matavz, 1-1 Leemans |
| 5 | 17/09/2017 | ADO Den Haag | Ajax | 1-1 | 12.016 | Nijhuis | 0-1 Veltman, 1-1 Johnsen |
| 5 | 17/09/2017 | FC Twente | FC Utrecht | 4-0 | 24.000 | Kamphuis | 1-0 Boere, 2-0 Lam, 3-0 Slagveer, 4-0 Assaïdi |
| 5 | 17/09/2017 | PSV | Feyenoord | 1-0 | 35.000 | Kuipers | 1-0 Pereiro; R: Berghuis |
| 6 | 23/09/2017 | Willem II | sc Heerenveen | 1-2 | 10.740 | Janssen | 1-0 Lieftink, 1-1 Schaars, 1-2 Kobayashi |
| 6 | 24/09/2017 | Ajax | Vitesse | 1-2 | 50.000 | Van Boekel | 0-1 Kashia, 0-2 Rashica, 1-2 Viergever |
| 6 | 23/09/2017 | Feyenoord | NAC Breda | 0-2 | 47.500 | Kamphuis | 0-1 Korte, 0-2 Enevoldsen |
| 6 | 23/09/2017 | ADO Den Haag | Sparta Rotterdam | 1-0 | 9.641 | Manschot | 1-0 El Khayati |
| 6 | 23/09/2017 | Heracles Almelo | Roda JC Kerkrade | 2-1 | 9.943 | Kuipers | 0-1 Paulissen, 1-1 Pröpper, 2-1 Vermeij |
| 6 | 24/09/2017 | FC Utrecht | PSV | 1-7 | 22.006 | Gözübüyük | 0-1 Locadia, 1-1 Labyad (pen), 1-2 Lozano, 1-3 en 1-4 Locadia, 1-5 Van Ginkel (pen), 1-6 Locadia, 1-7 Bergwijn; R: TRoupee (Utr) |
| 6 | 24/09/2017 | VVV-Venlo | PEC Zwolle | 1-1 | 6.621 | Nijhuis | 0-1 Ehizibue, 1-1 Leemans |
| 6 | 24/09/2017 | FC Groningen | FC Twente | 1-0 | 20.110 | Vd Kerkhof | 1-0 Idrissi |
| 6 | 24/09/2017 | AZ | Excelsior | 0-2 | 12.527 | Blom | 0-1 en 0-2 Bruins (pen) |
| 7 | 29/09/2017 | FC Twente | Heracles Almelo | 2-1 | 27.100 | Higler | 1-0 Jensen, 1-1 Gladon, 2-1 Holla |
| 7 | 30/09/2017 | NAC Breda | ADO Den Haag | 0-1 | 18.523 | S. Mulder | 0-1 Beugelsdijk |
| 7 | 30/09/2017 | PEC Zwolle | FC Groningen | 3-2 | 13.160 | Van Boekel | 0-1 Doan, 1-1 Nijland, 1-2 Van Weert, 2-2 Thomas, 3-2 Mokhtar; R: Van Weert (Gro) |
| 7 | 30/09/2017 | Excelsior | VVV-Venlo | 0-2 | 4.400 | Bax | 0-1 Leemans, 0-2 Seuntjens |
| 7 | 30/09/2017 | PSV | Willem II | 4-0 | 32.500 | Manschot | 1-0 Lozano, 2-0 Pereiro, 3-0 Lozano, 4-0 Van Ginkel (pen) |
| 7 | 01/10/2017 | Sparta Rotterdam | Roda JC Kerkrade | 1-2 | 9.834 | Makkelie | 0-1 Ndenge, 0-2 Schahin, 1-2 Mühren |
| 7 | 01/10/2017 | AZ | Feyenoord | 0-4 | 14.644 | Nijhuis | 0-1 Berghuis, 0-2 Larsson, 0-3 Berghuis, 0-4 Vilhena |
| 7 | 01/10/2017 | sc Heerenveen | Ajax | 0-4 | 25.600 | Gözübüyük | 0-1 en 0-2 Neres, 0-3 Schöne (pen), 0-4 Wöber |
| 7 | 01/10/2017 | Vitesse | FC Utrecht | 1-1 | 15.432 | Kuipers | 0-1 Dessers, 1-1 Mount |
| 8 | 14/10/2017 | Roda JC Kerkrade | NAC Breda | 1-0 | 12.230 | Vd Graaf | 1-0 Auassar |
| 8 | 14/10/2017 | Ajax | Sparta Rotterdam | 4-0 | 45.000 | Blom | 1-0 Sanusi (e.d.), 2-0n Floranus (e.d.), 3-0 Neres, 4-0 Younes |
| 8 | 14/10/2017 | Feyenoord | PEC Zwolle | 0-0 | 47.500 | Higler | |
| 8 | 14/10/2017 | FC Utrecht | sc Heerenveen | 3-1 | 17.771 | Mulder | 0-1 Schaars, 1-1 Ayoub, 2-1 en 3-1 Bahebeck |
| 8 | 15/10/2017 | Heracles Almelo | Vitesse | 1-1 | 11.164 | Lindhout | 1-0 Peterson, 1-1 Linssen |
| 8 | 15/10/2017 | Willem II | FC Twente | 3-1 | 12.019 | Martens | 0-1 Assaidi (pen), 1-1 Sol, 2-1 Azzaoui, 3-1 Sol |
| 8 | 15/10/2017 | VVV-Venlo | PSV | 2-5 | 8.000 | Makkelie | 0-1 Locadia, 1-1 Leemans (pen), 2-1 Hunte, 2-2 Pereiro, 2-3 Schwaab, 2-4 Junior, 2-5 Pereiro; R: Promes (VVV) |
| 8 | 15/10/2017 | FC Groningen | AZ | 1-1 | 17.680 | Kuipers | 0-1 Jahanbakshsh, 1-1 Mahi |
| 8 | 15/10/2017 | ADO Den Haag | Excelsior | 1-2 | 10.805 | Gözübüyük | 0-1 Caenepeel, 1-1 Becker, 1-2 Faik R: Duplan (ADO) |
| 9 | 20/10/2017 | FC Groningen | Willem II | 0-1 | 16.394 | Lindhout | 0-1 Sol; R: Hrustic (Gro) |
| 9 | 21/10/2017 | NAC Breda | PEC Zwolle | 0-2 | 18.423 | Vd Kerkhof | 0-1 Van Polen (pen), 0-2 Saymak |
| 9 | 21/10/2017 | Excelsior | Sparta Rotterdam | 1-1 | 4.400 | Mulder | 1-0 Massop, 1-1 Goodwin |
| 9 | 21/10/2017 | VVV-Venlo | ADO Den Haag | 0-2 | 6.532 | Manschot | 0-1 Falkenburg, 0-2 Johnsen |
| 9 | 21/10/2017 | FC Twente | Roda JC Kerkrade | 3-0 | 23.600 | Gözübüyük | 1-0 (pen) en 2-0 Assaidi, 3-0 Bijen |
| 9 | 22/10/2017 | PSV | Heracles Almelo | 3-0 | 32.800 | Janssen | 1-0 Lozano, 2-0 en 3-0 (pen) Van Ginkel R: Pröpper (Her) |
| 9 | 22/10/2017 | Feyenoord | Ajax | 1-4 | 47.500 | Makkelie | 0-1 Huntelaar, 1-1 Toornstra, 1-2 Dolberg, 1-3 S. de Jong, 1-4 Dolberg |
| 9 | 22/10/2017 | AZ | FC Utrecht | 3-0 | 14.056 | Kamphuis | 1-0 Koopmeiners, 2-0 Jahanbakhsh, 3-0 Van Overeem |
| 9 | 22/10/2017 | sc Heerenveen | Vitesse | 0-4 | 21.034 | Bax | 0-1 Rashica, 0-2 Linssen, 0-3 Foor, 0-4 Matavz |
| 10 | 27/10/2017 | FC Twente | Excelsior | 1-3 | 23.200 | Lindhout | 1-0 Boere, 1-1 Faik, 1-2 Massop, 1-3 Karami |
| 10 | 28/10/2017 | Heracles Almelo | VVV-Venlo | 3-0 | 10.364 | Pérez | 1-0 Kuwas, 2-0 en 3-0 Peterson |
| 10 | 28/10/2017 | Roda JC Kerkrade | Feyenoord | 1-1 | 13.491 | Blom | 0-1 Berghuis, 1-1 Schahin |
| 10 | 28/10/2017 | Willem II | Ajax | 1-3 | 13.907 | Higler | 1-0 Velikonja (pen), 1-1 Schöne, 1-2 S. de Jong, 1-3 Neres |
| 10 | 28/10/2017 | PEC Zwolle | ADO Den Haag | 2-0 | 13.020 | Vd Graaf | 1-0 Parzyszek, 2-0 Namli |
| 10 | 29/10/2017 | Vitesse | PSV | 2-4 | 18.232 | Gözübüyük | 0-1 Lozano, 1-1 Locadia (e.d.), 1-2, 1-3 en 1-4 Locadia, 2-4 Mount |
| 10 | 29/10/2017 | FC Utrecht | NAC Breda | 2-2 | 20.123 | Bax | 1-0 Janssen, 1-1 El Allouchi, 1-2 Korte, 2-2 Venema |
| 10 | 29/10/2017 | Sparta Rotterdam | FC Groningen | 2-1 | 10.010 | Nijhuis | 1-0 Mühren, 1-1 Reis, 2-1 Brogno (pen) R: Veenhoven (Spa) |
| 10 | 29/10/2017 | sc Heerenveen | AZ | 1-2 | 19.136 | Janssen | 1-0 Vlap, 1-1 en 1-2 Til |
| 11 | 03/11/2017 | Sparta Rotterdam | sc Heerenveen | 0-0 | 10.231 | Manschot | |
| 11 | 04/11/2017 | AZ | Willem II | 3-2 | 13.500 | Blom | 0-1 Rienstra, 1-1 Jahanbakhsh (pen), 2-1 Til, 3-1 Weghorst, 3-2 Azzaoui; R: Weghorst (AZ) |
| 11 | 04/11/2017 | Excelsior | Roda JC Kerkrade | 1-0 | 4.086 | Dieperink | 1-0 Bruins; R: Rosheuvel (Rod) |
| 11 | 04/11/2017 | Heracles Almelo | FC Groningen | 2-1 | 10.411 | Vd Kerkhof | 1-0 Niemeijer, 1-1 Veldwijk (p), 2-1 Hardeveld (p) |
| 11 | 04/11/2017 | VVV-Venlo | NAC Breda | 0-0 | 6.521 | Kamphuis | |
| 11 | 05/11/2017 | ADO Den Haag | Feyenoord | 2-2 | 13.870 | Nijhuis | 0-1 Jørgensen, 1-1 Meijers, 2-1 Kanon, 2-2 El Ahmadi |
| 11 | 05/11/2017 | Ajax | FC Utrecht | 1-2 | 50.000 | Kuipers | 0-1 Labyad, 1-1 Viergever, 1-2 Labyad |
| 11 | 05/11/2017 | Vitesse | PEC Zwolle | 0-0 | 18.349 | Makkelie | |
| 11 | 05/11/2017 | PSV | FC Twente | 4-3 | 33.040 | Higler | 1-0 Locadia, 1-1 Thesker, 2-1 Van Ginkel, 2-2 Lam, 3-2 L. de Jong, 3-3 Jensen, 4-3 Thesker (e.d.) |
| 12 | 18/11/2017 | FC Twente | sc Heerenveen | 0-4 | 24.000 | Kamphuis | 0-1 Høegh, 0-2 Vlap, 0-3 Ødegaard, 0-4 Veerman |
| 12 | 18/11/2017 | Feyenoord | VVV-Venlo | 1-1 | 47.500 | Higler | 1-0 Jørgensen, 1-1 Van Bruggen |
| 12 | 18/11/2017 | NAC Breda | Ajax | 0-8 | 18.969 | Makkelie | 0-1 De Ligt, 0-2 en 0-3 Van de Beek, 0-4 Neres, 0-5 De Ligt, 0-6 Schöne (pen), 0-7 Huntelaar, 0-8 Van de Beek |
| 12 | 18/11/2017 | Willem II | Sparta Rotterdam | 2-2 | 11.511 | Vd Graaf | 0-1 en 0-2 Duarte, 1-2 Haye, 2-2 Ogbeche |
| 12 | 19/11/2017 | ADO Den Haag | Heracles Almelo | 4-1 | 11.175 | Blom | 0-1 Niemeijer, 1-1 Lorenzen, 2-1 El Khayati, 3-1 Johnsen, 4-1 Hooi |
| 12 | 19/11/2017 | PEC Zwolle | PSV | 0-1 | 13.250 | Kuipers | 0-1 Isimat-Mirin |
| 12 | 19/11/2017 | FC Utrecht | Excelsior | 3-1 | 18.336 | Nijhuis | 1-0 Dessers, 2-0 Ayoub, 3-0 Janssen, 3-1 El Azzouzi |
| 12 | 19/11/2017 | FC Groningen | Vitesse | 4-2 | 17.263 | Manschot | 0-1 Larsen (e.d.), 1-1 Dabo (e.d.), 1-2 Matavz (p), 2-2 Idrissi, 3-2 Mahi, 4-2 V. Weert; R: Reis (Gro) |
| 12 | 19/11/2017 | Roda JC Kerkrade | AZ | 0-1 | 12.411 | Lindhout | 0-1 Seuntjens |
| 13 | 24/11/2017 | AZ | FC Twente | 2-0 | 14.601 | Vd Kerkhof | 1-0 Jahanbakhsh (pen), 2-0 Van Overeem |
| 13 | 25/11/2017 | VVV-Venlo | Willem II | 3-3 | 6.782 | Mulder | 1-0 Van Crooy, 2-0 Van Bruggen, 2-1 Ogbeche, 3-1 Leemans (pen), 3-2 en 3-3 Ogbeche |
| 13 | 25/11/2017 | Heracles Almelo | NAC Breda | 2-1 | 10.626 | Van Boekel | 0-1 Angelino, 1-1 Niemeijer, 2-1 Gladon |
| 13 | 25/11/2017 | FC Groningen | Feyenoord | 0-2 | 20.294 | Makkelie | 0-1 Vilhena, 0-2 Jørgensen |
| 13 | 25/11/2017 | sc Heerenveen | PEC Zwolle | 1-2 | 20.832 | Gözübüyük | 1-0 Vlap, 1-1 Freire, 1-2 Saymak |
| 13 | 26/11/2017 | Ajax | Roda JC Kerkrade | 5-1 | 40.000 | Nijhuis | 0-1 Kum, 1-1 Kluivert, 2-1 Dolberg, 3-1 Kluivert, 4-1 Van de Beek, 5-1 Kluivert |
| 13 | 26/11/2017 | Excelsior | PSV | 1-2 | 4.400 | Kamphuis | 0-1 Mattheij (e.d.), 0-2 Lozano, 1-2 Koolwijk |
| 13 | 26/11/2017 | Sparta Rotterdam | FC Utrecht | 1-3 | 10.432 | Lindhout | 0-1 Labyad, 1-1 Proschwitz, 1-2 Labyad, 1-3 Kerk |
| 13 | 26/11/2017 | Vitesse | ADO Den Haag | 2-0 | 14.754 | Janssen | 1-0 Miazga, 2-0 Linssen; R: Ebuehi (ADO) |
| 14 | 01/12/2017 | PEC Zwolle | FC Utrecht | 1-1 | 13.250 | Janssen | 0-1 Van de Streek, 1-1 Saymak |
| 14 | 02/12/2017 | ADO Den Haag | FC Groningen | 0-3 | 10.416 | Gözübüyük | 0-1 Doan, 0-2 Idrissi, 0-3 Bacuna |
| 14 | 02/12/2017 | FC Twente | Ajax | 3-3 | 27.500 | Higler | 0-1 en 0-2 Schöne, 1-2 en 2-2 Thesker, 2-3 Kluivert, 3-3 Boere |
| 14 | 02/12/2017 | Feyenoord | Vitesse | 1-0 | 47.500 | Van Boekel | 1-0 Jørgensen |
| 14 | 02/12/2017 | Willem II | Heracles Almelo | 3-1 | 11.230 | Makkelie | 1-0 Sol, 2-0 en 3-0 Ogbeche, 3-1 Jakubiak |
| 14 | 03/12/2017 | VVV-Venlo | AZ | 0-2 | 6.353 | Nijhuis | 0-1 Seuntjens (e.d.), 0-2 Hatzidiakos |
| 14 | 03/12/2017 | PSV | Sparta Rotterdam | 1-0 | 33.000 | Mulder | 1-0 De Jong |
| 14 | 03/12/2017 | Roda JC Kerkrade | sc Heerenveen | 2-1 | 10.482 | Bax | 0-1 Veerman, 1-1 Schahin, 2-1 Milts |
| 14 | 03/12/2017 | NAC Breda | Excelsior | 3-1 | 18.340 | Blom | 1-0 en 2-0 Ambrose (pen), 2-1 Van Duinen, 3-1 Fernandes |
| 15 | 08/12/2017 | Willem II | NAC Breda | 1-1 | 14.400 | Nijhuis | 1-0 Ogbeche, 1-1 Ambrose |
| 15 | 09/12/2017 | sc Heerenveen | VVV-Venlo | 2-2 | 17.500 | Dieperink | 0-1 Thy, 1-1 Dumfries, 2-1 Veerman, 2-2 Seuntjens |
| 15 | 09/12/2017 | AZ | Heracles Almelo | 5-0 | 13.863 | Vd Graaf | 1-0 Castro (e.d.), 2-0 Til, 3-0 Jahanbakhsh, 4-0 Weghorst, 5-0 Svensson |
| 15 | 09/12/2017 | Excelsior | PEC Zwolle | 1-2 | 4.069 | Manschot | 1-0 Van Duinen (pen), 1-1 Saymak, 1-2 Namli R: Elbers (Exc) |
| 15 | 09/12/2017 | FC Twente | ADO Den Haag | 2-3 | 23.000 | Lindhout | 1-0 Holla, 1-1 El Khayati, 1-2 Johnsen, 2-2 Holla, 2-3 El Khayati |
| 15 | 10/12/2017 | Roda JC Kerkrade | FC Groningen | 2-2 | 10.000 | Van Boekel | 1-0 en 2-0 Gustafson, 2-1 en 2-2 (p) Van Weert R: Auassar (Rod) |
| 15 | 10/12/2017 | Ajax | PSV | 3-0 | 52.379 | Blom | 1-0 Neres, 2-0 Schöne, 3-0 Van de Beek |
| 16 | 12/12/2017 | NAC Breda | FC Twente | 1-2 | 17.589 | Mulder | 0-1 Assaidi, 1-1 Bijen (e.d.), 1-2 Assaidi R: Bertrams (NAC) |
| 16 | 12/12/2017 | PEC Zwolle | AZ | 1-1 | 12.875 | Higler | 1-0 Ondaan, 1-1 Jahanbakhsh |
| 16 | 13/12/2017 | Vitesse | Willem II | 2-2 | 13.961 | Gözübüyük | 0-1 Ogbeche, 1-1 Matavz, 1-2 Rienstra, 2-2 Linssen |
| 16 | 13/12/2017 | FC Groningen | PSV | 3-3 | 20.000 | Nijhuis | 0-1 Van Ginkel, 0-2 Ramselaar, 1-2 Van Nieff, 1-3 Van Ginkel (pen), 2-3 Veldwijk (pen), 3-3 te Wierik |
| 16 | 13/12/2017 | VVV-Venlo | FC Utrecht | 0-1 | 5.778 | Manschot | 0-1 Kerk |
| 16 | 13/12/2017 | Feyenoord | sc Heerenveen | 1-1 | 40.000 | Blom | 1-0 Berghuis, 1-1 Veerman |
| 16 | 13/12/2017 | ADO Den Haag | Roda JC Kerkrade | 3-2 | 9.151 | Wiedemeijer | 0-1 Schahin, 1-1 Immers, 1-2 Gastafson (pen), 2-2 Immers, 3-2 Falkenburg R: Dijkhuizen (Rod) |
| 16 | 14/12/2017 | Heracles Almelo | Sparta Rotterdam | 3-2 | 9.203 | Kamphuis | 1-0 Wuytens, 1-1 Proschwitz, 2-1 Niemeijer, 2-2 Proschwitz, 3-2 Vermeij |
| 16 | 14/12/2017 | Ajax | Excelsior | 3-1 | 40.000 | Janssen | 1-0 S. de Jong, 1-1 Van Duinen, 2-1 Dolberg (p), 3-1 Ziyech |
| 17 | 16/12/2017 | sc Heerenveen | NAC Breda | 1-0 | 19.361 | Lindhout | 1-0 Van Amersfoort |
| 17 | 16/12/2017 | Willem II | PEC Zwolle | 2-3 | 12.900 | Wiedemeijer | 1-0 Sol, 2-0 Rienstra, 2-1 Bakker (pen), 2-2 en 2-3 Saymak |
| 17 | 16/12/2017 | PSV | ADO Den Haag | 3-0 | 32.700 | Kuipers | 1-0 en 2-0 De Jong, 3-0 Van Ginkel (pen) R: Meissner (ADO) |
| 17 | 16/12/2017 | FC Twente | Vitesse | 1-1 | 23.600 | Manschot | 1-0 Jensen, 1-1 Mount |
| 17 | 16/12/2017 | Roda JC Kerkrade | VVV-Venlo | 0-1 | 13.189 | Higler | 0-1 Leemans; R: Auassar (Rod) |
| 17 | 17/12/2017 | Sparta Rotterdam | Feyenoord | 0-7 | 10.400 | Gözübüyük | 0-1 Vilhena, 0-2 Vente, 0-3 St Juste, 0-4 Vilhena, 0-5 Tapia, 0-6 Berghuis, 0-7 Basacikoglu |
| 17 | 17/12/2017 | FC Utrecht | FC Groningen | 1-1 | 16.859 | Mulder | 1-0 Ayoub, 1-1 Gladon |
| 17 | 17/12/2017 | AZ | Ajax | 1-2 | 16.900 | Makkelie | 1-0 Jahanbakhsh (pen), 1-1 Huntelaar, 1-2 Schöne (pen); R: Svensson (AZ) |
| 17 | 17/12/2017 | Excelsior | Heracles Almelo | 2-0 | 3.808 | Vd Kerkhof | 1-0 Massop, 2-0 Elbers |
| 18 | 22/12/2017 | ADO Den Haag | PEC Zwolle | 4-0 | 11.107 | Blom | 1-0 Falkenburg, 2-0 Johnsen, 3-0 Falkenburg, 4-0 Johnsen |
| 18 | 24/12/2017 | VVV-Venlo | Heracles Almelo | 3-1 | 6.500 | Bax | 1-0 Thy, 1-1 Niemeijer (pen), 2-1 en 3-1 Thy |
| 18 | 23/12/2017 | AZ | sc Heerenveen | 3-1 | 15.012 | Van Boekel | 0-1 Van Amersfoort, 1-1 Dumfries (e.d.), 2-1 en 3-1 Friday; R: Thorsby (Hee) |
| 18 | 23/12/2017 | PSV | Vitesse | 2-1 | 33.000 | Higler | 0-1 Matavz, 1-1 Schwaab, 2-1 Lozano |
| 18 | 23/12/2017 | Excelsior | FC Twente | 0-0 | 4.369 | Martens | |
| 18 | 23/12/2017 | NAC Breda | FC Utrecht | 3-1 | 18.769 | Wiedemeijer | 1-0 Mari, 2-0 Ambrose, 2-1 Dessers, 3-1 Angelino; R: Strieder (Utr) |
| 18 | 24/12/2017 | Ajax | Willem II | 3-1 | 40.000 | Manschot | 0-1 Sol, 1-1 Kluivert, 2-1 Dolberg, 3-1 Neres |
| 18 | 24/12/2017 | FC Groningen | Sparta Rotterdam | 4-0 | 10.000 | Janssen | 1-0 Veldwijk, 2-0 Van Weert, 3-0 Holst (e.d.), 4-0 Doan |
| 18 | 24/12/2017 | Feyenoord | Roda JC Kerkrade | 5-1 | 40.000 | Kamphuis | 1-0 Jørgensen, 2-0 Toornstra, 2-1 Gustafson, 3-1 Jørgensen, 4-1 en 5-1 Berghuis |
| 15 | 16/01/2018 | Sparta Rotterdam | Vitesse | 0-1 | 9.258 | Makkelie | 0-1 Mount |
| 19 | 19/01/2018 | FC Utrecht | AZ | 1-1 | 18.457 | Gözübüyük | 0-1 Svensson, 1-1 Dessers |
| 19 | 20/01/2018 | Roda JC Kerkrade | FC Twente | 1-1 | 12.475 | Wiedemeijer | 0-1 Vuckic, 1-1 Schahin |
| 19 | 20/01/2018 | PEC Zwolle | NAC Breda | 1-0 | 13.120 | Kamphuis | 1-0 Mokhtar |
| 19 | 20/01/2018 | ADO Den Haag | VVV-Venlo | 1-1 | 11.008 | Higler | 1-0 Johnsen, 1-1 Opoku |
| 19 | 20/01/2018 | Vitesse | sc Heerenveen | 1-1 | 15.363 | Lindhout | 1-0 Høegh (e.d.), 1-1 Van Amersfoort |
| 19 | 21/01/2018 | Willem II | FC Groningen | 1-1 | 12.160 | Makkelie | 0-1 Doan, 1-1 Azzaoui |
| 19 | 21/01/2018 | Sparta Rotterdam | Excelsior | 2-3 | 10.224 | Van Boekel | 1-0 Massop (ed), 1-1 Messaoud, 2-1 Brogno (p), 2-2 Messaouid, 2-3 Hadouir |
| 19 | 21/01/2018 | Ajax | Feyenoord | 2-0 | 53.320 | Kuipers | 1-0 Vd Beek, 2-0 Huntelaar; R: Jørgensen (Fey) |
| 19 | 21/01/2018 | Heracles Almelo | PSV | 1-2 | 11.211 | Janssen | 0-1 Bergwijn, 1-1 Hardeveld (pen), 1-2 De Jong |
| 15 | 24/01/2018 | FC Utrecht | Feyenoord | 1-1 | 22.111 | Blom | 0-1 Larsson, 1-1 Kerk |
| 20 | 26/01/2018 | sc Heerenveen | Sparta Rotterdam | 2-1 | 18.790 | Gözübüyük | 0-1 Chabot, 1-1 Ghoochannejhad, 2-1 Dumfries |
| 20 | 27/01/2018 | FC Groningen | Heracles Almelo | 3-3 | 15.000 | Higler | 1-0 Van Weert, 1-1 Monteiro, 2-1 Drost, 3-1 Mahi, 3-2 Vermeij, 3-3 Pröpper |
| 20 | 27/01/2018 | FC Twente | PSV | 0-2 | 25.700 | Blom | 0-1 Lozano, 0-2 Arias |
| 20 | 27/01/2018 | PEC Zwolle | Vitesse | 1-2 | 13.115 | S. Mulder | 0-1 Linssen, 1-1 Namli, 1-2 Mount |
| 20 | 27/01/2018 | NAC Breda | VVV-Venlo | 0-1 | 18.443 | Manschot | 0-1 Thy |
| 20 | 28/01/2018 | FC Utrecht | Ajax | 0-0 | 21.768 | Makkelie | R: Görtler (Utr) |
| 20 | 28/01/2018 | Feyenoord | ADO Den Haag | 3-1 | 47.500 | Nijhuis | 1-0 Vilhena, 2-0 Berghuis, 2-1 Immers, 3-1 Toornstra |
| 20 | 28/01/2018 | Roda JC Kerkrade | Excelsior | 2-1 | 11.226 | Perez | 0-1 Massop, 1-1 Vancamp, 2-1 Schahin R: Bruins (Exc) |
| 20 | 28/01/2018 | Willem II | AZ | 0-2 | 11.350 | Wiedemeijer | 0-1 Seuntjens, 0-2 Jahanbakshsh |
| 21 | 02/02/2018 | Vitesse | FC Groningen | 2-0 | 14.675 | Wiedemeijer | 1-0 Miazga, 2-0 Mount |
| 21 | 03/02/2018 | sc Heerenveen | FC Twente | 1-0 | 22.290 | Manschot | 1-0 Høegh |
| 21 | 04/02/2018 | AZ | Roda JC Kerkrade | 2-2 | 15.007 | Blom | 1-0 Bangaard (e.d.), 1-1 Vancamp, 2-1 Midtsjø, 2-2 Ndenge |
| 21 | 03/02/2018 | PSV | PEC Zwolle | 4-0 | 32.800 | Gözübüyük | 1-0, 2-0 en 3-0 De Jong, 4-0 Brenet; R: Van der Hart (PEC) |
| 21 | 03/02/2018 | Heracles Almelo | ADO Den Haag | 1-1 | 10.127 | Lindhout | 0-1 Johnsen, 1-1 Niemeijer |
| 21 | 04/02/2018 | Excelsior | FC Utrecht | 2-2 | 3.997 | Kooij | 1-0 Elbers, 1-1 Van der Maarel, 1-2 Labyad, 2-2 Faik |
| 21 | 04/02/2018 | Sparta Rotterdam | Willem II | 1-0 | 10.433 | Bax | 1-0 Friday |
| 21 | 04/02/2018 | VVV-Venlo | Feyenoord | 1-0 | 8.000 | Kamphuis | 1-0 Leemans (pen) |
| 21 | 04/02/2018 | Ajax | NAC Breda | 3-1 | 45.000 | Janssen | 0-1 Ambrose, 1-1 Van de Beek, 2-1 Neres, 3-1 Ziyech; R: Meijers (NAC) |
| 22 | 07/02/2018 | FC Twente | AZ | 0-4 | 23.000 | S. Mulder | 0-1 Jahanbakshsh (pen), 0-2 en 0-3 Weghorst, 0-4 Jahanbakshsh; R: Cuevas (Twe) |
| 22 | 06/02/2018 | PEC Zwolle | sc Heerenveen | 3-2 | 12.920 | Van Boekel | 1-0 Marinus, 2-0 Namli, 2-1 Dumfries, 3-1 Saymak, 3-2 Ghoochannejhad |
| 22 | 07/02/2018 | FC Utrecht | Sparta Rotterdam | 1-0 | 15.929 | Higler | 1-0 Görtler |
| 22 | 07/02/2018 | PSV | Excelsior | 1-0 | 32.000 | Lindhout | 1-0 Lozano |
| 22 | 07/02/2018 | Willem II | VVV-Venlo | 3-0 | 11.500 | Vd Graaf | 1-0 Ogbeche, 2-0 Rienstra, 3-0 Croux |
| 22 | 07/02/2018 | NAC Breda | Heracles Almelo | 6-1 | 17.035 | Blom | 1-0 Vloet, 1-1 Vermeij, 2-1 Ambrose, 3-1 Garcia, 4-1 Te Vrede, 5-1 El Allouchi, 6-1 Sadiq; R: Breukers (Her) |
| 22 | 07/02/2018 | Roda JC Kerkrade | Ajax | 2-4 | 14.484 | Nijhuis | 1-0 Gustafson, 1-1 Van den Beek, 1-2 Ziyech, 1-3 Huntelaar, 2-3 Vancamp, 2-4 Huntelaar |
| 22 | 08/02/2018 | ADO Den Haag | Vitesse | 1-0 | 12.303 | Vd Kerkhof | 1-0 Becker |
| 22 | 08/02/2018 | Feyenoord | FC Groningen | 3-0 | 37.500 | Gözübüyük | 1-0 Toornstra, 2-0 St. Juste, 3-0 Van Persie |
| 23 | 10/02/2018 | Heracles Almelo | Willem II | 1-0 | 10.232 | Van Boekel | 1-0 Vermeij |
| 23 | 10/02/2018 | FC Utrecht | PEC Zwolle | 2-1 | 17.301 | Wiedemeijer | 1-0 Kerk, 2-0 Labyad, 2-1 Saymak |
| 23 | 10/02/2018 | Sparta Rotterdam | PSV | 1-2 | 10.591 | Nijhuis | 1-0 Dougall, 1-1 en 1-2 Bergwijn |
| 23 | 10/02/2018 | sc Heerenveen | Roda JC Kerkrade | 1-1 | 17.780 | Janssen | 0-1 Ngombo, 1-1 Zeneli |
| 23 | 10/02/2018 | AZ | VVV-Venlo | 0-0 | 13.500 | Lindhout | |
| 23 | 11/02/2018 | FC Groningen | ADO Den Haag | 0-0 | 12.500 | Manschot | |
| 23 | 11/02/2018 | Vitesse | Feyenoord | 3-1 | 16.459 | Higler | 0-1 Vilhena, 1-1 Kashia, 2-1 en 3-1 Linssen R: Basacikoglu, Malacia (Fey) |
| 23 | 11/02/2018 | Excelsior | NAC Breda | 0-0 | 3.876 | Makkelie | |
| 23 | 11/02/2018 | Ajax | FC Twente | 2-1 | 45.000 | Gözübüyük | 1-0 Kluivert, 1-1 Tighadouini, 2-1 Schöne (pen) |
| 24 | 16/02/2018 | VVV-Venlo | FC Groningen | 1-1 | 6.624 | Vd Graaf | 1-0 Van Crooy, 1-1 Doan |
| 24 | 17/02/2018 | Vitesse | Excelsior | 1-2 | 15.432 | Manschot | 1-0 Castaignos, 1-1 Faik, 1-2 Van Duinen |
| 24 | 17/02/2018 | NAC Breda | AZ | 1-3 | 18.628 | Kamphuis | 0-1 Jahanbakshsh, 0-2 Til, 0-3 Seuntjens 1-3 Sadiq |
| 24 | 17/02/2018 | PSV | sc Heerenveen | 2-2 | 33.500 | Higler | 1-0 Arias, 2-0 De Jong, 2-1 Schaars, 2-2 Ghoochannejhad; R: Lozano (PSV) |
| 24 | 17/02/2018 | ADO Den Haag | Willem II | 2-1 | 9.966 | Kooij | 0-1 Sol, 1-1 Johnsen, 2-1 El Khayati (pen) |
| 24 | 18/02/2018 | Roda JC Kerkrade | FC Utrecht | 1-4 | 10.000 | Lindhout | 0-1 Van de Streek, 0-2 Van der Maarel, 0-3 Van de Streek, 1-3 Vancamp, 1-4 Labyad |
| 24 | 18/02/2018 | Feyenoord | Heracles Almelo | 1-0 | 47.500 | Jsnssen | 1-0 Van Persie |
| 24 | 18/02/2018 | FC Twente | Sparta Rotterdam | 1-1 | 25.400 | Van Boekel | 0-1 Friday, 1-1 Vuckic |
| 24 | 18/02/2018 | PEC Zwolle | Ajax | 0-1 | 13.250 | Blom | 0-1 Huntelaar |
| 25 | 23/02/2018 | FC Groningen | NAC Breda | 1-1 | 20.000 | Higler | 1-0 Mari (e.d.), 1-1 Te Vrede |
| 25 | 24/02/2018 | AZ | Sparta Rotterdam | 2-1 | 14.884 | Gözübüyük | 0-1 Chabot, 1-1 Weghorst, 2-1 Idrissi |
| 25 | 24/02/2018 | sc Heerenveen | Excelsior | 0-1 | 18.920 | Wiedemeijer | 0-1 Van Duinen |
| 25 | 24/02/2018 | Heracles Almelo | PEC Zwolle | 2-1 | 9.031 | Nijhuis | 1-0 Peterson, 1-1 Parzyszek, 2-1 Vermeij |
| 25 | 24/02/2018 | VVV-Venlo | Vitesse | 2-2 | 6.168 | S. Mulder | 1-0 Hunte, 2-0 Thy, 2-1 Röseler (e.d.), 2-2 Mount |
| 25 | 25/02/2018 | Ajax | ADO Den Haag | 0-0 | 47.500 | Van Boekel | |
| 25 | 25/02/2018 | Feyenoord | PSV | 1-3 | 47.500 | Makkelie | 0-1 Arias, 0-2 Bergwijn, 1-2 Vilhena, 1-3 Pereiro |
| 25 | 25/02/2018 | Willem II | Roda JC Kerkrade | 1-0 | 13.277 | Manschot | 1-0 Rienstra |
| 25 | 25/02/2018 | FC Utrecht | FC Twente | 3-1 | 17.755 | Kamphuis | 0-1 Vuckic, 1-1 Klaiber, 2-1 Van de Streek, 3-1 Ayoub |
| 26 | 03/03/2018 | sc Heerenveen | Willem II | 2-0 | 10.000 | Gözübüyük | 1-0 Woudenberg, 2-0 Ghoochannejhad |
| 26 | 03/03/2018 | PSV | FC Utrecht | 3-0 | 33.800 | Blom | 1-0 Leeuwin, 2-0 De Jong, 3-0 Bergwijn |
| 26 | 03/03/2018 | Excelsior | AZ | 1-2 | 4.218 | Van Boekel | 0-1 Zwarthoed (e.d.), 0-2 Jahanbakshsh, 1-2 Massaoud |
| 26 | 02/03/2018 | Roda JC Kerkrade | Heracles Almelo | 0-3 | 10.000 | Kamphuis | 0-1 Kuwas, 0-2 Peterson, 0-2 Van Ooijen |
| 26 | 03/03/2018 | NAC Breda | Feyenoord | 2-1 | 18.963 | Nijhuis | 0-1 Toornsstra, 1-1 Ambrose, 2-1 Sadiq (pen) |
| 26 | 04/03/2018 | PEC Zwolle | VVV-Venlo | 1-1 | 12.965 | Manschot | 0-1 Van Crooy, 1-1 Saymak |
| 26 | 04/03/2018 | Sparta Rotterdam | ADO Den Haag | 2-1 | 10.482 | Wiedemeijer | 0-1 Falkenburg, 1-1 Kramer, 2-1 Mühren |
| 26 | 04/03/2018 | Vitesse | Ajax | 3-2 | 19.876 | Kuipers | 1-0 Foor, 2-0 Linssen, 2-1 Cassierra, 3-1 Linssen, 3-2 S. de Jong |
| 26 | 04/03/2018 | FC Twente | FC Groningen | 1-1 | 23.000 | Janssen | 0-1 Doan, 1-1 Boere |
| 27 | 09/03/2018 | Heracles Almelo | FC Twente | 2-1 | 12.080 | Blom | 0-1 Tighadouini, 1-1 Petersen, 2-1 Maher (e.d.) |
| 27 | 10/03/2018 | ADO Den Haag | NAC Breda | 0-2 | 13.620 | Makkelie | 0-1 El Allouchi, 0-2 Ambrose (p); R: Kanon (DH) |
| 27 | 10/03/2018 | VVV-Venlo | Excelsior | 2-3 | 6.021 | Martens | 0-1 Garcia, 1-1 Mattheij (e.d.), 1-2 Faik, 1-3 Van Duinen, 2-3 Thy |
| 27 | 10/03/2018 | Willem II | PSV | 5-0 | 13.650 | Kuipers | 1-0 Rienstra, 2-0 en 3-0 (pen) Sol, 4-0 Rienstra, 5-0 Sol; R: Luckassen (PSV) |
| 27 | 10/03/2018 | Roda JC Kerkrade | Sparta Rotterdam | 0-2 | 12.644 | Nijhuis | 0-1 Fischer, 0-2 Mühren |
| 27 | 11/03/2018 | FC Groningen | PEC Zwolle | 2-0 | 15.000 | Lindhout | 1-0 Thomas, 2-0 Hrustic |
| 27 | 11/03/2018 | FC Utrecht | Vitesse | 5-1 | 19.607 | Janssen | 1-0 Janssen, 2-0 Labyad, 2-1 Foor, 3-1 Van de Streek, 4-1 en 5-1 Ayoub |
| 27 | 11/03/2018 | Ajax | sc Heerenveen | 4-1 | 47.500 | Kamphuis | 1-0 De Ligt, 1-1 Ødegaard, 2-1 Tagliafico, 3-1 Van de Beek, 4-1 Neres |
| 27 | 11/03/2018 | Feyenoord | AZ | 2-1 | 45.000 | Higler | 1-0 Boëtius, 2-0 Jørgensen, 2-1 Weghorst |
| 28 | 16/03/2018 | Excelsior | ADO Den Haag | 1-2 | 4.400 | S. Mulder | 1-0 Massop, 1-1 en 1-2 Johnsen |
| 28 | 18/03/2018 | AZ | FC Groningen | 3-2 | 16.459 | Vd kerkhof | 1-0 Svensson, 2-0 Til, 2-1 Doan, 2-2 Van Weert, 3-2 Jahanbakhsh |
| 28 | 17/03/2018 | PSV | VVV-Venlo | 3-0 | 33.900 | Gözübüyük | 1-0 Van Ginkel, 2-0 Lozano, 3-0 Van Ginkel (p) R: Seuntjens (VVV) |
| 28 | 17/03/2018 | Vitesse | Heracles Almelo | 0-0 | 16.231 | Lindhout | |
| 28 | 17/03/2018 | sc Heerenveen | FC Utrecht | 2-2 | 18.700 | Nijhuis | 0-1 Van der Maarel, 1-1 Thorsby, 2-1 Ghoochannejhad, 2-2 Dessers |
| 28 | 17/03/2018 | FC Twente | Willem II | 2-2 | 29.000 | Wiedemeijer | 0-1 Tsimikas, 1-1 Lam, 1-2 Sol, 2-2 Bijen |
| 28 | 18/03/2018 | Sparta Rotterdam | Ajax | 2-5 | 10.606 | Higler | 0-1 Kramer, 1-1 Huntelaar, 1-2 Schöne. 1-3 Kluivert, 1-4 en 1-5 Ziyech, 2-5 Sanusi |
| 28 | 18/03/2018 | NAC Breda | Roda JC Kerkrade | 0-1 | 18.412 | Janssen | 0-1 Avdijaj |
| 28 | 18/03/2018 | PEC Zwolle | Feyenoord | 3-4 | 13.250 | Van Boekel | 0-1 en 0-2 V. Persie, 0-3 El Ahmadi, 1-3 Saymak, 1-4 Vilhena, 2-4 (pen) en 3-4 Parzyszek |
| 29 | 31/03/2018 | PEC Zwolle | Sparta Rotterdam | 2-0 | 13.250 | Nijhuis | 1-0 Mokhtar, 2-0 Parzyszek |
| 29 | 31/03/2018 | Vitesse | Roda JC Kerkrade | 0-3 | 16.591 | Higler | 0-1 Schahin, 0-2 Avdijaj, 0-3 Schahin |
| 29 | 31/03/2018 | PSV | NAC Breda | 5-1 | 34.300 | Van Boekel | 1-0 Van Ginkel (pen), 2-0 Sadiq (e.d.), 2-1 Sadiq, 3-1 De Jong, 4-1 Mets (e.d.), 5-1 Pereiro |
| 29 | 31/03/2018 | Willem II | FC Utrecht | 3-2 | 13.660 | Kamphuis | 0-1 Kerk, 0-2 Van de Streek, 1-2 Haye, 2-2 Tsimikas, 3-2 Sol; R: Heerkens (Wil) |
| 29 | 31/03/2018 | ADO Den Haag | AZ | 0-3 | 13.115 | Kuipers | 0-1 Weghorst, 0-2 Idrissi, 0-3 Jahanbakshsh |
| 29 | 01/04/2018 | Feyenoord | Excelsior | 5-0 | 45.000 | Gözübüyük | 1-0 Boëtius, 2-0 Toornstra, 3-0 Vilhena, 4-0 Berghuis, 5-0 De Wijs (e.d.) |
| 29 | 01/04/2018 | Heracles Almelo | sc Heerenveen | 1-2 | 10.086 | Janssen | 0-1 Thorsby, 0-2 Zeneli (pen), 1-2 Darri |
| 29 | 01/04/2018 | FC Groningen | Ajax | 1-2 | 22.000 | Blom | 1-0 Van Weert, 1-1 Kluivert, 1-2 Huntelaar R": Veltman (Aja) |
| 29 | 01/04/2018 | VVV-Venlo | FC Twente | 0-0 | 6.623 | Lindhout | |
| 30 | 06/04/2018 | Excelsior | Willem II | 2-1 | 4.400 | Vd Graaf | 0-1 Sol, 1-1 Bruins (pen), 2-1 Elbers R: Lachman (Wil) |
| 30 | 07/04/2018 | NAC Breda | Vitesse | 1-0 | 18.567 | Gözübüyük | 1-0 Angelino |
| 30 | 07/04/2018 | Roda JC Kerkrade | PEC Zwolle | 3-2 | 14.115 | Kuipers | 1-0 Avdijaj, 2-0 Gustafson, 2-1 Namli, 2-2 Menig, 3-2 Rosheuvel |
| 30 | 07/04/2018 | FC Twente | Feyenoord | 1-3 | 25.600 | Makkelie | 0-1 Boëtius, 1-1 Maher, 1-2 Berghuis, 1-3 Jørgensen |
| 30 | 07/04/2018 | Sparta Rotterdam | VVV-Venlo | 3-2 | 10.139 | Mulder | 1-0 Ahannach, 1-1 en 1-2 Leemans, 2-2 en 3-2 Mühren |
| 30 | 08/04/2018 | FC Utrecht | ADO Den Haag | 3-3 | 20.145 | Higler | 1-0 Van de Streek, 1-1 Johnsen, 1-2 Beugelsdijk, 2-2 Kerk, 2-3 Hooi, 3-3 Labyad |
| 30 | 08/04/2018 | sc Heerenveen | FC Groningen | 1-1 | 23.150 | Van Boekel | 1-0 Vlap, 1-1 Van Weert |
| 30 | 07/04/2018 | AZ | PSV | 2-3 | 17.002 | Blom | 0-1 en 0-2 Weghorst, 1-2 Pereiro, 2-2 Lozano, 2-3 Van Ginkel (pen); R: Vlaar (AZ) |
| 30 | 08/04/2018 | Ajax | Heracles Almelo | 1-0 | 45.000 | Nijhuis | 1-0 Neres |
| 31 | 13/04/2018 | Heracles Almelo | AZ | 0-3 | 10.724 | Kamphuis | 0-1 Til, 0-2 Idrissi, 0-3 Jahanbakhsh |
| 31 | 14/04/2018 | ADO Den Haag | FC Twente | 2-1 | 13.876 | Gözübüyük | 0-1 F. Jensen, 1-1 en 2-1 Johnsen |
| 31 | 14/04/2018 | Vitesse | Sparta Rotterdam | 7-0 | 16.345 | Blom | 1-0 Serero, 2-0 Beerens, 3-0 Fischer (e.d.), 4-0 Linssen, 5-0 Matavz, 6-0 Bruns, 7-0 Linssen; R: Kramer (Spa) |
| 31 | 14/04/2018 | VVV-Venlo | sc Heerenveen | 0-2 | 7.054 | Higler | 0-1 Ghoochannejhad, 0-2 Mihajlovic |
| 31 | 14/04/2018 | PEC Zwolle | Excelsior | 1-1 | 13.028 | Bax | 1-0 Mokhtar, 1-1 Van Duinen (pen) |
| 31 | 15/04/2018 | NAC Breda | Willem II | 1-2 | 18.481 | Janssen | 0-1 Rienstra, 1-1 Verschueren, 1-2 Rienstra |
| 31 | 15/04/2018 | Feyenoord | FC Utrecht | 3-1 | 47.500 | Nijhuis | 1-0 Jørgensen, 1-1 Dessers, 2-1 Van Persie, 3-1 Larsson |
| 31 | 15/04/2018 | FC Groningen | Roda JC Kerkrade | 2-1 | 20.000 | Lindhout | 1-0 Doan, 2-0 Drost, 2-1 Kum |
| 31 | 15/04/2018 | PSV | Ajax | 3-0 | 35.000 | Makkelie | 1-0 pereiro, 2-0 De Jong, 3-0 Bergwijn R: Tagliafico, S. de Jong (Aja) |
| 32 | 17/04/2018 | FC Twente | PEC Zwolle | 2-0 | 24.000 | Van Boekel | 1-0 Van der Lely, 2-0 Maria |
| 32 | 17/04/2018 | sc Heerenveen | ADO Den Haag | 2-0 | 18.730 | Vd Kerkhof | 1-0 en 2-0 Rojas |
| 32 | 18/04/2018 | AZ | Vitesse | 4-3 | 15.200 | Nijhuis | 1-0 Weghorst, 2-0 Jahanbakhsh, 2-1 Linssen, 2-2 Matavz, 3-2 en 4-2 Jahanbakhsh, 4-3 Mount |
| 32 | 18/04/2018 | Roda JC Kerkrade | PSV | 2-2 | 15.383 | Gözübüyük | 1-0 Vansteenkiste, 1-1 Lozano, 2-1 Gustafson, 2-2 Hendrix |
| 32 | 18/04/2018 | Sparta Rotterdam | NAC Breda | 2-1 | 10.606 | Lindhout | 1-0 Duarte, 1-1 Sadiq, 2-1 Spierings |
| 32 | 18/04/2018 | Excelsior | Heracles Almelo | 2-2 | 4.065 | Mulder | 1-0 Massaoud, 2-0 Van Duinen (pen), 2-1 en 2-2 (pen) Monteiro; R: Van Ooijen (Her) |
| 32 | 18/04/2018 | Willem II | Feyenoord | 1-5 | 13.320 | Blom | 0-1 Vente, 0-2 Amrabat, 0-3 Vilhena, 1-3 Ogbeche, 1-4 Vente, 1-5 Basacikoglu |
| 32 | 19/04/2018 | FC Utrecht | FC Groningen | 1-1 | 19.540 | Janssen | 1-0 Janssen, 1-1 Van Weert (pen) |
| 32 | 19/04/2018 | Ajax | VVV-Venlo | 4-1 | 25.000 | Kamphuis | 0-1 Seuntjes, 1-1 en 2-1 Neres, 3-1 Huntelaar, 4-1 Ziyech |
| 33 | 29/04/2018 | Feyenoord | Sparta Rotterdam | 3-1 | 45.000 | Higler | 0-1 Friday, 1-1 Berghuis, 2-1 Holst (e.d.), 3-1 Berghuis |
| 33 | 29/04/2018 | NAC Breda | sc Heerenveen | 3-0 | 18.456 | Nijhuis | 1-0 Fernandes, 2-0 Te Vrede, 3-0 Mari |
| 33 | 29/04/2018 | PEC Zwolle | Willem II | 0-1 | 13.055 | Dieperink | 0-1 Azzaoui |
| 33 | 29/04/2018 | Ajax | AZ | 3-0 | 40.000 | Gözübüyük | 1-0 Van de Beek, 2-0 Kluivert, 3-0 Neres |
| 33 | 29/04/2018 | Heracles Almelo | Excelsior | 2-2 | 11.187 | Blom | 1-0 Kuwas, 2-0 Navratil. 2-1 Van de Streek, 2-2 Van der Maarel |
| 33 | 29/04/2018 | Vitesse | FC Twente | 5-0 | 17.939 | Kamphuis | 1-0 Sereo, 2-0 Matavz, 3-0 Mount, 4-0 Linssen, 5-0 Matavz |
| 33 | 29/04/2018 | VVV-Venlo | Roda JC Kerkrade | 1-4 | 7.255 | Makkelie | 0-1 Vansteenkiste, 1-1 Hunte, 1-2 Auassar, 1-3 Schahin, 1-4 Engels |
| 33 | 29/04/2018 | FC Groningen | Excelsior | 4-0 | 15.000 | Vd Kerkhof | 1-0 Van Weert, 2-0 Memisevic, 3-0 Doan, 4-0 Van Weert |
| 33 | 29/04/2018 | ADO Den Haag | PSV | 3-3 | 14.031 | Van Boekel | 0-1 Lozano, 1-1 Johnsen, 2-1 El Khayati (pen), 2-2 Pereiro, 3-2 Johnsen, 3-3 Pereiro |
| 34 | 06/05/2018 | sc Heerenveen | Feyenoord | 2-3 | 24.640 | Makkelie | 0-1 en 0-2 Berghuis, 1-2 Bruijn, 2-2 Van der Heijden (e.d.), 2-3 Basacikoglu |
| 34 | 06/05/2018 | FC Utrecht | VVV-Venlo | 1-0 | 19.669 | Perez | 1-0 Klich |
| 34 | 06/05/2018 | Sparta Rotterdam | Heracles Almelo | 2-5 | 8.846 | Bax | 1-0 Friday, 1-1 Peterson, 1-2 Spierings, 2-2 Vermeij, 2-3 Breukers, 2-4 Gladon, 2-5 Vermeij |
| 34 | 06/05/2018 | AZ | PEC Zwolle | 6-0 | 16.532 | Lindhout | 1-0 en 2-0 Jahanbakhsh, 3-0 Midtsjø, 4-0 en 5-0 Weghorst, 6-0 Jahanbakhsh |
| 34 | 06/05/2018 | Willem II | Vitesse | 2-2 | 11.600 | S. Mulder | 1-0 Tsimikas, 1-1 Miazga, 1-2 Rienstra, 2-2 Matavz |
| 34 | 06/05/2018 | PSV | FC Groningen | 0-0 | 33.700 | Janssen | |
| 34 | 06/05/2018 | Excelsior | Ajax | 1-2 | 4.400 | Nijhuis | 1-0 De Ligt (e.d.), 1-1 Kluivert, 1-2 Dolberg (pen) |
| 34 | 06/05/2018 | Roda JC Kerkrade | ADO Den Haag | 2-3 | 13.794 | Manschot | 0-1 Johnsen, 0-2 Immers, 0-3 Johnsen, 1-3 Schahin, 2-3 Gustafson (pen) |
| 34 | 06/05/2018 | FC Twente | NAC Breda | 1-1 | 20.000 | Vd Graaf | 0-1 Koch, 1-1 George |
Play offs voor Europa League
| 1e ronde | ||||||
| 09/05/2018 | ADO Den Haag | Vitesse | 2-5 | 11.930 | Makkelie | 0-1 Matavz, 0-2 en 0-3 Mount, 0-4 Linssen, 1-4 El Khayati (pen), 1-5 Mount, 2-5 El Khayati |
| 09/05/2018 | sc Heerenveen | FC Utrecht | 4-3 | 17.225 | Janssen | 1-0 Kobayashi, 2-0 Ghoochannejhad, 3-0 Høegh, 3-1 en 3-2 Labyad, 3-3 Bulthuis (e.d.), 4-3 Dumfries; R: Ayoub (Utr) |
| 12/05/2018 | Vitesse | ADO Den Haag | 2-1 | 13.715 | Blom | 1-0 Matavz, 2-0 Mount, 2-1 El Khayati |
| 12/05/2018 | FC Utrecht | sc Heerenveen | 2-1 | 14.632 | Gözübüyük | 1-0 Strieder, 2-0 Van der Maarel, 2-1 Rojas |
| 2e ronde | ||||||
| 15/05/2018 | Vitesse | FC Utrecht | 3-2 | 14.236 | Kamphuis | 1-0 Mount, 1-1 leeuwin, 2-1 Linssen, 2-2 Labyad, 3-2 Kashia |
| 19/05/2018 | FC Utrecht | Vitesse | 1+2 | 21.353 | Nijhuis | 0-1 Leeuwin (e.d.), 0-2 Miazga, 1-2 Van der Maarel |
Play offs voor promotie/degradatie
| 1e ronde | ||||||
| 01/05/2018 | MVV Maastricht | Almere City FC | 1-3 | 4.264 | Janssen | 0-1 Mirani, 1-1 Ciranni, 1-2 en 1-3 Mirani |
| 01/05/2018 | FC Dordrecht | SC Cambuur | 1-4 | 2.412 | Bax | 0-1 Crowley, 0-2 Mathieu, 1-2 Bliek, 1-3 en 1-4 Barto |
| 05/05/2018 | Almere City FC | MVV Maastricht | 3-2 | 1.792 | Gözübüyük | 0-1 Janssen, 1-1 Van der Water, 1-2 Okita, 2-2 en 3-2 MacDonald |
| 05/05/2018 | SC Cambuur | FC Dordrecht *** | 1-4 | 7.542 | 1-0 Kallon, 1-1 Cijntje, 1-2 Arias, 1-3 (pen) en 1-4 Mahmudov | |
| 2e ronde | ||||||
| 10/05/2018 | Telstar | De Graafschap | 3-2 | 4.663 | Kamphuis | 1-0 Platje, 2-0 Navokovich, 1-1 Van Mieghem, 2-2 Serrarens, 3-2 Hamdaoui; R: Nieuwpoort (Gra), Van Huizen (Tel) |
| 10/05/2018 | FC Emmen | NEC | 4-0 | 5.378 | Vd Kerkhof | 1-0 Veldmate, 2-0 Bakker, 3-0 Loen, 4-0 Bijl |
| 10/05/2018 | FC Dordrecht | Sparta Rotterdam | 1-2 | 4.235 | S. Mulder | 0-1 Brogno, 1-1 Spierings (e.d.), 1-2 Muhren |
| 10/05/2018 | Almere City FC | Roda JC Kerkrade | 0-0 | 2.826 | Nijhuis | |
| 13/05/2018 | De Graafschap | Telstar | 4-2 | 11.083 | Van Boekel | 1-0 Nieuwpoort, 2-0 El Jebli, 2-1 Hamdaoui, 3-1 Serrarens, 3-2 Novakovich (pen), 4-2 Van Mieghem |
| 13/05/2018 | NEC | FC Emmen | 4-1 | 5.321 | Nijhuis | 1-0 en 2-0 Achahbar, 2-1 Bannink, 3-1 Sturing, 4-1 Romeny |
| 13/05/2018 | Sparta Rotterdam | FC Dordrecht | 2-2 | 10.132 | Manschot | 0-1 Mahmudov, 0-2 Cijntje, 1-2 Duarte, 2-2 Mühren |
| 13/05/2018 | Roda JC Kerkrade | Almere City FC | 1-2 | 12.489 | Lindhout | 0-1 Van der Water, 1-1 Schahin, 1-2 Hammouti |
| 3e ronde | ||||||
| 17/05/2018 | FC Emmen | Sparta Rotterdam | 0-0 | 8.301 | Lindhout | |
| 17/05/2018 | Almere City FC | De Graafschap | 1-1 | 3.430 | Blom | 1-0 Van der Water, 1-1 Serrarens (pen); R: Overtoom (Alm) |
| 20/05/2018 | Sparta Rotterdam | FC Emmen | 1-3 | 10.606 | Higler | 1-0 Sp[ierings, 1-1 Chacon, 1-2 Jansen, 1-3 Bannink R: Dougall (Spa) |
| 20/05/2018 | De Graafschap | Almere City FC | 2-1 | 12.600 | Makkelie | 0-1 Hoefdraad, 1-1 Tissoudali, 2-1 Serrarens |
FC Emmen en De Graafschap gepromoveerd, Sparta en Roda JC gedegradeerd.
Topscorers
| 1 | Alireza Jahanbakhsh | AZ | 21 |
| 2 | Bjørn Johnsen | ADO Den Haag | 19 |
| 3 | Steven Berghuis | Feyenoord | 18 |
| 4 | Wout Weghorst | AZ | 18 |
| 5 | Hirving Lozano | PSV | 17 |
| 6 | Fran Sol | Willem II | 16 |
| 7 | Bryan Linssen | Vitesse | 15 |
| 8 | Marco van Ginkel | PSV | 14 |
| 9 | Tim Matavz | Vitesse | 14 |
| 10 | David Neres | Ajax | 14 |