Wedstrijdenmatrix
| AJA | AZ | CAM | FEY | FOR | GOA | GRO | HEE | HER | NEC | PEC | PSV | RKC | SPA | TWE | UTR | VIT | WIL | |
 | * | 1-2 | 9-0 | 3-2 | 5-0 | 0-0 | 3-0 | 5-0 | 3-0 | 5-0 | 3-0 | 5-0 | 3-2 | 2-1 | 5-0 | 0-1 | 5-0 | 5-0 |
 | 2-0 | * | 0-0 | 2-1 | 2-1 | 5-0 | 1-0 | 2-1 | 2-1 | 1-1 | 3-2 | 0-3 | 1-3 | 3-1 | 0-1 | 5-1 | 3-1 | 4-1 |
 | 2-3 | 1-3 | * | 2-3 | 2-1 | 5-2 | 1-2 | 1-2 | 2-1 | 1-2 | 3-4 | 1-2 | 1-1 | 1-1 | 2-0 | 2-1 | 1-6 | 1-1 |
 | 0-2 | 1-0 | 3-1 | * | 5-0 | 2-0 | 1-1 | 3-1 | 2-1 | 5-3 | 4-0 | 2-2 | 2-2 | 4-0 | 1-2 | 2-1 | 0-1 | 2-0 |
 | 0-5 | 1-2 | 1-0 | 1-3 | * | 1-0 | 1-4 | 2-0 | 0-2 | 1-3 | 0-1 | 1-4 | 2-2 | 3-0 | 2-1 | 2-2 | 1-2 | 1-0 |
 | 2-1 | 1-4 | 3-0 | 0-1 | 4-3 | * | 0-1 | 0-1 | 4-2 | 0-2 | 1-0 | 1-2 | 0-2 | 2-0 | 1-2 | 1-1 | 1-2 | 4-0 |
 | 1-3 | 2-0 | 2-3 | 1-1 | 0-1 | 2-1 | * | 1-1 | 0-1 | 4-3 | 1-1 | 0-1 | 1-1 | 1-2 | 1-1 | 0-0 | 0-1 | 1-0 |
 | 0-2 | 1-3 | 3-3 | 0-3 | 1-0 | 3-1 | 3-1 | * | 2-0 | 0-1 | 0-1 | 1-1 | 3-2 | 0-0 | 2-3 | 1-2 | 1-2 | 2-1 |
 | 0-0 | 3-2 | 1-1 | 1-4 | 3-1 | 1-1 | 4-2 | 0-1 | * | 0-1 | 2-0 | 0-2 | 1-0 | 1-3 | 1-1 | 1-0 | 0-0 | 3-2 |
 | 0-1 | 1-3 | 2-3 | 1-4 | 0-1 | 1-0 | 3-0 | 1-1 | 0-0 | * | 2-0 | 1-2 | 1-1 | 0-0 | 0-2 | 0-3 | 0-1 | 0-0 |
 | 0-2 | 2-1 | 1-2 | 1-2 | 0-1 | 0-1 | 1-1 | 0-1 | 1-0 | 1-1 | * | 1-2 | 0-0 | 1-1 | 1-3 | 1-1 | 0-1 | 2-0 |
 | 1-2 | 1-2 | 4-1 | 0-4 | 5-0 | 2-0 | 5-2 | 3-1 | 3-1 | 3-2 | 3-1 | * | 2-0 | 2-1 | 5-2 | 4-1 | 2-0 | 4-2 |
 | 0-5 | 1-0 | 0-1 | 0-2 | 2-1 | 1-1 | 3-1 | 0-0 | 2-0 | 2-1 | 0-2 | 1-4 | * | 1-0 | 1-2 | 1-1 | 1-2 | 1-2 |
| 0-1 | 1-1 | 0-4 | 0-1 | 3-1 | 1-0 | 1-1 | 1-1 | 1-1 | 1-1 | 2-0 | 1-2 | 1-1 | * | 0-1 | 0-3 | 2-2 | 1-0 |
| 1-1 | 3-1 | 1-0 | 0-0 | 1-2 | 2-2 | 3-0 | 2-0 | 1-0 | 1-2 | 1-0 | 3-3 | 2-1 | 2-0 | * | 1-0 | 3-0 | 1-1 |
 | 0-3 | 2-2 | 3-2 | 3-1 | 1-1 | 0-0 | 1-3 | 2-1 | 1-0 | 1-0 | 5-1 | 0-1 | 2-2 | 4-0 | 1-1 | * | 1-1 | 5-1 |
 | 2-2 | 0-0 | 1-0 | 2-1 | 1-1 | 1-2 | 1-3 | 1-2 | 2-1 | 4-1 | 1-0 | 0-5 | 1-2 | 0-1 | 1-4 | 2-1 | * | 0-3 |
 | 0-1 | 2-2 | 1-3 | 0-4 | 1-1 | 0-1 | 2-1 | 0-0 | 2-0 | 0-1 | 1-0 | 2-1 | 3-1 | 0-3 | 0-1 | 3-1 | 1-0 | * |
Eindstand
| 1 | | Ajax | 34 | 26 | 5 | 3 | 83 | 98 | 19 |
| 2 | | PSV | 34 | 26 | 3 | 5 | 81 | 86 | 42 |
| 3 | | Feyenoord | 34 | 22 | 5 | 7 | 71 | 76 | 34 |
| 4 | | FC Twente | 34 | 20 | 8 | 6 | 68 | 55 | 37 |
| 5 | | AZ | 34 | 18 | 7 | 9 | 61 | 64 | 44 |
| 6 | | Vitesse | 34 | 15 | 6 | 13 | 51 | 42 | 51 |
| 7 | | FC Utrecht | 34 | 12 | 11 | 11 | 47 | 51 | 46 |
| 8 | | sc Heerenveen | 34 | 11 | 8 | 15 | 41 | 37 | 50 |
| 9 | | SC Cambuur | 34 | 11 | 6 | 17 | 39 | 53 | 70 |
| 10 | | RKC Waalwijk | 34 | 9 | 11 | 14 | 38 | 40 | 51 |
| 11 | | NEC | 34 | 10 | 8 | 16 | 38 | 38 | 52 |
| 12 | | FC Groningen | 34 | 9 | 9 | 16 | 36 | 41 | 55 |
| 13 | | Go Ahead Eagles | 34 | 10 | 6 | 18 | 36 | 37 | 51 |
| 14 | | Sparta Rotterdam | 34 | 8 | 11 | 15 | 35 | 30 | 48 |
| 15 | | Fortuna Sittard | 34 | 10 | 5 | 19 | 35 | 36 | 67 |
| 16 | | Heracles Almelo | 34 | 9 | 7 | 18 | 34 | 33 | 49 |
| 17 | | Willem II | 34 | 9 | 6 | 19 | 33 | 32 | 57 |
| 18 | | PEC Zwolle | 34 | 7 | 6 | 21 | 27 | 26 | 52 |
Wedstrijden
| R: | Datum: | Thuis: | Uit: | Sc: | Ts: | Ar: | Details: |
|---|---|---|---|---|---|---|---|
| 1 | 13/08/2021 | Go Ahead Eagles | sc Heerenveen | 0-1 | 6.650 | Blom | 0-1 Halilovic |
| 1 | 14/08/2021 | RKC Waalwijk | AZ | 1-0 | 3.860 | Kooij | 1-0 Kramer |
| 1 | 14/08/2021 | Heracles Almelo | PSV | 0-2 | 8.053 | Makkelie | 0-1 Bruma, 0-2 Madueke |
| 1 | 14/08/2021 | Fortuna Sittard | FC Twente | 2-1 | 6.300 | Kamphuis | 0-1 Van Wolfswinkel, 1-1 Seuntjens, 2-1 Lake |
| 1 | 14/08/2021 | Ajax | NEC | 5-0 | 32.275 | Nijhuis | 1-0 Haller, 2-0 Mazraoui, 3-0 Van Rooij (e.d.), 4-0 en 5-0 Tadic |
| 1 | 15/08/2021 | SC Cambuur | FC Groningen | 1-2 | 7.000 | Lindhout | 0-1 El Massaoudi, 1-1 Maulun, 1-2 Larsen |
| 1 | 15/08/2021 | FC Utrecht | Sparta Rotterdam | 4-0 | 16.000 | Vd Kerkhof | 1-0 Maher, 2-0 Van der Maarel, 3-0 Douvikas, 4-0 Gustafrson (pen) |
| 1 | 15/08/2021 | PEC Zwolle | Vitesse | 0-1 | 9.000 | Martens | 0-1 Frederiksen |
| 1 | 15/08/2021 | Willem II | Feyenoord | 0-4 | 9.700 | Gözübüyük | 0-1 Linssen, 0-2 Sinisterra, 0-3 Til, 0-4 Bannis R: Bergström (Wil) |
| 2 | 20/08/2021 | NEC | PEC Zwolle | 2-0 | 8.500 | Vd Eijk | 1-0 Akman, 2-0 Okita; R: Kersten (PEC) |
| 2 | 21/08/2021 | sc Heerenveen | RKC Waalwijk | 3-2 | 13.600 | Nagtegaal | 1-0 H. Veerman (pen), 2-0 Halilovic 3-0 H. Veerman, 3-1 Odgaard, 3-2 Van der Venne |
| 2 | 21/08/2021 | PSV | SC Cambuur | 4-1 | 23.500 | Vd Kerkhof | 1-0 Pröpper, 2-0 Zahavi, 3-0 Madueke, 3-1 Bangura, 4-1 Boscagli |
| 2 | 21/08/2021 | Sparta Rotterdam | Heracles Almelo | 1-1 | 6.725 | Nijhuis | 1-0 Vriends, 1-1 Burgzorg |
| 2 | 21/08/2021 | FC Groningen | FC Utrecht | 0-0 | 14.800 | Makkelie | |
| 2 | 22/08/2021 | FC Twente | Ajax | 1-1 | 20.000 | Higler | 0-1 Haller, 1-1 Pröpper |
| 2 | 22/08/2021 | Feyenoord | Go Ahead Eagles | 2-0 | 34.384 | Dieperink | 1-0 en 2-0 Linssen |
| 2 | 22/08/2021 | Vitesse | Willem II | 0-3 | 10.157 | Lindhout | 0-1 Wriedt, 0-2 Nunnely, 0-3 Spieringhs |
| 3 | 27/08/2021 | Fortuna Sittard | RKC Waalwijk | 2-2 | 6.470 | Manschot | 1-0 Baghdadi, 1-1 en 1-2 Kramer, 2-2 Seuntjens |
| 3 | 28/08/2021 | SC Cambuur | FC Twente | 2-0 | 6.672 | Blom | 1-0 en 2-0 Jacobs; R: Ilic (Twe) |
| 3 | 28/08/2021 | Go Ahead Eagles | Sparta Rotterdam | 2-0 | 6.650 | Vd Laan | 1-0 Bakker (pen), 2-0 Botos; R: Pinto (Spa) |
| 3 | 28/08/2021 | PSV | FC Groningen | 5-2 | 23.447 | Gözübüyük | 1-0 Gakpo, 1-1 en 1-2 Ngonge, 2-2 El Hankouri (e.d.), 3-2 Ramalho, 4-2 Zahavi, 5-2 Bruma |
| 3 | 28/08/2021 | Willem II | PEC Zwolle | 1-0 | 9.352 | Oostrom | 1-0 Saglam |
| 3 | 29/08/2021 | FC Utrecht | Feyenoord | 3-1 | 16.000 | Higler | 0-1 Sinisterra, 1-1 Janssen, 2-1 Sylla, 3-1 Gustafson (pen) |
| 3 | 29/08/2021 | Ajax | Vitesse | 5-0 | 36.816 | Makkelie | 1-0 Antony, 2-0 Alvarez, 3-0 Gravenberch, 4-0 Hajek (e.d.), 5-0 Klaassen |
| 3 | 29/08/2021 | Heracles Almelo | NEC | 0-1 | 8.053 | Kamphuis | 0-1 Akman; R: Bakis (Her) |
| 3 | 29/08/2021 | sc Heerenveen | AZ | 1-3 | 16.000 | Nijhuis | 1-0 H. Veerman, 1-1 Pavlidis, 1-2 Witry, 1-3 De Wit |
| 4 | 11/09/2021 | FC Twente | FC Utrecht | 1-0 | 20.000 | Gözübüyük | 1-0 Pröpper |
| 4 | 11/09/2021 | PEC Zwolle | Ajax | 0-2 | 9.000 | Manschot | 0-1 en 0-2 Haller |
| 4 | 11/09/2021 | SC Cambuur | Go Ahead Eagles | 5-2 | 6.682 | Makkelie | 0-1 Brouwers, 1-1 en 2-1 Boere, 3-1 Tol, 4-1 Jacobs, 5-1 Kiss, 5-2 Cordoba |
| 4 | 11/09/2021 | AZ | PSV | 0-3 | 13.000 | Lindhout | 0-1 Boscagli, 0-2 Vertessen, 0-3 Doan |
| 4 | 12/09/2021 | NEC | Willem II | 0-0 | 8.333 | Van Boekel | R: Bondeel (Wil) |
| 4 | 12/09/2021 | Sparta Rotterdam | Fortuna Sittard | 3-1 | 6.623 | Blank | 1-0 Smeets, 2-0 Thy, 2-1 Seuntjens, 3-1 Emegha |
| 4 | 12/09/2021 | FC Groningen | sc Heerenveen | 1-1 | 15.000 | Dieperink | 0-1 Halilovic, 1-1 Ngonge; R: Te Wierik (Gro) |
| 4 | 12/09/2021 | RKC Waalwijk | Vitesse | 1-2 | 4.989 | Kamphuis | 0-1 Doekhi, 1-1 Bakari, 1-2 Gboho |
| 5 | 17/09/2021 | Sparta Rotterdam | NEC | 1-1 | 7.041 | Vd Graaf | 0-1 Okita, 1-1 Mijnans |
| 5 | 18/09/2021 | sc Heerenveen | Fortuna Sittard | 1-0 | 16.400 | Gerrets | 1-0 H. Veerman |
| 5 | 18/09/2021 | Willem II | FC Groningen | 2-1 | 9.463 | Manschot | 1-0 Wriedt, 2-0 Saddiki, 2-1 Suslov R: Ngonge (Gro) |
| 5 | 18/09/2021 | Ajax | SC Cambuur | 9-0 | 36.711 | Vd Eijk | 1-0 Timber, 2-0 Bergghuis, 3-0 Mazraoui, 4-0 Neres, 5-0 Tadic, 6-0 Daramy, 7-0 Haller, 8-0 Danilo, 9-0 Neres |
| 5 | 18/09/2021 | FC Utrecht | RKC Waalwijk | 2-0 | 16.000 | Martens | 1-0 Gustafson, 1-1 Odgaard, 1-2 Büttner, 2-2 Doufikas (pen) |
| 5 | 19/09/2021 | Go Ahead Eagles | PEC Zwolle | 1-0 | 6.600 | Blom | 1-0 Botos |
| 5 | 19/09/2021 | PSV | Feyenoord | 0-4 | 24.356 | Makkelie | 0-1 Toornstra, 0-2 Linssen, 0-3 Toornstra, 0-4 Dessers |
| 5 | 19/09/2021 | Vitesse | FC Twente | 1-4 | 13.808 | Van Boekel | 0-1 Pröpper, 0-2 Van Wolfswinkel, 0-3 Pröpper, 0-4 Vlap, 1-4 Darfalou; R: Doekhi (Vit) |
| 5 | 19/09/2021 | Heracles Almelo | AZ | 3-2 | 8.053 | Gözübüyük | 0-1 Gudmundsson, 1-1 Sierhuis, 2-1 Burgzorg, 2-2 Reijnders, 3-2 Vloet; R: Clasie (AZ) |
| 6 | 21/09/2021 | Fortuna Sittard | Ajax | 0-5 | 8.333 | Kamphuis | 0-1 Berghuis, 0-2 Mazraoui, 0-3 Tadic, 0-4 Kudus, 0-5 Tagliafico |
| 6 | 21/09/2021 | RKC Waalwijk | Willem II | 1-2 | 5.957 | Higler | 0-1 Wriedt, 0-2 Köhlert, 1-2 Meulensteen |
| 6 | 22/09/2021 | Go Ahead Eagles | PSV | 1-2 | 6.650 | Nijhuis | 0-1 Gakpo, 1-1 Cordoba, 1-2 Van Ginkel |
| 6 | 22/09/2021 | NEC | FC Utrecht | 0-3 | 8.333 | Nagtegaal | 0-1 Ramselaar, 0-2 Douvikas, 0-3 Ramselaar |
| 6 | 22/09/2021 | FC Groningen | Vitesse | 0-1 | 14.963 | Lindhout | 0-1 Gboho 0-1; R: Te Wierik, Van Kaam (Gro) |
| 6 | 22/09/2021 | Feyenoord | sc Heerenveen | 3-1 | 32.775 | Vd Kerkhof | 1-0 Til, 2-0 Linssen, 2-1 J. Veerman, 3-1 Til |
| 6 | 22/09/2021 | PEC Zwolle | Sparta Rotterdam | 1-1 | 9.000 | Perez | 0-1 Van Crooij, 1-1 Redan |
| 6 | 23/09/2021 | SC Cambuur | Heracles Almelo | 2-1 | 6.676 | Bos | 1-0 Breij, 2-0 Hoedemakers, 2-1 Bakis |
| 6 | 23/09/2021 | FC Twente | AZ | 3-1 | 18.000 | Makkelie | 1-0 Van Wolfswinkel, 2-0 Rots, 2-1 Karlsson, 3-1 Limnios |
| 7 | 25/09/2021 | Willem II | PSV | 2-1 | 14.397 | Blom | 1-0 Zahavi (e.d.), 1-1 Zahavi, 2-1 Nunnely |
| 7 | 25/09/2021 | Ajax | FC Groningen | 3-0 | 53.148 | Van Boekel | 1-0 Alvarez, 2-0 Antony, 3-0 Mazraoui |
| 7 | 25/09/2021 | Vitesse | Fortuna Sittard | 1-1 | 11.361 | Oostrom | 0-1 Seuntjens, 1-1 Frederiksen |
| 7 | 25/09/2021 | Feyenoord | NEC | 5-3 | 45.495 | Kooij | 1-0 Kökcü (pen), 2-0 Sinisterra, 2-1 Mattsson, 2-2 Odenthal, 2-3 Verdonk, 3-3 en 4-3 Til, 5-3 Dessers |
| 7 | 25/09/2021 | FC Utrecht | PEC Zwolle | 5-1 | 19.451 | Lindhout | 1-0 Douvikas (pen), 2-0 Sylla, 3-0 Ramselaar (pen), 4-0 Mahi, 4-1 Saymak, 5-1 Janssen |
| 7 | 26/09/2021 | Sparta Rotterdam | SC Cambuur | 0-4 | 8.645 | Vd Kerkhof | 0-1 Bangoura, 0-2 en 0-3 Kallon, 0-4 Boere R: Meijers (Spa) |
| 7 | 26/09/2021 | AZ | Go Ahead Eagles | 5-0 | 13.612 | Higler | 1-0 Karlsson, 2-0 De Wit, 3-0 Karlsson (pen), 4-0 Aboukhlal, 5-0 Reijnders |
| 7 | 26/09/2021 | sc Heerenveen | FC Twente | 2-3 | 18.500 | Manschot | 0-1 Van Wolfswinkel (pen), 0-2 Rots, 0-3 Van Beek (e.d.), 1-3 Pröpper (e,d.), 2-3 H. Veerman |
| 7 | 26/09/2021 | Heracles Almelo | RKC Waalwijk | 1-0 | 10.035 | Nijhuis | 1-0 Burgzorg |
| 8 | 01/10/2021 | FC Groningen | FC Twente | 1-1 | 16.250 | Vd Kerkhof | 1-0 Ngonge, 1-1 Ugalde |
| 8 | 02/10/2021 | RKC Waalwijk | Go Ahead Eagles | 1-1 | 6.018 | Blank | 0-1 Cordoba, 1-1 Büttner (pen) |
| 8 | 02/10/2021 | Heracles Almelo | Willem II | 3-2 | 9.251 | Dieperink | 1-0 Vloet (pen), 2-0 Burgzorg, 2-1 Köhlert, 2-2 Svensson, 3-2 Azzaoui |
| 8 | 02/10/2021 | PEC Zwolle | sc Heerenveen | 0-1 | 13.655 | Higler | 0-1 Van Polen (e.d.) |
| 8 | 02/10/2021 | Fortuna Sittard | NEC | 1-3 | 7.011 | Manschot | 0-1 Okita, 0-2 Tavsan, 1-2 Seuntjens (pen), 1-3 Bruijn |
| 8 | 03/10/2021 | Ajax | FC Utrecht | 0-1 | 52.621 | Nijhuis | 0-1 Warmerdam |
| 8 | 03/10/2021 | SC Cambuur | AZ | 1-3 | 10.000 | Kamphuis | 0-1 De Wit, 0-2 Wijndal, 0-3 Clasie, 1-3 Uldrikis R: Bangoura (Cam) |
| 8 | 03/10/2021 | Vitesse | Feyenoord | 2-1 | 14.238 | Gözübüyük | 1-0 Openda, 1-1 Til, 2-1 Openda R: Bero, Buitink (Vit) |
| 8 | 03/10/2021 | PSV | Sparta Rotterdam | 2-1 | 30.500 | Vd Eijk | 1-0 Sangaré, 2-0 Thomas, 2-1 Thy |
| 9 | 16/10/2021 | Feyenoord | RKC Waalwijk | 2-2 | 47.183 | Van Boekel | 1-0 Toornstra, 1-1 Odgaard, 1-2 Anita, 2-2 Til |
| 9 | 16/10/2021 | Go Ahead Eagles | Heracles Almelo | 4-2 | 9.701 | Martens | 1-0 Brouwers, 1-1 Vloet, 2-1 Knoester (e.d.), 3-1 Brouwers, 3-2 rente, 4-2 Deijl R: Botos, Lidberg (GoA) |
| 9 | 16/10/2021 | sc Heerenveen | Ajax | 0-2 | 25.133 | Makkelie | 0-1 Haller, 0-2 Neres |
| 9 | 16/10/2021 | Fortuna Sittard | SC Cambuur | 1-0 | 6.873 | Higler | 1-0 Cox |
| 9 | 16/10/2021 | PSV | PEC Zwolle | 3-1 | 30.500 | Kooij | 0-1 Redan, 1-1 Ramalho, 2-2 Gakpo, 3-1 Boscagli |
| 9 | 17/10/2021 | AZ | FC Utrecht | 5-1 | 17.037 | Blom | 1-0 Pavlidis, 2-0 Karlsson, 3-0 en 4-0 De Wit, 5-0 Gudmundsson (pen), 5-1 Timber |
| 9 | 17/10/2021 | NEC | Vitesse | 0-1 | 12.500 | Lindhout | 0-1 Frederiksen |
| 9 | 17/10/2021 | Sparta Rotterdam | FC Groningen | 1-1 | 9.038 | Gözübüyük | 0-1 Ngonge, 1-1 Smeets |
| 9 | 17/10/2021 | FC Twente | Willem II | 1-1 | 27.000 | Kamphuis | 1-0 Limnios, 1-1 Nunnely R: Zerrouki (Twe), Köhn (Wil) |
| 10 | 22/10/2021 | Willem II | Fortuna Sittard | 1-1 | 14.057 | Vd Laan | 0-1 Noslin, 1-1 Köhlert |
| 10 | 23/10/2021 | FC Utrecht | sc Heerenveen | 2-1 | 21.875 | Kamphuis | 1-0 Sylla, 1-1 Janssen (e.d.), 2-1 Van de Streek |
| 10 | 23/10/2021 | PEC Zwolle | Heracles Almelo | 1-0 | 13.026 | Nagtegaal | 1-0 Van Polen (pen) |
| 10 | 23/10/2021 | RKC Waalwijk | Sparta Rotterdam | 1-0 | 5.304 | Manschot | 1-0 Kramer |
| 10 | 24/10/2021 | FC Twente | NEC | 1-2 | 26.000 | Blom | 0-1 Tavsan, 1-1 Misidjan, 1-2 Vet |
| 10 | 24/10/2021 | SC Cambuur | Feyenoord | 2-3 | 10.000 | Nijhuis | 1-0 Sambissa, 1-1 Linssen, 1-2 Aursnes, 2-2 Sambissa, 2-3 Malacia |
| 10 | 24/10/2021 | Vitesse | Go Ahead Eagles | 1-2 | 12.783 | Higler | 1-0 Openda (pen), 1-1 Cordoba, 1-2 Brouwers (p) |
| 10 | 24/10/2021 | Ajax | PSV | 5-0 | 53.585 | Gözübüyük | 1-0 Berghuis, 2-0 Haller, 3-0 Antony, 4-0 Klaassen, 5-0 Tadic |
| 10 | 24/10/2021 | FC Groningen | AZ | 2-0 | 11.300 | Makkelie | 1-0 Ngonge, 2-0 De Leeuw |
| 11 | 30/10/2021 | PSV | FC Twente | 5-2 | 32.500 | Makkelie | 0-1 Vlap, 1-1 Vertessen, 2-1 Zahavi, 2-2 Zerrouki, 3-2 Vertessen, 4-2 en 5-2 Vinicius |
| 11 | 30/10/2021 | Heracles Almelo | Ajax | 0-0 | 12.080 | Manschot | |
| 11 | 30/10/2021 | sc Heerenveen | Vitesse | 1-2 | 17.187 | Vd Kerkhof | 1-0 Van Ewijk, 1-1 en 1-2 Openda R: Dresevic (Hee) |
| 11 | 30/10/2021 | AZ | PEC Zwolle | 3-2 | 15.328 | Gözübüyük | 0-1 en 0-2 M. de Wit, 1-2 D. de Wit, 2-2 en 3-2 Pavlidis |
| 11 | 31/10/2021 | Sparta Rotterdam | Feyenoord | 0-1 | 10.599 | Blom | 0-1 Dessers |
| 11 | 31/10/2021 | NEC | FC Groningen | 3-0 | 0 | Oostrom | 1-0 Akman, 2-0 Tavsan, 3-0 Okita |
| 11 | 31/10/2021 | RKC Waalwijk | SC Cambuur | 0-1 | 4.754 | Vd Graaf | 0-1 Kallon |
| 11 | 31/10/2021 | FC Utrecht | Willem II | 5-1 | 20.469 | Van Boekel | 1-0 en 2-0 Ramselaar, 2-1 Wriedt, 3-1 Ramselaar, 4-1 Mallahi, 5-2 Van Overeem |
| 11 | 31/10/2021 | Go Ahead Eagles | Fortuna Sittard | 4-3 | 8.807 | Bos | 0-1 Seuntjens, 0-2 Rienstra, 1-2 Brouwers, 1-3 Tekie, 2-3 Cardona, 3-3 Cordoba, 4-3 Kramer |
| 12 | 05/11/2021 | FC Twente | Heracles Almelo | 1-0 | 30.000 | Higler | 1-0 Hilgers |
| 12 | 06/11/2021 | NEC | sc Heerenveen | 1-1 | 0 | Nijhuis | 1-0 Akman, 1-1 Veerman |
| 12 | 06/11/2021 | Willem II | Sparta Rotterdam | 0-3 | 13.028 | Kooij | 0-1 en 0-2 Vriends, 0-3 Emegha |
| 12 | 06/11/2021 | PEC Zwolle | SC Cambuur | 1-2 | 13.098 | Vd Eijk | 0-1 Hoedemakers, 0-2 Maulun, 1-2 Huiberts |
| 12 | 07/11/2021 | FC Groningen | RKC Waalwijk | 1-1 | 20.313 | Blom | 0-1 Kramer, 1-1 Strand Larsen |
| 12 | 07/11/2021 | Fortuna Sittard | PSV | 1-4 | 9.527 | Van Boekel | 0-1 Doan, 0-2 Bruma, 0-3 Sangaré, 1-3 Ramalho (e.d.), 1-4 Bruma |
| 12 | 07/11/2021 | Vitesse | FC Utrecht | 2-1 | 15.867 | Kamphuis | 1-0 Frederiksen, 2-0 Bazoer, 2-1 Zagré |
| 12 | 07/11/2021 | Feyenoord | AZ | 1-0 | 47.500 | Lindhout | 1-0 Dessers |
| 12 | 07/11/2021 | Ajax | Go Ahead Eagles | 0-0 | 53.497 | Dieperink | |
| 13 | 20/11/2021 | PSV | Vitesse | 2-0 | 0 | Nijhuis | 1-0 Sangaré, 2-0 Bruma |
| 13 | 20/11/2021 | Sparta Rotterdam | FC Twente | 0-1 | 0 | Vd Graaf | 0-1 Van Wolfswinkel (pen) |
| 13 | 20/11/2021 | AZ | NEC | 1-1 | 0 | Manschot | 0-1 Bruijn, 1-1 Aboukhlal |
| 13 | 20/11/2021 | Heracles Almelo | Fortuna Sittard | 3-1 | 0 | Makkelie | 1-0 Azzaoui, 1-1 Flemming, 2-1 Azzaoui, 3-1 Sierhuis |
| 13 | 21/11/2021 | Go Ahead Eagles | FC Groningen | 0-1 | 0 | Vd Eijk | 0-1 Strand Larsen; R: Cordoba, Kramer (GoA) |
| 13 | 21/11/2021 | Feyenoord | PEC Zwolle | 4-0 | 0 | Vd Kerkhof | 1-0 Linssen, 2-0 Sinisterra, 3-0 Linssen, 4-0 Til |
| 13 | 21/11/2021 | sc Heerenveen | Willem II | 2-1 | 0 | Gözübüyük | 0-1 Nunnely, 1-1 Stefanovic, 2-1 Bakker R: Musaba (Hee), Nelom (Wil) |
| 13 | 21/11/2021 | RKC Waalwijk | Ajax | 0-5 | 0 | Lindhout | 0-1 Haller, 0-2 en 0-3 Berghuis, 0-4 Timber, 0-5 Haller |
| 13 | 21/11/2021 | SC Cambuur | FC Utrecht | 2-1 | 0 | Higler | 1-0 Uldrikis, 1-1 Sylla, 2-1 Jacobs |
| 14 | 26/11/2021 | NEC | SC Cambuur | 2-3 | 0 | Dieperink | 0-1 Jacobs, 1-1 Barreto, 2-1 Akman, 2-2 Uldrikis, 2-3 Bangoura |
| 14 | 27/11/2021 | Fortuna Sittard | FC Groningen | 1-4 | 0 | Manschot | 1-0 Seuntjens, 1-1 Ngonge, 1-2 Cox (e.d.), 1-3 Irandust, 1-4 Strand Larsen; R: Janssen (For) |
| 14 | 27/11/2021 | PEC Zwolle | RKC Waalwijk | 0-0 | 0 | Kooij | |
| 14 | 27/11/2021 | Willem II | Go Ahead Eagles | 0-1 | 0 | Gerrets | 0-1 Lucassen |
| 14 | 28/11/2021 | Sparta Rotterdam | Ajax | 0-1 | 0 | Kamphuis | 0-1 Tadic |
| 14 | 28/11/2021 | FC Utrecht | Heracles Almelo | 1-0 | 0 | Vd Kerkhof | 1-0 Knoester (e.d.) |
| 14 | 28/11/2021 | FC Twente | Feyenoord | 0-0 | 0 | Higler | |
| 14 | 28/11/2021 | sc Heerenveen | PSV | 1-1 | 0 | Lindhout | 0-1 Vinicius, 1-1 Al Hajj |
| 14 | 28/11/2021 | Vitesse | AZ | 0-0 | 0 | Makkelie | |
| 4 | 01/12/2021 | Feyenoord | Heracles Almelo | 2-1 | 0 | Nijhuis | 0-1 Bakis, 1-1 en 2-1 Sinisterra |
| 2 | 02/12/2021 | AZ | Fortuna Sittard | 2-1 | 0 | Higler | 0-1 Flemming, 1-1 Pavlidis, 2-1 Karlsson |
| 15 | 02/12/2021 | Ajax | Willem II | 5-0 | 0 | Vd Graaf | 1-0 Antony, 2-0 Martinez, 3-0 Antony, 4-0 Klaassen, 5-0 Danilo |
| 15 | 03/12/2021 | FC Groningen | PEC Zwolle | 1-1 | 0 | Martens | 0-1 De Wit, 1-1 Van den Belt (e.d.) |
| 15 | 04/12/2021 | PSV | FC Utrecht | 4-1 | 0 | Makkelie | 0-1 Van der Hoorn, 1-1 Gakpo, 2-1 Ramalho, 3-1 Doan, 4-1 Mwene |
| 15 | 04/12/2021 | SC Cambuur | Vitesse | 1-6 | 0 | Gözübüyük | 0-1 Tronstad, 0-2 Openda, 0-3 Buitink, 1-3 Tol, 1-4 Tronstad, 1-5 Openda, 1-6 Frederiksen |
| 15 | 04/12/2021 | Heracles Almelo | sc Heerenveen | 0-1 | 0 | Van Boekel | 0-1 J. Veerman |
| 15 | 05/12/2021 | RKC Waalwijk | NEC | 2-1 | 0 | Higler | 0-1 Bruijn, 1-1 Odgaard, 2-1 Kuipers |
| 15 | 05/12/2021 | AZ | Sparta Rotterdam | 3-1 | 0 | Vd Eijk | 0-1 Auassar, 1-1 (pen) en 2-1 Karlsson, 3-1 Pavlidis |
| 15 | 05/12/2021 | Go Ahead Eagles | FC Twente | 1-2 | 0 | Lindhout | 1-0 Cordoba, 1-1 Van Wolfswinkel, 1-2 Zerrouki |
| 15 | 05/12/2021 | Feyenoord | Fortuna Sittard | 5-0 | 0 | Dieperink | 1-0 Til, 2-0 en 3-0 Linssen, 4-0 Sinisterra, 5-0 Jahanbakhsh |
| 16 | 10/12/2021 | Willem II | SC Cambuur | 0 | |||
| 16 | 11/12/2021 | FC Utrecht | Go Ahead Eagles | 0 | |||
| 16 | 11/12/2021 | sc Heerenveen | Sparta Rotterdam | 0 | |||
| 16 | 11/12/2021 | PEC Zwolle | Fortuna Sittard | 0 | |||
| 16 | 12/12/2021 | FC Twente | RKC Waalwijk | 0 | |||
| 16 | 12/12/2021 | FC Groningen | Feyenoord | 0 | |||
| 16 | 12/12/2021 | Vitesse | Heracles Almelo | 0 | |||
| 16 | 12/12/2021 | Ajax | AZ | 0 | |||
| 16 | 12/12/2021 | NEC | PSV | 0 | |||
| 17 | 17/12/2021 | Fortuna Sittard | FC Utrecht | 0 | |||
| 17 | 18/12/2021 | Sparta Rotterdam | Vitesse | 0 | |||
| 17 | 18/12/2021 | AZ | Willem II | 0 | |||
| 17 | 18/12/2021 | Heracles Almelo | FC Groningen | 0 | |||
| 17 | 18/12/2021 | PEC Zwolle | FC Twente | 0 | |||
| 17 | 19/12/2021 | SC Cambuur | sc Heerenveen | 0 | |||
| 17 | 19/12/2021 | Feyenoord | Ajax | 0 | |||
| 17 | 19/12/2021 | Go Ahead Eagles | NEC | 0 | |||
| 17 | 19/12/2021 | RKC Waalwijk | PSV | 0 | |||
| 18 | 21/12/2021 | Vitesse | PEC Zwolle | 0 | |||
| 18 | 21/12/2021 | AZ | FC Groningen | 0 | |||
| 18 | 22/12/2021 | Heracles Almelo | SC Cambuur | 0 | |||
| 18 | 22/12/2021 | Sparta Rotterdam | RKC Waalwijk | 0 | |||
| 18 | 22/12/2021 | sc Heerenveen | Feyenoord | 0 | |||
| 18 | 22/12/2021 | FC Utrecht | FC Twente | 0 | |||
| 18 | 22/12/2021 | Willem II | NEC | 0 | |||
| 18 | 23/12/2021 | PSV | Go Ahead Eagles | 0 | |||
| 18 | 23/12/2021 | Ajax | Fortuna Sittard | 0 | |||
| 19 | 14/01/2022 | PEC Zwolle | Willem II | 0 | |||
| 19 | 15/01/2022 | Feyenoord | Vitesse | 0 | |||
| 19 | 15/01/2022 | NEC | Heracles Almelo | 0 | |||
| 19 | 15/01/2022 | FC Groningen | PSV | 0 | |||
| 19 | 15/01/2022 | Go Ahead Eagles | RKC Waalwijk | 0 | |||
| 19 | 16/01/2022 | FC Utrecht | Ajax | 0 | |||
| 19 | 16/01/2022 | SC Cambuur | Sparta Rotterdam | 0 | |||
| 19 | 16/01/2022 | FC Twente | sc Heerenveen | 0 | |||
| 19 | 16/01/2022 | Fortuna Sittard | AZ | 0 | |||
| 20 | 22/01/2022 | Vitesse | FC Groningen | 0 | |||
| 20 | 22/01/2022 | AZ | SC Cambuur | 0 | |||
| 20 | 22/01/2022 | Willem II | FC Twente | 0 | |||
| 20 | 23/01/2022 | NEC | Feyenoord | 0 | |||
| 20 | 23/01/2022 | Heracles Almelo | Go Ahead Eagles | 0 | |||
| 20 | 23/01/2022 | PSV | Ajax | 0 | |||
| 20 | 23/01/2022 | Sparta Rotterdam | FC Utrecht | 0 | |||
| 21 | 05/02/2022 | FC Utrecht | SC Cambuur | 3-2 | 8.000 | Vd Graaf | |
| 21 | 05/02/2022 | Fortuna Sittard | sc Heerenveen | ||||
| 21 | 05/02/2022 | PEC Zwolle | NEC | ||||
| 21 | 05/02/2022 | PSV | AZ | ||||
| 21 | 05/02/2022 | FC Twente | Vitesse | ||||
| 21 | 06/02/2022 | Feyenoord | Sparta Rotterdam | ||||
| 21 | 06/02/2022 | FC Groningen | Go Ahead Eagles | ||||
| 21 | 06/02/2022 | Willem II | RKC Waalwijk | ||||
| 21 | 06/02/2022 | Ajax | Heracles Almelo | ||||
| 22 | 13/02/2022 | Ajax | FC Twente | 5-0 | 17.859 | ||
| 22 | 12/02/2022 | FC Groningen | Fortuna Sittard | ||||
| 22 | 12/02/2022 | Go Ahead Eagles | AZ | ||||
| 22 | 12/02/2022 | Heracles Almelo | FC Utrecht | ||||
| 22 | 12/02/2022 | RKC Waalwijk | Feyenoord | ||||
| 22 | 12/02/2022 | SC Cambuur | PEC Zwolle | ||||
| 22 | 12/02/2022 | sc Heerenveen | NEC | ||||
| 22 | 12/02/2022 | Sparta Rotterdam | Willem II | ||||
| 22 | 12/02/2022 | Vitesse | PSV | ||||
| 23 | 19/02/2022 | AZ | Heracles Almelo | ||||
| 23 | 19/02/2022 | FC Utrecht | Vitesse | ||||
| 23 | 19/02/2022 | Feyenoord | SC Cambuur | ||||
| 23 | 19/02/2022 | Fortuna Sittard | Sparta Rotterdam | ||||
| 23 | 19/02/2022 | NEC | RKC Waalwijk | ||||
| 23 | 19/02/2022 | PEC Zwolle | FC Groningen | ||||
| 23 | 19/02/2022 | PSV | sc Heerenveen | ||||
| 23 | 19/02/2022 | FC Twente | Go Ahead Eagles | ||||
| 23 | 19/02/2022 | Willem II | Ajax | ||||
| 20 | 21/02/2022 | RKC Waalwijk | Fortuna Sittard | ||||
| 20 | 21/02/2022 | sc Heerenveen | PEC Zwolle | ||||
| 24 | 26/02/2022 | AZ | Feyenoord | ||||
| 24 | 26/02/2022 | FC Groningen | Willem II | ||||
| 24 | 26/02/2022 | Go Ahead Eagles | Ajax | ||||
| 24 | 26/02/2022 | Heracles Almelo | PEC Zwolle | ||||
| 24 | 26/02/2022 | RKC Waalwijk | FC Twente | ||||
| 24 | 26/02/2022 | SC Cambuur | Fortuna Sittard | ||||
| 24 | 26/02/2022 | sc Heerenveen | FC Utrecht | ||||
| 24 | 26/02/2022 | Sparta Rotterdam | PSV | ||||
| 24 | 26/02/2022 | Vitesse | NEC | ||||
| 25 | 02/03/2022 | Ajax | RKC Waalwijk | ||||
| 25 | 05/03/2022 | Feyenoord | FC Groningen | ||||
| 25 | 08/03/2022 | Fortuna Sittard | PEC Zwolle | ||||
| 25 | 11/03/2022 | Go Ahead Eagles | FC Utrecht | ||||
| 26 | 12/03/2022 | AZ | FC Twente | ||||
| 26 | 12/03/2022 | FC Groningen | NEC | ||||
| 26 | 12/03/2022 | FC Utrecht | PSV | ||||
| 26 | 12/03/2022 | Fortuna Sittard | Willem II | ||||
| 26 | 12/03/2022 | Heracles Almelo | Vitesse | ||||
| 26 | 12/03/2022 | PEC Zwolle | Feyenoord | ||||
| 26 | 12/03/2022 | RKC Waalwijk | sc Heerenveen | ||||
| 26 | 12/03/2022 | SC Cambuur | Ajax | ||||
| 26 | 12/03/2022 | Sparta Rotterdam | Go Ahead Eagles | ||||
| 25 | 14/03/2022 | NEC | AZ | ||||
| 25 | 17/03/2022 | PSV | Heracles Almelo | ||||
| 27 | 19/03/2022 | Ajax | Feyenoord | ||||
| 27 | 19/03/2022 | FC Utrecht | FC Groningen | ||||
| 27 | 19/03/2022 | Go Ahead Eagles | SC Cambuur | ||||
| 27 | 19/03/2022 | NEC | Sparta Rotterdam | ||||
| 27 | 19/03/2022 | PSV | Fortuna Sittard | ||||
| 27 | 19/03/2022 | sc Heerenveen | Heracles Almelo | ||||
| 27 | 19/03/2022 | FC Twente | PEC Zwolle | ||||
| 27 | 19/03/2022 | Vitesse | RKC Waalwijk | ||||
| 27 | 19/03/2022 | Willem II | AZ | ||||
| 25 | 20/03/2022 | FC Twente | SC Cambuur | ||||
| 25 | 23/03/2022 | Vitesse | Sparta Rotterdam | ||||
| 25 | 26/03/2022 | Willem II | sc Heerenveen | ||||
| 28 | 02/04/2022 | AZ | Vitesse | ||||
| 28 | 02/04/2022 | FC Groningen | Ajax | ||||
| 28 | 02/04/2022 | Feyenoord | Willem II | ||||
| 28 | 02/04/2022 | Fortuna Sittard | Heracles Almelo | ||||
| 28 | 02/04/2022 | PEC Zwolle | Go Ahead Eagles | ||||
| 28 | 02/04/2022 | RKC Waalwijk | FC Utrecht | ||||
| 28 | 02/04/2022 | SC Cambuur | NEC | ||||
| 28 | 02/04/2022 | Sparta Rotterdam | sc Heerenveen | ||||
| 28 | 02/04/2022 | FC Twente | PSV | ||||
| 29 | 09/04/2022 | Ajax | Sparta Rotterdam | ||||
| 29 | 09/04/2022 | FC Utrecht | Fortuna Sittard | ||||
| 29 | 09/04/2022 | Go Ahead Eagles | Willem II | ||||
| 29 | 09/04/2022 | Heracles Almelo | Feyenoord | ||||
| 29 | 09/04/2022 | NEC | FC Twente | ||||
| 29 | 09/04/2022 | PEC Zwolle | AZ | ||||
| 29 | 09/04/2022 | PSV | RKC Waalwijk | ||||
| 29 | 09/04/2022 | sc Heerenveen | FC Groningen | ||||
| 29 | 09/04/2022 | Vitesse | SC Cambuur | ||||
| 30 | 23/04/2022 | AZ | sc Heerenveen | ||||
| 30 | 23/04/2022 | FC Groningen | Heracles Almelo | ||||
| 30 | 23/04/2022 | Feyenoord | FC Utrecht | ||||
| 30 | 23/04/2022 | Fortuna Sittard | Go Ahead Eagles | ||||
| 30 | 23/04/2022 | NEC | Ajax | ||||
| 30 | 23/04/2022 | RKC Waalwijk | PEC Zwolle | ||||
| 30 | 23/04/2022 | SC Cambuur | PSV | ||||
| 30 | 23/04/2022 | FC Twente | Sparta Rotterdam | ||||
| 30 | 23/04/2022 | Willem II | Vitesse | ||||
| 31 | 30/04/2022 | Ajax | PEC Zwolle | ||||
| 31 | 30/04/2022 | FC Utrecht | NEC | ||||
| 31 | 30/04/2022 | Fortuna Sittard | Feyenoord | ||||
| 31 | 30/04/2022 | Go Ahead Eagles | Vitesse | ||||
| 31 | 30/04/2022 | Heracles Almelo | FC Twente | ||||
| 31 | 30/04/2022 | PSV | Willem II | ||||
| 31 | 30/04/2022 | RKC Waalwijk | FC Groningen | ||||
| 31 | 30/04/2022 | sc Heerenveen | SC Cambuur | ||||
| 31 | 30/04/2022 | Sparta Rotterdam | AZ | ||||
| 32 | 07/05/2022 | AZ | Ajax | ||||
| 32 | 07/05/2022 | FC Groningen | Sparta Rotterdam | ||||
| 32 | 07/05/2022 | Feyenoord | PSV | ||||
| 32 | 07/05/2022 | NEC | Go Ahead Eagles | ||||
| 32 | 07/05/2022 | PEC Zwolle | FC Utrecht | ||||
| 32 | 07/05/2022 | SC Cambuur | RKC Waalwijk | ||||
| 32 | 07/05/2022 | FC Twente | Fortuna Sittard | ||||
| 32 | 07/05/2022 | Vitesse | sc Heerenveen | ||||
| 32 | 07/05/2022 | Willem II | Heracles Almelo | ||||
| 33 | 11/05/2022 | Ajax | sc Heerenveen | ||||
| 33 | 11/05/2022 | FC Utrecht | AZ | ||||
| 33 | 11/05/2022 | Fortuna Sittard | Vitesse | ||||
| 33 | 11/05/2022 | Go Ahead Eagles | Feyenoord | ||||
| 33 | 11/05/2022 | PSV | NEC | ||||
| 33 | 11/05/2022 | RKC Waalwijk | Heracles Almelo | ||||
| 33 | 11/05/2022 | SC Cambuur | Willem II | ||||
| 33 | 11/05/2022 | Sparta Rotterdam | PEC Zwolle | ||||
| 33 | 11/05/2022 | FC Twente | FC Groningen | ||||
| 34 | 15/05/2022 | AZ | RKC Waalwijk | ||||
| 34 | 15/05/2022 | FC Groningen | SC Cambuur | ||||
| 34 | 15/05/2022 | Feyenoord | FC Twente | ||||
| 34 | 15/05/2022 | Heracles Almelo | Sparta Rotterdam | ||||
| 34 | 15/05/2022 | NEC | Fortuna Sittard | ||||
| 34 | 15/05/2022 | PEC Zwolle | PSV | ||||
| 34 | 15/05/2022 | sc Heerenveen | Go Ahead Eagles | ||||
| 34 | 15/05/2022 | Vitesse | Ajax | ||||
| 34 | 15/05/2022 | Willem II | FC Utrecht |